Casticin is a lipid of Polyketides (PK) class. The involved functions are known as Ligand Binding. The related lipids are linoleates.
To understand associated biological information of Casticin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with Casticin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim HJ and Jin CY | Stem cells in drug screening for neurodegenerative disease. | 2012 | Korean J. Physiol. Pharmacol. | pmid:22416213 |
| Zeng F et al. | Induction of apoptosis by casticin in cervical cancer cells: reactive oxygen species-dependent sustained activation of Jun N-terminal kinase. | 2012 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:22427461 |
| Righeschi C et al. | Microarray-based mRNA expression profiling of leukemia cells treated with the flavonoid, casticin. | 2012 May-Jun | Cancer Genomics Proteomics | pmid:22593249 |
| Weathers PJ and Towler MJ | The flavonoids casticin and artemetin are poorly extracted and are unstable in an Artemisia annua tea infusion. | 2012 | Planta Med. | pmid:22673829 |
| Feng X et al. | Drug screening study using glioma stem-like cells. | 2012 | Mol Med Rep | pmid:22923060 |
| He L et al. | Casticin induces growth suppression and cell cycle arrest through activation of FOXO3a in hepatocellular carcinoma. | 2013 | Oncol. Rep. | pmid:23064420 |
| Tang SY et al. | Casticin, a flavonoid, potentiates TRAIL-induced apoptosis through modulation of anti-apoptotic proteins and death receptor 5 in colon cancer cells. | 2013 | Oncol. Rep. | pmid:23135489 |
| Meng FM et al. | Vitexicarpin induces apoptosis in human prostate carcinoma PC-3 cells through G2/M phase arrest. | 2012 | Asian Pac. J. Cancer Prev. | pmid:23464460 |
| Zhou Y et al. | Casticin potentiates TRAIL-induced apoptosis of gastric cancer cells through endoplasmic reticulum stress. | 2013 | PLoS ONE | pmid:23536831 |
| Zhou Y et al. | Casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer cells. | 2013 | Asian Pac J Trop Med | pmid:23608376 |
| Liu E et al. | Casticin induces human glioma cell death through apoptosis and mitotic arrest. | 2013 | Cell. Physiol. Biochem. | pmid:23816816 |
| Lee C et al. | Anti-inflammatory constituents from the fruits of Vitex rotundifolia. | 2013 | Bioorg. Med. Chem. Lett. | pmid:24035341 |
| Kikuchi H et al. | Involvement of histone H3 phosphorylation through p38 MAPK pathway activation in casticin-induced cytocidal effects against the human promyelocytic cell line HL-60. | 2013 | Int. J. Oncol. | pmid:24064676 |
| Kikuchi H et al. | Cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin, correlates with differentiation status in leukemia cell lines. | 2013 | Int. J. Oncol. | pmid:24126491 |
| Liu F et al. | Casticin suppresses self-renewal and invasion of lung cancer stem-like cells from A549 cells through down-regulation of pAkt. | 2014 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:24247269 |
| Fukahori M et al. | Quality evaluation of medicinal products and health foods containing chaste berry (Vitex agnus-castus) in Japanese, European and American markets. | 2014 | Chem. Pharm. Bull. | pmid:24695348 |
| Rasul A et al. | Molecular mechanisms of casticin action: an update on its antitumor functions. | 2014 | Asian Pac. J. Cancer Prev. | pmid:25422178 |
| Liou CJ et al. | Casticin inhibits COX-2 and iNOS expression via suppression of NF-κB and MAPK signaling in lipopolysaccharide-stimulated mouse macrophages. | 2014 | J Ethnopharmacol | pmid:25446583 |
| Li YJ et al. | Flavonoids casticin and chrysosplenol D from Artemisia annua L. inhibit inflammation in vitro and in vivo. | 2015 | Toxicol. Appl. Pharmacol. | pmid:25891417 |
| Lee H et al. | Casticin, an active compound isolated from Vitex Fructus, ameliorates the cigarette smoke-induced acute lung inflammatory response in a murine model. | 2015 | Int. Immunopharmacol. | pmid:26321116 |