| MeSH term | MeSH ID | Detail |
|---|---|---|
| Familial Mediterranean Fever | D010505 | 12 associated lipids |
| Pregnancy Complications | D011248 | 19 associated lipids |
| Mammary Neoplasms, Animal | D015674 | 27 associated lipids |
| Helicobacter Infections | D016481 | 21 associated lipids |
| Mastocytosis | D008415 | 5 associated lipids |
| Carotid Artery Injuries | D020212 | 8 associated lipids |
5S-HETE
5s-hete is a lipid of Fatty Acyls (FA) class. 5s-hete often locates in Microsomes.
Cross Reference
Introduction
To understand associated biological information of 5S-HETE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 5S-HETE?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 5S-HETE
PubChem Associated disorders and diseases
What pathways are associated with 5S-HETE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 5S-HETE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 5S-HETE?
There are no associated biomedical information in the current reference collection.
What lipids are associated with 5S-HETE?
There are no associated biomedical information in the current reference collection.
What genes are associated with 5S-HETE?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with 5S-HETE?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 5S-HETE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Grimminger F et al. | Inhibition of cytoskeletal rearrangement by botulinum C2 toxin amplifies ligand-evoked lipid mediator generation in human neutrophils. | 1991 | Mol. Pharmacol. | pmid:1656192 |
| Rossi AG et al. | Enhancement of human neutrophil responses to platelet activating factor by 5(S)-hydroxy-eicosatetraenoate. | 1991 Sep-Oct | J Lipid Mediat | pmid:1659464 |
| Engels F et al. | Production of arachidonic acid and linoleic acid metabolites by human bronchoalveolar lavage cells. | 1991 | Prostaglandins | pmid:1662406 |
| Badwey JA et al. | Products of inflammatory cells synergistically enhance superoxide production by phagocytic leukocytes. | 1991 | Adv. Exp. Med. Biol. | pmid:1667963 |
| Rossi AG and O'Flaherty JT | Bioactions of 5-hydroxyicosatetraenoate and its interaction with platelet-activating factor. | 1991 | Lipids | pmid:1668115 |
| Soter NA | The skin in mastocytosis. | 1991 | J. Invest. Dermatol. | pmid:1672136 |
| Shashkin PN et al. | Insulin and glucose play a role in foam cell formation and function. | 2006 | Cardiovasc Diabetol | pmid:16787541 |
| Tommasini I et al. | 5-Hydroxyeicosatetraenoic acid is a key intermediate of the arachidonate-dependent protective signaling in monocytes/macrophages exposed to peroxynitrite. | 2006 | J. Leukoc. Biol. | pmid:16885503 |
| Chouinard S et al. | Isoform-specific regulation of uridine diphosphate-glucuronosyltransferase 2B enzymes in the human prostate: differential consequences for androgen and bioactive lipid inactivation. | 2006 | Endocrinology | pmid:16887906 |
| Hayashi T et al. | Inhibition of 5-lipoxygenase pathway suppresses the growth of bladder cancer cells. | 2006 | Int. J. Urol. | pmid:16903934 |
| Erlemann KR et al. | Metabolism of 5-hydroxy-6,8,11,14-eicosatetraenoic acid by human endothelial cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16997273 |
| Cerioni L and Cantoni O | ERK1/2 regulates two sequential steps promoting monocyte survival to peroxynitrite. | 2007 | J. Cell. Physiol. | pmid:16998804 |
| Dołegowska B et al. | Metabolism of eicosanoids and their action on renal function during ischaemia and reperfusion: the effect of alprostadil. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17011760 |
| Berg C et al. | Platelet-induced growth of human fibroblasts is associated with an increased expression of 5-lipoxygenase. | 2006 | Thromb. Haemost. | pmid:17080223 |
| Gillis RC et al. | Regulation of apoptosis in eicosapentaenoic acid-treated HL-60 cells. | 2007 | J. Surg. Res. | pmid:17084410 |
| Suzuki A et al. | Possible roles of arachidonic acid and its metabolites in induction of tissue plasminogen activator (t-PA) production in human fibroblast, IMR-90 cells by proteose peptone. | 1992 | Biochim. Biophys. Acta | pmid:1731958 |
| Park S et al. | Inhibitory activities and attenuated expressions of 5-LOX with red ginseng in Helicobacter pylori-infected gastric epithelial cells. | 2007 | Dig. Dis. Sci. | pmid:17333352 |
| Sanna F et al. | Production of inflammatory molecules in peripheral blood mononuclear cells from severely glucose-6-phosphate dehydrogenase-deficient subjects. | 2007 | J. Vasc. Res. | pmid:17361089 |
| MacNaughton WK et al. | A role for phospholipid-derived inflammatory mediators in intestinal anaphylaxis in the rat. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1738123 |
| Altmann R et al. | 13-Oxo-ODE is an endogenous ligand for PPARgamma in human colonic epithelial cells. | 2007 | Biochem. Pharmacol. | pmid:17604003 |
| Mike I et al. | The differences in 12-hydroxyeicosatetraenoic acid and thromboxane B2 release from guinea pig platelets. | 1991 | Prostaglandins | pmid:1763200 |
| Cossette C et al. | Human neutrophils convert the sebum-derived polyunsaturated fatty acid Sebaleic acid to a potent granulocyte chemoattractant. | 2008 | J. Biol. Chem. | pmid:18287092 |
| Patel P et al. | Structural requirements for activation of the 5-oxo-6E,8Z, 11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) receptor: identification of a mead acid metabolite with potent agonist activity. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18292294 |
| Zweifel BS et al. | A rat air pouch model for evaluating the efficacy and selectivity of 5-lipoxygenase inhibitors. | 2008 | Eur. J. Pharmacol. | pmid:18295198 |
| Schulam PG et al. | Platelet-activating factor induces phospholipid turnover, calcium flux, arachidonic acid liberation, eicosanoid generation, and oncogene expression in a human B cell line. | 1991 | J. Immunol. | pmid:1847170 |
| Docherty JC and Wilson TW | Effect of indomethacin on arachidonic acid metabolism in human leukocytes stimulated ex vivo. | 1991 | Clin. Pharmacol. Ther. | pmid:1848800 |
| pmid:18538544 | ||||
| pmid:18555664 | ||||
| Pasechnikov VD et al. | 5-Lipoxygenase products: their biosynthesis in human gastric mucosa and possible involvement in inflammatory response and oxygen saturation index reduction in gastric ulcer patients. | 1991 | Biochim. Biophys. Acta | pmid:1859850 |
| Maier TJ et al. | Celecoxib inhibits 5-lipoxygenase. | 2008 | Biochem. Pharmacol. | pmid:18692027 |
| Tommasini I et al. | Prostaglandin E2 signals monocyte/macrophage survival to peroxynitrite via protein kinase A converging in bad phosphorylation with the protein kinase C alpha-dependent pathway driven by 5-hydroxyeicosatetraenoic acid. | 2008 | J. Immunol. | pmid:18832722 |
| Bukantz SC | Asthma: the molecular light at the end of the tracheal tunnel. | 1991 | Hosp. Pract. (Off. Ed.) | pmid:1899249 |
| Willey MB et al. | The development of methodology for clinical measurement of 5-lipoxygenase pathway intermediates from human peripheral blood mononuclear cells. | 2008 | J Pharm Biomed Anal | pmid:18996667 |
| Gilliam EB et al. | Phorbol ester plus calcium ionophore induces release of arachidonic acid from membrane phospholipids of a human B cell line. | 1991 | Cell. Immunol. | pmid:1905589 |
| Dohi T et al. | Inhibition of lipoxygenase by phenolic compounds. | 1991 | Jpn. J. Pharmacol. | pmid:1909391 |
| Patel P et al. | Substrate selectivity of 5-hydroxyeicosanoid dehydrogenase and its inhibition by 5-hydroxy-Delta6-long-chain fatty acids. | 2009 | J. Pharmacol. Exp. Ther. | pmid:19164464 |
| pmid:19246624 | ||||
| Paige M et al. | HPLC quantification of 5-hydroxyeicosatetraenoic acid in human lung cancer tissues. | 2009 | Biomed. Chromatogr. | pmid:19353686 |
| Graham FD et al. | Oxidative stress-induced changes in pyridine nucleotides and chemoattractant 5-lipoxygenase products in aging neutrophils. | 2009 | Free Radic. Biol. Med. | pmid:19376220 |
| Jian W et al. | 5-Lipoxygenase-mediated endogenous DNA damage. | 2009 | J. Biol. Chem. | pmid:19390118 |
| Dołegowska B et al. | Platelets arachidonic acid metabolism in patients with essential hypertension. | 2009 | Platelets | pmid:19440924 |
| Radogna F et al. | Lipoxygenase-mediated pro-radical effect of melatonin via stimulation of arachidonic acid metabolism. | 2009 | Toxicol. Appl. Pharmacol. | pmid:19460395 |
| pmid:19529568 | ||||
| pmid:19541232 | ||||
| pmid:198 | ||||
| Khan GN et al. | Pomegranate fruit extract impairs invasion and motility in human breast cancer. | 2009 | Integr Cancer Ther | pmid:19815594 |
| Brinkman HJ et al. | Selective conversion and esterification of monohydroxyeicosatetraenoic acids by human vascular smooth muscle cells: relevance to smooth muscle cell proliferation. | 1991 | Exp. Cell Res. | pmid:1984423 |
| Liu JY et al. | Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model. | 2010 | Biochem. Pharmacol. | pmid:19896470 |
| Tanaka N et al. | Comparison of inhibitory actions of indomethacin and epostane on ovulation in rats. | 1991 | Am. J. Physiol. | pmid:1996619 |
| pmid:2 | ||||
| Henricks PA et al. | 9- and 13-hydroxy-linoleic acid possess chemotactic activity for bovine and human polymorphonuclear leukocytes. | 1991 | Prostaglandins | pmid:2020743 |
| Niknami M et al. | Decrease in expression or activity of cytosolic phospholipase A2alpha increases cyclooxygenase-1 action: A cross-talk between key enzymes in arachidonic acid pathway in prostate cancer cells. | 2010 | Biochim. Biophys. Acta | pmid:20227521 |
| pmid:2032 | ||||
| Kim DH et al. | Epoxyeicosatrienoic acid agonist regulates human mesenchymal stem cell-derived adipocytes through activation of HO-1-pAKT signaling and a decrease in PPARγ. | 2010 | Stem Cells Dev. | pmid:20412023 |
| Dolegowska B et al. | Lipoxygenase-derived hydroxyeicosatetraenoic acids--novel perioperative markers of early post-transplant allograft function? | 2010 | Nephrol. Dial. Transplant. | pmid:20530808 |
| Walsh SW | Evidence for 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene C4(LTC4) in the onset of labor. | 1991 | Ann. N. Y. Acad. Sci. | pmid:2064194 |
| Imaizumi S et al. | L-4F differentially alters plasma levels of oxidized fatty acids resulting in more anti-inflammatory HDL in mice. | 2010 | Drug Metab Lett | pmid:20642447 |
| pmid:20913920 | ||||
| pmid:20914784 | ||||
| pmid:20916880 | ||||
| pmid:20917360 | ||||
| pmid:20917744 | ||||
| pmid:20918056 | ||||
| pmid:20918104 | ||||
| pmid:20918128 | ||||
| pmid:20918528 | ||||
| pmid:20918544 | ||||
| pmid:20918976 | ||||
| pmid:20919056 | ||||
| pmid:20919192 | ||||
| pmid:20919328 | ||||
| pmid:20919432 | ||||
| pmid:20920128 | ||||
| pmid:20922736 | ||||
| pmid:20922832 | ||||
| pmid:20923752 | ||||
| pmid:20925216 | ||||
| Ichikawa F et al. | [Effects of 5-hydroxyeicosatetraenoic acid (5-HETE) on progesterone and prostaglandin production by human corpora lutea]. | 1990 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:2105363 |
| Ichikawa F et al. | The effects of lipoxygenase products on progesterone and prostaglandin production by human corpora lutea. | 1990 | J. Clin. Endocrinol. Metab. | pmid:2108184 |
| Schulam PG and Shearer WT | Evidence for 5-lipoxygenase activity in human B cell lines. A possible role for arachidonic acid metabolites during B cell signal transduction. | 1990 | J. Immunol. | pmid:2108210 |
| Vonakis BM and Vanderhoek JY | A calcium-independent 5-lipoxygenase system in mast/basophil PT-18 cells. | 1990 | Biochim. Biophys. Acta | pmid:2116176 |
| Clark SR et al. | Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. | 2011 | Blood | pmid:21177434 |
| Grimminger F et al. | Inflammatory lipid mediator generation elicited by viable hemolysin-forming Escherichia coli in lung vasculature. | 1990 | J. Exp. Med. | pmid:2120384 |
| Graff G et al. | Preparation and purification of soybean lipoxygenase-derived unsaturated hydroperoxy and hydroxy fatty acids and determination of molar absorptivities of hydroxy fatty acids. | 1990 | Anal. Biochem. | pmid:2121063 |
| Postoak D et al. | 15-Lipoxygenase products of arachidonate play a role in proliferation of transformed erythroid cells. | 1990 | Am. J. Physiol. | pmid:2124416 |
| Chu J and Praticò D | 5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo. | 2011 | Ann. Neurol. | pmid:21280074 |
| Ikegami H et al. | 5-Hydroxyeicosatetraenoic acid and phorbol ester stimulate prolactin release from rat anterior pituitary cells by different mechanisms. | 1990 | Endocrinol. Jpn. | pmid:2129302 |
| Shureiqi I and Baron JA | Curcumin chemoprevention: the long road to clinical translation. | 2011 | Cancer Prev Res (Phila) | pmid:21372027 |
| Grant GE et al. | Enhanced formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by cancer cells in response to oxidative stress, docosahexaenoic acid and neutrophil-derived 5-hydroxy-6,8,11,14-eicosatetraenoic acid. | 2011 | Carcinogenesis | pmid:21393477 |
| Farias SE et al. | Lipid mediators in cerebral spinal fluid of traumatic brain injured patients. | 2011 | J Trauma | pmid:21427623 |
| Heidel JR et al. | Functional studies of bovine alveolar neutrophils elicited with recombinant bovine IL-1 beta. | 1990 | J. Immunol. | pmid:2153175 |
| Grimminger F et al. | Influence of microvascular adherence on neutrophil leukotriene generation. Evidence for cooperative eicosanoid synthesis. | 1990 | J. Immunol. | pmid:2155266 |
| Fan SY et al. | The anti-inflammatory activities of an extract and compounds isolated from Platycladus orientalis (Linnaeus) Franco in vitro and ex vivo. | 2012 | J Ethnopharmacol | pmid:21619922 |
| Sperling RI et al. | Inhibition of leukotriene B4 synthesis in neutrophils from patients with rheumatoid arthritis by a single oral dose of methotrexate. | 1990 | Arthritis Rheum. | pmid:2167685 |
| Ysrael MC and Croft KD | Inhibition of leukotriene and platelet activating factor synthesis in leukocytes by the sesquiterpene lactone scandenolide. | 1990 | Planta Med. | pmid:2168055 |
| Huwyler J and Gut J | Single-step organic extraction of leukotrienes and related compounds and their simultaneous analysis by high-performance liquid chromatography. | 1990 | Anal. Biochem. | pmid:2171381 |
| Jett M et al. | Staphylococcus aureus enterotoxin B challenge of monkeys: correlation of plasma levels of arachidonic acid cascade products with occurrence of illness. | 1990 | Infect. Immun. | pmid:2172165 |
| Rodriguez de Turco EB and Spitzer JA | Eicosanoid production in nonparenchymal liver cells isolated from rats infused with E. coli endotoxin. | 1990 | J. Leukoc. Biol. | pmid:2172432 |
| Yu CL et al. | Serum stimulation of NIH 3T3 cells induces the production of lipids able to inhibit GTPase-activating protein activity. | 1990 | Mol. Cell. Biol. | pmid:2174114 |
| Careaga-Houck M and Sprecher H | Effects of a fish oil diet on the metabolism of endogenous (n-6) and (n-3) fatty acids in rat neutrophils. | 1990 | Biochim. Biophys. Acta | pmid:2174263 |