| MeSH term | MeSH ID | Detail |
|---|---|---|
| Mammary Neoplasms, Animal | D015674 | 27 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
5S-HETE
5s-hete is a lipid of Fatty Acyls (FA) class. 5s-hete often locates in Microsomes.
Cross Reference
Introduction
To understand associated biological information of 5S-HETE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 5S-HETE?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 5S-HETE
PubChem Associated disorders and diseases
What pathways are associated with 5S-HETE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 5S-HETE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 5S-HETE?
There are no associated biomedical information in the current reference collection.
What lipids are associated with 5S-HETE?
There are no associated biomedical information in the current reference collection.
What genes are associated with 5S-HETE?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with 5S-HETE?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 5S-HETE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:8243123684731666020 | ||||
| pmid:8243123685744200003 | ||||
| pmid:8245937344203941197 | ||||
| pmid:8245937481775080819 | ||||
| pmid:8246769648769792069 | ||||
| pmid:8246987235215552814 | ||||
| pmid:8247338198484791603 | ||||
| Edwin SS et al. | 5-Hydroxyeicosatetraenoic acid biosynthesis by gestational tissues: effects of inflammatory cytokines. | 1993 | Am. J. Obstet. Gynecol. | pmid:8267048 |
| Müller K and Ziereis K | Effects of oxygen radicals, hydrogen peroxide and water-soluble singlet oxygen carriers on 5- and 12-lipoxygenase. | 1993 | Arch. Pharm. (Weinheim) | pmid:8267517 |
| O'Flaherty JT et al. | Comparison of 1-O-alkyl-, 1-O-alk-1'-enyl-, and 1-O-acyl-2-acetyl-sn-glycero-3-phosphoethanolamines and -3-phosphocholines as agonists of the platelet-activating factor family. | 1994 | Biochim. Biophys. Acta | pmid:8280772 |
| pmid:8295756293720925555 | ||||
| Lepley RA and Fitzpatrick FA | Irreversible inactivation of 5-lipoxygenase by leukotriene A4. Characterization of product inactivation with purified enzyme and intact leukocytes. | 1994 | J. Biol. Chem. | pmid:8300592 |
| pmid:8313999212739978605 | ||||
| pmid:8315181416903224690 | ||||
| pmid:8316291872320418927 | ||||
| pmid:8316293057735914865 | ||||
| Kargman S et al. | Leukotriene synthesis in U937 cells expressing recombinant 5-lipoxygenase. | 1993 | J Lipid Mediat | pmid:8358023 |
| Sjolander A et al. | A human epithelial cell line, intestine 407, can produce 5-hydroxyeicosatetraenoic acid and leukotriene B4. | 1993 | Prostaglandins | pmid:8380938 |
| Hatzelmann A et al. | Mode of action of the new selective leukotriene synthesis inhibitor BAY X 1005 ((R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid) and structurally related compounds. | 1993 | Biochem. Pharmacol. | pmid:8381000 |
| Gresele P et al. | Cloricromene inhibits leukotriene formation by human polymorphonuclear leucocytes by suppressing arachidonate release from membrane phospholipids. | 1993 | Biochem. Pharmacol. | pmid:8381001 |
| Sperling RI et al. | Dietary omega-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils. | 1993 | J. Clin. Invest. | pmid:8381824 |
| Oishi K and Yamaguchi M | Regulatory effect of arachidonic acid on the calcium transport system in rat liver nuclei. | 1993 | Biochem. Pharmacol. | pmid:8385946 |
| Kruse-Elliott KT and Olson NC | CGS 8515 and indomethacin attenuate cytokine-induced cardiopulmonary dysfunction in pigs. | 1993 | Am. J. Physiol. | pmid:8386479 |
| O'Flaherty JT et al. | 5-Oxo-eicosatetraenoate, a potent human neutrophil stimulus. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8386504 |
| Radeau T et al. | Effect of nedocromil sodium on sulfidopeptide leukotrienes-stimulated human alveolar macrophages in asthma. | 1993 | Pulm Pharmacol | pmid:8386571 |
| pmid:8386658456067597103 | ||||
| pmid:8387200243874148670 | ||||
| Powell WS et al. | Stimulation of human neutrophils by 5-oxo-6,8,11,14-eicosatetraenoic acid by a mechanism independent of the leukotriene B4 receptor. | 1993 | J. Biol. Chem. | pmid:8387490 |
| Winkler JD et al. | Influence of arachidonic acid on indices of phospholipase A2 activity in the human neutrophil. | 1993 | Biochem. J. | pmid:8387780 |
| pmid:8389209344365979747 | ||||
| pmid:8389209344365980780 | ||||
| pmid:8390010884050023013 | ||||
| pmid:8390317583685217902 | ||||
| pmid:8390891595995685437 | ||||
| pmid:8391166289687232121 | ||||
| pmid:8391166290381985084 | ||||
| pmid:8391166307542311012 | ||||
| O'Flaherty JT and Rossi AG | 5-hydroxyicosatetraenoate stimulates neutrophils by a stereospecific, G protein-linked mechanism. | 1993 | J. Biol. Chem. | pmid:8392058 |
| Nihei Y et al. | Epocarbazolins A and B, novel 5-lipoxygenase inhibitors. Taxonomy, fermentation, isolation, structures and biological activities. | 1993 | J. Antibiot. | pmid:8436556 |
| Alpert SE and Walenga RW | Human tracheal epithelial cells selectively incorporate 15-hydroxyeicosatetraenoic acid into phosphatidylinositol. | 1993 | Am. J. Respir. Cell Mol. Biol. | pmid:8448017 |
| pmid:8450493686380185183 | ||||
| Marcoz P et al. | Phosphatidic acid stimulates the rolipram-sensitive cyclic nucleotide phosphodiesterase from rat thymocytes. | 1993 | Biochim. Biophys. Acta | pmid:8452869 |
| pmid:8462656579418944097 | ||||
| Gallwitz WE et al. | 5-Lipoxygenase metabolites of arachidonic acid stimulate isolated osteoclasts to resorb calcified matrices. | 1993 | J. Biol. Chem. | pmid:8486677 |
| pmid:8516135837169443442 | ||||
| Hamer RR et al. | Dibenzoxepinone hydroxylamines and hydroxamic acids: dual inhibitors of cyclooxygenase and 5-lipoxygenase with potent topical antiinflammatory activity. | 1996 | J. Med. Chem. | pmid:8568814 |
| Motta AB et al. | Role of interferon-alpha in arachidonic acid metabolism by the rat uteri from spayed animals: effect of 17 beta-estradiol. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8577780 |
| Nakagawa Y and Ishii E | Changes in arachidonic acid metabolism and the aggregation of polymorphonuclear leukocytes in rats with streptozotocin-induced diabetes. | 1996 | Biochim. Biophys. Acta | pmid:8608172 |
| Petrich K et al. | The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leucocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid: structure-activity relationship and mechanism of action. | 1996 | Biochem. J. | pmid:8615788 |
| Cleland LG et al. | Dietary (n-9) eicosatrienoic acid from a cultured fungus inhibits leukotriene B4 synthesis in rats and the effect is modified by dietary linoleic acid. | 1996 | J. Nutr. | pmid:8648425 |
| Lepley RA and Fitzpatrick FA | Inhibition of mitogen-activated protein kinase kinase blocks activation and redistribution of 5-lipoxygenase in HL-60 cells. | 1996 | Arch. Biochem. Biophys. | pmid:8660693 |
| Norgauer J et al. | Chemotactic 5-oxo-icosatetraenoic acids activate a unique pattern of neutrophil responses. Analysis of phospholipid metabolism, intracellular Ca2+ transients, actin reorganization, superoxide-anion production and receptor up-regulation. | 1996 | Eur. J. Biochem. | pmid:8665888 |
| Shraga-Levine Z et al. | Arachidonic acid and lipoxygenase products stimulate protein kinase C beta mRNA levels in pituitary alpha T3-1 cell line: role in gonadotropin-releasing hormone action. | 1996 | Biochem. J. | pmid:8687415 |
| Zhang Y et al. | Synthesis of 5-oxo-6,8,11,14-eicosatetraenoic acid by human monocytes and lymphocytes. | 1996 | J. Leukoc. Biol. | pmid:8691070 |
| pmid:87 | ||||
| pmid:8751168581022215714 | ||||
| pmid:8751709536245660681 | ||||
| Sun D and Funk CD | Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein. | 1996 | J. Biol. Chem. | pmid:8798642 |
| Ulbricht B et al. | Differential secretion of cathepsins B and L from normal and tumor human lung cells stimulated by 12(S)-hydroxy-eicosatetraenoic acid. | 1996 | Exp. Cell Res. | pmid:8806429 |
| Bhatia PA et al. | 5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones. | 1996 | J. Med. Chem. | pmid:8831760 |
| Edwin SS et al. | 5-Hydroxyeicosatetraenoic acid and human parturition. | 1996 | Prostaglandins | pmid:8873235 |
| Sozzani S et al. | Stimulating properties of 5-oxo-eicosanoids for human monocytes: synergism with monocyte chemotactic protein-1 and -3. | 1996 | J. Immunol. | pmid:8906847 |
| Abe M et al. | Lung cancer cell lines inhibit leukotriene B4 production by human polymorphonuclear leukocytes at the level of phospholipase A2. | 1996 | Am. J. Respir. Cell Mol. Biol. | pmid:8918363 |
| Sochanowicz B and Szumiel I | Arachidonic acid metabolism in murine lymphoma cell sublines differing in radiation sensitivity. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8951992 |
| Lin N et al. | Increased synthesis of specific eicosanoids in rejected corneal grafts. | 1996 | Curr. Eye Res. | pmid:9018436 |
| Wheelan P and Murphy RC | Quantitation of 5-lipoxygenase products by electrospray mass spectrometry: effect of ethanol on zymosan-stimulated production of 5-lipoxygenase products by human neutrophils. | 1997 | Anal. Biochem. | pmid:9025916 |
| Grimminger F et al. | Synthesis of 4- and 5-series leukotrienes in the lung microvasculature challenged with Escherichia coli hemolysin: critical dependence on exogenous free fatty acid supply. | 1997 | Am. J. Respir. Cell Mol. Biol. | pmid:9070617 |
| Krischer SM et al. | Protein-facilitated export of arachidonic acid from pig neutrophils. | 1997 | J. Biol. Chem. | pmid:9099707 |
| Arai M et al. | Preferential esterification of endogenously formed 5-hydroxyeicosatetraenoic acid to phospholipids in activated polymorphonuclear leukocytes. | 1997 | Eur. J. Biochem. | pmid:9119019 |
| Carty TJ et al. | Tenidap inhibits 5-lipoxygenase product formation in vitro, but this activity is not observed in three animal models. | 1997 | Inflamm. Res. | pmid:9197987 |
| Foley TD | 5-HPETE is a potent inhibitor of neuronal Na+, K(+)-ATPase activity. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9199200 |
| Ghosh J and Myers CE | Arachidonic acid stimulates prostate cancer cell growth: critical role of 5-lipoxygenase. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9199209 |
| Hada T et al. | Discovery of 5R-lipoxygenase activity in oocytes of the surf clam, Spisula solidissima. | 1997 | Biochim. Biophys. Acta | pmid:9219894 |
| pmid:93 | ||||
| Watanabe T et al. | Ebselen (DR3305) ameliorates delayed cerebral vasospasm in a canine two-hemorrhage model. | 1997 | Neurol. Res. | pmid:9329038 |
| Martinsson T et al. | Effects of ropivacaine on eicosanoid release from human granulocytes and endothelial cells in vitro. | 1997 | Inflamm. Res. | pmid:9372311 |
| Tang DG et al. | Suppression of W256 carcinosarcoma cell apoptosis by arachidonic acid and other polyunsaturated fatty acids. | 1997 | Int. J. Cancer | pmid:9378543 |
| Edwin SS et al. | Action of immunoregulatory agents on 5-HETE production by cultured human amnion cells. | 1997 | J. Reprod. Immunol. | pmid:9430742 |
| Imai H et al. | Suppression of leukotriene formation in RBL-2H3 cells that overexpressed phospholipid hydroperoxide glutathione peroxidase. | 1998 | J. Biol. Chem. | pmid:9442035 |
| Yamazaki R et al. | Anti-inflammatory effect of YPE-01, a novel diarylheptanoid derivative, on dermal inflammation in mice. | 1998 | Inflamm. Res. | pmid:9628261 |
| Traianedes K et al. | 5-Lipoxygenase metabolites inhibit bone formation in vitro. | 1998 | Endocrinology | pmid:9645691 |
| Capodici C et al. | Integrin-dependent homotypic adhesion of neutrophils. Arachidonic acid activates Raf-1/Mek/Erk via a 5-lipoxygenase- dependent pathway. | 1998 | J. Clin. Invest. | pmid:9649570 |
| Ishihara K et al. | Inhibition of icosanoid production in MC/9 mouse mast cells by n-3 polyunsaturated fatty acids isolated from edible marine algae. | 1998 | Biosci. Biotechnol. Biochem. | pmid:9720225 |
| Wen FQ et al. | Eicosanoid profile in cultured human pulmonary artery smooth muscle cells treated with IL-1 beta and TNF alpha. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758210 |
| Hall LM and Murphy RC | Activation of human polymorphonuclear leukocytes by products derived from the peroxidation of human red blood cell membranes. | 1998 | Chem. Res. Toxicol. | pmid:9760276 |
| Fiedler J et al. | Exogenous leukotriene B4 (LTB4) inhibits human neutrophil generation of LTB4 from endogenous arachidonic acid during opsonized zymosan phagocytosis. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9765334 |
| Ghosh J and Myers CE | Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9789062 |
| Hall LM and Murphy RC | Electrospray mass spectrometric analysis of 5-hydroperoxy and 5-hydroxyeicosatetraenoic acids generated by lipid peroxidation of red blood cell ghost phospholipids. | 1998 | J. Am. Soc. Mass Spectrom. | pmid:9879367 |
| Powell WS et al. | Biological inactivation of 5-oxo-6,8,11,14-eicosatetraenoic acid by human platelets. | 1999 | Blood | pmid:9920859 |