| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tuberculosis | D014376 | 20 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
Lipoxin A4
Lipoxin a4 is a lipid of Fatty Acyls (FA) class. Lipoxin a4 is associated with abnormalities such as Asthma, Cystic Fibrosis, Pneumonia, Obesity and Septicemia. The involved functions are known as Inflammation, Signal, Signal Transduction, Regulation and Metabolic Inhibition. Lipoxin a4 often locates in Immune system, Blood, soluble, Extracellular and Splenic Tissue. The associated genes with Lipoxin A4 are FPR2 gene, Homologous Gene, SAA1 gene, Trp-Lys-Tyr-Met-Val-Met and Annexin 1. The related lipids are Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Lipoxin A4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Lipoxin A4?
Lipoxin A4 is suspected in Asthma, Cystic Fibrosis, Chagas Cardiomyopathy, Pneumonia, Obesity, Septicemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Lipoxin A4
PubChem Associated disorders and diseases
What pathways are associated with Lipoxin A4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Lipoxin A4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Lipoxin A4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Lipoxin A4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Lipoxin A4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Lipoxin A4?
Knock-out
Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Lipoxin A4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Anuforo OUU et al. | Natural killer cells play an essential role in resolution of antigen-induced inflammation in mice. | 2018 | Mol. Immunol. | pmid:29112834 |
| Muralikumar S et al. | Probing the intermolecular interactions of PPARγ-LBD with polyunsaturated fatty acids and their anti-inflammatory metabolites to infer most potential binding moieties. | 2017 | Lipids Health Dis | pmid:28109294 |
| Singh A et al. | Lipoxin A4, a 5-lipoxygenase pathway metabolite, modulates immune response during acute respiratory tularemia. | 2017 | J. Leukoc. Biol. | pmid:27630217 |
| Reis MB et al. | Lipoxin A4 encapsulated in PLGA microparticles accelerates wound healing of skin ulcers. | 2017 | PLoS ONE | pmid:28753648 |
| Yang Y et al. | The effects of different frequency treadmill exercise on lipoxin A4 and articular cartilage degeneration in an experimental model of monosodium iodoacetate-induced osteoarthritis in rats. | 2017 | PLoS ONE | pmid:28594958 |
| Shi Y et al. | Lipoxin A4 mitigates experimental autoimmune myocarditis by regulating inflammatory response, NF-κB and PI3K/Akt signaling pathway in mice. | 2017 | Eur Rev Med Pharmacol Sci | pmid:28485793 |
| Wu SH et al. | Signal transduction involved in lipoxin A4‑induced protection of tubular epithelial cells against hypoxia/reoxygenation injury. | 2017 | Mol Med Rep | pmid:28259922 |
| González-Herrera F et al. | Simvastatin Attenuates Endothelial Activation through 15-Epi-Lipoxin A4 Production in Murine Chronic Chagas Cardiomyopathy. | 2017 | Antimicrob. Agents Chemother. | pmid:27993857 |
| Hodges RR et al. | Lipoxin A4 activates ALX/FPR2 receptor to regulate conjunctival goblet cell secretion. | 2017 | Mucosal Immunol | pmid:27072607 |
| Zong L et al. | Lipoxin A4 Attenuates Cell Invasion by Inhibiting ROS/ERK/MMP Pathway in Pancreatic Cancer. | 2016 | Oxid Med Cell Longev | pmid:26649143 |
| Colby JK et al. | Lipoxin Signaling in Murine Lung Host Responses to Cryptococcus neoformans Infection. | 2016 | Am. J. Respir. Cell Mol. Biol. | pmid:26039320 |
| Pedruzzi G et al. | Understanding PGE2, LXA4 and LTB4 balance during Mycobacterium tuberculosis infection through mathematical model. | 2016 | J. Theor. Biol. | pmid:26551160 |
| Diaz-Gerevini GT et al. | Beneficial action of resveratrol: How and why? | 2016 | Nutrition | pmid:26706021 |
| Elias I et al. | ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance. | 2016 | Diabetes | pmid:27207555 |
| Havixbeck JJ et al. | Neutrophil contributions to the induction and regulation of the acute inflammatory response in teleost fish. | 2016 | J. Leukoc. Biol. | pmid:26292979 |
| Pazdrak K et al. | Cytokine-Induced Glucocorticoid Resistance from Eosinophil Activation: Protein Phosphatase 5 Modulation of Glucocorticoid Receptor Phosphorylation and Signaling. | 2016 | J. Immunol. | pmid:27742828 |
| Chandrasekharan JA et al. | Altering the Anti-inflammatory Lipoxin Microenvironment: a New Insight into Kaposi's Sarcoma-Associated Herpesvirus Pathogenesis. | 2016 | J. Virol. | pmid:27681120 |
| Han X et al. | Lipoxin A4 Preconditioning Attenuates Intestinal Ischemia Reperfusion Injury through Keap1/Nrf2 Pathway in a Lipoxin A4 Receptor Independent Manner. | 2016 | Oxid Med Cell Longev | pmid:27375835 |
| Brigatte P et al. | Walker 256 Tumor Growth Suppression by Crotoxin Involves Formyl Peptide Receptors and Lipoxin Aâ‚„. | 2016 | Mediators Inflamm. | pmid:27190493 |
| Higgins G et al. | Lipoxin A4 prevents tight junction disruption and delays the colonization of cystic fibrosis bronchial epithelial cells by Pseudomonas aeruginosa. | 2016 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:27084849 |
| Wang CS et al. | ALX/FPR2 Modulates Anti-Inflammatory Responses in Mouse Submandibular Gland. | 2016 | Sci Rep | pmid:27064029 |
| Martini AC et al. | Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection. | 2016 | J Neuroinflammation | pmid:27059991 |
| Tahan F et al. | Increased Postexercise Lipoxin A4 Levels in Exhaled Breath Condensate in Asthmatic Children With Exercise-Induced Bronchoconstriction. | 2016 | J Investig Allergol Clin Immunol | pmid:27012012 |
| Wu B et al. | Lipoxin A4 augments host defense in sepsis and reduces Pseudomonas aeruginosa virulence through quorum sensing inhibition. | 2016 | FASEB J. | pmid:26965685 |
| Das UN | Inflammatory bowel disease as a disorder of an imbalance between pro- and anti-inflammatory molecules and deficiency of resolution bioactive lipids. | 2016 | Lipids Health Dis | pmid:26762544 |
| Guo Z et al. | Lipoxin A4 Reduces Inflammation Through Formyl Peptide Receptor 2/p38 MAPK Signaling Pathway in Subarachnoid Hemorrhage Rats. | 2016 | Stroke | pmid:26732571 |
| Li L et al. | New development in studies of formyl-peptide receptors: critical roles in host defense. | 2016 | J. Leukoc. Biol. | pmid:26701131 |
| Yu D et al. | Inverse Relationship between Serum Lipoxin A4 Level and the Risk of Metabolic Syndrome in a Middle-Aged Chinese Population. | 2015 | PLoS ONE | pmid:26565966 |
| Dakin SG et al. | Inflammation activation and resolution in human tendon disease. | 2015 | Sci Transl Med | pmid:26511510 |
| Prieto P et al. | Activation of autophagy in macrophages by pro-resolving lipid mediators. | 2015 | Autophagy | pmid:26506892 |
| Gao Y et al. | Female-Specific Downregulation of Tissue Polymorphonuclear Neutrophils Drives Impaired Regulatory T Cell and Amplified Effector T Cell Responses in Autoimmune Dry Eye Disease. | 2015 | J. Immunol. | pmid:26324767 |
| Qi W et al. | Lipoxin A4 activates alveolar epithelial sodium channel gamma via the microRNA-21/PTEN/AKT pathway in lipopolysaccharide-induced inflammatory lung injury. | 2015 | Lab. Invest. | pmid:26302186 |
| DoÄŸan B et al. | Lipoxin A4 and Neutrophil/Lymphocyte Ratio: A Possible Indicator in Achieved Systemic Risk Factors for Periodontitis. | 2015 | Med. Sci. Monit. | pmid:26298769 |
| Lehmann C et al. | Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein. | 2015 | FASEB J. | pmid:26289316 |
| Roach KM et al. | Lipoxin A4 Attenuates Constitutive and TGF-β1-Dependent Profibrotic Activity in Human Lung Myofibroblasts. | 2015 | J. Immunol. | pmid:26276873 |
| Sha YH et al. | Lipoxin A4 promotes ABCA1 expression and cholesterol efflux through the LXRα signaling pathway in THP-1 macrophage-derived foam cells. | 2015 | Int J Clin Exp Pathol | pmid:26261553 |
| Yuan ZX and Rapoport SI | Transient postnatal fluoxetine decreases brain concentrations of 20-HETE and 15-epi-LXA4, arachidonic acid metabolites in adult mice. | 2015 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:26234927 |
| Herrera BS et al. | LXA4 actions direct fibroblast function and wound closure. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26188508 |
| Fang X et al. | Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4. | 2015 | J. Immunol. | pmid:26116507 |
| Ramirez JL et al. | A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae. | 2015 | Nat Commun | pmid:26100162 |
| Börgeson E et al. | Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease. | 2015 | Cell Metab. | pmid:26052006 |
| Campos-Estrada C et al. | Simvastatin and Benznidazole-Mediated Prevention of Trypanosoma cruzi-Induced Endothelial Activation: Role of 15-epi-lipoxin A4 in the Action of Simvastatin. | 2015 | PLoS Negl Trop Dis | pmid:25978361 |
| Higgins G et al. | Physiological impact of abnormal lipoxin Aâ‚„ production on cystic fibrosis airway epithelium and therapeutic potential. | 2015 | Biomed Res Int | pmid:25866809 |
| Kong X et al. | Roles of lipoxin A4 receptor activation and anti-interleukin-1β antibody on the toll-like receptor 2/mycloid differentiation factor 88/nuclear factor-κB pathway in airway inflammation induced by ovalbumin. | 2015 | Mol Med Rep | pmid:25760938 |
| Barnig C and Levy BD | Innate immunity is a key factor for the resolution of inflammation in asthma. | 2015 | Eur Respir Rev | pmid:25726564 |
| Souza MC et al. | Lipoxin A4 attenuates endothelial dysfunction during experimental cerebral malaria. | 2015 | Int. Immunopharmacol. | pmid:25576659 |
| Rinaldi SF et al. | 15-epi-lipoxin A4 reduces the mortality of prematurely born pups in a mouse model of infection-induced preterm birth. | 2015 | Mol. Hum. Reprod. | pmid:25567326 |
| Petri MH et al. | Aspirin-triggered 15-epi-lipoxin Aâ‚„ signals through FPR2/ALX in vascular smooth muscle cells and protects against intimal hyperplasia after carotid ligation. | 2015 | Int. J. Cardiol. | pmid:25464488 |
| Alvarez AM et al. | Aspirin-triggered lipoxin prevents antiphospholipid antibody effects on human trophoblast migration and endothelial cell interactions. | 2015 | pmid:25370166 | |
| Gobbetti T et al. | Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor. | 2015 | Br. J. Pharmacol. | pmid:25296998 |
| Awji EG et al. | Wood smoke enhances cigarette smoke-induced inflammation by inducing the aryl hydrocarbon receptor repressor in airway epithelial cells. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:25137396 |
| Dunn HC et al. | Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model. | 2015 | J. Alzheimers Dis. | pmid:25125468 |
| Meng F et al. | Attenuation of lipopolysaccharide-induced lung vascular stiffening by lipoxin reduces lung inflammation. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:24992633 |
| Karra L et al. | Lipoxin Bâ‚„ promotes the resolution of allergic inflammation in the upper and lower airways of mice. | 2015 | Mucosal Immunol | pmid:25465102 |
| Wang X et al. | Resolution of inflammation is altered in Alzheimer's disease. | 2015 | Alzheimers Dement | pmid:24530025 |
| Lee JY et al. | Immune parameters differentiating active from latent tuberculosis infection in humans. | 2015 | Tuberculosis (Edinb) | pmid:26520601 |
| Homann J et al. | In Vivo Availability of Pro-Resolving Lipid Mediators in Oxazolone Induced Dermal Inflammation in the Mouse. | 2015 | PLoS ONE | pmid:26599340 |
| Zhang C et al. | Growth inhibitory effect of polyunsaturated fatty acids (PUFAs) on colon cancer cells via their growth inhibitory metabolites and fatty acid composition changes. | 2015 | PLoS ONE | pmid:25886460 |
| Tateishi N et al. | Dietary supplementation with arachidonic acid increases arachidonic acid content in paw, but does not affect arthritis severity or prostaglandin E2 content in rat adjuvant-induced arthritis model. | 2015 | Lipids Health Dis | pmid:25595700 |
| Fahel JS et al. | 5-Lipoxygenase negatively regulates Th1 response during Brucella abortus infection in mice. | 2015 | Infect. Immun. | pmid:25583526 |
| Ribeiro LR et al. | Lipoxin Inhibits Fungal Uptake by Macrophages and Reduces the Severity of Acute Pulmonary Infection Caused by Paracoccidioides brasiliensis. | 2015 | Mediators Inflamm. | pmid:26635449 |
| Wenceslau CF et al. | Lipoxin A4 mediates aortic contraction via RHOA/RHO kinase, endothelial dysfunction and reactive oxygen species. | 2014 | J. Vasc. Res. | pmid:25612650 |
| Polavarapu S et al. | Effect of polyunsaturated fatty acids and their metabolites on bleomycin-induced cytotoxic action on human neuroblastoma cells in vitro. | 2014 | PLoS ONE | pmid:25536345 |
| Zimring JC | The fat and the skinny on acute lung injury. | 2014 | Blood | pmid:25342661 |
| Martini AC et al. | Neuroprotective effects of lipoxin A4 in central nervous system pathologies. | 2014 | Biomed Res Int | pmid:25276776 |
| Esquivias P et al. | Effect of aspirin treatment on the prevention of esophageal adenocarcinoma in a rat experimental model. | 2014 | Oncol. Rep. | pmid:24737143 |
| Yang F et al. | Regional arterial infusion with lipoxin A4 attenuates experimental severe acute pancreatitis. | 2014 | PLoS ONE | pmid:25265022 |
| Ono E et al. | Lipoxin generation is related to soluble epoxide hydrolase activity in severe asthma. | 2014 | Am. J. Respir. Crit. Care Med. | pmid:25162465 |
| Ortiz-Muñoz G et al. | Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice. | 2014 | Blood | pmid:25143486 |
| Andersson P et al. | Inhibition of neutrophil-dependent cytotoxicity for human endothelial cells by ACE inhibitors. | 2014 | Scand. J. Immunol. | pmid:25124788 |
| Wu R et al. | Lipoxin A4 suppresses the development of endometriosis in an ALX receptor-dependent manner via the p38 MAPK pathway. | 2014 | Br. J. Pharmacol. | pmid:24923883 |
| Zhou XL et al. | Protective effects of lipoxin A4 in testis injury following testicular torsion and detorsion in rats. | 2014 | Mediators Inflamm. | pmid:24904198 |
| Martin CR et al. | Resolvin D1 and lipoxin A4 improve alveolarization and normalize septal wall thickness in a neonatal murine model of hyperoxia-induced lung injury. | 2014 | PLoS ONE | pmid:24892762 |
| Tani Y et al. | Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice. | 2014 | FASEB J. | pmid:24891522 |
| Wu H et al. | Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. | 2014 | PLoS ONE | pmid:24671173 |
| Kumar R et al. | Lipoxin Aâ‚„ prevents the progression of de novo and established endometriosis in a mouse model by attenuating prostaglandin Eâ‚‚ production and estrogen signaling. | 2014 | PLoS ONE | pmid:24587003 |
| Zhao Q et al. | LipoxinA4 attenuates myocardial ischemia reperfusion injury via a mechanism related to downregulation of GRP-78 and caspase-12 in rats. | 2014 | Heart Vessels | pmid:24129401 |
| Yao C et al. | Aspirin-triggered lipoxin A4 attenuates lipopolysaccharide induced inflammatory response in primary astrocytes. | 2014 | Int. Immunopharmacol. | pmid:24269179 |
| Ramon S et al. | Lipoxin Aâ‚„ modulates adaptive immunity by decreasing memory B-cell responses via an ALX/FPR2-dependent mechanism. | 2014 | Eur. J. Immunol. | pmid:24166736 |
| Xu Z et al. | Preeclampsia is associated with a deficiency of lipoxin A4, an endogenous anti-inflammatory mediator. | 2014 | Fertil. Steril. | pmid:24796762 |
| Chen S et al. | Lipoxin A4 regulates expression of the estrogen receptor and inhibits 17β-estradiol induced p38 mitogen-activated protein kinase phosphorylation in human endometriotic stromal cells. | 2014 | Fertil. Steril. | pmid:24835059 |
| Nanhwan MK et al. | Chronic treatment with ticagrelor limits myocardial infarct size: an adenosine and cyclooxygenase-2-dependent effect. | 2014 | Arterioscler. Thromb. Vasc. Biol. | pmid:25012137 |
| Li C et al. | Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells. | 2014 | J. Exp. Med. | pmid:24395886 |
| Ballesteros I et al. | Rosiglitazone-induced CD36 up-regulation resolves inflammation by PPARγ and 5-LO-dependent pathways. | 2014 | J. Leukoc. Biol. | pmid:24338629 |
| Eke Gungor H et al. | Decreased levels of lipoxin A4 and annexin A1 in wheezy infants. | 2014 | Int. Arch. Allergy Immunol. | pmid:24525704 |
| Osuchowski MF | Tender mediation in a ruthless environment: can lipoxins provide lifesaving modifications to fatally deregulated immunoinflammatory responses in sepsis?*. | 2014 | Crit. Care Med. | pmid:24633114 |
| Leo LM et al. | Age-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice. | 2014 | PLoS ONE | pmid:24416334 |
| Hamza B et al. | Retrotaxis of human neutrophils during mechanical confinement inside microfluidic channels. | 2014 | Integr Biol (Camb) | pmid:24419464 |
| Ueda T et al. | Combination therapy of 15-epi-lipoxin A4 with antibiotics protects mice from Escherichia coli-induced sepsis*. | 2014 | Crit. Care Med. | pmid:24463858 |
| Higgins G et al. | Activation of P2RY11 and ATP release by lipoxin A4 restores the airway surface liquid layer and epithelial repair in cystic fibrosis. | 2014 | Am. J. Respir. Cell Mol. Biol. | pmid:24588705 |
| Zhang D et al. | Glucocorticoids sensitize rat placental inflammatory responses via inhibiting lipoxin A4 biosynthesis. | 2014 | Biol. Reprod. | pmid:24571985 |
| Tateishi N et al. | Dietary supplementation of arachidonic acid increases arachidonic acid and lipoxin Aâ‚„ contents in colon, but does not affect severity or prostaglandin Eâ‚‚ content in murine colitis model. | 2014 | Lipids Health Dis | pmid:24507383 |
| Fischer CD et al. | Tulathromycin exerts proresolving effects in bovine neutrophils by inhibiting phospholipases and altering leukotriene B4, prostaglandin E2, and lipoxin A4 production. | 2014 | Antimicrob. Agents Chemother. | pmid:24820086 |
| Ringholz FC et al. | Reduced 15-lipoxygenase 2 and lipoxin A4/leukotriene B4 ratio in children with cystic fibrosis. | 2014 | Eur. Respir. J. | pmid:24696116 |
| Divangahi M et al. | Dying to live: how the death modality of the infected macrophage affects immunity to tuberculosis. | 2013 | Adv. Exp. Med. Biol. | pmid:23468106 |
| Wang Q et al. | Lipoxin A(4) activates alveolar epithelial sodium channel, Na,K-ATPase, and increases alveolar fluid clearance. | 2013 | Am. J. Respir. Cell Mol. Biol. | pmid:23470626 |
| Peebles RS | A new horizon in asthma: inhibiting ILC function. | 2013 | Sci Transl Med | pmid:23447016 |
| Barnig C and Levy BD | Lipoxin A4: a new direction in asthma therapy? | 2013 | Expert Rev Clin Immunol | pmid:23730877 |
| Brancaleone V et al. | A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation. | 2013 | Blood | pmid:23733341 |
| Costa ES et al. | Involvement of formyl peptide receptors in the stimulatory effect of crotoxin on macrophages co-cultivated with tumour cells. | 2013 | Toxicon | pmid:23998941 |