| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tuberculosis | D014376 | 20 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
Lipoxin A4
Lipoxin a4 is a lipid of Fatty Acyls (FA) class. Lipoxin a4 is associated with abnormalities such as Asthma, Cystic Fibrosis, Pneumonia, Obesity and Septicemia. The involved functions are known as Inflammation, Signal, Signal Transduction, Regulation and Metabolic Inhibition. Lipoxin a4 often locates in Immune system, Blood, soluble, Extracellular and Splenic Tissue. The associated genes with Lipoxin A4 are FPR2 gene, Homologous Gene, SAA1 gene, Trp-Lys-Tyr-Met-Val-Met and Annexin 1. The related lipids are Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Lipoxin A4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Lipoxin A4?
Lipoxin A4 is suspected in Asthma, Cystic Fibrosis, Chagas Cardiomyopathy, Pneumonia, Obesity, Septicemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Immunol. (2)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Antimicrob. Agents Chemother. (1)
- Others (7)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Lipoxin A4
PubChem Associated disorders and diseases
What pathways are associated with Lipoxin A4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Lipoxin A4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Lipoxin A4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Lipoxin A4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Lipoxin A4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Lipoxin A4?
Knock-out
Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Lipoxin A4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Serhan CN et al. | Aspirin-triggered 15-epi-lipoxin A4 and stable analogs on lipoxin A4 are potent inhibitors of acute inflammation. Receptors and pathways. | 1999 | Adv. Exp. Med. Biol. | pmid:10086190 |
| Lin KT et al. | Modulation of LTB4 receptor in T-lymphocytes by lipoxin A4 (LXA4) and its role in delayed-type hypersensitivity. | 1999 | Adv. Exp. Med. Biol. | pmid:10086191 |
| Gewirtz AT et al. | LXA4, aspirin-triggered 15-epi-LXA4, and their analogs selectively downregulate PMN azurophilic degranulation. | 1999 | Am. J. Physiol. | pmid:10199831 |
| Levy BD et al. | Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a 'stop' signaling switch for aspirin-triggered lipoxin A4. | 1999 | FASEB J. | pmid:10224233 |
| Spokas EG et al. | Leukotrienes, lipoxins, and hydroxyeicosatetraenoic acids. | 1999 | Methods Mol. Biol. | pmid:10343320 |
| Serhan CN et al. | Lipoxin and aspirin-triggered 15-epi-lipoxin cellular interactions anti-inflammatory lipid mediators. | 1999 | Clin. Chem. Lab. Med. | pmid:10353476 |
| Schaldach CM et al. | Lipoxin A4: a new class of ligand for the Ah receptor. | 1999 | Biochemistry | pmid:10360957 |
| Hachicha M et al. | Lipoxin (LX)A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor 1alpha-initiated neutrophil responses and trafficking: regulators of a cytokine-chemokine axis. | 1999 | J. Exp. Med. | pmid:10377187 |
| Clish CB et al. | Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393980 |
| Besse A et al. | Prostaglandin E2 regulates macrophage colony stimulating factor secretion by human bone marrow stromal cells. | 1999 | Biochim. Biophys. Acta | pmid:10395955 |
| Chiang N et al. | Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion. | 1999 | J. Clin. Invest. | pmid:10430612 |
| Kikuta Y et al. | Purification and characterization of recombinant rat hepatic CYP4F1. | 1999 | Arch. Biochem. Biophys. | pmid:10486137 |
| Titos E et al. | Hepatocytes are a rich source of novel aspirin-triggered 15-epi-lipoxin A(4). | 1999 | Am. J. Physiol. | pmid:10564079 |
| Bratt J and Heimbürger M | Prednisolone interferes with neutrophil adhesion and neutrophil mediated endothelial injury. | 1999 | Scand. J. Rheumatol. | pmid:10568428 |
| Filep JG et al. | Anti-inflammatory actions of lipoxin A(4) stable analogs are demonstrable in human whole blood: modulation of leukocyte adhesion molecules and inhibition of neutrophil-endothelial interactions. | 1999 | Blood | pmid:10590058 |
| Bandeira-Melo C et al. | Cyclooxygenase-2-derived prostaglandin E2 and lipoxin A4 accelerate resolution of allergic edema in Angiostrongylus costaricensis-infected rats: relationship with concurrent eosinophilia. | 2000 | J. Immunol. | pmid:10623853 |
| Godson C et al. | Cutting edge: lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages. | 2000 | J. Immunol. | pmid:10657608 |
| Bandeira-Melo C et al. | Cutting edge: lipoxin (LX) A4 and aspirin-triggered 15-epi-LXA4 block allergen-induced eosinophil trafficking. | 2000 | J. Immunol. | pmid:10679058 |
| Sodin-Semrl S et al. | Lipoxin A4 inhibits IL-1 beta-induced IL-6, IL-8, and matrix metalloproteinase-3 production in human synovial fibroblasts and enhances synthesis of tissue inhibitors of metalloproteinases. | 2000 | J. Immunol. | pmid:10679106 |
| Pouliot M and Serhan CN | Lipoxin A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor-alpha-initiated neutrophil responses and trafficking: novel regulators of a cytokine-chemokine axis relevant to periodontal diseases. | 1999 | J. Periodont. Res. | pmid:10685363 |
| Desplat V et al. | Incorporation and effect of arachidonic acid on the growth of human myeloma cell lines. | 1999 | Mediators Inflamm. | pmid:10704149 |
| Chiang N et al. | Activation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation. | 2000 | J. Exp. Med. | pmid:10748237 |
| Tornhamre S et al. | 15-Lipoxygenation of leukotriene A(4). Studies Of 12- and 15-lipoxygenase efficiency to catalyze lipoxin formation. | 2000 | Biochim. Biophys. Acta | pmid:10760478 |
| Pouliot M et al. | Lipoxin A(4) analogues inhibit leukocyte recruitment to Porphyromonas gingivalis: a role for cyclooxygenase-2 and lipoxins in periodontal disease. | 2000 | Biochemistry | pmid:10769133 |
| Clish CB et al. | Local and systemic delivery of an aspirin-triggered lipoxin stable analog inhibits neutrophil trafficking. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818463 |
| Clish CB et al. | Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-onoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation. | 2000 | J. Biol. Chem. | pmid:10837478 |
| Denizot Y et al. | Effect of cytokines and lipid mediators on the synthesis of interleukin 1 beta by human bone marrow stromal cells. | 2000 | Cytokine | pmid:10857767 |
| McMahon B et al. | Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. Differential activation of MAP kinases through distinct receptors. | 2000 | J. Biol. Chem. | pmid:10869343 |
| Sanak M et al. | Aspirin-tolerant asthmatics generate more lipoxins than aspirin-intolerant asthmatics. | 2000 | Eur. Respir. J. | pmid:10933083 |
| Gewirtz AT and Madara JL | Lipoxin-stable analogs: potential therapeutic downregulators of intestinal inflammation. | 2000 | Ernst Schering Res. Found. Workshop | pmid:10943333 |
| Serhan CN and Clish CB | Aspirin triggered lipid mediators: novel inhibitors of leucocyte trafficking. | 2000 | Thorax | pmid:10992546 |
| Maderna P et al. | Influence of lipoxin A(4) and other lipoxygenase-derived eicosanoids on tissue factor expression. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:11003574 |
| Kang Y et al. | Mutations of serine 236-237 and tyrosine 302 residues in the human lipoxin A4 receptor intracellular domains result in sustained signaling. | 2000 | Biochemistry | pmid:11063592 |
| Desplat V et al. | Effects of lipoxygenase metabolites of arachidonic acid on the growth of human blood CD34(+) progenitors. | 2000 | Blood Cells Mol. Dis. | pmid:11112380 |
| Gronert K et al. | Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses. | 2001 | Am. J. Pathol. | pmid:11141472 |
| Kikuta Y et al. | Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14. | 2000 | Arch. Biochem. Biophys. | pmid:11185557 |
| Serhan CN et al. | Cutting edge: nociceptin stimulates neutrophil chemotaxis and recruitment: inhibition by aspirin-triggered-15-epi-lipoxin A4. | 2001 | J. Immunol. | pmid:11238602 |
| Wada K et al. | Inosine monophosphate and aspirin-triggered 15-epi-lipoxin A4 act in concert to regulate neutrophil trafficking: additive actions of two new endogenous anti-inflammatory mediators. | 2001 | J. Hematother. Stem Cell Res. | pmid:11276361 |
| Fierro IM and Serhan CN | Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins. | 2001 | Braz. J. Med. Biol. Res. | pmid:11323741 |
| Levy BD et al. | Lipid mediator class switching during acute inflammation: signals in resolution. | 2001 | Nat. Immunol. | pmid:11429545 |
| Wardle N | New vistas in anti-inflammatory therapy. | 2001 | Nephron | pmid:11474222 |
| McMahon B et al. | Lipoxins: revelations on resolution. | 2001 | Trends Pharmacol. Sci. | pmid:11478982 |
| Goh J et al. | Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo. | 2001 | J. Immunol. | pmid:11509622 |
| Qiu FH et al. | Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils. | 2001 | FASEB J. | pmid:11687510 |
| Goulet JL et al. | Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice. | 2001 | J. Immunol. | pmid:11714834 |
| Aliberti J et al. | Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity. | 2002 | Nat. Immunol. | pmid:11743584 |
| Vachier I et al. | Endogenous anti-inflammatory mediators from arachidonate in human neutrophils. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11779156 |
| Fierro IM et al. | Novel lipid mediator regulators of endothelial cell proliferation and migration: aspirin-triggered-15R-lipoxin A(4) and lipoxin A(4). | 2002 | J. Pharmacol. Exp. Ther. | pmid:11805195 |
| Resnati M et al. | The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11818541 |
| Gewirtz AT et al. | Lipoxin a4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis. | 2002 | J. Immunol. | pmid:11994483 |
| Aliberti J and Sher A | Positive and negative regulation of pathogen induced dendritic cell function by G-protein coupled receptors. | 2002 | Mol. Immunol. | pmid:12009566 |
| Bonnans C et al. | Lipoxins are potential endogenous antiinflammatory mediators in asthma. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:12045128 |
| Maderna P et al. | Lipoxins induce actin reorganization in monocytes and macrophages but not in neutrophils: differential involvement of rho GTPases. | 2002 | Am. J. Pathol. | pmid:12057930 |
| Tam FW | Role of selectins in glomerulonephritis. | 2002 | Clin. Exp. Immunol. | pmid:12100015 |
| Levy BD et al. | Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4). | 2002 | Nat. Med. | pmid:12172542 |
| Peters-Golden M | 'Good' lipids for asthma. | 2002 | Nat. Med. | pmid:12205450 |
| Romano M et al. | Urinary excretion of lipoxin A(4) and related compounds: development of new extraction techniques for lipoxins. | 2002 | Lab. Invest. | pmid:12218086 |
| Vaughn MW et al. | Identification, cloning, and functional characterization of a murine lipoxin A4 receptor homologue gene. | 2002 | J. Immunol. | pmid:12218158 |
| McMahon B et al. | Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation. | 2002 | FASEB J. | pmid:12223454 |
| József L et al. | Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12235371 |
| Planagumà A et al. | Aspirin (ASA) regulates 5-lipoxygenase activity and peroxisome proliferator-activated receptor alpha-mediated CINC-1 release in rat liver cells: novel actions of lipoxin A4 (LXA4) and ASA-triggered 15-epi-LXA4. | 2002 | FASEB J. | pmid:12368230 |
| Fiorucci S et al. | Cyclooxygenase-2-derived lipoxin A4 increases gastric resistance to aspirin-induced damage. | 2002 | Gastroenterology | pmid:12404234 |
| Christophe T et al. | Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4. | 2002 | Scand. J. Immunol. | pmid:12410796 |
| Aliberti J et al. | Parasite-induced lipoxin A4 is an endogenous regulator of IL-12 production and immunopathology in Toxoplasma gondii infection. | 2002 | J. Exp. Med. | pmid:12417634 |
| Kucharzik T et al. | Lateral membrane LXA4 receptors mediate LXA4's anti-inflammatory actions on intestinal epithelium. | 2003 | Am. J. Physiol., Cell Physiol. | pmid:12456400 |
| Schottelius AJ et al. | An aspirin-triggered lipoxin A4 stable analog displays a unique topical anti-inflammatory profile. | 2002 | J. Immunol. | pmid:12471142 |
| Bonnans C et al. | Lipoxin A4 stimulates a cytosolic Ca2+ increase in human bronchial epithelium. | 2003 | J. Biol. Chem. | pmid:12500974 |
| Van Dyke TE and Serhan CN | Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases. | 2003 | J. Dent. Res. | pmid:12562878 |
| Gangemi S et al. | Physical exercise increases urinary excretion of lipoxin A4 and related compounds. | 2003 | J. Appl. Physiol. | pmid:12588790 |
| Kantarci A et al. | Neutrophil-mediated tissue injury in periodontal disease pathogenesis: findings from localized aggressive periodontitis. | 2003 | J. Periodontol. | pmid:12593599 |
| Fierro IM et al. | Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit human neutrophil migration: comparisons between synthetic 15 epimers in chemotaxis and transmigration with microvessel endothelial cells and epithelial cells. | 2003 | J. Immunol. | pmid:12594298 |
| Souza MH et al. | Gastritis increases resistance to aspirin-induced mucosal injury via COX-2-mediated lipoxin synthesis. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12637254 |
| Titos E et al. | Aspirin-triggered 15-epi-lipoxin A4 biosynthesis in rat liver cells. | 2002 | Adv. Exp. Med. Biol. | pmid:12664586 |
| Bandeira-Melo C et al. | Inhibition of allergen-induced eosinophil migration by lipoxin (LX)A4 and aspirin-triggered 15-epi-LXA4. | 2002 | Adv. Exp. Med. Biol. | pmid:12664587 |
| Filep JG et al. | Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 modulate adhesion molecule expression on human leukocytes in whole blood and inhibit neutrophil-endothelial cell adhesion. | 2002 | Adv. Exp. Med. Biol. | pmid:12664589 |
| Devchand PR et al. | Human ALX receptor regulates neutrophil recruitment in transgenic mice: roles in inflammation and host defense. | 2003 | FASEB J. | pmid:12665478 |
| Goh J et al. | Lipoxins: pro-resolution lipid mediators in intestinal inflammation. | 2003 | Gastroenterology | pmid:12671901 |
| Fiorucci S et al. | Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin. | 2003 | FASEB J. | pmid:12709408 |
| Chiang N et al. | A novel rat lipoxin A4 receptor that is conserved in structure and function. | 2003 | Br. J. Pharmacol. | pmid:12746227 |
| Levy BD et al. | Lipoxins and aspirin-triggered lipoxins in airway responses. | 2003 | Adv. Exp. Med. Biol. | pmid:12751730 |
| Ariel A et al. | Aspirin-triggered lipoxin A4 and B4 analogs block extracellular signal-regulated kinase-dependent TNF-alpha secretion from human T cells. | 2003 | J. Immunol. | pmid:12794159 |
| Wallace JL and Fiorucci S | A magic bullet for mucosal protection...and aspirin is the trigger! | 2003 | Trends Pharmacol. Sci. | pmid:12871661 |
| Fiorucci S et al. | Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin. | 2003 | Br. J. Pharmacol. | pmid:12890715 |
| Bae YS et al. | Differential signaling of formyl peptide receptor-like 1 by Trp-Lys-Tyr-Met-Val-Met-CONH2 or lipoxin A4 in human neutrophils. | 2003 | Mol. Pharmacol. | pmid:12920210 |
| Phillips ED et al. | Synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11,13-hexadecatetraenoate, an analogue of 15R-lipoxin A4. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12951097 |
| Fiore S et al. | Lipoxin recognition sites. Specific binding of labeled lipoxin A4 with human neutrophils. | 1992 | J. Biol. Chem. | pmid:1322894 |
| Sharp GJ et al. | Lipoxin-induced migration of fish leukocytes. | 1992 | J. Leukoc. Biol. | pmid:1331277 |
| Kowalski ML et al. | Differential effects of aspirin and misoprostol on 15-hydroxyeicosatetraenoic acid generation by leukocytes from aspirin-sensitive asthmatic patients. | 2003 | J. Allergy Clin. Immunol. | pmid:13679808 |
| Meini S et al. | Pharmacologic and neurochemical evidence for the activation of capsaicin-sensitive sensory nerves by lipoxin A4 in guinea pig bronchus. | 1992 | Am. Rev. Respir. Dis. | pmid:1384407 |
| Badr KF | 15-Lipoxygenase products as leukotriene antagonists: therapeutic potential in glomerulonephritis. | 1992 | Kidney Int. Suppl. | pmid:1405359 |
| Katoh T et al. | Renal hemodynamic actions of lipoxins in rats: a comparative physiological study. | 1992 | Am. J. Physiol. | pmid:1415572 |
| Serhan CN et al. | Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators. | 2003 | J. Immunol. | pmid:14662892 |
| Wallace JL et al. | Aspirin, but not NO-releasing aspirin (NCX-4016), interacts with selective COX-2 inhibitors to aggravate gastric damage and inflammation. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:14665439 |
| Boutet P et al. | Imbalance between lipoxin A4 and leukotriene B4 in chronic mastitis-affected cows. | 2003 | J. Dairy Sci. | pmid:14672172 |
| Wikström E et al. | Lipoxin A4-induced release of thromboxane in the guinea-pig lung: studies of its characteristics using lipoxin A4-methyl ester. | 1992 | J Lipid Mediat | pmid:1467461 |
| Bannenberg GL et al. | Exogenous pathogen and plant 15-lipoxygenase initiate endogenous lipoxin A4 biosynthesis. | 2004 | J. Exp. Med. | pmid:14970178 |
| Sodin-Semrl S et al. | Lipoxin A4 counteracts synergistic activation of human fibroblast-like synoviocytes. | 2004 Jan-Apr | Int J Immunopathol Pharmacol | pmid:15000862 |
| Gilroy DW et al. | A novel role for phospholipase A2 isoforms in the checkpoint control of acute inflammation. | 2004 | FASEB J. | pmid:15003994 |
| Guilford WJ et al. | Novel 3-oxa lipoxin A4 analogues with enhanced chemical and metabolic stability have anti-inflammatory activity in vivo. | 2004 | J. Med. Chem. | pmid:15056011 |