5S-HETE

5s-hete is a lipid of Fatty Acyls (FA) class. 5s-hete often locates in Microsomes.

Cross Reference

Introduction

To understand associated biological information of 5S-HETE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 5S-HETE?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 5S-HETE

MeSH term MeSH ID Detail
Mastocytosis D008415 5 associated lipids
Carotid Artery Injuries D020212 8 associated lipids
Leukemia, Basophilic, Acute D015471 9 associated lipids
Obstetric Labor, Premature D007752 9 associated lipids
Familial Mediterranean Fever D010505 12 associated lipids
Bronchial Spasm D001986 18 associated lipids
Pregnancy Complications D011248 19 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Helicobacter Infections D016481 21 associated lipids
Vomiting D014839 21 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Coronary Disease D003327 70 associated lipids
Leukemia D007938 74 associated lipids
Arteriosclerosis D001161 86 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Per page 10 20 | Total 16

PubChem Associated disorders and diseases

What pathways are associated with 5S-HETE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 5S-HETE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 5S-HETE?

There are no associated biomedical information in the current reference collection.

What lipids are associated with 5S-HETE?

There are no associated biomedical information in the current reference collection.

What genes are associated with 5S-HETE?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with 5S-HETE?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 5S-HETE

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Per page 10 20 50 100 | Total 789
Authors Title Published Journal PubMed Link
O'Flaherty JT et al. 5-L-hydroxy-6,8,11,14-eicosatetraenoate potentiates the human neutrophil degranulating action of platelet-activating factor. 1983 Biochem. Biophys. Res. Commun. pmid:6403011
O'Flaherty JT and Nishihira J 5-Hydroxyeicosatetraenoate promotes Ca2+ and protein kinase C mobilization in neutrophils. 1987 Biochem. Biophys. Res. Commun. pmid:3689361
Fair A and Pritchard KA Oxidized low density lipoprotein increases U937 cell 5-lipoxygenase activity: induction of 5-lipoxygenase activating protein. 1994 Biochem. Biophys. Res. Commun. pmid:8002971
Jakobsson PJ et al. Human B lymphocytes possess 5-lipoxygenase activity and convert arachidonic acid to leukotriene B4. 1991 Biochem. Biophys. Res. Commun. pmid:1648910
Ghosh J and Myers CE Arachidonic acid stimulates prostate cancer cell growth: critical role of 5-lipoxygenase. 1997 Biochem. Biophys. Res. Commun. pmid:9199209
Salari SH et al. Inhibition of leukotriene B4 synthesis in human polymorphonuclear leukocytes after exposure to meningococcal lipopolysaccharide. 1982 Biochem. Biophys. Res. Commun. pmid:6280717
Dodge W and Thomas M The effect of 5-hydroxyeicosatetraenoic acid on the proliferation of granulocyte progenitors and embryonic fibroblasts of the chick. 1985 Biochem. Biophys. Res. Commun. pmid:4052072
Tong WG et al. The mechanisms of lipoxygenase inhibitor-induced apoptosis in human breast cancer cells. 2002 Biochem. Biophys. Res. Commun. pmid:12200139
Foley TD 5-HPETE is a potent inhibitor of neuronal Na+, K(+)-ATPase activity. 1997 Biochem. Biophys. Res. Commun. pmid:9199200
McColl SR et al. Modulation by phorbol myristate acetate of arachidonic acid release and leukotriene synthesis by human polymorphonuclear leukocytes stimulated with A23187. 1986 Biochem. Biophys. Res. Commun. pmid:3026382
McColl SR et al. Modulation of human neutrophil LTA hydrolase activity by phorbol myristate acetate. 1987 Biochem. Biophys. Res. Commun. pmid:2820409
Hosoi T et al. TG1019/OXE, a Galpha(i/o)-protein-coupled receptor, mediates 5-oxo-eicosatetraenoic acid-induced chemotaxis. 2005 Biochem. Biophys. Res. Commun. pmid:16039985
Erlemann KR et al. Metabolism of 5-hydroxy-6,8,11,14-eicosatetraenoic acid by human endothelial cells. 2006 Biochem. Biophys. Res. Commun. pmid:16997273
O'Flaherty JT et al. Interactions of arachidonate metabolism and protein kinase C in mediating neutrophil function. 1985 Biochem. Biophys. Res. Commun. pmid:2985065
Bonser RW et al. Chemotactic peptide stimulated endogenous arachidonic acid metabolism in HL-60 granulocytes. 1981 Biochem. Biophys. Res. Commun. pmid:6797423
Raza H et al. Specific high affinity binding of lipoxygenase metabolites of arachidonic acid by liver fatty acid binding protein. 1989 Biochem. Biophys. Res. Commun. pmid:2500117
Walstra P et al. 12-Lipoxygenase from bovine polymorphonuclear leukocytes, an enzyme with leukotriene A4-synthase activity. 1987 Biochem. Biophys. Res. Commun. pmid:2825701
Riendeau D et al. Stimulation of 5-lipoxygenase activity under conditions which promote lipid peroxidation. 1989 Biochem. J. pmid:2512907
Winkler JD et al. Influence of arachidonic acid on indices of phospholipase A2 activity in the human neutrophil. 1993 Biochem. J. pmid:8387780
Petrich K et al. The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leucocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid: structure-activity relationship and mechanism of action. 1996 Biochem. J. pmid:8615788
Shraga-Levine Z et al. Arachidonic acid and lipoxygenase products stimulate protein kinase C beta mRNA levels in pituitary alpha T3-1 cell line: role in gonadotropin-releasing hormone action. 1996 Biochem. J. pmid:8687415
Safayhi H et al. A novel biologically active seleno-organic compound--V. Inhibition by ebselen (PZ 51) of rat peritoneal neutrophil lipoxygenase. 1985 Biochem. Pharmacol. pmid:2990494
Köhler T et al. Phospholipase A2 inhibition by alkylbenzoylacrylic acids. 1992 Biochem. Pharmacol. pmid:1324685
Mathews WR and Murphy RC Inhibition of leukotriene biosynthesis in mastocytoma cells by diethylcarbamazine. 1982 Biochem. Pharmacol. pmid:6288051
Maier TJ et al. Celecoxib inhibits 5-lipoxygenase. 2008 Biochem. Pharmacol. pmid:18692027
Oishi K and Yamaguchi M Regulatory effect of arachidonic acid on the calcium transport system in rat liver nuclei. 1993 Biochem. Pharmacol. pmid:8385946
Beetens JR et al. Ketoconazole inhibits the biosynthesis of leukotrienes in vitro and in vivo. 1986 Biochem. Pharmacol. pmid:3006695
Chang J et al. Inhibition of platelet and neutrophil phospholipase A2 by hydroxyeicosatetraenoic acids (HETES). A novel pharmacological mechanism for regulating free fatty acid release. 1985 Biochem. Pharmacol. pmid:3994765
Hatzelmann A et al. Mode of action of the new selective leukotriene synthesis inhibitor BAY X 1005 ((R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid) and structurally related compounds. 1993 Biochem. Pharmacol. pmid:8381000
Gresele P et al. Cloricromene inhibits leukotriene formation by human polymorphonuclear leucocytes by suppressing arachidonate release from membrane phospholipids. 1993 Biochem. Pharmacol. pmid:8381001
Liu JY et al. Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model. 2010 Biochem. Pharmacol. pmid:19896470
Altmann R et al. 13-Oxo-ODE is an endogenous ligand for PPARgamma in human colonic epithelial cells. 2007 Biochem. Pharmacol. pmid:17604003
Kudryavtsev IA et al. Lipoxygenase pathway of arachidonic acid metabolism in growth control of tumor cells of different type. 2005 Biochemistry Mosc. pmid:16417464
Ku EC et al. Characterization of CGS 8515 as a selective 5-lipoxygenase inhibitor using in vitro and in vivo models. 1988 Biochim. Biophys. Acta pmid:2833314
Kimura Y et al. Inhibition of the formation of 5-hydroxy-6,8,11,14-eicosatetraenoic acid from arachidonic acid in polymorphonuclear leukocytes by various coumarins. 1985 Biochim. Biophys. Acta pmid:3922420
Haas TA et al. Binding of 13-HODE and 5-, 12- and 15-HETE to endothelial cells and subsequent platelet, neutrophil and tumor cell adhesion. 1988 Biochim. Biophys. Acta pmid:3390452
Kimura Y et al. Effects of stilbenes on arachidonate metabolism in leukocytes. 1985 Biochim. Biophys. Acta pmid:3922423
Balsinde J et al. The interaction of ethanol and exogenous arachidonic acid in the generation of extracellular messengers by mouse peritoneal macrophages. 1988 Biochim. Biophys. Acta pmid:2835991
Brown ML et al. Ionophore-induced metabolism of phospholipids and eicosanoid production in porcine aortic endothelial cells: selective release of arachidonic acid from diacyl and ether phospholipids. 1987 Biochim. Biophys. Acta pmid:3115300
Hada T et al. Discovery of 5R-lipoxygenase activity in oocytes of the surf clam, Spisula solidissima. 1997 Biochim. Biophys. Acta pmid:9219894
Marcoz P et al. Phosphatidic acid stimulates the rolipram-sensitive cyclic nucleotide phosphodiesterase from rat thymocytes. 1993 Biochim. Biophys. Acta pmid:8452869
Careaga-Houck M and Sprecher H Effects of a fish oil diet on the metabolism of endogenous (n-6) and (n-3) fatty acids in rat neutrophils. 1990 Biochim. Biophys. Acta pmid:2174263
Serhan CN On the relationship between leukotriene and lipoxin production by human neutrophils: evidence for differential metabolism of 15-HETE and 5-HETE. 1989 Biochim. Biophys. Acta pmid:2546590
O'Flaherty JT et al. 5-Oxo-ETE analogs and the proliferation of cancer cells. 2005 Biochim. Biophys. Acta pmid:16154383
O'Flaherty JT et al. Chemical and biological characterization of oxo-eicosatetraenoic acids. 1994 Biochim. Biophys. Acta pmid:7803484
Long EK et al. Fatty acids induce leukotriene C4 synthesis in macrophages in a fatty acid binding protein-dependent manner. 2013 Biochim. Biophys. Acta pmid:24046860
Takayama H et al. Preferential incorporation of eicosanoid precursor fatty acids into human umbilical vein endothelial cell phospholipids. 1987 Biochim. Biophys. Acta pmid:2825796
Hampson AJ et al. Biosynthesis of eicosanoids by blood cells of the crab, Carcinus maenas. 1992 Biochim. Biophys. Acta pmid:1543736
Crutchley DJ and Maynard JR Induction of plasminogen activator by 12-O-tetradecanoylphorbol-13-acetate and calcium ionophore. Suppression by inhibitors of fatty acid lipoxygenase. 1983 Biochim. Biophys. Acta pmid:6403051
Westcott JY and Murphy RC Effect of alcohols on arachidonic acid metabolism in murine mastocytoma cells and human polymorphonuclear leukocytes. 1985 Biochim. Biophys. Acta pmid:2982416
Suzuki A et al. Possible roles of arachidonic acid and its metabolites in induction of tissue plasminogen activator (t-PA) production in human fibroblast, IMR-90 cells by proteose peptone. 1992 Biochim. Biophys. Acta pmid:1731958
Vonakis BM and Vanderhoek JY A calcium-independent 5-lipoxygenase system in mast/basophil PT-18 cells. 1990 Biochim. Biophys. Acta pmid:2116176
Mathur SN et al. Increased production of lipoxygenase products by cholesterol-rich mouse macrophages. 1985 Biochim. Biophys. Acta pmid:3931684
Niknami M et al. Decrease in expression or activity of cytosolic phospholipase A2alpha increases cyclooxygenase-1 action: A cross-talk between key enzymes in arachidonic acid pathway in prostate cancer cells. 2010 Biochim. Biophys. Acta pmid:20227521
Shoam H and Razin E BW755C inhibits the 5-lipoxygenase in E-mast cells without affecting degranulation. 1985 Biochim. Biophys. Acta pmid:2413896
Kim JH et al. Conjugated linoleic acid reduction of murine mammary tumor cell growth through 5-hydroxyeicosatetraenoic acid. 2005 Biochim. Biophys. Acta pmid:15708358
Mobley A et al. Selective inhibition of 5-lipoxygenase pathway in rat pulmonary alveolar macrophages by cigarette smoking. 1987 Biochim. Biophys. Acta pmid:3030439
van der Donk EM et al. 12-Lipoxygenase from rat basophilic leukemia cells, an oxygenase with leukotriene A4-synthase activity. 1992 Biochim. Biophys. Acta pmid:1390874
Nakagawa Y and Ishii E Changes in arachidonic acid metabolism and the aggregation of polymorphonuclear leukocytes in rats with streptozotocin-induced diabetes. 1996 Biochim. Biophys. Acta pmid:8608172
Yamaoka A et al. Inhibition of leukotriene formation in human leukocytes by halothane. 1987 Biochim. Biophys. Acta pmid:3032266
Pasechnikov VD et al. 5-Lipoxygenase products: their biosynthesis in human gastric mucosa and possible involvement in inflammatory response and oxygen saturation index reduction in gastric ulcer patients. 1991 Biochim. Biophys. Acta pmid:1859850
O'Flaherty JT et al. Comparison of 1-O-alkyl-, 1-O-alk-1'-enyl-, and 1-O-acyl-2-acetyl-sn-glycero-3-phosphoethanolamines and -3-phosphocholines as agonists of the platelet-activating factor family. 1994 Biochim. Biophys. Acta pmid:8280772
Turk J et al. Arachidonic acid metabolism in isolated pancreatic islets. III. Effects of exogenous lipoxygenase products and inhibitors on insulin secretion. 1985 Biochim. Biophys. Acta pmid:3919770
Kimura Y et al. Effects of stilbene derivatives on arachidonate metabolism in leukocytes. 1985 Biochim. Biophys. Acta pmid:3931689
Kim JH et al. Attenuation of breast tumor cell growth by conjugated linoleic acid via inhibition of 5-lipoxygenase activating protein. 2005 Biochim. Biophys. Acta pmid:16185917
Richards CF et al. Specific incorporation of 5-hydroxy-6,8,11,14-eicosatetraenoic acid into phosphatidylcholine in human endothelial cells. 1986 Biochim. Biophys. Acta pmid:3004591
Gukovskaya AS et al. Effect of the sulfhydryl reagent thimerosal on cytosolic free Ca2+ and membrane potential of thymocytes. 1992 Biochim. Biophys. Acta pmid:1390866
Antoine C et al. Time-dependent utilization of platelet arachidonic acid by the neutrophil in formation of 5-lipoxygenase products in platelet-neutrophil co-incubations. 1992 Biochim. Biophys. Acta pmid:1329972
Milvae RA et al. Involvement of lipoxygenase products of arachidonic acid metabolism in bovine luteal function. 1986 Biol. Reprod. pmid:3103701
Paige M et al. HPLC quantification of 5-hydroxyeicosatetraenoic acid in human lung cancer tissues. 2009 Biomed. Chromatogr. pmid:19353686
Miller TA et al. 5-HETE congeners as modulators of cell proliferation. 2000 Bioorg. Med. Chem. Lett. pmid:10987416
Ishihara K et al. Inhibition of icosanoid production in MC/9 mouse mast cells by n-3 polyunsaturated fatty acids isolated from edible marine algae. 1998 Biosci. Biotechnol. Biochem. pmid:9720225
Canetti C et al. Syk activation is a leukotriene B4-regulated event involved in macrophage phagocytosis of IgG-coated targets but not apoptotic cells. 2003 Blood pmid:12730109
Rhee BG et al. Platelet modulation of polymorphonuclear leukocyte shear induced aggregation. 1986 Blood pmid:3000480
Schafer AI et al. Incorporation of platelet and leukocyte lipoxygenase metabolites by cultured vascular cells. 1986 Blood pmid:3002525
Powell WS et al. Biological inactivation of 5-oxo-6,8,11,14-eicosatetraenoic acid by human platelets. 1999 Blood pmid:9920859
Kanaji K et al. Deficient induction of leukotriene synthesis in human neutrophils by lipoxygenase-deficient platelets. 1986 Blood pmid:3006834
Palmblad J et al. Leukotriene B4 is a potent and stereospecific stimulator of neutrophil chemotaxis and adherence. 1981 Blood pmid:6266432
Clark SR et al. Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. 2011 Blood pmid:21177434
Spanbroek R et al. 5-lipoxygenase expression in dendritic cells generated from CD34(+) hematopoietic progenitors and in lymphoid organs. 2000 Blood pmid:11090070
Chabannes B et al. Platelets may inhibit leucotriene biosynthesis by human neutrophils at the integrin level. 2003 Br. J. Haematol. pmid:12694258
Ford-Hutchinson AW et al. Generation of leukotriene B4, its all trans isomers and 5-hydroxyeicosatetraenoic acid by rat basophilic leukaemia cells. 1982 Br. J. Pharmacol. pmid:6282374
Sonnhof U et al. Inhibitory postsynaptic actions of taurine, GABA and other amino acids on motoneurons of the isolated frog spinal cord. 1975 Brain Res. pmid:128
Gupta S et al. Lipoxygenase-5 is overexpressed in prostate adenocarcinoma. 2001 Cancer pmid:11241241
Shureiqi I and Baron JA Curcumin chemoprevention: the long road to clinical translation. 2011 Cancer Prev Res (Phila) pmid:21372027
Lewis JG and Adams DO Enhanced release of hydrogen peroxide and metabolites of arachidonic acid by macrophages from SENCAR mice following stimulation with phorbol esters. 1986 Cancer Res. pmid:3019532
O'Flaherty JT et al. 5(S)-Hydroxy-6,8,11,14-E,Z,Z,Z-eicosatetraenoate stimulates PC3 cell signaling and growth by a receptor-dependent mechanism. 2002 Cancer Res. pmid:12460891
Chen X et al. Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model. 2002 Carcinogenesis pmid:12507933
Grant GE et al. Enhanced formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by cancer cells in response to oxidative stress, docosahexaenoic acid and neutrophil-derived 5-hydroxy-6,8,11,14-eicosatetraenoic acid. 2011 Carcinogenesis pmid:21393477
Weitberg AB and Corvese D Hydroxy- and hydroperoxy-6,8,11,14-eicosatetraenoic acids induce DNA strand breaks in human lymphocytes. 1989 Carcinogenesis pmid:2497998
Shashkin PN et al. Insulin and glucose play a role in foam cell formation and function. 2006 Cardiovasc Diabetol pmid:16787541
Valone FH et al. Alveolar macrophage lipoxygenase products of arachidonic acid: isolation and recognition as the predominant constituents of the neutrophil chemotactic activity elaborated by alveolar macrophages. 1980 Cell. Immunol. pmid:6774816
Gilliam EB et al. Phorbol ester plus calcium ionophore induces release of arachidonic acid from membrane phospholipids of a human B cell line. 1991 Cell. Immunol. pmid:1905589
Hall LM and Murphy RC Activation of human polymorphonuclear leukocytes by products derived from the peroxidation of human red blood cell membranes. 1998 Chem. Res. Toxicol. pmid:9760276
Lewis RA A presumptive role for leukotrienes in obstructive airways diseases. 1985 Chest pmid:2990824
Burhop KE et al. Monohydroxyeicosatetraenoic acids (5-HETE and 15-HETE) induce pulmonary vasoconstriction and edema. 1988 Circ. Res. pmid:3349572
Moqbel R et al. Enhancement of neutrophil- and eosinophil-mediated complement-dependent killing of schistosomula of Schistosoma mansoni in vitro by leukotriene B4. 1983 Clin. Exp. Immunol. pmid:6307558
Nagy L et al. Complement receptor enhancement and chemotaxis of human neutrophils and eosinophils by leukotrienes and other lipoxygenase products. 1982 Clin. Exp. Immunol. pmid:6282507
Nielsen OH et al. Release of leukotriene B4 and 5-hydroxyeicosatetraenoic acid during phagocytosis of artificial immune complexes by peripheral neutrophils in chronic inflammatory bowel disease. 1986 Clin. Exp. Immunol. pmid:3024887
Docherty JC and Wilson TW Effect of indomethacin on arachidonic acid metabolism in human leukocytes stimulated ex vivo. 1991 Clin. Pharmacol. Ther. pmid:1848800