| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension, Pulmonary | D006976 | 32 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Hypertrophy, Right Ventricular | D017380 | 4 associated lipids |
Total
4
14,15-dihetre
14,15-dihetre is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 204 references associated with 14,15-dihetre in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for 14,15-dihetre
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 14,15-dihetre
PubChem Biomolecular Interactions and Pathways
NCBI Entrez Crosslinks
All references with 14,15-dihetre
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhang K et al. | Apocynin improving cardiac remodeling in chronic renal failure disease is associated with up-regulation of epoxyeicosatrienoic acids. | 2015 | Oncotarget | pmid:26322503 |
| Zhang S et al. | CYP2J2 overexpression ameliorates hyperlipidemia via increased fatty acid oxidation mediated by the AMPK pathway. | 2015 | Obesity (Silver Spring) | pmid:26053032 |
| Nelson JW et al. | Role of soluble epoxide hydrolase in age-related vascular cognitive decline. | 2014 | Prostaglandins Other Lipid Mediat. | pmid:25277097 |
| Chen W et al. | CYP2J2 and EETs Protect against Oxidative Stress and Apoptosis in Vivo and in Vitro Following Lung Ischemia/Reperfusion. | 2014 | Cell. Physiol. Biochem. | pmid:24903033 |
| Oni-Orisan A et al. | Dual modulation of cyclooxygenase and CYP epoxygenase metabolism and acute vascular inflammation in mice. | 2013 Jul-Aug | Prostaglandins Other Lipid Mediat. | pmid:23000418 |
| Chaudhary KR et al. | Differential effects of soluble epoxide hydrolase inhibition and CYP2J2 overexpression on postischemic cardiac function in aged mice. | 2013 Jul-Aug | Prostaglandins Other Lipid Mediat. | pmid:22922020 |
| Strauss KI et al. | Altered behavioral phenotypes in soluble epoxide hydrolase knockout mice: effects of traumatic brain injury. | 2013 Jul-Aug | Prostaglandins Other Lipid Mediat. | pmid:22922090 |
| Podolin PL et al. | In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor. | 2013 Jul-Aug | Prostaglandins Other Lipid Mediat. | pmid:23434473 |
| Chen L et al. | Beneficial effects of inhibition of soluble epoxide hydrolase on glucose homeostasis and islet damage in a streptozotocin-induced diabetic mouse model. | 2013 Jul-Aug | Prostaglandins Other Lipid Mediat. | pmid:23247129 |
| Nelson JW et al. | Soluble epoxide hydrolase dimerization is required for hydrolase activity. | 2013 | J. Biol. Chem. | pmid:23362272 |
| Yang T et al. | The role of 14,15-dihydroxyeicosatrienoic acid levels in inflammation and its relationship to lipoproteins. | 2013 | Lipids Health Dis | pmid:24148690 |
| Park SW et al. | The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells. | 2012 | Cell Oncol (Dordr) | pmid:21656078 |
| Zhao G et al. | Delivery of AAV2-CYP2J2 protects remnant kidney in the 5/6-nephrectomized rat via inhibition of apoptosis and fibrosis. | 2012 | Hum. Gene Ther. | pmid:22260463 |
| Zhao G et al. | Epoxyeicosatrienoic acids protect rat hearts against tumor necrosis factor-α-induced injury. | 2012 | J. Lipid Res. | pmid:22223859 |
| Theken KN et al. | Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease. | 2012 | Atherosclerosis | pmid:22503544 |
| Anwar-Mohamed A et al. | Acute arsenic toxicity alters cytochrome P450 and soluble epoxide hydrolase and their associated arachidonic acid metabolism in C57Bl/6 mouse heart. | 2012 | Xenobiotica | pmid:22680237 |
| Schebb NH et al. | Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors. | 2011 | Anal Bioanal Chem | pmid:21479549 |
| Kopf PG et al. | Angiotensin II regulates adrenal vascular tone through zona glomerulosa cell-derived EETs and DHETs. | 2011 | Hypertension | pmid:21199991 |
| Zhu P et al. | Development of a semi-automated LC/MS/MS method for the simultaneous quantitation of 14,15-epoxyeicosatrienoic acid, 14,15-dihydroxyeicosatrienoic acid, leukotoxin and leukotoxin diol in human plasma as biomarkers of soluble epoxide hydrolase activity in vivo. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21798825 |
| Xiao B et al. | Overexpression of cytochrome P450 epoxygenases prevents development of hypertension in spontaneously hypertensive rats by enhancing atrial natriuretic peptide. | 2010 | J. Pharmacol. Exp. Ther. | pmid:20501636 |
| Zheng C et al. | Gene delivery of cytochrome p450 epoxygenase ameliorates monocrotaline-induced pulmonary artery hypertension in rats. | 2010 | Am. J. Respir. Cell Mol. Biol. | pmid:20118222 |
| Xu X et al. | Increased CYP2J3 expression reduces insulin resistance in fructose-treated rats and db/db mice. | 2010 | Diabetes | pmid:20068141 |
| Liu JY et al. | Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model. | 2010 | Biochem. Pharmacol. | pmid:19896470 |
| Zhang W et al. | Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia. | 2009 | J. Cereb. Blood Flow Metab. | pmid:19471280 |
| Shen HC et al. | Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19682899 |
| Ghosh S et al. | Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats. | 2008 | Basic Clin. Pharmacol. Toxicol. | pmid:18312493 |
| Ng VY et al. | Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha. | 2007 | Drug Metab. Dispos. | pmid:17431031 |
| Fang X et al. | 14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-alpha. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16113065 |
| Gauthier KM et al. | Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15528233 |
| Roy U et al. | Cytochrome P450/NADPH-dependent formation of trans epoxides from trans-arachidonic acids. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15013014 |
| Spiecker M et al. | Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2. | 2004 | Circulation | pmid:15466638 |
| Nithipatikom K et al. | Inhibition of cytochrome P450omega-hydroxylase: a novel endogenous cardioprotective pathway. | 2004 | Circ. Res. | pmid:15388642 |
| Fang X et al. | Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15284062 |
| Krötz F et al. | Membrane-potential-dependent inhibition of platelet adhesion to endothelial cells by epoxyeicosatrienoic acids. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14715644 |
| Oleksiak MF et al. | Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase. | 2003 | Arch. Biochem. Biophys. | pmid:12623071 |
| Widstrom RL et al. | Fatty acid-binding proteins inhibit hydration of epoxyeicosatrienoic acids by soluble epoxide hydrolase. | 2003 | Biochemistry | pmid:14529287 |
| Campbell WB et al. | 14,15-Dihydroxyeicosatrienoic acid relaxes bovine coronary arteries by activation of K(Ca) channels. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11959628 |
| Tréluyer JM et al. | Ontogenesis of CYP2C-dependent arachidonic acid metabolism in the human liver: relationship with sudden infant death syndrome. | 2000 | Pediatr. Res. | pmid:10813596 |
| Weintraub NL et al. | Epoxide hydrolases regulate epoxyeicosatrienoic acid incorporation into coronary endothelial phospholipids. | 1999 | Am. J. Physiol. | pmid:10564166 |
| Fang X et al. | 14,15-Epoxyeicosatrienoic acid inhibits prostaglandin E2 production in vascular smooth muscle cells. | 1998 | Am. J. Physiol. | pmid:9843811 |
| Oltman CL et al. | Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation. | 1998 | Circ. Res. | pmid:9797342 |
| Nithipatikom K et al. | Determination of 14,15-epoxyeicosatrienoic acid and 14,15-dihydroxyeicosatrienoic acid by fluoroimmunoassay. | 1997 | Anal. Biochem. | pmid:9073364 |
| Fang X et al. | Cytochrome P450 metabolites of arachidonic acid: rapid incorporation and hydration of 14,15-epoxyeicosatrienoic acid in arterial smooth muscle cells. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9430380 |
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