Casticin is a lipid of Polyketides (PK) class. The involved functions are known as Ligand Binding. The related lipids are linoleates.
To understand associated biological information of Casticin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with Casticin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
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| Elford BC et al. | Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones. | 1987 | Trans. R. Soc. Trop. Med. Hyg. | pmid:3318019 |
| You KM et al. | Vitexicarpin, a flavonoid from the fruits of Vitex rotundifolia, inhibits mouse lymphocyte proliferation and growth of cell lines in vitro. | 1998 | Planta Med. | pmid:9741302 |
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| Alam G et al. | Tracheospasmolytic activity of viteosin-A and vitexicarpin isolated from vitex trifolia. | 2002 | Planta Med. | pmid:12451502 |
| DÃaz F et al. | Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo. | 2003 | J. Nat. Prod. | pmid:12828478 |
| Remberg P et al. | Characteristics, clinical effect profile and tolerability of a nasal spray preparation of Artemisia abrotanum L. for allergic rhinitis. | 2004 | Phytomedicine | pmid:14971719 |
| Kobayakawa J et al. | G2-M arrest and antimitotic activity mediated by casticin, a flavonoid isolated from Viticis Fructus (Vitex rotundifolia Linne fil.). | 2004 | Cancer Lett. | pmid:15105046 |
| Wang HY et al. | [Vitexicarpin, a flavonoid from Vitex trifolia L., induces apoptosis in K562 cells via mitochondria-controlled apoptotic pathway]. | 2005 | Yao Xue Xue Bao | pmid:15881322 |
| Olalde Rangel JA et al. | The Systemic Theory of Living Systems. Part IV: Systemic Medicine--The Praxis. | 2005 | Evid Based Complement Alternat Med | pmid:16322799 |
| Haïdara K et al. | The flavonoid Casticin has multiple mechanisms of tumor cytotoxicity action. | 2006 | Cancer Lett. | pmid:16387422 |
| Basalo C et al. | Are extraction methods in quantitative assays of pharmacopoeia monographs exhaustive? A comparison with pressurized liquid extraction. | 2006 | Planta Med. | pmid:16924586 |
| Hu Y et al. | Evaluation of the estrogenic activity of the constituents in the fruits of Vitex rotundifolia L. for the potential treatment of premenstrual syndrome. | 2007 | J. Pharm. Pharmacol. | pmid:17883902 |
| Han X et al. | Isolation of high-purity casticin from Artemisia annua L. by high-speed counter-current chromatography. | 2007 | J Chromatogr A | pmid:17374377 |
| Lin S et al. | In vivo effect of casticin on acute inflammation. | 2007 | Zhong Xi Yi Jie He Xue Bao | pmid:17854563 |
| Hajdú Z et al. | Diterpenoids and flavonoids from the fruits of Vitex agnus-castus and antioxidant activity of the fruit extracts and their constituents. | 2007 | Phytother Res | pmid:17262892 |
| Hu Y et al. | Anti-nociceptive and anti-hyperprolactinemia activities of Fructus Viticis and its effective fractions and chemical constituents. | 2007 | Phytomedicine | pmid:17350238 |
| Androutsopoulos V et al. | Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism. | 2008 | Breast Cancer Res. | pmid:18454852 |
| Shen JK et al. | Casticin induces leukemic cell death through apoptosis and mitotic catastrophe. | 2009 | Ann. Hematol. | pmid:19139893 |
| Mesaik MA et al. | Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus-castus. | 2009 | Phytother Res | pmid:19441009 |
| Csupor-Löffler B et al. | Antiproliferative effect of flavonoids and sesquiterpenoids from Achillea millefolium s.l. on cultured human tumour cell lines. | 2009 | Phytother Res | pmid:19107850 |
| Choudhary MI et al. | Antiinflammatory and lipoxygenase inhibitory compounds from Vitex agnus-castus. | 2009 | Phytother Res | pmid:19173281 |
| YE Q et al. | Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro. | 2010 | Acta Pharmacol. Sin. | pmid:21042288 |
| Guan R et al. | [Preparative isolation and purification of the active components from Viticis Fructus by high-speed counter-current chromatography]. | 2010 | Se Pu | pmid:21381420 |
| de Sampaio e Spohr TC et al. | Effects of the flavonoid casticin from Brazilian Croton betulaster in cerebral cortical progenitors in vitro: direct and indirect action through astrocytes. | 2010 | J. Neurosci. Res. | pmid:19746423 |
| Song YC et al. | [Vitexicarpin affects proliferation and apoptosis in mutated p53 breast cancer cell]. | 2010 | Zhonghua Yi Xue Za Zhi | pmid:20450732 |
| Kunwar RM et al. | Traditional herbal medicine in far-west Nepal: a pharmacological appraisal. | 2010 | J Ethnobiol Ethnomed | pmid:21144003 |
| Lewin G et al. | Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin. | 2010 | J. Nat. Prod. | pmid:20356063 |
| Webster DE et al. | Opioidergic mechanisms underlying the actions of Vitex agnus-castus L. | 2011 | Biochem. Pharmacol. | pmid:20854795 |
| Koh DJ et al. | Inhibitory effects of casticin on migration of eosinophil and expression of chemokines and adhesion molecules in A549 lung epithelial cells via NF-κB inactivation. | 2011 | J Ethnopharmacol | pmid:21251967 |
| Yang J et al. | Casticin-induced apoptosis involves death receptor 5 upregulation in hepatocellular carcinoma cells. | 2011 | World J. Gastroenterol. | pmid:22090786 |
| Chen D et al. | Induction of apoptosis by casticin in cervical cancer cells through reactive oxygen species-mediated mitochondrial signaling pathways. | 2011 | Oncol. Rep. | pmid:21725610 |
| Barnes EC et al. | Mitchellenes A-E, cyclic sesquiterpenes from the Australian plant Eremophila mitchellii. | 2011 | J. Nat. Prod. | pmid:21877688 |
| Su CC et al. | An investigation into the cytotoxic effects of 13-acetoxysarcocrassolide from the soft coral Sarcophyton crassocaule on bladder cancer cells. | 2011 | Mar Drugs | pmid:22363243 |
| Chen SN et al. | Phytoconstituents from Vitex agnus-castus fruits. | 2011 | Fitoterapia | pmid:21163339 |
| Rasoanaivo P et al. | Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions. | 2011 | Malar. J. | pmid:21411015 |
| Freitas S et al. | Flavonoids inhibit angiogenic cytokine production by human glioma cells. | 2011 | Phytother Res | pmid:21170924 |
| Ginsburg H and Deharo E | A call for using natural compounds in the development of new antimalarial treatments - an introduction. | 2011 | Malar. J. | pmid:21411010 |
| Kim HJ and Jin CY | Stem cells in drug screening for neurodegenerative disease. | 2012 | Korean J. Physiol. Pharmacol. | pmid:22416213 |
| Lee SM et al. | Vascular protective role of vitexicarpin isolated from Vitex rotundifolia in human umbilical vein endothelial cells. | 2012 | Inflammation | pmid:21614554 |
| Xu J et al. | Quantitative determination and pharmacokinetic study of casticin in rat plasma by liquid chromatography-mass spectrometry. | 2012 | J Pharm Biomed Anal | pmid:22177414 |
| Zeng F et al. | Induction of apoptosis by casticin in cervical cancer cells: reactive oxygen species-dependent sustained activation of Jun N-terminal kinase. | 2012 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:22427461 |
| Weathers PJ and Towler MJ | The flavonoids casticin and artemetin are poorly extracted and are unstable in an Artemisia annua tea infusion. | 2012 | Planta Med. | pmid:22673829 |
| Ling Y et al. | Metabolism studies of casticin in rats using HPLC-ESI-MS(n). | 2012 | Biomed. Chromatogr. | pmid:22407499 |
| Januar HI et al. | In silico study of fucoxanthin as a tumor cytotoxic agent. | 2012 | J Pharm Bioallied Sci | pmid:22368399 |
| Meng FM et al. | Vitexicarpin induces apoptosis in human prostate carcinoma PC-3 cells through G2/M phase arrest. | 2012 | Asian Pac. J. Cancer Prev. | pmid:23464460 |
| Feng X et al. | Drug screening study using glioma stem-like cells. | 2012 | Mol Med Rep | pmid:22923060 |
| Righeschi C et al. | Microarray-based mRNA expression profiling of leukemia cells treated with the flavonoid, casticin. | 2012 May-Jun | Cancer Genomics Proteomics | pmid:22593249 |
| Kikuchi H et al. | Cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin, correlates with differentiation status in leukemia cell lines. | 2013 | Int. J. Oncol. | pmid:24126491 |