Lipoxin b4

Lipoxin b4 is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 325 references associated with Lipoxin b4 in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Lipoxin b4

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Lipoxin b4

MeSH term MeSH ID Detail
Asthma D001249 52 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Nasal Polyps D009298 26 associated lipids
Total 3

PubChem Biomolecular Interactions and Pathways

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All references with Lipoxin b4

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Authors Title Published Journal PubMed Link
Karra L et al. Lipoxin Bâ‚„ promotes the resolution of allergic inflammation in the upper and lower airways of mice. 2015 Mucosal Immunol pmid:25465102
Fer M et al. Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism. 2008 J. Lipid Res. pmid:18577768
O'Sullivan TP et al. Aromatic lipoxin A4 and lipoxin B4 analogues display potent biological activities. 2007 J. Med. Chem. pmid:17960922
Parkinson JF Lipoxin and synthetic lipoxin analogs: an overview of anti-inflammatory functions and new concepts in immunomodulation. 2006 Inflamm Allergy Drug Targets pmid:16613568
Harmon SD et al. Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16820285
Serhan CN Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution. 2005 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:16005201
Ariel A et al. Aspirin-triggered lipoxin A4 and B4 analogs block extracellular signal-regulated kinase-dependent TNF-alpha secretion from human T cells. 2003 J. Immunol. pmid:12794159
Goh J et al. Lipoxins: pro-resolution lipid mediators in intestinal inflammation. 2003 Gastroenterology pmid:12671901
Bonnans C et al. Lipoxins are potential endogenous antiinflammatory mediators in asthma. 2002 Am. J. Respir. Crit. Care Med. pmid:12045128
Sontag TJ and Parker RS Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status. 2002 J. Biol. Chem. pmid:11997390
McMahon B et al. Lipoxins: revelations on resolution. 2001 Trends Pharmacol. Sci. pmid:11478982
Tornhamre S et al. 15-Lipoxygenation of leukotriene A(4). Studies Of 12- and 15-lipoxygenase efficiency to catalyze lipoxin formation. 2000 Biochim. Biophys. Acta pmid:10760478
Desplat V et al. Effects of lipoxygenase metabolites of arachidonic acid on the growth of human blood CD34(+) progenitors. 2000 Blood Cells Mol. Dis. pmid:11112380
Sanak M et al. Aspirin-tolerant asthmatics generate more lipoxins than aspirin-intolerant asthmatics. 2000 Eur. Respir. J. pmid:10933083
Denizot Y et al. Effect of cytokines and lipid mediators on the synthesis of interleukin 1 beta by human bone marrow stromal cells. 2000 Cytokine pmid:10857767
Kikuta Y et al. Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14. 2000 Arch. Biochem. Biophys. pmid:11185557
Desplat V et al. Incorporation and effect of arachidonic acid on the growth of human myeloma cell lines. 1999 Mediators Inflamm. pmid:10704149
Takano T et al. Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogues. 1998 J. Clin. Invest. pmid:9466977
Maddox JF et al. Lipoxin B4 regulates human monocyte/neutrophil adherence and motility: design of stable lipoxin B4 analogs with increased biologic activity. 1998 FASEB J. pmid:9535221
Tang DG et al. Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8643560
Romano M et al. Activation of human monocytes and the acute monocytic leukemia cell line (THP-1) by lipoxins involves unique signaling pathways for lipoxin A4 versus lipoxin B4: evidence for differential Ca2+ mobilization. 1996 J. Immunol. pmid:8757340
Papayianni A et al. Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells. 1996 J. Immunol. pmid:8690917
Maddox JF and Serhan CN Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction. 1996 J. Exp. Med. pmid:8551217
Serhan CN and Romano M Lipoxin biosynthesis and actions: role of the human platelet LX-synthase. 1995 J Lipid Mediat Cell Signal pmid:8777573
Tamaoki J et al. Lipoxin A4 inhibits cholinergic neurotransmission through nitric oxide generation in the rabbit trachea. 1995 Eur. J. Pharmacol. pmid:8991795
Mizukami Y et al. omega-Oxidation of lipoxin B4 by rat liver. Identification of an omega-carboxy metabolite of lipoxin B4. 1994 Eur. J. Biochem. pmid:7925420
Edenius C et al. Stimulation of lipoxin synthesis from leukotriene A4 by endogenously formed 12-hydroperoxyeicosatetraenoic acid in activated human platelets. 1994 Biochim. Biophys. Acta pmid:8305492
Levy BD et al. Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins. 1993 J. Clin. Invest. pmid:8376607
Lerner R et al. Lipoxin A4 induces hyperadhesiveness in human endothelial cells for neutrophils. 1993 Blood pmid:8393356
Mizukami Y et al. Omega-hydroxylation of lipoxin B4 by human neutrophil microsomes: identification of omega-hydroxy metabolite of lipoxin B4 and catalysis by leukotriene B4 omega-hydroxylase (cytochrome P-450LTB omega). 1993 Biochim. Biophys. Acta pmid:8389204
Romano M et al. Lipoxin synthase activity of human platelet 12-lipoxygenase. 1993 Biochem. J. pmid:8250832
Conti P et al. Role of lipoxins A4 and B4 in the generation of arachidonic acid metabolites by rat mast cells and their effect on [3H]serotonin release. 1992 Immunol. Lett. pmid:1612634
Uski TK and Högestätt ED Effects of various cyclooxygenase and lipoxygenase metabolites on guinea-pig cerebral arteries. 1992 Gen. Pharmacol. pmid:1592217
Katoh T et al. Renal hemodynamic actions of lipoxins in rats: a comparative physiological study. 1992 Am. J. Physiol. pmid:1415572
Edenius C et al. On the mechanism of transcellular lipoxin formation in human platelets and granulocytes. 1991 Eur. J. Biochem. pmid:1906402
Stenke L et al. Formation and proliferative effects of lipoxins in human bone marrow. 1991 Biochem. Biophys. Res. Commun. pmid:1930222
Stenke L et al. Deficient lipoxin synthesis: a novel platelet dysfunction in myeloproliferative disorders with special reference to blastic crisis of chronic myelogenous leukemia. 1991 Blood pmid:1659470
Pettitt TR et al. Synthesis of lipoxins and other lipoxygenase products by macrophages from the rainbow trout, Oncorhynchus mykiss. 1991 J. Biol. Chem. pmid:1902832
Boucher JL et al. Metabolism of lipoxins A4 and B4 and of their all-trans isomers by human leukocytes and rat liver microsomes. 1991 Biochem. Biophys. Res. Commun. pmid:2043100
Edenius C et al. Lipoxin formation in human nasal polyps and bronchial tissue. 1990 FEBS Lett. pmid:2172016
Serhan CN and Sheppard KA Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro. 1990 J. Clin. Invest. pmid:2155925
Conti P et al. Lipoxins A4 and B4 inhibit leukotriene B4 generation from human neutrophil leukocyte suspensions. 1990 Immunol. Lett. pmid:2167876
Brady HR et al. Leukotrienes stimulate neutrophil adhesion to mesangial cells: modulation with lipoxins. 1990 Am. J. Physiol. pmid:2173421
Kim SJ Elevated formation of lipoxins in viral antibody-positive rat alveolar macrophages. 1990 Am. J. Respir. Cell Mol. Biol. pmid:2116155
Nigam S et al. Lipoxin A4 and lipoxin B4 stimulate the release but not the oxygenation of arachidonic acid in human neutrophils: dissociation between lipid remodeling and adhesion. 1990 J. Cell. Physiol. pmid:2162850
Serhan CN High-performance liquid chromatography separation and determination of lipoxins. 1990 Meth. Enzymol. pmid:2233343
Steinhilber D and Roth HJ New series of lipoxins isolated from human eosinophils. 1989 FEBS Lett. pmid:2507350
Serhan CN On the relationship between leukotriene and lipoxin production by human neutrophils: evidence for differential metabolism of 15-HETE and 5-HETE. 1989 Biochim. Biophys. Acta pmid:2546590
Lee TH et al. Lipoxin A4 and lipoxin B4 inhibit chemotactic responses of human neutrophils stimulated by leukotriene B4 and N-formyl-L-methionyl-L-leucyl-L-phenylalanine. 1989 Clin. Sci. pmid:2548801
Brezinski ME et al. Lipoxins stimulate prostacyclin generation by human endothelial cells. 1989 FEBS Lett. pmid:2494071
Garrick R et al. Transformation of leukotriene A4 to lipoxins by rat kidney mesangial cell. 1989 Biochem. Biophys. Res. Commun. pmid:2547366
Nicolaou KC et al. Identification of a novel 7-cis-11-trans-lipoxin A4 generated by human neutrophils: total synthesis, spasmogenic activities and comparison with other geometric isomers of lipoxins A4 and B4. 1989 Biochim. Biophys. Acta pmid:2713393
Busija DW et al. Lipoxins A4 and B4 dilate cerebral arterioles of newborn pigs. 1989 Am. J. Physiol. pmid:2916679
Ng CF et al. Agonist-dependent generation of lipoxins from rat basophilic leukemia cell (RBL-1). 1989 Biochim. Biophys. Acta pmid:2503031
Walstra P et al. Evidence for lipoxin formation by bovine polymorphonuclear leukocytes via triple dioxygenation of arachidonic acid. 1988 FEBS Lett. pmid:3125064
Jacques CA et al. The contractile activities of lipoxin A4 and lipoxin B4 for guinea-pig airway tissues. 1988 Br. J. Pharmacol. pmid:2852525
Walden TL Radioprotection of mouse hematopoietic stem cells by leukotriene A4 and lipoxin B4. 1988 J. Radiat. Res. pmid:2854562
Borgeat P and Picard S 19-Hydroxyprostaglandin B2 as an internal standard for on-line extraction-high-performance liquid chromatography analysis of lipoxygenase products. 1988 Anal. Biochem. pmid:2841889
Brasseur R et al. Conformational analysis of lipoxin A, lipoxin B and their trans-isomers. 1988 Biochim. Biophys. Acta pmid:3365446
Feuerstein G and Siren AL Mesenteric vascular responses to i.v. administration of lipoxin A4 and lipoxin B4 in the conscious rat. 1988 FEBS Lett. pmid:3366247
Lefer AM et al. Lipoxins A4 and B4: comparison of icosanoids having bronchoconstrictor and vasodilator actions but lacking platelet aggregatory activity. 1988 Proc. Natl. Acad. Sci. U.S.A. pmid:3186729
Lam BK et al. Phospholipase A2 (PLA2) releases lipoxins and leukotrienes from endogenous sources. 1988 Ann. N. Y. Acad. Sci. pmid:2837961
Sok DE et al. Soybean lipoxygenase-catalyzed formation of lipoxin A and lipoxin B isomers from arachidonic acid via 5,15-dihydroperoxyeicosatetraenoic acid. 1988 Biochem. Biophys. Res. Commun. pmid:3132921
Ueda N et al. Lipoxin synthesis by arachidonate 12-lipoxygenase purified from porcine leukocytes. 1987 Biochem. Biophys. Res. Commun. pmid:3122743
Samuelsson B et al. Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. 1987 Science pmid:2820055
Lam BK et al. A phospholipase A2 isoenzyme provokes lipoxin B formation from endogenous sources of arachidonic acid in porcine leukocytes. 1987 Biochem. Biophys. Res. Commun. pmid:3107549
Palmblad J et al. The effects of lipoxin A and lipoxin B on functional responses of human granulocytes. 1987 Biochem. Biophys. Res. Commun. pmid:3593338
Kühn H et al. Formation of lipoxin B by the pure reticulocyte lipoxygenase via sequential oxygenation of the substrate. 1987 Eur. J. Biochem. pmid:3121318
Kühn H et al. Formation of lipoxin B by the pure reticulocyte lipoxygenase. 1986 FEBS Lett. pmid:3096777
Serhan CN et al. On the stereochemistry and biosynthesis of lipoxin B. 1986 Proc. Natl. Acad. Sci. U.S.A. pmid:3083410
Puustinen T et al. Evidence for a 5(6)-epoxytetraene intermediate in the biosynthesis of lipoxins in human leukocytes. Conversion into lipoxin A by cytosolic epoxide hydrolase. 1986 FEBS Lett. pmid:3770188
Fitzsimmons BJ et al. The lipoxins. Stereochemical identification and determination of their biosynthesis. 1985 J. Biol. Chem. pmid:2997152
Ramstedt U et al. Action of novel eicosanoids lipoxin A and B on human natural killer cell cytotoxicity: effects on intracellular cAMP and target cell binding. 1985 J. Immunol. pmid:2995494
Serhan CN et al. Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes. 1984 Proc. Natl. Acad. Sci. U.S.A. pmid:6089195
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