| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tuberculosis | D014376 | 20 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
Lipoxin A4
Lipoxin a4 is a lipid of Fatty Acyls (FA) class. Lipoxin a4 is associated with abnormalities such as Asthma, Cystic Fibrosis, Pneumonia, Obesity and Septicemia. The involved functions are known as Inflammation, Signal, Signal Transduction, Regulation and Metabolic Inhibition. Lipoxin a4 often locates in Immune system, Blood, soluble, Extracellular and Splenic Tissue. The associated genes with Lipoxin A4 are FPR2 gene, Homologous Gene, SAA1 gene, Trp-Lys-Tyr-Met-Val-Met and Annexin 1. The related lipids are Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Lipoxin A4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Lipoxin A4?
Lipoxin A4 is suspected in Asthma, Cystic Fibrosis, Chagas Cardiomyopathy, Pneumonia, Obesity, Septicemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Lipoxin A4
PubChem Associated disorders and diseases
What pathways are associated with Lipoxin A4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Lipoxin A4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Lipoxin A4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Lipoxin A4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Lipoxin A4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Lipoxin A4?
Knock-out
Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Lipoxin A4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wu Y et al. | Aspirin-triggered lipoxin Aâ‚„ attenuates lipopolysaccharide-induced intracellular ROS in BV2 microglia cells by inhibiting the function of NADPH oxidase. | 2012 | Neurochem. Res. | pmid:22552474 |
| Scully M et al. | Protective role of cyclooxygenase (COX)-2 in experimental lung injury: evidence of a lipoxin A4-mediated effect. | 2012 | J. Surg. Res. | pmid:21944479 |
| Krönke G et al. | The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis. | 2012 | Ann. Rheum. Dis. | pmid:22267335 |
| Birnbaum Y et al. | Phosphodiesterase III inhibition increases cAMP levels and augments the infarct size limiting effect of a DPP-4 inhibitor in mice with type-2 diabetes mellitus. | 2012 | Cardiovasc Drugs Ther | pmid:22936458 |
| Gangemi S et al. | Ultrarush venom immunotherapy and the lipoxin a4 inflammation resolution pathway. | 2012 | Ann. Allergy Asthma Immunol. | pmid:22920084 |
| Deng LL et al. | [Protective effect of lipoxin A4 against rhabdomyolysis-induced acute kidney injury in rats]. | 2012 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:22980651 |
| Xu Z et al. | Lipoxin A4 inhibits the development of endometriosis in mice: the role of anti-inflammation and anti-angiogenesis. | 2012 | Am. J. Reprod. Immunol. | pmid:22229383 |
| Chinthamani S et al. | Lipoxin A4 inhibits immune cell binding to salivary epithelium and vascular endothelium. | 2012 | Am. J. Physiol., Cell Physiol. | pmid:22205391 |
| Das UN | Is lipoxins A₄ a better alternative to anti-VEGF and anti-TNF-α antibody to prevent and treat age-related macular degeneration, diabetic macular edema and retinopathy? | 2012 | Med. Sci. Monit. | pmid:22207123 |
| Bozinovski S et al. | Serum amyloid A opposes lipoxin Aâ‚„ to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22215599 |
| Vong L et al. | Up-regulation of Annexin-A1 and lipoxin A(4) in individuals with ulcerative colitis may promote mucosal homeostasis. | 2012 | PLoS ONE | pmid:22723974 |
| Zhou CH et al. | [Protective effects and possible mechanism of lipoxin A(4) analogue in rats with acute pancreatitis]. | 2012 | Zhonghua Yi Xue Za Zhi | pmid:22781577 |
| Börgeson E et al. | Lipoxin A4 attenuates adipose inflammation. | 2012 | FASEB J. | pmid:22700871 |
| Esper L et al. | Role of SOCS2 in modulating heart damage and function in a murine model of acute Chagas disease. | 2012 | Am. J. Pathol. | pmid:22658486 |
| Verrière V et al. | Lipoxin A4 stimulates calcium-activated chloride currents and increases airway surface liquid height in normal and cystic fibrosis airway epithelia. | 2012 | PLoS ONE | pmid:22662206 |
| Jin H et al. | Lipoxin A4 analog attenuates morphine antinociceptive tolerance, withdrawal-induced hyperalgesia, and glial reaction and cytokine expression in the spinal cord of rat. | 2012 | Neuroscience | pmid:22366510 |
| Gras D et al. | An ex vivo model of severe asthma using reconstituted human bronchial epithelium. | 2012 | J. Allergy Clin. Immunol. | pmid:22409990 |
| Kakazu A et al. | Lipoxin Aâ‚„ inhibits platelet-activating factor inflammatory response and stimulates corneal wound healing of injuries that compromise the stroma. | 2012 | Exp. Eye Res. | pmid:22828048 |
| Pertwee RG | Lipoxin A4 is an allosteric endocannabinoid that strengthens anandamide-induced CB1 receptor activation. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23204441 |
| Pamplona FA et al. | Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23150578 |
| Lin F et al. | Treatment of Lipoxin A(4) and its analogue on low-dose endotoxin induced preeclampsia in rat and possible mechanisms. | 2012 | Reprod. Toxicol. | pmid:23063943 |
| Sun T et al. | LipoxinA(4) induced antinociception and decreased expression of NF-κB and pro-inflammatory cytokines after chronic dorsal root ganglia compression in rats. | 2012 | Eur J Pain | pmid:21658981 |
| Dakin SG et al. | Macrophage sub-populations and the lipoxin A4 receptor implicate active inflammation during equine tendon repair. | 2012 | PLoS ONE | pmid:22384219 |
| Tsai WH et al. | Role of lipoxin A4 in the cell-to-cell interaction between all-trans retinoic acid-treated acute promyelocytic leukemic cells and alveolar macrophages. | 2012 | J. Cell. Physiol. | pmid:21567401 |
| Zimmerman JJ | Exhaled breath condensate: a breathalyzer for lung inflammation. | 2012 | Pediatr Crit Care Med | pmid:22391827 |
| Martin N et al. | Primary human airway epithelial cell-dependent inhibition of human lung mast cell degranulation. | 2012 | PLoS ONE | pmid:22970103 |
| Wu L et al. | Lipoxin A4 inhibits 5-lipoxygenase translocation and leukotrienes biosynthesis to exert a neuroprotective effect in cerebral ischemia/reperfusion injury. | 2012 | J. Mol. Neurosci. | pmid:22661361 |
| Hasan RA et al. | Lipoxin A(4) and 8-isoprostane in the exhaled breath condensate of children hospitalized for status asthmaticus. | 2012 | Pediatr Crit Care Med | pmid:21666533 |
| Balode L et al. | Lipoxygenase-derived arachidonic acid metabolites in chronic obstructive pulmonary disease. | 2012 | Medicina (Kaunas) | pmid:22885362 |
| Jones CN et al. | Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23185003 |
| Su X et al. | Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. | 2012 | Mol. Med. | pmid:23296426 |
| Bitto A et al. | Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis. | 2012 | Crit Care | pmid:22356547 |
| Dakin SG et al. | Inflamm-aging and arachadonic acid metabolite differences with stage of tendon disease. | 2012 | PLoS ONE | pmid:23155437 |
| Rozsasi A et al. | Cyclooxygenase 2 and lipoxin Aâ‚„ in nasal polyps in cystic fibrosis. | 2011 Nov-Dec | Am J Rhinol Allergy | pmid:22185734 |
| Levy BD et al. | The endogenous pro-resolving mediators lipoxin A4 and resolvin E1 preserve organ function in allograft rejection. | 2011 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20869861 |
| Yamaguchi H et al. | Urinary concentrations of 15-epimer of lipoxin A(4) are lower in patients with aspirin-intolerant compared with aspirin-tolerant asthma. | 2011 | Clin. Exp. Allergy | pmid:22093074 |
| Börgeson E et al. | Lipoxin A₄ and benzo-lipoxin A₄ attenuate experimental renal fibrosis. | 2011 | FASEB J. | pmid:21628447 |
| Walker J et al. | Lipoxin a4 increases survival by decreasing systemic inflammation and bacterial load in sepsis. | 2011 | Shock | pmid:21701419 |
| Hao H et al. | Lipoxin A4 and its analog suppress hepatocellular carcinoma via remodeling tumor microenvironment. | 2011 | Cancer Lett. | pmid:21683517 |
| Ni CM et al. | Serum levels of lipoxin A(4) do not predict the development of subsequent asthma among young children with acute bronchiolitis. | 2011 | J Asthma | pmid:21671842 |
| Prescott D and McKay DM | Aspirin-triggered lipoxin enhances macrophage phagocytosis of bacteria while inhibiting inflammatory cytokine production. | 2011 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:21659618 |
| Chen H et al. | Lipoxin A(4), a potential anti-inflammatory drug targeting the skin. | 2011 | J. Dermatol. Sci. | pmid:21334856 |
| Brancaleone V et al. | Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature. | 2011 | J. Immunol. | pmid:21398608 |
| Wu J et al. | Lipoxin A4 inhibits the production of proinflammatory cytokines induced by β-amyloid in vitro and in vivo. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21501589 |
| Das UN | Lipoxin A4 may function as an endogenous anti-arrhythmic molecule. | 2011 | Med. Hypotheses | pmid:20833483 |
| Macdonald LJ et al. | A role for lipoxin Aâ‚„ as an anti-inflammatory mediator in the human endometrium. | 2011 | Reproduction | pmid:21555360 |
| Forsman H et al. | What formyl peptide receptors, if any, are triggered by compound 43 and lipoxin A4? | 2011 | Scand. J. Immunol. | pmid:21535079 |
| Russell R et al. | Lipoxin A4 is a novel estrogen receptor modulator. | 2011 | FASEB J. | pmid:21885654 |
| Wang YP et al. | Aspirin-triggered lipoxin A4 attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-κB and MAPKs in BV-2 microglial cells. | 2011 | J Neuroinflammation | pmid:21831303 |
| Wan M et al. | Leukotriene B4/antimicrobial peptide LL-37 proinflammatory circuits are mediated by BLT1 and FPR2/ALX and are counterregulated by lipoxin A4 and resolvin E1. | 2011 | FASEB J. | pmid:21307335 |