Casticin is a lipid of Polyketides (PK) class. The involved functions are known as Ligand Binding. The related lipids are linoleates.
To understand associated biological information of Casticin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with Casticin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mohos V et al. | Interactions of casticin, ipriflavone, and resveratrol with serum albumin and their inhibitory effects on CYP2C9 and CYP3A4 enzymes. | 2018 | Biomed. Pharmacother. | pmid:30142539 |
| Gong Q et al. | Casticin suppresses the carcinogenesis of small cell lung cancer H446 cells through activation of AMPK/FoxO3a signaling. | 2018 | Oncol. Rep. | pmid:30015975 |
| Ma J et al. | Casticin prevents DSS induced ulcerative colitis in mice through inhibitions of NF-κB pathway and ROS signaling. | 2018 | Phytother Res | pmid:29876982 |
| Dai Y et al. | Casticin inhibits PDGF-induced proliferation and migration of airway smooth muscle cells. | 2018 | Eur. J. Pharmacol. | pmid:29665364 |
| Chan EWC et al. | Casticin from Vitex species: a short review on its anticancer and anti-inflammatory properties. | 2018 | J Integr Med | pmid:29559215 |
| Wang J | Casticin alleviates lipopolysaccharide-induced inflammatory responses and expression of mucus and extracellular matrix in human airway epithelial cells through Nrf2/Keap1 and NF-κB pathways. | 2018 | Phytother Res | pmid:29508465 |
| Chou GL et al. | Casticin impairs cell growth and induces cell apoptosis via cell cycle arrest in human oral cancer SCC-4 cells. | 2018 | Environ. Toxicol. | pmid:29098808 |
| Shih YL et al. | Casticin impairs cell migration and invasion of mouse melanoma B16F10 cells via PI3K/AKT and NF-κB signaling pathways. | 2017 | Environ. Toxicol. | pmid:28444820 |
| Shang HS et al. | Casticin induced apoptotic cell death and altered associated gene expression in human colon cancer colo 205 cells. | 2017 | Environ. Toxicol. | pmid:27862857 |
| Wu ZY et al. | Casticin Inhibits A375.S2 Human Melanoma Cell Migration/Invasion through Downregulating NF-κB and Matrix Metalloproteinase-2 and -1. | 2016 | Molecules | pmid:27007357 |
| Shih YL et al. | Casticin induces DNA damage and inhibits DNA repair-associated protein expression in B16F10 mouse melanoma cancer cells. | 2016 | Oncol. Rep. | pmid:27572101 |
| Wang C et al. | Casticin inhibits lipopolysaccharide-induced acute lung injury in mice. | 2016 | Eur. J. Pharmacol. | pmid:27450485 |
| Chung YH and Kim D | RIP kinase-mediated ROS production triggers XAF1 expression through activation of TAp73 in casticin-treated bladder cancer cells. | 2016 | Oncol. Rep. | pmid:27349281 |
| Shiue YW et al. | Casticin Induced Apoptosis in A375.S2 Human Melanoma Cells through the Inhibition of NF-[Formula: see text]B and Mitochondria-Dependent Pathways In Vitro and Inhibited Human Melanoma Xenografts in a Mouse Model In Vivo. | 2016 | Am. J. Chin. Med. | pmid:27109154 |
| Cretton S et al. | Antifungal Quinoline Alkaloids from Waltheria indica. | 2016 | J. Nat. Prod. | pmid:26848627 |
| Li YJ et al. | Flavonoids casticin and chrysosplenol D from Artemisia annua L. inhibit inflammation in vitro and in vivo. | 2015 | Toxicol. Appl. Pharmacol. | pmid:25891417 |
| Lee H et al. | Casticin, an active compound isolated from Vitex Fructus, ameliorates the cigarette smoke-induced acute lung inflammatory response in a murine model. | 2015 | Int. Immunopharmacol. | pmid:26321116 |
| Rasul A et al. | Molecular mechanisms of casticin action: an update on its antitumor functions. | 2014 | Asian Pac. J. Cancer Prev. | pmid:25422178 |
| Fukahori M et al. | Quality evaluation of medicinal products and health foods containing chaste berry (Vitex agnus-castus) in Japanese, European and American markets. | 2014 | Chem. Pharm. Bull. | pmid:24695348 |
| Liu F et al. | Casticin suppresses self-renewal and invasion of lung cancer stem-like cells from A549 cells through down-regulation of pAkt. | 2014 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:24247269 |