| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tuberculosis | D014376 | 20 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
Lipoxin A4
Lipoxin a4 is a lipid of Fatty Acyls (FA) class. Lipoxin a4 is associated with abnormalities such as Asthma, Cystic Fibrosis, Pneumonia, Obesity and Septicemia. The involved functions are known as Inflammation, Signal, Signal Transduction, Regulation and Metabolic Inhibition. Lipoxin a4 often locates in Immune system, Blood, soluble, Extracellular and Splenic Tissue. The associated genes with Lipoxin A4 are FPR2 gene, Homologous Gene, SAA1 gene, Trp-Lys-Tyr-Met-Val-Met and Annexin 1. The related lipids are Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Lipoxin A4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Lipoxin A4?
Lipoxin A4 is suspected in Asthma, Cystic Fibrosis, Chagas Cardiomyopathy, Pneumonia, Obesity, Septicemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Immunol. (2)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Antimicrob. Agents Chemother. (1)
- Others (7)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Lipoxin A4
PubChem Associated disorders and diseases
What pathways are associated with Lipoxin A4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Lipoxin A4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Lipoxin A4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Lipoxin A4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Lipoxin A4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Lipoxin A4?
Knock-out
Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Lipoxin A4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zheng S et al. | Novel biphasic role of LipoxinA(4) on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts. | 2011 | Mediators Inflamm. | pmid:21765620 |
| Börgeson E et al. | Lipoxin A₄ and benzo-lipoxin A₄ attenuate experimental renal fibrosis. | 2011 | FASEB J. | pmid:21628447 |
| Börgeson E et al. | Lipoxin A₄ inhibits porphyromonas gingivalis-induced aggregation and reactive oxygen species production by modulating neutrophil-platelet interaction and CD11b expression. | 2011 | Infect. Immun. | pmid:21263017 |
| Kenchegowda S et al. | EGF stimulates lipoxin A4 synthesis and modulates repair in corneal epithelial cells through ERK and p38 activation. | 2011 | Invest. Ophthalmol. Vis. Sci. | pmid:21220563 |
| Das UN | Lipoxins as biomarkers of lupus and other inflammatory conditions. | 2011 | Lipids Health Dis | pmid:21569625 |
| Pang HY et al. | [Effect of lipoxin A(4) on lipopolysaccharide-induced endothelial hyperpermeability in human umbilical vein endothelial cell]. | 2011 | Zhonghua Fu Chan Ke Za Zhi | pmid:21575454 |
| He J et al. | Aspirin-triggered lipoxin A4 (15-epi-LXA4) increases the endothelial viability of human corneas storage in Optisol-GS. | 2011 | J Ocul Pharmacol Ther | pmid:21548792 |
| Pang H et al. | Effect of lipoxin A4 on lipopolysaccharide-induced endothelial hyperpermeability. | 2011 | ScientificWorldJournal | pmid:21552771 |
| Macdonald LJ et al. | A role for lipoxin Aâ‚„ as an anti-inflammatory mediator in the human endometrium. | 2011 | Reproduction | pmid:21555360 |
| Forsman H et al. | What formyl peptide receptors, if any, are triggered by compound 43 and lipoxin A4? | 2011 | Scand. J. Immunol. | pmid:21535079 |
| Norling LV et al. | Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing. | 2011 | J. Immunol. | pmid:21460209 |
| Basselin M et al. | Anti-inflammatory effects of chronic aspirin on brain arachidonic acid metabolites. | 2011 | Neurochem. Res. | pmid:20981485 |
| Tang K et al. | Microparticles mediate enzyme transfer from platelets to mast cells: a new pathway for lipoxin A4 biosynthesis. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20801099 |
| Das UN | Is lipoxins A4 a better alternative to anti-TNF-alpha antibody to prevent and treat diabetic macular edema and retinopathy? | 2010 | Med. Sci. Monit. | pmid:20802423 |
| Wu SH et al. | Lipoxin A(4) inhibits transition of epithelial to mesenchymal cells in proximal tubules. | 2010 | Am. J. Nephrol. | pmid:20714129 |
| Chen Y et al. | Lipoxin A4 and its analogue suppress the tumor growth of transplanted H22 in mice: the role of antiangiogenesis. | 2010 | Mol. Cancer Ther. | pmid:20682645 |
| Zhang B et al. | Depletion of regulatory T cells facilitates growth of established tumors: a mechanism involving the regulation of myeloid-derived suppressor cells by lipoxin A4. | 2010 | J. Immunol. | pmid:21068404 |
| Spite M and Serhan CN | Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins. | 2010 | Circ. Res. | pmid:21071715 |
| Ho KJ et al. | Aspirin-triggered lipoxin and resolvin E1 modulate vascular smooth muscle phenotype and correlate with peripheral atherosclerosis. | 2010 | Am. J. Pathol. | pmid:20709806 |
| Conte FP et al. | Lipoxin A(4) attenuates zymosan-induced arthritis by modulating endothelin-1 and its effects. | 2010 | Br. J. Pharmacol. | pmid:20860668 |
| Yin PL et al. | [Reversed changes of the 15-lipoxygenase product lipoxin Aâ‚„ and the 5-lipoxygenase product leukotriene Câ‚„ in children with asthma]. | 2010 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:20979801 |
| Planagumà A et al. | Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4. | 2010 | Mucosal Immunol | pmid:20130564 |
| Wang J et al. | Effect of lipoxin A₄ on IL-1β production of monocytes and its possible mechanism in severe preeclampsia. | 2010 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:21181369 |
| Leemans J et al. | Prophylactic effects of omega-3 polyunsaturated fatty acids and luteolin on airway hyperresponsiveness and inflammation in cats with experimentally-induced asthma. | 2010 | Vet. J. | pmid:19231257 |
| Chen QH et al. | 15-Epi-lipoxin A(4) inhibits the progression of endometriosis in a murine model. | 2010 | Fertil. Steril. | pmid:19268934 |
| Krishnamoorthy S et al. | Resolvin D1 binds human phagocytes with evidence for proresolving receptors. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20080636 |
| Wu Y et al. | Neuroprotective effect of lipoxin A4 methyl ester in a rat model of permanent focal cerebral ischemia. | 2010 | J. Mol. Neurosci. | pmid:20401639 |
| Kure I et al. | Lipoxin A(4) reduces lipopolysaccharide-induced inflammation in macrophages and intestinal epithelial cells through inhibition of nuclear factor-kappaB activation. | 2010 | J. Pharmacol. Exp. Ther. | pmid:19846590 |
| Leedom AJ et al. | Endogenous LXA4 circuits are determinants of pathological angiogenesis in response to chronic injury. | 2010 | Am. J. Pathol. | pmid:20008149 |
| Bhavsar PK et al. | Corticosteroid suppression of lipoxin A4 and leukotriene B4 from alveolar macrophages in severe asthma. | 2010 | Respir. Res. | pmid:20529300 |
| Chan MM and Moore AR | Resolution of inflammation in murine autoimmune arthritis is disrupted by cyclooxygenase-2 inhibition and restored by prostaglandin E2-mediated lipoxin A4 production. | 2010 | J. Immunol. | pmid:20435922 |
| Wu SH et al. | Reversed changes of lipoxin A4 and leukotrienes in children with asthma in different severity degree. | 2010 | Pediatr. Pulmonol. | pmid:20232472 |
| Zhou G et al. | Atorvastatin reduces plaque vulnerability in an atherosclerotic rabbit model by altering the 5-lipoxygenase pathway. | 2010 | Cardiology | pmid:20234134 |
| Maderna P et al. | FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis. | 2010 | FASEB J. | pmid:20570963 |
| Duffy CD et al. | Synthesis and biological evaluation of pyridine-containing lipoxin A4 analogues. | 2010 | ChemMedChem | pmid:20127785 |
| Prieto P et al. | Lipoxin A4 impairment of apoptotic signaling in macrophages: implication of the PI3K/Akt and the ERK/Nrf-2 defense pathways. | 2010 | Cell Death Differ. | pmid:20094061 |
| Wu SH et al. | NF-kappaB is involved in inhibition of lipoxin A4 on dermal inflammation and hyperplasia induced by mezerein. | 2010 | Exp. Dermatol. | pmid:20100194 |
| Dufton N et al. | Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation. | 2010 | J. Immunol. | pmid:20107188 |
| Sanchez Y et al. | The unexpected role for the aryl hydrocarbon receptor on susceptibility to experimental toxoplasmosis. | 2010 | J. Biomed. Biotechnol. | pmid:20111744 |
| Pamplona FA et al. | Aspirin-triggered lipoxin induces CB1-dependent catalepsy in mice. | 2010 | Neurosci. Lett. | pmid:20036315 |
| Morris T et al. | Dichotomy in duration and severity of acute inflammatory responses in humans arising from differentially expressed proresolution pathways. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20421472 |
| Simões RL et al. | A synthetic analog of 15-epi-lipoxin A4 inhibits human monocyte apoptosis: involvement of ERK-2 and PI3-kinase. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20004734 |
| Marcheselli VL et al. | Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19931440 |
| Sun YP et al. | Anti-inflammatory and pro-resolving properties of benzo-lipoxin A(4) analogs. | 2009 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19853429 |
| Sobrado M et al. | Synthesis of lipoxin A4 by 5-lipoxygenase mediates PPARgamma-dependent, neuroprotective effects of rosiglitazone in experimental stroke. | 2009 | J. Neurosci. | pmid:19321784 |
| Beck-Speier I et al. | Oxymetazoline inhibits and resolves inflammatory reactions in human neutrophils. | 2009 | J. Pharmacol. Sci. | pmid:19609065 |
| Wu SH et al. | Elevated expressions of 15-lipoxygenase and lipoxin A4 in children with acute poststreptococcal glomerulonephritis. | 2009 | Am. J. Pathol. | pmid:19095947 |
| Calandria JM et al. | Selective survival rescue in 15-lipoxygenase-1-deficient retinal pigment epithelial cells by the novel docosahexaenoic acid-derived mediator, neuroprotectin D1. | 2009 | J. Biol. Chem. | pmid:19403949 |
| Baker N et al. | Lipoxin A4: anti-inflammatory and anti-angiogenic impact on endothelial cells. | 2009 | J. Immunol. | pmid:19265161 |
| Grumbach Y et al. | LXA4 stimulates ZO-1 expression and transepithelial electrical resistance in human airway epithelial (16HBE14o-) cells. | 2009 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:18849442 |
| Decker Y et al. | Lipoxin A4 inhibits IL-1beta-induced IL-8 and ICAM-1 expression in 1321N1 human astrocytoma cells. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19357230 |
| Forsman H and Dahlgren C | Lipoxin A(4) metabolites/analogues from two commercial sources have no effects on TNF-alpha-mediated priming or activation through the neutrophil formyl peptide receptors. | 2009 | Scand. J. Immunol. | pmid:19751275 |
| Carvalho RR et al. | Effect of mangiferin on the development of periodontal disease: involvement of lipoxin A4, anti-chemotaxic action in leukocyte rolling. | 2009 | Chem. Biol. Interact. | pmid:19026997 |
| Zurier RB et al. | Ajulemic acid, a synthetic cannabinoid, increases formation of the endogenous proresolving and anti-inflammatory eicosanoid, lipoxin A4. | 2009 | FASEB J. | pmid:19124557 |
| Kupczyk M et al. | Lipoxin A4 generation is decreased in aspirin-sensitive patients in lysine-aspirin nasal challenge in vivo model. | 2009 | Allergy | pmid:19385948 |
| Perretti M and D'Acquisto F | Annexin A1 and glucocorticoids as effectors of the resolution of inflammation. | 2009 | Nat. Rev. Immunol. | pmid:19104500 |
| El Kebir D et al. | 15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury. | 2009 | Am. J. Respir. Crit. Care Med. | pmid:19483113 |
| Li G et al. | The effect of Lipoxin A4 on the interaction between macrophage and osteoblast: possible role in the treatment of aseptic loosening. | 2009 | BMC Musculoskelet Disord | pmid:19490628 |
| Chen Q et al. | The inhibitory effect of 15-R-LXA4 on experimental endometriosis. | 2009 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:19523744 |
| Ereso AQ et al. | Lipoxin a(4) attenuates microvascular fluid leak during inflammation. | 2009 | J. Surg. Res. | pmid:19524267 |
| Liu S et al. | Effects of lipoxin A(4) on CoCl(2)-induced angiogenesis and its possible mechanisms in human umbilical vein endothelial cells. | 2009 | Pharmacology | pmid:19478549 |
| Morris T et al. | Effects of low-dose aspirin on acute inflammatory responses in humans. | 2009 | J. Immunol. | pmid:19597002 |
| Divangahi M et al. | Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair. | 2009 | Nat. Immunol. | pmid:19561612 |
| Liu SJ et al. | [Protective effects and its mechanism of lipoxins on human umbilical vein endothelial cells under hypoxia]. | 2009 | Zhonghua Fu Chan Ke Za Zhi | pmid:19570467 |
| Martins V et al. | ATLa, an aspirin-triggered lipoxin A4 synthetic analog, prevents the inflammatory and fibrotic effects of bleomycin-induced pulmonary fibrosis. | 2009 | J. Immunol. | pmid:19380784 |
| Karim MJ et al. | Anti-inflammatory effects of lipoxins on lipopolysaccharide-induced uveitis in rats. | 2009 | J Ocul Pharmacol Ther | pmid:20021273 |
| Wu SH et al. | Inverse temporal changes of lipoxin A4 and leukotrienes in children with Henoch-Schönlein purpura. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19264468 |
| Li YS et al. | Formyl-peptide receptor like 1: a potent mediator of the Ca2+ release-activated Ca2+ current ICRAC. | 2008 | Arch. Biochem. Biophys. | pmid:18652801 |
| Wu SH et al. | Signal pathway involved in inhibition by lipoxin A(4) of production of interleukins induced in endothelial cells by lipopolysaccharide. | 2008 | Inflamm. Res. | pmid:18777114 |
| Ye Y et al. | Phosphorylation of 5-lipoxygenase at ser523 by protein kinase A determines whether pioglitazone and atorvastatin induce proinflammatory leukotriene B4 or anti-inflammatory 15-epi-lipoxin a4 production. | 2008 | J. Immunol. | pmid:18714024 |
| Starosta V et al. | Lipoxin A4 counterregulates GM-CSF signaling in eosinophilic granulocytes. | 2008 | J. Immunol. | pmid:19050289 |
| Chen M et al. | Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death. | 2008 | J. Exp. Med. | pmid:18955568 |
| Menzies D et al. | Effect of aspirin on airway inflammation and pulmonary function in patients with persistent asthma. | 2008 | J. Allergy Clin. Immunol. | pmid:18313127 |
| Petasis NA et al. | Design and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory properties. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18249111 |
| Cezar-de-Mello PF et al. | ATL-1, an analogue of aspirin-triggered lipoxin A4, is a potent inhibitor of several steps in angiogenesis induced by vascular endothelial growth factor. | 2008 | Br. J. Pharmacol. | pmid:18193074 |
| Tahan F et al. | The role of lipoxin A4 in exercise-induced bronchoconstriction in asthma. | 2008 | J Asthma | pmid:18350409 |
| Merched AJ et al. | Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators. | 2008 | FASEB J. | pmid:18559988 |
| Haworth O et al. | Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation. | 2008 | Nat. Immunol. | pmid:18568027 |
| El Kebir D et al. | Opposing regulation of neutrophil apoptosis through the formyl peptide receptor-like 1/lipoxin A4 receptor: implications for resolution of inflammation. | 2008 | J. Leukoc. Biol. | pmid:18495783 |
| Weinberger B et al. | Mechanisms mediating reduced responsiveness of neonatal neutrophils to lipoxin A4. | 2008 | Pediatr. Res. | pmid:18535486 |
| Chiron R et al. | Lipoxin A(4) and interleukin-8 levels in cystic fibrosis sputum after antibiotherapy. | 2008 | J. Cyst. Fibros. | pmid:18541460 |
| Planagumà A et al. | Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma. | 2008 | Am. J. Respir. Crit. Care Med. | pmid:18583575 |
| Kim DM et al. | The effect of aspirin on gingival crevicular fluid levels of inflammatory and anti-inflammatory mediators in patients with gingivitis. | 2007 | J. Periodontol. | pmid:17668982 |
| Biteman B et al. | Interdependence of lipoxin A4 and heme-oxygenase in counter-regulating inflammation during corneal wound healing. | 2007 | FASEB J. | pmid:17384141 |
| Weylandt KH et al. | Lipoxins and resolvins in inflammatory bowel disease. | 2007 | Inflamm. Bowel Dis. | pmid:17262807 |
| Wu SH et al. | Signal transduction involved in protective effects of 15(R/S)-methyl- lipoxin A(4) on mesangioproliferative nephritis in rats. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17329090 |
| Celik GE et al. | Lipoxin A4 levels in asthma: relation with disease severity and aspirin sensitivity. | 2007 | Clin. Exp. Allergy | pmid:17883729 |
| Hashimoto A et al. | Antiinflammatory mediator lipoxin A4 and its receptor in synovitis of patients with rheumatoid arthritis. | 2007 | J. Rheumatol. | pmid:17918787 |
| O'Sullivan TP et al. | Aromatic lipoxin A4 and lipoxin B4 analogues display potent biological activities. | 2007 | J. Med. Chem. | pmid:17960922 |
| El-Sharkawy H et al. | Platelet-rich plasma: growth factors and pro- and anti-inflammatory properties. | 2007 | J. Periodontol. | pmid:17397313 |
| El Kebir D et al. | Aspirin-triggered lipoxins override the apoptosis-delaying action of serum amyloid A in human neutrophils: a novel mechanism for resolution of inflammation. | 2007 | J. Immunol. | pmid:17579083 |
| Bonnans C et al. | Synthesis and anti-inflammatory effect of lipoxins in human airway epithelial cells. | 2007 | Biomed. Pharmacother. | pmid:17418999 |
| Peres CM et al. | Inhibition of leukotriene biosynthesis abrogates the host control of Mycobacterium tuberculosis. | 2007 | Microbes Infect. | pmid:17347013 |
| Zhang L et al. | Lipoxin A4 negatively regulates lipopolysaccharide-induced differentiation of RAW264.7 murine macrophages into dendritic-like cells. | 2007 | Chin. Med. J. | pmid:17624266 |
| Levy BD et al. | Lipoxin A4 stable analogs reduce allergic airway responses via mechanisms distinct from CysLT1 receptor antagonism. | 2007 | FASEB J. | pmid:17625069 |
| Rao NL et al. | Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17371808 |
| Hashimoto A et al. | Glucocorticoids co-interact with lipoxin A4 via lipoxin A4 receptor (ALX) up-regulation. | 2007 | Biomed. Pharmacother. | pmid:17184966 |
| Nascimento-Silva V et al. | Aspirin-triggered lipoxin A4 blocks reactive oxygen species generation in endothelial cells: a novel antioxidative mechanism. | 2007 | Thromb. Haemost. | pmid:17200775 |
| Jin SW et al. | Posttreatment with aspirin-triggered lipoxin A4 analog attenuates lipopolysaccharide-induced acute lung injury in mice: the role of heme oxygenase-1. | 2007 | Anesth. Analg. | pmid:17242094 |
| Svensson CI et al. | Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing. | 2007 | J. Exp. Med. | pmid:17242163 |