| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tuberculosis | D014376 | 20 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
Lipoxin A4
Lipoxin a4 is a lipid of Fatty Acyls (FA) class. Lipoxin a4 is associated with abnormalities such as Asthma, Cystic Fibrosis, Pneumonia, Obesity and Septicemia. The involved functions are known as Inflammation, Signal, Signal Transduction, Regulation and Metabolic Inhibition. Lipoxin a4 often locates in Immune system, Blood, soluble, Extracellular and Splenic Tissue. The associated genes with Lipoxin A4 are FPR2 gene, Homologous Gene, SAA1 gene, Trp-Lys-Tyr-Met-Val-Met and Annexin 1. The related lipids are Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Lipoxin A4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Lipoxin A4?
Lipoxin A4 is suspected in Asthma, Cystic Fibrosis, Chagas Cardiomyopathy, Pneumonia, Obesity, Septicemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Immunol. (2)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Antimicrob. Agents Chemother. (1)
- Others (7)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Lipoxin A4
PubChem Associated disorders and diseases
What pathways are associated with Lipoxin A4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Lipoxin A4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Lipoxin A4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Lipoxin A4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Lipoxin A4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Lipoxin A4?
Knock-out
Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Lipoxin A4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Souza DG et al. | The required role of endogenously produced lipoxin A4 and annexin-1 for the production of IL-10 and inflammatory hyporesponsiveness in mice. | 2007 | J. Immunol. | pmid:18056401 |
| Zhou XY et al. | Effects of lipoxin A(4) on lipopolysaccharide induced proliferation and reactive oxygen species production in RAW264.7 macrophages through modulation of G-CSF secretion. | 2007 | Inflamm. Res. | pmid:17687517 |
| Rao NL et al. | Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17371808 |
| Schwab JM and Serhan CN | Lipoxins and new lipid mediators in the resolution of inflammation. | 2006 | Curr Opin Pharmacol | pmid:16750421 |
| Chiang N and Serhan CN | New mechanism for an old drug: aspirin triggers anti-inflammatory lipid mediators with gender implications. | 2006 | Compr Ther | pmid:17435267 |
| Parkinson JF | Lipoxin and synthetic lipoxin analogs: an overview of anti-inflammatory functions and new concepts in immunomodulation. | 2006 | Inflamm Allergy Drug Targets | pmid:16613568 |
| Wu SH et al. | Lipoxin A4 inhibits connective tissue growth factor-induced production of chemokines in rat mesangial cells. | 2006 | Kidney Int. | pmid:16408113 |
| Wada K et al. | Leukotriene B4 and lipoxin A4 are regulatory signals for neural stem cell proliferation and differentiation. | 2006 | FASEB J. | pmid:16940150 |
| Chiang N et al. | The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo. | 2006 | Pharmacol. Rev. | pmid:16968948 |
| Birnbaum Y et al. | Augmentation of myocardial production of 15-epi-lipoxin-a4 by pioglitazone and atorvastatin in the rat. | 2006 | Circulation | pmid:16908763 |
| Menezes-de-Lima O et al. | Lipoxin A4 inhibits acute edema in mice: implications for the anti-edematogenic mechanism induced by aspirin. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16939877 |
| Levy BD | Myocardial 15-epi-lipoxin A4 generation provides a new mechanism for the immunomodulatory effects of statins and thiazolidinediones. | 2006 | Circulation | pmid:16940203 |
| Wallace JL | Commonality of defensive roles of COX-2 in the lung and gut. | 2006 | Am. J. Pathol. | pmid:16565482 |
| Bonnans C et al. | Lipoxin A(4) regulates bronchial epithelial cell responses to acid injury. | 2006 | Am. J. Pathol. | pmid:16565483 |
| Reville K et al. | Lipoxin A4 redistributes myosin IIA and Cdc42 in macrophages: implications for phagocytosis of apoptotic leukocytes. | 2006 | J. Immunol. | pmid:16424219 |
| Mangino MJ et al. | Lipoxin biosynthesis in inflammatory bowel disease. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16516812 |
| Rodriguez M and Clare-Salzler M | Eicosanoid imbalance in the NOD mouse is related to a dysregulation in soluble epoxide hydrolase and 15-PGDH expression. | 2006 | Ann. N. Y. Acad. Sci. | pmid:17130543 |
| Chiang N et al. | Aspirin has a gender-dependent impact on antiinflammatory 15-epi-lipoxin A4 formation: a randomized human trial. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:16293793 |
| Morris T et al. | Not all eicosanoids are bad. | 2006 | Trends Pharmacol. Sci. | pmid:17055068 |
| Tran U et al. | Staphylococcal enterotoxin B initiates protein kinase C translocation and eicosanoid metabolism while inhibiting thrombin-induced aggregation in human platelets. | 2006 | Mol. Cell. Biochem. | pmid:16550298 |
| Machado FS et al. | Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent. | 2006 | Nat. Med. | pmid:16415877 |
| Romano M | Lipid mediators: lipoxin and aspirin-triggered 15-epi-lipoxins. | 2006 | Inflamm Allergy Drug Targets | pmid:16613567 |
| Perretti M and D'Acquisto F | Novel aspects of annexin 1 and glucocorticoid biology: intersection with nitric oxide and the lipoxin receptor. | 2006 | Inflamm Allergy Drug Targets | pmid:16613569 |
| Wallace JL | Nitric oxide, aspirin-triggered lipoxins and NO-aspirin in gastric protection. | 2006 | Inflamm Allergy Drug Targets | pmid:16613572 |
| Starosta V et al. | Anti-inflammatory cytokines in cystic fibrosis lung disease. | 2006 | Eur. Respir. J. | pmid:16807263 |
| Wu SH et al. | Lipoxin A4 inhibits proliferation of human lung fibroblasts induced by connective tissue growth factor. | 2006 | Am. J. Respir. Cell Mol. Biol. | pmid:16141446 |
| Cezar-de-Mello PF et al. | Aspirin-triggered Lipoxin A4 inhibition of VEGF-induced endothelial cell migration involves actin polymerization and focal adhesion assembly. | 2006 | Oncogene | pmid:16132039 |
| Serhan CN | Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16005201 |
| Wallace JL et al. | Lipoxins in gastric mucosal health and disease. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16024242 |
| Romano M | Lipoxin analogs and lipoxin formation in vivo. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15979293 |
| Gronert K | Lipoxins in the eye and their role in wound healing. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15979295 |
| Filep JG et al. | Lipoxins and aspirin-triggered lipoxins in neutrophil adhesion and signal transduction. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15979865 |
| Clà ria J and Planagumà A | Liver: the formation and actions of aspirin-triggered lipoxins. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16006110 |
| Gavins FN et al. | A twist in anti-inflammation: annexin 1 acts via the lipoxin A4 receptor. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15982865 |
| Guilford WJ and Parkinson JF | Second-generation beta-oxidation resistant 3-oxa-lipoxin A4 analogs. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15985364 |
| Fiore S et al. | Lipoxin A4 biology in the human synovium. Role of the ALX signaling pathways in modulation of inflammatory arthritis. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16125377 |
| Vachier I et al. | Severe asthma is associated with a loss of LX4, an endogenous anti-inflammatory compound. | 2005 | J. Allergy Clin. Immunol. | pmid:15637547 |
| Kowal-Bielecka O et al. | Cyclooxygenase- and lipoxygenase-derived eicosanoids in bronchoalveolar lavage fluid from patients with scleroderma lung disease: an imbalance between proinflammatory and antiinflammatory lipid mediators. | 2005 | Arthritis Rheum. | pmid:16320329 |
| Fukunaga K et al. | Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury. | 2005 | J. Immunol. | pmid:15814734 |
| Schröder H | New signaling routes for an old drug: lipoxin A4 might mediate heme oxygenase-1 induction by aspirin. Focus on "Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells". | 2005 | Am. J. Physiol., Cell Physiol. | pmid:16100387 |
| Titos E et al. | Inhibition of 5-lipoxygenase-activating protein abrogates experimental liver injury: role of Kupffer cells. | 2005 | J. Leukoc. Biol. | pmid:16033810 |
| Simões RL and Fierro IM | Involvement of the Rho-kinase/myosin light chain kinase pathway on human monocyte chemotaxis induced by ATL-1, an aspirin-triggered lipoxin A4 synthetic analog. | 2005 | J. Immunol. | pmid:16034127 |
| Devchand PR et al. | A synthetic eicosanoid LX-mimetic unravels host-donor interactions in allogeneic BMT-induced GvHD to reveal an early protective role for host neutrophils. | 2005 | FASEB J. | pmid:15677343 |
| Lu C et al. | [Transfection of Lipoxin A4 receptor-like protein gene enhanced the inhibitory effect of Lipoxin A4 on human lung fibroblasts proliferation induced by connective tissue growth factor]. | 2005 | Zhonghua Er Ke Za Zhi | pmid:15924723 |
| Nascimento-Silva V et al. | Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15901601 |
| Levy BD et al. | Diminished lipoxin biosynthesis in severe asthma. | 2005 | Am. J. Respir. Crit. Care Med. | pmid:15961693 |
| Devchand PR | Lipoxin agonists: turn right! to path of resolving neutrophil. | 2005 | Mem. Inst. Oswaldo Cruz | pmid:15962099 |
| Sakakibara H and Yoneda Y | [Aspirin-induced asthma (AIA)]. | 2005 | Nippon Rinsho | pmid:15954335 |
| Wu SH et al. | Lipoxin A4 inhibits TNF-alpha-induced production of interleukins and proliferation of rat mesangial cells. | 2005 | Kidney Int. | pmid:15954894 |
| Karp CL and Cooper AM | An oily, sustained counter-regulatory response to TB. | 2005 | J. Clin. Invest. | pmid:15931386 |
| Bafica A et al. | Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production. | 2005 | J. Clin. Invest. | pmid:15931391 |
| Gangemi S et al. | Aging is characterized by a profound reduction in anti-inflammatory lipoxin A4 levels. | 2005 | Exp. Gerontol. | pmid:15935589 |
| Wu SH et al. | High dose of lipoxin A4 induces apoptosis in rat renal interstitial fibroblasts. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15936930 |
| Rodgers K et al. | Lipoxin A4 modifies platelet-derived growth factor-induced pro-fibrotic gene expression in human renal mesangial cells. | 2005 | Am. J. Pathol. | pmid:16127149 |
| Sodin-Semrl S et al. | Opposing regulation of interleukin-8 and NF-kappaB responses by lipoxin A4 and serum amyloid A via the common lipoxin A receptor. | 2004 May-Aug | Int J Immunopathol Pharmacol | pmid:15171815 |
| Sato Y et al. | Down-regulation of lipoxin A4 receptor by thromboxane A2 signaling in RAW246.7 cells in vitro and bleomycin-induced lung fibrosis in vivo. | 2004 Jul-Aug | Biomed. Pharmacother. | pmid:15271420 |
| Sodin-Semrl S et al. | Lipoxin A4 counteracts synergistic activation of human fibroblast-like synoviocytes. | 2004 Jan-Apr | Int J Immunopathol Pharmacol | pmid:15000862 |
| Wallace JL et al. | Aspirin, but not NO-releasing aspirin (NCX-4016), interacts with selective COX-2 inhibitors to aggravate gastric damage and inflammation. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:14665439 |
| Bannenberg G et al. | Lipoxins and novel 15-epi-lipoxin analogs display potent anti-inflammatory actions after oral administration. | 2004 | Br. J. Pharmacol. | pmid:15302682 |
| von der Weid PY et al. | Aspirin-triggered, cyclooxygenase-2-dependent lipoxin synthesis modulates vascular tone. | 2004 | Circulation | pmid:15326064 |
| Paul-Clark MJ et al. | 15-epi-lipoxin A4-mediated induction of nitric oxide explains how aspirin inhibits acute inflammation. | 2004 | J. Exp. Med. | pmid:15238606 |
| Guilford WJ et al. | Novel 3-oxa lipoxin A4 analogues with enhanced chemical and metabolic stability have anti-inflammatory activity in vivo. | 2004 | J. Med. Chem. | pmid:15056011 |
| Andersson P et al. | Interactions between lipoxin A4, the stable analogue 16-phenoxy-lipoxin A4 and leukotriene B4 in cytokine generation by human monocytes. | 2004 | Scand. J. Immunol. | pmid:15320881 |
| Gilroy DW et al. | A novel role for phospholipase A2 isoforms in the checkpoint control of acute inflammation. | 2004 | FASEB J. | pmid:15003994 |
| Serhan CN | Clues for new therapeutics in osteoporosis and periodontal disease: new roles for lipoxygenases? | 2004 | Expert Opin. Ther. Targets | pmid:15584868 |
| Bannenberg GL et al. | Exogenous pathogen and plant 15-lipoxygenase initiate endogenous lipoxin A4 biosynthesis. | 2004 | J. Exp. Med. | pmid:14970178 |
| Chiang N et al. | Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trial. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15471991 |
| Souza MH et al. | Gastritis increases resistance to aspirin-induced mucosal injury via COX-2-mediated lipoxin synthesis. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12637254 |
| Wallace JL and Fiorucci S | A magic bullet for mucosal protection...and aspirin is the trigger! | 2003 | Trends Pharmacol. Sci. | pmid:12871661 |
| Phillips ED et al. | Synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11,13-hexadecatetraenoate, an analogue of 15R-lipoxin A4. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12951097 |
| Chiang N et al. | A novel rat lipoxin A4 receptor that is conserved in structure and function. | 2003 | Br. J. Pharmacol. | pmid:12746227 |
| Levy BD et al. | Lipoxins and aspirin-triggered lipoxins in airway responses. | 2003 | Adv. Exp. Med. Biol. | pmid:12751730 |
| Fierro IM et al. | Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit human neutrophil migration: comparisons between synthetic 15 epimers in chemotaxis and transmigration with microvessel endothelial cells and epithelial cells. | 2003 | J. Immunol. | pmid:12594298 |
| Van Dyke TE and Serhan CN | Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases. | 2003 | J. Dent. Res. | pmid:12562878 |
| Gangemi S et al. | Physical exercise increases urinary excretion of lipoxin A4 and related compounds. | 2003 | J. Appl. Physiol. | pmid:12588790 |
| Kucharzik T et al. | Lateral membrane LXA4 receptors mediate LXA4's anti-inflammatory actions on intestinal epithelium. | 2003 | Am. J. Physiol., Cell Physiol. | pmid:12456400 |
| Bonnans C et al. | Lipoxin A4 stimulates a cytosolic Ca2+ increase in human bronchial epithelium. | 2003 | J. Biol. Chem. | pmid:12500974 |
| Bae YS et al. | Differential signaling of formyl peptide receptor-like 1 by Trp-Lys-Tyr-Met-Val-Met-CONH2 or lipoxin A4 in human neutrophils. | 2003 | Mol. Pharmacol. | pmid:12920210 |
| Devchand PR et al. | Human ALX receptor regulates neutrophil recruitment in transgenic mice: roles in inflammation and host defense. | 2003 | FASEB J. | pmid:12665478 |
| Fiorucci S et al. | Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin. | 2003 | FASEB J. | pmid:12709408 |
| Kantarci A et al. | Neutrophil-mediated tissue injury in periodontal disease pathogenesis: findings from localized aggressive periodontitis. | 2003 | J. Periodontol. | pmid:12593599 |
| Serhan CN et al. | Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators. | 2003 | J. Immunol. | pmid:14662892 |
| Fiorucci S et al. | Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin. | 2003 | Br. J. Pharmacol. | pmid:12890715 |
| Kowalski ML et al. | Differential effects of aspirin and misoprostol on 15-hydroxyeicosatetraenoic acid generation by leukocytes from aspirin-sensitive asthmatic patients. | 2003 | J. Allergy Clin. Immunol. | pmid:13679808 |
| Boutet P et al. | Imbalance between lipoxin A4 and leukotriene B4 in chronic mastitis-affected cows. | 2003 | J. Dairy Sci. | pmid:14672172 |
| Ariel A et al. | Aspirin-triggered lipoxin A4 and B4 analogs block extracellular signal-regulated kinase-dependent TNF-alpha secretion from human T cells. | 2003 | J. Immunol. | pmid:12794159 |
| Goh J et al. | Lipoxins: pro-resolution lipid mediators in intestinal inflammation. | 2003 | Gastroenterology | pmid:12671901 |
| McMahon B et al. | Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation. | 2002 | FASEB J. | pmid:12223454 |
| Gewirtz AT et al. | Lipoxin a4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis. | 2002 | J. Immunol. | pmid:11994483 |
| Aliberti J and Sher A | Positive and negative regulation of pathogen induced dendritic cell function by G-protein coupled receptors. | 2002 | Mol. Immunol. | pmid:12009566 |
| Tam FW | Role of selectins in glomerulonephritis. | 2002 | Clin. Exp. Immunol. | pmid:12100015 |
| Maderna P et al. | Lipoxins induce actin reorganization in monocytes and macrophages but not in neutrophils: differential involvement of rho GTPases. | 2002 | Am. J. Pathol. | pmid:12057930 |
| Romano M et al. | Urinary excretion of lipoxin A(4) and related compounds: development of new extraction techniques for lipoxins. | 2002 | Lab. Invest. | pmid:12218086 |
| Vaughn MW et al. | Identification, cloning, and functional characterization of a murine lipoxin A4 receptor homologue gene. | 2002 | J. Immunol. | pmid:12218158 |
| József L et al. | Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12235371 |
| Fiorucci S et al. | Cyclooxygenase-2-derived lipoxin A4 increases gastric resistance to aspirin-induced damage. | 2002 | Gastroenterology | pmid:12404234 |
| Christophe T et al. | Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4. | 2002 | Scand. J. Immunol. | pmid:12410796 |
| Aliberti J et al. | Parasite-induced lipoxin A4 is an endogenous regulator of IL-12 production and immunopathology in Toxoplasma gondii infection. | 2002 | J. Exp. Med. | pmid:12417634 |
| Titos E et al. | Aspirin-triggered 15-epi-lipoxin A4 biosynthesis in rat liver cells. | 2002 | Adv. Exp. Med. Biol. | pmid:12664586 |
| Bandeira-Melo C et al. | Inhibition of allergen-induced eosinophil migration by lipoxin (LX)A4 and aspirin-triggered 15-epi-LXA4. | 2002 | Adv. Exp. Med. Biol. | pmid:12664587 |