| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tuberculosis | D014376 | 20 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
Lipoxin A4
Lipoxin a4 is a lipid of Fatty Acyls (FA) class. Lipoxin a4 is associated with abnormalities such as Asthma, Cystic Fibrosis, Pneumonia, Obesity and Septicemia. The involved functions are known as Inflammation, Signal, Signal Transduction, Regulation and Metabolic Inhibition. Lipoxin a4 often locates in Immune system, Blood, soluble, Extracellular and Splenic Tissue. The associated genes with Lipoxin A4 are FPR2 gene, Homologous Gene, SAA1 gene, Trp-Lys-Tyr-Met-Val-Met and Annexin 1. The related lipids are Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Lipoxin A4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Lipoxin A4?
Lipoxin A4 is suspected in Asthma, Cystic Fibrosis, Chagas Cardiomyopathy, Pneumonia, Obesity, Septicemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Lipoxin A4
PubChem Associated disorders and diseases
What pathways are associated with Lipoxin A4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Lipoxin A4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Lipoxin A4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Lipoxin A4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Lipoxin A4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Lipoxin A4?
Knock-out
Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Lipoxin A4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hill DJ et al. | Trout thrombocytes contain 12- but not 5-lipoxygenase activity. | 1999 | Biochim. Biophys. Acta | pmid:9931438 |
| Chiang N et al. | Aspirin-triggered 15-epi-lipoxin A4 (ATL) generation by human leukocytes and murine peritonitis exudates: development of a specific 15-epi-LXA4 ELISA. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9808710 |
| Nassar GM and Badr KF | Novel approaches to treatment of glomerulonephritis. | 1998 Jul-Aug | J. Nephrol. | pmid:9702868 |
| Clà ria J et al. | Altered biosynthesis of leukotrienes and lipoxins and host defense disorders in patients with cirrhosis and ascites. | 1998 | Gastroenterology | pmid:9649470 |
| Gewirtz AT et al. | Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs. | 1998 | J. Clin. Invest. | pmid:9576749 |
| Levy BD et al. | Agonist-induced lipoxin A4 generation in vitro and in aspirin-sensitive asthmatics: detection by a novel lipoxin A4-ELISA. | 1997 | Adv. Exp. Med. Biol. | pmid:9547611 |
| Gronert K et al. | Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release. | 1998 | J. Exp. Med. | pmid:9547339 |
| Gronert K et al. | Characterization of human neutrophil and endothelial cell ligand-operated extracellular acidification rate by microphysiometry: impact of reoxygenation. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9536019 |
| Takano T et al. | Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogues. | 1998 | J. Clin. Invest. | pmid:9466977 |
| Scalia R et al. | Lipoxin A4 stable analogs inhibit leukocyte rolling and adherence in the rat mesenteric microvasculature: role of P-selectin. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9275235 |
| Stahl GL et al. | Eicosanoid production from porcine neutrophils and platelets: differential production with various agonists. | 1997 | Am. J. Physiol. | pmid:9227410 |
| Takano T et al. | Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. | 1997 | J. Exp. Med. | pmid:9151906 |
| Serhan CN | Lipoxins and novel aspirin-triggered 15-epi-lipoxins (ATL): a jungle of cell-cell interactions or a therapeutic opportunity? | 1997 | Prostaglandins | pmid:9112289 |
| Maddox JF et al. | Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor. | 1997 | J. Biol. Chem. | pmid:9054386 |
| Tamaoki J et al. | Lipoxin A4 inhibits cholinergic neurotransmission through nitric oxide generation in the rabbit trachea. | 1995 | Eur. J. Pharmacol. | pmid:8991795 |
| Brady HR | Complex roles for P-selectin in the pathophysiology of glomerulonephritis. | 1996 | Curr. Opin. Nephrol. Hypertens. | pmid:8937811 |
| Chung-a-on KO et al. | Stimulation of protein kinase C redistribution and inhibition of leukotriene B4-induced inositol 1,4,5-trisphosphate generation in human neutrophils by lipoxin A4. | 1996 | Br. J. Pharmacol. | pmid:8882633 |
| Hébert MJ et al. | Sequential morphologic events during apoptosis of human neutrophils. Modulation by lipoxygenase-derived eicosanoids. | 1996 | J. Immunol. | pmid:8816421 |
| Serhan CN and Romano M | Lipoxin biosynthesis and actions: role of the human platelet LX-synthase. | 1995 | J Lipid Mediat Cell Signal | pmid:8777573 |
| Feng Z et al. | Leukotriene B4 modulates in vivo expression of delayed-type hypersensitivity by a receptor-mediated mechanism: regulation by lipoxin A4. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8768752 |
| Romano M et al. | Activation of human monocytes and the acute monocytic leukemia cell line (THP-1) by lipoxins involves unique signaling pathways for lipoxin A4 versus lipoxin B4: evidence for differential Ca2+ mobilization. | 1996 | J. Immunol. | pmid:8757340 |
| Badr KF | Lipoxygenases as therapeutic targets in the acute and subacute phases of glomerular immune injury. | 1996 | Contrib Nephrol | pmid:8744048 |
| Mayadas TN et al. | Acute passive anti-glomerular basement membrane nephritis in P-selectin-deficient mice. | 1996 | Kidney Int. | pmid:8731099 |
| Papayianni A et al. | Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells. | 1996 | J. Immunol. | pmid:8690917 |
| Tang DG et al. | Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8643560 |
| Lin KT et al. | Identification and characterization of a high-affinity leukotriene B4 receptor on guinea pig T lymphocytes and its regulation by lipoxin A4. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8627545 |
| Maddox JF and Serhan CN | Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction. | 1996 | J. Exp. Med. | pmid:8551217 |
| Serhan CN et al. | Lipoxin A4 metabolism by differentiated HL-60 cells and human monocytes: conversion to novel 15-oxo and dihydro products. | 1993 | Biochemistry | pmid:8518275 |
| Sumimoto H et al. | Formation of a novel 20-hydroxylated metabolite of lipoxin A4 by human neutrophil microsomes. | 1993 | FEBS Lett. | pmid:8422907 |
| Lerner R et al. | Lipoxin A4 induces hyperadhesiveness in human endothelial cells for neutrophils. | 1993 | Blood | pmid:8393356 |
| Fiore S et al. | Induction of functional lipoxin A4 receptors in HL-60 cells. | 1993 | Blood | pmid:8389617 |
| Levy BD et al. | Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins. | 1993 | J. Clin. Invest. | pmid:8376607 |
| Colgan SP et al. | Lipoxin A4 modulates transmigration of human neutrophils across intestinal epithelial monolayers. | 1993 | J. Clin. Invest. | pmid:8326019 |
| Edenius C et al. | Stimulation of lipoxin synthesis from leukotriene A4 by endogenously formed 12-hydroperoxyeicosatetraenoic acid in activated human platelets. | 1994 | Biochim. Biophys. Acta | pmid:8305492 |
| Romano M et al. | Lipoxin synthase activity of human platelet 12-lipoxygenase. | 1993 | Biochem. J. | pmid:8250832 |
| Knight J et al. | Effect of lipoxins and other eicosanoids on phagocytosis and intracellular calcium mobilisation in rainbow trout (Oncorhynchus mykiss) leukocytes. | 1993 | J. Leukoc. Biol. | pmid:8245703 |
| Bratt J et al. | Lipoxin A4 induces neutrophil-dependent cytotoxicity for human endothelial cells. | 1994 | Scand. J. Immunol. | pmid:8146594 |
| Levy BD et al. | Agonist-induced lipoxin A4 generation: detection by a novel lipoxin A4-ELISA. | 1993 | Lipids | pmid:8121246 |
| Soyombo O et al. | Effects of lipoxin A4 on chemotaxis and degranulation of human eosinophils stimulated by platelet-activating factor and N-formyl-L-methionyl-L-leucyl-L-phenylalanine. | 1994 | Allergy | pmid:8037356 |
| Fiore S et al. | Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor. | 1994 | J. Exp. Med. | pmid:8006586 |
| Serhan CN et al. | Cell-cell interactions in lipoxin generation and characterization of lipoxin A4 receptors. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7825838 |
| Simchowitz L et al. | Carrier-mediated transport of lipoxin A4 in human neutrophils. | 1994 | Am. J. Physiol. | pmid:7810593 |
| Bratt J and Gyllenhammar H | The role of nitric oxide in lipoxin A4-induced polymorphonuclear neutrophil-dependent cytotoxicity to human vascular endothelium in vitro. | 1995 | Arthritis Rheum. | pmid:7779119 |
| Serhan CN and Fiore S | Lipoxin recognition sites of human neutrophils. | 1994 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7771345 |
| Lee TH | Lipoxin A4: a novel anti-inflammatory molecule? | 1995 | Thorax | pmid:7701445 |
| Bratt J et al. | Mechanisms for lipoxin A4-induced neutrophil-dependent cytotoxicity for human endothelial cells. | 1995 | J. Lab. Clin. Med. | pmid:7602232 |
| Serhan CN et al. | Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils. | 1995 | Biochemistry | pmid:7578068 |
| Papayianni A et al. | Transcellular biosynthesis of lipoxin A4 during adhesion of platelets and neutrophils in experimental immune complex glomerulonephritis. | 1995 | Kidney Int. | pmid:7543622 |
| Serhan CN et al. | Trihydroxytetraenes: a novel series of compounds formed from arachidonic acid in human leukocytes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6422933 |
| Serhan CN et al. | Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6089195 |
| Ramstedt U et al. | Lipoxin A-induced inhibition of human natural killer cell cytotoxicity: studies on stereospecificity of inhibition and mode of action. | 1987 | J. Immunol. | pmid:3782800 |
| Puustinen T et al. | Evidence for a 5(6)-epoxytetraene intermediate in the biosynthesis of lipoxins in human leukocytes. Conversion into lipoxin A by cytosolic epoxide hydrolase. | 1986 | FEBS Lett. | pmid:3770188 |
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| Palmblad J et al. | The effects of lipoxin A and lipoxin B on functional responses of human granulocytes. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3593338 |
| Ueda N et al. | Lipoxin synthesis by arachidonate 5-lipoxygenase purified from porcine leukocytes. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3579953 |
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| Dahlén SE et al. | Actions of lipoxin A4 and related compounds in smooth muscle preparations and on the microcirculation in vivo. | 1988 | Adv. Exp. Med. Biol. | pmid:3421155 |
| Feuerstein G and Siren AL | Mesenteric vascular responses to i.v. administration of lipoxin A4 and lipoxin B4 in the conscious rat. | 1988 | FEBS Lett. | pmid:3366247 |
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| Reis MB et al. | Lipoxin A4 encapsulated in PLGA microparticles accelerates wound healing of skin ulcers. | 2017 | PLoS ONE | pmid:28753648 |
| Yang Y et al. | The effects of different frequency treadmill exercise on lipoxin A4 and articular cartilage degeneration in an experimental model of monosodium iodoacetate-induced osteoarthritis in rats. | 2017 | PLoS ONE | pmid:28594958 |
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