| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tuberculosis | D014376 | 20 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
Lipoxin A4
Lipoxin a4 is a lipid of Fatty Acyls (FA) class. Lipoxin a4 is associated with abnormalities such as Asthma, Cystic Fibrosis, Pneumonia, Obesity and Septicemia. The involved functions are known as Inflammation, Signal, Signal Transduction, Regulation and Metabolic Inhibition. Lipoxin a4 often locates in Immune system, Blood, soluble, Extracellular and Splenic Tissue. The associated genes with Lipoxin A4 are FPR2 gene, Homologous Gene, SAA1 gene, Trp-Lys-Tyr-Met-Val-Met and Annexin 1. The related lipids are Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Lipoxin A4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Lipoxin A4?
Lipoxin A4 is suspected in Asthma, Cystic Fibrosis, Chagas Cardiomyopathy, Pneumonia, Obesity, Septicemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Lipoxin A4
PubChem Associated disorders and diseases
What pathways are associated with Lipoxin A4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Lipoxin A4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Lipoxin A4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Lipoxin A4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Lipoxin A4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Lipoxin A4?
Knock-out
Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Lipoxin A4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Maderna P et al. | Lipoxins induce actin reorganization in monocytes and macrophages but not in neutrophils: differential involvement of rho GTPases. | 2002 | Am. J. Pathol. | pmid:12057930 |
| Romano M et al. | Urinary excretion of lipoxin A(4) and related compounds: development of new extraction techniques for lipoxins. | 2002 | Lab. Invest. | pmid:12218086 |
| Vaughn MW et al. | Identification, cloning, and functional characterization of a murine lipoxin A4 receptor homologue gene. | 2002 | J. Immunol. | pmid:12218158 |
| József L et al. | Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12235371 |
| Fiorucci S et al. | Cyclooxygenase-2-derived lipoxin A4 increases gastric resistance to aspirin-induced damage. | 2002 | Gastroenterology | pmid:12404234 |
| Christophe T et al. | Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4. | 2002 | Scand. J. Immunol. | pmid:12410796 |
| Aliberti J et al. | Parasite-induced lipoxin A4 is an endogenous regulator of IL-12 production and immunopathology in Toxoplasma gondii infection. | 2002 | J. Exp. Med. | pmid:12417634 |
| Schottelius AJ et al. | An aspirin-triggered lipoxin A4 stable analog displays a unique topical anti-inflammatory profile. | 2002 | J. Immunol. | pmid:12471142 |
| Bonnans C et al. | Lipoxins are potential endogenous antiinflammatory mediators in asthma. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:12045128 |
| Fierro IM et al. | Novel lipid mediator regulators of endothelial cell proliferation and migration: aspirin-triggered-15R-lipoxin A(4) and lipoxin A(4). | 2002 | J. Pharmacol. Exp. Ther. | pmid:11805195 |
| Fierro IM and Serhan CN | Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins. | 2001 | Braz. J. Med. Biol. Res. | pmid:11323741 |
| Wada K et al. | Inosine monophosphate and aspirin-triggered 15-epi-lipoxin A4 act in concert to regulate neutrophil trafficking: additive actions of two new endogenous anti-inflammatory mediators. | 2001 | J. Hematother. Stem Cell Res. | pmid:11276361 |
| Goulet JL et al. | Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice. | 2001 | J. Immunol. | pmid:11714834 |
| McMahon B et al. | Lipoxins: revelations on resolution. | 2001 | Trends Pharmacol. Sci. | pmid:11478982 |
| Qiu FH et al. | Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils. | 2001 | FASEB J. | pmid:11687510 |
| Levy BD et al. | Lipid mediator class switching during acute inflammation: signals in resolution. | 2001 | Nat. Immunol. | pmid:11429545 |
| Gronert K et al. | Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses. | 2001 | Am. J. Pathol. | pmid:11141472 |
| Serhan CN et al. | Cutting edge: nociceptin stimulates neutrophil chemotaxis and recruitment: inhibition by aspirin-triggered-15-epi-lipoxin A4. | 2001 | J. Immunol. | pmid:11238602 |
| Goh J et al. | Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo. | 2001 | J. Immunol. | pmid:11509622 |
| Wardle N | New vistas in anti-inflammatory therapy. | 2001 | Nephron | pmid:11474222 |
| Godson C et al. | Cutting edge: lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages. | 2000 | J. Immunol. | pmid:10657608 |
| Clish CB et al. | Local and systemic delivery of an aspirin-triggered lipoxin stable analog inhibits neutrophil trafficking. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818463 |
| Clish CB et al. | Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-onoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation. | 2000 | J. Biol. Chem. | pmid:10837478 |
| Kang Y et al. | Mutations of serine 236-237 and tyrosine 302 residues in the human lipoxin A4 receptor intracellular domains result in sustained signaling. | 2000 | Biochemistry | pmid:11063592 |
| McMahon B et al. | Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. Differential activation of MAP kinases through distinct receptors. | 2000 | J. Biol. Chem. | pmid:10869343 |
| Serhan CN and Clish CB | Aspirin triggered lipid mediators: novel inhibitors of leucocyte trafficking. | 2000 | Thorax | pmid:10992546 |
| Gewirtz AT and Madara JL | Lipoxin-stable analogs: potential therapeutic downregulators of intestinal inflammation. | 2000 | Ernst Schering Res. Found. Workshop | pmid:10943333 |
| Maderna P et al. | Influence of lipoxin A(4) and other lipoxygenase-derived eicosanoids on tissue factor expression. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:11003574 |
| Chiang N et al. | Activation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation. | 2000 | J. Exp. Med. | pmid:10748237 |
| Bandeira-Melo C et al. | Cutting edge: lipoxin (LX) A4 and aspirin-triggered 15-epi-LXA4 block allergen-induced eosinophil trafficking. | 2000 | J. Immunol. | pmid:10679058 |
| Sodin-Semrl S et al. | Lipoxin A4 inhibits IL-1 beta-induced IL-6, IL-8, and matrix metalloproteinase-3 production in human synovial fibroblasts and enhances synthesis of tissue inhibitors of metalloproteinases. | 2000 | J. Immunol. | pmid:10679106 |
| Pouliot M et al. | Lipoxin A(4) analogues inhibit leukocyte recruitment to Porphyromonas gingivalis: a role for cyclooxygenase-2 and lipoxins in periodontal disease. | 2000 | Biochemistry | pmid:10769133 |
| Bandeira-Melo C et al. | Cyclooxygenase-2-derived prostaglandin E2 and lipoxin A4 accelerate resolution of allergic edema in Angiostrongylus costaricensis-infected rats: relationship with concurrent eosinophilia. | 2000 | J. Immunol. | pmid:10623853 |
| Tornhamre S et al. | 15-Lipoxygenation of leukotriene A(4). Studies Of 12- and 15-lipoxygenase efficiency to catalyze lipoxin formation. | 2000 | Biochim. Biophys. Acta | pmid:10760478 |
| Desplat V et al. | Effects of lipoxygenase metabolites of arachidonic acid on the growth of human blood CD34(+) progenitors. | 2000 | Blood Cells Mol. Dis. | pmid:11112380 |
| Sanak M et al. | Aspirin-tolerant asthmatics generate more lipoxins than aspirin-intolerant asthmatics. | 2000 | Eur. Respir. J. | pmid:10933083 |
| Denizot Y et al. | Effect of cytokines and lipid mediators on the synthesis of interleukin 1 beta by human bone marrow stromal cells. | 2000 | Cytokine | pmid:10857767 |
| Kikuta Y et al. | Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14. | 2000 | Arch. Biochem. Biophys. | pmid:11185557 |
| Kikuta Y et al. | Purification and characterization of recombinant rat hepatic CYP4F1. | 1999 | Arch. Biochem. Biophys. | pmid:10486137 |
| Bratt J and Heimbürger M | Prednisolone interferes with neutrophil adhesion and neutrophil mediated endothelial injury. | 1999 | Scand. J. Rheumatol. | pmid:10568428 |
| Filep JG et al. | Anti-inflammatory actions of lipoxin A(4) stable analogs are demonstrable in human whole blood: modulation of leukocyte adhesion molecules and inhibition of neutrophil-endothelial interactions. | 1999 | Blood | pmid:10590058 |
| Pouliot M and Serhan CN | Lipoxin A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor-alpha-initiated neutrophil responses and trafficking: novel regulators of a cytokine-chemokine axis relevant to periodontal diseases. | 1999 | J. Periodont. Res. | pmid:10685363 |
| Titos E et al. | Hepatocytes are a rich source of novel aspirin-triggered 15-epi-lipoxin A(4). | 1999 | Am. J. Physiol. | pmid:10564079 |
| Clish CB et al. | Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393980 |
| Desplat V et al. | Incorporation and effect of arachidonic acid on the growth of human myeloma cell lines. | 1999 | Mediators Inflamm. | pmid:10704149 |
| Besse A et al. | Prostaglandin E2 regulates macrophage colony stimulating factor secretion by human bone marrow stromal cells. | 1999 | Biochim. Biophys. Acta | pmid:10395955 |
| Levy BD et al. | Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a 'stop' signaling switch for aspirin-triggered lipoxin A4. | 1999 | FASEB J. | pmid:10224233 |
| Serhan CN et al. | Lipoxin and aspirin-triggered 15-epi-lipoxin cellular interactions anti-inflammatory lipid mediators. | 1999 | Clin. Chem. Lab. Med. | pmid:10353476 |
| Schaldach CM et al. | Lipoxin A4: a new class of ligand for the Ah receptor. | 1999 | Biochemistry | pmid:10360957 |
| Hachicha M et al. | Lipoxin (LX)A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor 1alpha-initiated neutrophil responses and trafficking: regulators of a cytokine-chemokine axis. | 1999 | J. Exp. Med. | pmid:10377187 |
| Gewirtz AT et al. | LXA4, aspirin-triggered 15-epi-LXA4, and their analogs selectively downregulate PMN azurophilic degranulation. | 1999 | Am. J. Physiol. | pmid:10199831 |
| Serhan CN et al. | Aspirin-triggered 15-epi-lipoxin A4 and stable analogs on lipoxin A4 are potent inhibitors of acute inflammation. Receptors and pathways. | 1999 | Adv. Exp. Med. Biol. | pmid:10086190 |
| Lin KT et al. | Modulation of LTB4 receptor in T-lymphocytes by lipoxin A4 (LXA4) and its role in delayed-type hypersensitivity. | 1999 | Adv. Exp. Med. Biol. | pmid:10086191 |
| Chiang N et al. | Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion. | 1999 | J. Clin. Invest. | pmid:10430612 |
| Spokas EG et al. | Leukotrienes, lipoxins, and hydroxyeicosatetraenoic acids. | 1999 | Methods Mol. Biol. | pmid:10343320 |
| Hill DJ et al. | Trout thrombocytes contain 12- but not 5-lipoxygenase activity. | 1999 | Biochim. Biophys. Acta | pmid:9931438 |
| Nassar GM and Badr KF | Novel approaches to treatment of glomerulonephritis. | 1998 Jul-Aug | J. Nephrol. | pmid:9702868 |
| Takano T et al. | Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogues. | 1998 | J. Clin. Invest. | pmid:9466977 |
| Gronert K et al. | Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release. | 1998 | J. Exp. Med. | pmid:9547339 |
| Gewirtz AT et al. | Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs. | 1998 | J. Clin. Invest. | pmid:9576749 |
| Clà ria J et al. | Altered biosynthesis of leukotrienes and lipoxins and host defense disorders in patients with cirrhosis and ascites. | 1998 | Gastroenterology | pmid:9649470 |
| Chiang N et al. | Aspirin-triggered 15-epi-lipoxin A4 (ATL) generation by human leukocytes and murine peritonitis exudates: development of a specific 15-epi-LXA4 ELISA. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9808710 |
| Gronert K et al. | Characterization of human neutrophil and endothelial cell ligand-operated extracellular acidification rate by microphysiometry: impact of reoxygenation. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9536019 |
| Takano T et al. | Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. | 1997 | J. Exp. Med. | pmid:9151906 |
| Serhan CN | Lipoxins and novel aspirin-triggered 15-epi-lipoxins (ATL): a jungle of cell-cell interactions or a therapeutic opportunity? | 1997 | Prostaglandins | pmid:9112289 |
| Scalia R et al. | Lipoxin A4 stable analogs inhibit leukocyte rolling and adherence in the rat mesenteric microvasculature: role of P-selectin. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9275235 |
| Stahl GL et al. | Eicosanoid production from porcine neutrophils and platelets: differential production with various agonists. | 1997 | Am. J. Physiol. | pmid:9227410 |
| Maddox JF et al. | Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor. | 1997 | J. Biol. Chem. | pmid:9054386 |
| Levy BD et al. | Agonist-induced lipoxin A4 generation in vitro and in aspirin-sensitive asthmatics: detection by a novel lipoxin A4-ELISA. | 1997 | Adv. Exp. Med. Biol. | pmid:9547611 |
| Lin KT et al. | Identification and characterization of a high-affinity leukotriene B4 receptor on guinea pig T lymphocytes and its regulation by lipoxin A4. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8627545 |
| Chung-a-on KO et al. | Stimulation of protein kinase C redistribution and inhibition of leukotriene B4-induced inositol 1,4,5-trisphosphate generation in human neutrophils by lipoxin A4. | 1996 | Br. J. Pharmacol. | pmid:8882633 |
| Hébert MJ et al. | Sequential morphologic events during apoptosis of human neutrophils. Modulation by lipoxygenase-derived eicosanoids. | 1996 | J. Immunol. | pmid:8816421 |
| Feng Z et al. | Leukotriene B4 modulates in vivo expression of delayed-type hypersensitivity by a receptor-mediated mechanism: regulation by lipoxin A4. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8768752 |
| Tang DG et al. | Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8643560 |
| Romano M et al. | Activation of human monocytes and the acute monocytic leukemia cell line (THP-1) by lipoxins involves unique signaling pathways for lipoxin A4 versus lipoxin B4: evidence for differential Ca2+ mobilization. | 1996 | J. Immunol. | pmid:8757340 |
| Papayianni A et al. | Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells. | 1996 | J. Immunol. | pmid:8690917 |
| Maddox JF and Serhan CN | Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction. | 1996 | J. Exp. Med. | pmid:8551217 |
| Badr KF | Lipoxygenases as therapeutic targets in the acute and subacute phases of glomerular immune injury. | 1996 | Contrib Nephrol | pmid:8744048 |
| Mayadas TN et al. | Acute passive anti-glomerular basement membrane nephritis in P-selectin-deficient mice. | 1996 | Kidney Int. | pmid:8731099 |
| Brady HR | Complex roles for P-selectin in the pathophysiology of glomerulonephritis. | 1996 | Curr. Opin. Nephrol. Hypertens. | pmid:8937811 |
| Serhan CN and Romano M | Lipoxin biosynthesis and actions: role of the human platelet LX-synthase. | 1995 | J Lipid Mediat Cell Signal | pmid:8777573 |
| Tamaoki J et al. | Lipoxin A4 inhibits cholinergic neurotransmission through nitric oxide generation in the rabbit trachea. | 1995 | Eur. J. Pharmacol. | pmid:8991795 |
| Bratt J and Gyllenhammar H | The role of nitric oxide in lipoxin A4-induced polymorphonuclear neutrophil-dependent cytotoxicity to human vascular endothelium in vitro. | 1995 | Arthritis Rheum. | pmid:7779119 |
| Lee TH | Lipoxin A4: a novel anti-inflammatory molecule? | 1995 | Thorax | pmid:7701445 |
| Serhan CN et al. | Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils. | 1995 | Biochemistry | pmid:7578068 |
| Bratt J et al. | Mechanisms for lipoxin A4-induced neutrophil-dependent cytotoxicity for human endothelial cells. | 1995 | J. Lab. Clin. Med. | pmid:7602232 |
| Papayianni A et al. | Transcellular biosynthesis of lipoxin A4 during adhesion of platelets and neutrophils in experimental immune complex glomerulonephritis. | 1995 | Kidney Int. | pmid:7543622 |
| Edenius C et al. | Stimulation of lipoxin synthesis from leukotriene A4 by endogenously formed 12-hydroperoxyeicosatetraenoic acid in activated human platelets. | 1994 | Biochim. Biophys. Acta | pmid:8305492 |
| Serhan CN and Fiore S | Lipoxin recognition sites of human neutrophils. | 1994 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7771345 |
| Soyombo O et al. | Effects of lipoxin A4 on chemotaxis and degranulation of human eosinophils stimulated by platelet-activating factor and N-formyl-L-methionyl-L-leucyl-L-phenylalanine. | 1994 | Allergy | pmid:8037356 |
| Bratt J et al. | Lipoxin A4 induces neutrophil-dependent cytotoxicity for human endothelial cells. | 1994 | Scand. J. Immunol. | pmid:8146594 |
| Fiore S et al. | Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor. | 1994 | J. Exp. Med. | pmid:8006586 |
| Serhan CN et al. | Cell-cell interactions in lipoxin generation and characterization of lipoxin A4 receptors. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7825838 |
| Simchowitz L et al. | Carrier-mediated transport of lipoxin A4 in human neutrophils. | 1994 | Am. J. Physiol. | pmid:7810593 |
| Levy BD et al. | Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins. | 1993 | J. Clin. Invest. | pmid:8376607 |
| Lerner R et al. | Lipoxin A4 induces hyperadhesiveness in human endothelial cells for neutrophils. | 1993 | Blood | pmid:8393356 |
| Romano M et al. | Lipoxin synthase activity of human platelet 12-lipoxygenase. | 1993 | Biochem. J. | pmid:8250832 |
| Levy BD et al. | Agonist-induced lipoxin A4 generation: detection by a novel lipoxin A4-ELISA. | 1993 | Lipids | pmid:8121246 |
| Sumimoto H et al. | Formation of a novel 20-hydroxylated metabolite of lipoxin A4 by human neutrophil microsomes. | 1993 | FEBS Lett. | pmid:8422907 |
| Fiore S et al. | Induction of functional lipoxin A4 receptors in HL-60 cells. | 1993 | Blood | pmid:8389617 |