| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tuberculosis | D014376 | 20 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
Lipoxin A4
Lipoxin a4 is a lipid of Fatty Acyls (FA) class. Lipoxin a4 is associated with abnormalities such as Asthma, Cystic Fibrosis, Pneumonia, Obesity and Septicemia. The involved functions are known as Inflammation, Signal, Signal Transduction, Regulation and Metabolic Inhibition. Lipoxin a4 often locates in Immune system, Blood, soluble, Extracellular and Splenic Tissue. The associated genes with Lipoxin A4 are FPR2 gene, Homologous Gene, SAA1 gene, Trp-Lys-Tyr-Met-Val-Met and Annexin 1. The related lipids are Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Lipoxin A4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Lipoxin A4?
Lipoxin A4 is suspected in Asthma, Cystic Fibrosis, Chagas Cardiomyopathy, Pneumonia, Obesity, Septicemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Immunol. (2)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Antimicrob. Agents Chemother. (1)
- Others (7)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Lipoxin A4
PubChem Associated disorders and diseases
What pathways are associated with Lipoxin A4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Lipoxin A4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Lipoxin A4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Lipoxin A4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Lipoxin A4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Lipoxin A4?
Knock-out
Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Lipoxin A4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
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| Serhan CN et al. | Trihydroxytetraenes: a novel series of compounds formed from arachidonic acid in human leukocytes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6422933 |
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| Ramstedt U et al. | Lipoxin A-induced inhibition of human natural killer cell cytotoxicity: studies on stereospecificity of inhibition and mode of action. | 1987 | J. Immunol. | pmid:3782800 |
| Ueda N et al. | Lipoxin synthesis by arachidonate 5-lipoxygenase purified from porcine leukocytes. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3579953 |
| Badr KF et al. | The action of lipoxin-A on glomerular microcirculatory dynamics in the rat. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3593345 |
| Dahlén SE et al. | Biological activities of lipoxin A include lung strip contraction and dilation of arterioles in vivo. | 1987 | Acta Physiol. Scand. | pmid:3630737 |
| Serhan CN et al. | Formation of lipoxin A by granulocytes from eosinophilic donors. | 1987 | FEBS Lett. | pmid:3109942 |
| Conti P et al. | Lipoxin A augments release of thromboxane from human polymorphonuclear leukocyte suspensions. | 1987 | FEBS Lett. | pmid:3121389 |
| Walstra P et al. | Evidence for lipoxin formation by bovine polymorphonuclear leukocytes via triple dioxygenation of arachidonic acid. | 1988 | FEBS Lett. | pmid:3125064 |
| Edenius C et al. | Transcellular conversion of endogenous arachidonic acid to lipoxins in mixed human platelet-granulocyte suspensions. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2849436 |
| Jacques CA et al. | The contractile activities of lipoxin A4 and lipoxin B4 for guinea-pig airway tissues. | 1988 | Br. J. Pharmacol. | pmid:2852525 |
| Borgeat P and Picard S | 19-Hydroxyprostaglandin B2 as an internal standard for on-line extraction-high-performance liquid chromatography analysis of lipoxygenase products. | 1988 | Anal. Biochem. | pmid:2841889 |
| Brasseur R et al. | Conformational analysis of lipoxin A, lipoxin B and their trans-isomers. | 1988 | Biochim. Biophys. Acta | pmid:3365446 |
| Feuerstein G and Siren AL | Mesenteric vascular responses to i.v. administration of lipoxin A4 and lipoxin B4 in the conscious rat. | 1988 | FEBS Lett. | pmid:3366247 |
| Lefer AM et al. | Lipoxins A4 and B4: comparison of icosanoids having bronchoconstrictor and vasodilator actions but lacking platelet aggregatory activity. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3186729 |
| Sok DE et al. | Soybean lipoxygenase-catalyzed formation of lipoxin A and lipoxin B isomers from arachidonic acid via 5,15-dihydroperoxyeicosatetraenoic acid. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3132921 |
| Dahlén SE et al. | Actions of lipoxin A4 and related compounds in smooth muscle preparations and on the microcirculation in vivo. | 1988 | Adv. Exp. Med. Biol. | pmid:3421155 |
| Badr KF | The glomerular physiology of lipoxin-A. | 1988 | Adv. Exp. Med. Biol. | pmid:3421156 |
| Cristol JP and Sirois P | Comparative activity of leukotriene D4, 5,6-dihydroxy-eicosatetraenoic acid and lipoxin A on guinea pig lung parenchyma and ileum smooth muscle. | 1988 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:3363228 |
| Steinhilber D and Roth HJ | New series of lipoxins isolated from human eosinophils. | 1989 | FEBS Lett. | pmid:2507350 |
| Serhan CN | On the relationship between leukotriene and lipoxin production by human neutrophils: evidence for differential metabolism of 15-HETE and 5-HETE. | 1989 | Biochim. Biophys. Acta | pmid:2546590 |
| Lee TH et al. | Lipoxin A4 and lipoxin B4 inhibit chemotactic responses of human neutrophils stimulated by leukotriene B4 and N-formyl-L-methionyl-L-leucyl-L-phenylalanine. | 1989 | Clin. Sci. | pmid:2548801 |
| Brezinski ME et al. | Lipoxins stimulate prostacyclin generation by human endothelial cells. | 1989 | FEBS Lett. | pmid:2494071 |
| Badr KF et al. | Lipoxin A4 antagonizes cellular and in vivo actions of leukotriene D4 in rat glomerular mesangial cells: evidence for competition at a common receptor. | 1989 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2541448 |
| Yoshimoto T | [Mammalian lipoxygenases]. | 1989 | Seikagaku | pmid:2516108 |
| Hedqvist P et al. | Lipoxin A4 inhibits leukotriene B4-induced inflammation in the hamster cheek pouch. | 1989 | Acta Physiol. Scand. | pmid:2557732 |
| Wikström E et al. | Lipoxin A4 causes generation of thromboxane A2 in the guinea-pig lung. | 1989 | Agents Actions | pmid:2711953 |
| Dahlén SE et al. | Pharmacodynamics of lipoxin A4 in airway smooth muscle. | 1989 | Agents Actions | pmid:2711954 |
| Ng CF et al. | Agonist-dependent generation of lipoxins from rat basophilic leukemia cell (RBL-1). | 1989 | Biochim. Biophys. Acta | pmid:2503031 |