| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tuberculosis | D014376 | 20 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
Lipoxin A4
Lipoxin a4 is a lipid of Fatty Acyls (FA) class. Lipoxin a4 is associated with abnormalities such as Asthma, Cystic Fibrosis, Pneumonia, Obesity and Septicemia. The involved functions are known as Inflammation, Signal, Signal Transduction, Regulation and Metabolic Inhibition. Lipoxin a4 often locates in Immune system, Blood, soluble, Extracellular and Splenic Tissue. The associated genes with Lipoxin A4 are FPR2 gene, Homologous Gene, SAA1 gene, Trp-Lys-Tyr-Met-Val-Met and Annexin 1. The related lipids are Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Lipoxin A4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Lipoxin A4?
Lipoxin A4 is suspected in Asthma, Cystic Fibrosis, Chagas Cardiomyopathy, Pneumonia, Obesity, Septicemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Lipoxin A4
PubChem Associated disorders and diseases
What pathways are associated with Lipoxin A4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Lipoxin A4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Lipoxin A4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Lipoxin A4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Lipoxin A4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Lipoxin A4?
Knock-out
Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Lipoxin A4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mustafa M et al. | Resolvin D1 protects periodontal ligament. | 2013 | Am. J. Physiol., Cell Physiol. | pmid:23864609 |
| Lee HJ et al. | Resolvin D1 inhibits TGF-β1-induced epithelial mesenchymal transition of A549 lung cancer cells via lipoxin A4 receptor/formyl peptide receptor 2 and GPR32. | 2013 | Int. J. Biochem. Cell Biol. | pmid:24120851 |
| Das UN | Lipoxins, resolvins, and protectins in the prevention and treatment of diabetic macular edema and retinopathy. | 2013 | Nutrition | pmid:22677359 |
| Hong H et al. | Molecular mechanisms elucidating why old stomach is more vulnerable to indomethacin-induced damage than young stomach. | 2013 | Dig. Dis. Sci. | pmid:22843164 |
| Canny GO and Lessey BA | The role of lipoxin A4 in endometrial biology and endometriosis. | 2013 | Mucosal Immunol | pmid:23485944 |
| Xiong J et al. | Lipoxin A4 blocks embryo implantation by controlling estrogen receptor α activity. | 2013 | Reproduction | pmid:23426803 |
| Divangahi M et al. | Dying to live: how the death modality of the infected macrophage affects immunity to tuberculosis. | 2013 | Adv. Exp. Med. Biol. | pmid:23468106 |
| Wang Q et al. | Lipoxin A(4) activates alveolar epithelial sodium channel, Na,K-ATPase, and increases alveolar fluid clearance. | 2013 | Am. J. Respir. Cell Mol. Biol. | pmid:23470626 |
| Peebles RS | A new horizon in asthma: inhibiting ILC function. | 2013 | Sci Transl Med | pmid:23447016 |
| Gori I et al. | Augmented epithelial multidrug resistance-associated protein 4 expression in peritoneal endometriosis: regulation by lipoxin A(4). | 2013 | Fertil. Steril. | pmid:23472950 |
| Kirkby NS et al. | Aspirin-triggered 15-epi-lipoxin A4 predicts cyclooxygenase-2 in the lungs of LPS-treated mice but not in the circulation: implications for a clinical test. | 2013 | FASEB J. | pmid:23792301 |
| Wu L et al. | Lipoxin A4 ameliorates cerebral ischaemia/reperfusion injury through upregulation of nuclear factor erythroid 2-related factor 2. | 2013 | Neurol. Res. | pmid:23880501 |
| Endo H | [Resolving factors of inflammation - a bridge between innate immunity and adaptive immunity]. | 2013 | Nihon Rinsho Meneki Gakkai Kaishi | pmid:23812073 |
| Sordi R et al. | Dual role of lipoxin A4 in pneumosepsis pathogenesis. | 2013 | Int. Immunopharmacol. | pmid:23816538 |
| Park SW et al. | Apolipoprotein A1 potentiates lipoxin A4 synthesis and recovery of allergen-induced disrupted tight junctions in the airway epithelium. | 2013 | Clin. Exp. Allergy | pmid:23889245 |
| Zhang G et al. | Resolution of PMA-induced skin inflammation involves interaction of IFN-γ and ALOX15. | 2013 | Mediators Inflamm. | pmid:23818745 |
| Chen XQ et al. | Lipoxin A4-induced heme oxygenase-1 protects cardiomyocytes against hypoxia/reoxygenation injury via p38 MAPK activation and Nrf2/ARE complex. | 2013 | PLoS ONE | pmid:23826208 |
| Xia J et al. | Roles of lipoxin A4 in preventing paracetamol-induced acute hepatic injury in a rabbit model. | 2013 | Inflammation | pmid:23851615 |
| Chen XQ et al. | Involvement of K+ channel-dependant pathways in lipoxin A4-induced protective effects on hypoxia/reoxygenation injury of cardiomyocytes. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23602847 |
| Planagumà A et al. | Lack of activity of 15-epi-lipoxin A₄ on FPR2/ALX and CysLT1 receptors in interleukin-8-driven human neutrophil function. | 2013 | Clin. Exp. Immunol. | pmid:23607720 |
| Wu B et al. | Lipoxin A(4) promotes more complete inflammation resolution in sepsis compared to stable lipoxin A(4) analog. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23688707 |
| Molina-BerrÃos A et al. | Protective role of acetylsalicylic acid in experimental Trypanosoma cruzi infection: evidence of a 15-epi-lipoxin Aâ‚„-mediated effect. | 2013 | PLoS Negl Trop Dis | pmid:23638194 |
| Das UN | Arachidonic acid and lipoxin A4 as possible endogenous anti-diabetic molecules. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23295193 |
| Wang C et al. | IFN-γ-mediated downregulation of LXA4 is necessary for the maintenance of nonresolving inflammation and papilloma persistence. | 2013 | Cancer Res. | pmid:23319805 |
| Luo CL et al. | Lipoxin A4 attenuates brain damage and downregulates the production of pro-inflammatory cytokines and phosphorylated mitogen-activated protein kinases in a mouse model of traumatic brain injury. | 2013 | Brain Res. | pmid:23370001 |
| Ye Y et al. | Phosphodiesterase-3 inhibition augments the myocardial infarct size-limiting effects of exenatide in mice with type 2 diabetes. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:23103492 |
| Chen Z et al. | Effect of lipoxin A4 on myocardial ischemia reperfusion injury following cardiac arrest in a rabbit model. | 2013 | Inflammation | pmid:23114480 |
| Brennan EP et al. | Lipoxins attenuate renal fibrosis by inducing let-7c and suppressing TGFβR1. | 2013 | J. Am. Soc. Nephrol. | pmid:23520204 |
| Carlo T et al. | 15-Epi-lipoxin A4 inhibits human neutrophil superoxide anion generation by regulating polyisoprenyl diphosphate phosphatase 1. | 2013 | FASEB J. | pmid:23568778 |
| Yang Y et al. | Contribution of CFTR to alveolar fluid clearance by lipoxin A4 via PI3K/Akt pathway in LPS-induced acute lung injury. | 2013 | Mediators Inflamm. | pmid:23766562 |
| Tsai WH et al. | Plasma levels in sepsis patients of annexin A1, lipoxin A4, macrophage inflammatory protein-3a, and neutrophil gelatinase-associated lipocalin. | 2013 | J Chin Med Assoc | pmid:23769883 |
| Barnig C and Levy BD | Lipoxin A4: a new direction in asthma therapy? | 2013 | Expert Rev Clin Immunol | pmid:23730877 |
| Brancaleone V et al. | A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation. | 2013 | Blood | pmid:23733341 |
| Costa ES et al. | Involvement of formyl peptide receptors in the stimulatory effect of crotoxin on macrophages co-cultivated with tumour cells. | 2013 | Toxicon | pmid:23998941 |
| Lv W et al. | Lipoxin A4 attenuation of endothelial inflammation response mimicking pancreatitis-induced lung injury. | 2013 | Exp. Biol. Med. (Maywood) | pmid:24000382 |
| Zhao Q et al. | Lipoxin a4 preconditioning and postconditioning protect myocardial ischemia/reperfusion injury in rats. | 2013 | Mediators Inflamm. | pmid:23956501 |
| Moreno C et al. | Modulation of voltage-dependent and inward rectifier potassium channels by 15-epi-lipoxin-A4 in activated murine macrophages: implications in innate immunity. | 2013 | J. Immunol. | pmid:24249731 |
| Lin F et al. | A synthetic analog of lipoxin A4 partially alleviates dexamethasone-induced fetal growth restriction in rats. | 2013 | Placenta | pmid:23910525 |
| Zhao QF et al. | [Effects of lipoxinA4 on endoplasmic reticulum stress during myocardial ischemia reperfusion injury in rats]. | 2013 | Zhonghua Yi Xue Za Zhi | pmid:23863683 |
| Meng H et al. | Effect of n-3 and n-6 unsaturated fatty acids on prostate cancer (PC-3) and prostate epithelial (RWPE-1) cells in vitro. | 2013 | Lipids Health Dis | pmid:24168453 |
| Buchanan PJ et al. | Lipoxin Aâ‚„-mediated KATP potassium channel activation results in cystic fibrosis airway epithelial repair. | 2013 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:23686859 |
| Shimizu S et al. | Pro-resolution mediator lipoxin A4 and its receptor in upper airway inflammation. | 2013 | Ann. Otol. Rhinol. Laryngol. | pmid:24358628 |
| Dai J et al. | Effects of polyunsaturated fatty acids on the growth of gastric cancer cells in vitro. | 2013 | Lipids Health Dis | pmid:23663688 |
| Weiss GA et al. | High levels of anti-inflammatory and pro-resolving lipid mediators lipoxins and resolvins and declining docosahexaenoic acid levels in human milk during the first month of lactation. | 2013 | Lipids Health Dis | pmid:23767972 |
| Kazani S et al. | Exhaled breath condensate eicosanoid levels associate with asthma and its severity. | 2013 | J. Allergy Clin. Immunol. | pmid:23608729 |
| Gil-Villa AM et al. | Aspirin triggered-lipoxin A4 reduces the adhesion of human polymorphonuclear neutrophils to endothelial cells initiated by preeclamptic plasma. | 2012 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22974760 |
| Das UN | Radiation resistance, invasiveness and metastasis are inflammatory events that could be suppressed by lipoxin A4. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22014542 |
| Wu Y et al. | Aspirin-triggered lipoxin Aâ‚„ attenuates lipopolysaccharide-induced intracellular ROS in BV2 microglia cells by inhibiting the function of NADPH oxidase. | 2012 | Neurochem. Res. | pmid:22552474 |
| Scully M et al. | Protective role of cyclooxygenase (COX)-2 in experimental lung injury: evidence of a lipoxin A4-mediated effect. | 2012 | J. Surg. Res. | pmid:21944479 |
| Krönke G et al. | The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis. | 2012 | Ann. Rheum. Dis. | pmid:22267335 |
| Birnbaum Y et al. | Phosphodiesterase III inhibition increases cAMP levels and augments the infarct size limiting effect of a DPP-4 inhibitor in mice with type-2 diabetes mellitus. | 2012 | Cardiovasc Drugs Ther | pmid:22936458 |
| Gangemi S et al. | Ultrarush venom immunotherapy and the lipoxin a4 inflammation resolution pathway. | 2012 | Ann. Allergy Asthma Immunol. | pmid:22920084 |
| Deng LL et al. | [Protective effect of lipoxin A4 against rhabdomyolysis-induced acute kidney injury in rats]. | 2012 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:22980651 |
| Xu Z et al. | Lipoxin A4 inhibits the development of endometriosis in mice: the role of anti-inflammation and anti-angiogenesis. | 2012 | Am. J. Reprod. Immunol. | pmid:22229383 |
| Chinthamani S et al. | Lipoxin A4 inhibits immune cell binding to salivary epithelium and vascular endothelium. | 2012 | Am. J. Physiol., Cell Physiol. | pmid:22205391 |
| Das UN | Is lipoxins A₄ a better alternative to anti-VEGF and anti-TNF-α antibody to prevent and treat age-related macular degeneration, diabetic macular edema and retinopathy? | 2012 | Med. Sci. Monit. | pmid:22207123 |
| Bozinovski S et al. | Serum amyloid A opposes lipoxin Aâ‚„ to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22215599 |
| Vong L et al. | Up-regulation of Annexin-A1 and lipoxin A(4) in individuals with ulcerative colitis may promote mucosal homeostasis. | 2012 | PLoS ONE | pmid:22723974 |
| Zhou CH et al. | [Protective effects and possible mechanism of lipoxin A(4) analogue in rats with acute pancreatitis]. | 2012 | Zhonghua Yi Xue Za Zhi | pmid:22781577 |
| Gilbert NC et al. | Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663. | 2012 | FASEB J. | pmid:22516296 |
| Gutierrez AD et al. | The effect of pioglitazone treatment on 15-epi-lipoxin A4 levels in patients with type 2 diabetes. | 2012 | Atherosclerosis | pmid:22687642 |
| Börgeson E et al. | Lipoxin A4 attenuates adipose inflammation. | 2012 | FASEB J. | pmid:22700871 |
| Esper L et al. | Role of SOCS2 in modulating heart damage and function in a murine model of acute Chagas disease. | 2012 | Am. J. Pathol. | pmid:22658486 |
| Verrière V et al. | Lipoxin A4 stimulates calcium-activated chloride currents and increases airway surface liquid height in normal and cystic fibrosis airway epithelia. | 2012 | PLoS ONE | pmid:22662206 |
| Jin H et al. | Lipoxin A4 analog attenuates morphine antinociceptive tolerance, withdrawal-induced hyperalgesia, and glial reaction and cytokine expression in the spinal cord of rat. | 2012 | Neuroscience | pmid:22366510 |
| Gras D et al. | An ex vivo model of severe asthma using reconstituted human bronchial epithelium. | 2012 | J. Allergy Clin. Immunol. | pmid:22409990 |
| Kakazu A et al. | Lipoxin Aâ‚„ inhibits platelet-activating factor inflammatory response and stimulates corneal wound healing of injuries that compromise the stroma. | 2012 | Exp. Eye Res. | pmid:22828048 |
| Mumm JP | Single-molecule microscopy of Cre recombination. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23204438 |
| Pertwee RG | Lipoxin A4 is an allosteric endocannabinoid that strengthens anandamide-induced CB1 receptor activation. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23204441 |
| Pamplona FA et al. | Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23150578 |
| Lin F et al. | Treatment of Lipoxin A(4) and its analogue on low-dose endotoxin induced preeclampsia in rat and possible mechanisms. | 2012 | Reprod. Toxicol. | pmid:23063943 |
| Sun T et al. | LipoxinA(4) induced antinociception and decreased expression of NF-κB and pro-inflammatory cytokines after chronic dorsal root ganglia compression in rats. | 2012 | Eur J Pain | pmid:21658981 |
| Dakin SG et al. | Macrophage sub-populations and the lipoxin A4 receptor implicate active inflammation during equine tendon repair. | 2012 | PLoS ONE | pmid:22384219 |
| Tsai WH et al. | Role of lipoxin A4 in the cell-to-cell interaction between all-trans retinoic acid-treated acute promyelocytic leukemic cells and alveolar macrophages. | 2012 | J. Cell. Physiol. | pmid:21567401 |
| Zimmerman JJ | Exhaled breath condensate: a breathalyzer for lung inflammation. | 2012 | Pediatr Crit Care Med | pmid:22391827 |
| Martin N et al. | Primary human airway epithelial cell-dependent inhibition of human lung mast cell degranulation. | 2012 | PLoS ONE | pmid:22970103 |
| Wu L et al. | Lipoxin A4 inhibits 5-lipoxygenase translocation and leukotrienes biosynthesis to exert a neuroprotective effect in cerebral ischemia/reperfusion injury. | 2012 | J. Mol. Neurosci. | pmid:22661361 |
| Hasan RA et al. | Lipoxin A(4) and 8-isoprostane in the exhaled breath condensate of children hospitalized for status asthmaticus. | 2012 | Pediatr Crit Care Med | pmid:21666533 |
| Balode L et al. | Lipoxygenase-derived arachidonic acid metabolites in chronic obstructive pulmonary disease. | 2012 | Medicina (Kaunas) | pmid:22885362 |
| Jones CN et al. | Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23185003 |
| Su X et al. | Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. | 2012 | Mol. Med. | pmid:23296426 |
| Bitto A et al. | Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis. | 2012 | Crit Care | pmid:22356547 |
| Dakin SG et al. | Inflamm-aging and arachadonic acid metabolite differences with stage of tendon disease. | 2012 | PLoS ONE | pmid:23155437 |
| Rozsasi A et al. | Cyclooxygenase 2 and lipoxin Aâ‚„ in nasal polyps in cystic fibrosis. | 2011 Nov-Dec | Am J Rhinol Allergy | pmid:22185734 |
| Levy BD et al. | The endogenous pro-resolving mediators lipoxin A4 and resolvin E1 preserve organ function in allograft rejection. | 2011 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20869861 |
| Zheng S et al. | Novel biphasic role of LipoxinA(4) on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts. | 2011 | Mediators Inflamm. | pmid:21765620 |
| Yamaguchi H et al. | Urinary concentrations of 15-epimer of lipoxin A(4) are lower in patients with aspirin-intolerant compared with aspirin-tolerant asthma. | 2011 | Clin. Exp. Allergy | pmid:22093074 |
| Börgeson E et al. | Lipoxin A₄ and benzo-lipoxin A₄ attenuate experimental renal fibrosis. | 2011 | FASEB J. | pmid:21628447 |
| Walker J et al. | Lipoxin a4 increases survival by decreasing systemic inflammation and bacterial load in sepsis. | 2011 | Shock | pmid:21701419 |
| Das UN | Lipoxins as biomarkers of lupus and other inflammatory conditions. | 2011 | Lipids Health Dis | pmid:21569625 |
| Pang HY et al. | [Effect of lipoxin A(4) on lipopolysaccharide-induced endothelial hyperpermeability in human umbilical vein endothelial cell]. | 2011 | Zhonghua Fu Chan Ke Za Zhi | pmid:21575454 |
| He J et al. | Aspirin-triggered lipoxin A4 (15-epi-LXA4) increases the endothelial viability of human corneas storage in Optisol-GS. | 2011 | J Ocul Pharmacol Ther | pmid:21548792 |
| Pang H et al. | Effect of lipoxin A4 on lipopolysaccharide-induced endothelial hyperpermeability. | 2011 | ScientificWorldJournal | pmid:21552771 |
| Macdonald LJ et al. | A role for lipoxin Aâ‚„ as an anti-inflammatory mediator in the human endometrium. | 2011 | Reproduction | pmid:21555360 |
| Forsman H et al. | What formyl peptide receptors, if any, are triggered by compound 43 and lipoxin A4? | 2011 | Scand. J. Immunol. | pmid:21535079 |
| Norling LV et al. | Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing. | 2011 | J. Immunol. | pmid:21460209 |
| Russell R et al. | Lipoxin A4 is a novel estrogen receptor modulator. | 2011 | FASEB J. | pmid:21885654 |
| Basselin M et al. | Anti-inflammatory effects of chronic aspirin on brain arachidonic acid metabolites. | 2011 | Neurochem. Res. | pmid:20981485 |
| Wang YP et al. | Aspirin-triggered lipoxin A4 attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-κB and MAPKs in BV-2 microglial cells. | 2011 | J Neuroinflammation | pmid:21831303 |
| Wan M et al. | Leukotriene B4/antimicrobial peptide LL-37 proinflammatory circuits are mediated by BLT1 and FPR2/ALX and are counterregulated by lipoxin A4 and resolvin E1. | 2011 | FASEB J. | pmid:21307335 |