Giménez-Bastida JA et al. |
Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E2 and D2 by activated human leukocytes. |
2017 |
FASEB J. |
pmid:28096231
|
Maayah ZH and El-Kadi AO |
5-, 12- and 15-Hydroxyeicosatetraenoic acids induce cellular hypertrophy in the human ventricular cardiomyocyte, RL-14 cell line, through MAPK- and NF-κB-dependent mechanism. |
2016 |
Arch. Toxicol. |
pmid:25600587
|
Barbour SE et al. |
Group VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells. |
2015 |
J. Biol. Chem. |
pmid:25762722
|
Allain EP et al. |
The Intracellular Localisation and Phosphorylation Profile of the Human 5-Lipoxygenase Δ13 Isoform Differs from That of Its Full Length Counterpart. |
2015 |
PLoS ONE |
pmid:26173130
|
RodrÃguez-Lagunas MJ et al. |
5-Hydroxyeicosatetraenoic acid and leukotriene D4 increase intestinal epithelial paracellular permeability. |
2013 |
Int. J. Biochem. Cell Biol. |
pmid:23583294
|
Long EK et al. |
Fatty acids induce leukotriene C4 synthesis in macrophages in a fatty acid binding protein-dependent manner. |
2013 |
Biochim. Biophys. Acta |
pmid:24046860
|
Chatterjee M et al. |
Overexpression of 5-lipoxygenase and its relation with cell proliferation and angiogenesis in 7,12-dimethylbenz(α)anthracene-induced rat mammary carcinogenesis. |
2013 |
Mol. Carcinog. |
pmid:22213124
|
Kang KH et al. |
Protection of dopaminergic neurons by 5-lipoxygenase inhibitor. |
2013 |
Neuropharmacology |
pmid:23800665
|
Meng Z et al. |
Inhibitor of 5-lipoxygenase, zileuton, suppresses prostate cancer metastasis by upregulating E-cadherin and paxillin. |
2013 |
Urology |
pmid:24295266
|
Sisignano M et al. |
Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice. |
2013 |
PLoS ONE |
pmid:24349046
|
Neilson AP et al. |
Effect of fish oil on levels of R- and S-enantiomers of 5-, 12-, and 15-hydroxyeicosatetraenoic acids in mouse colonic mucosa. |
2012 |
Nutr Cancer |
pmid:22149144
|
He C et al. |
Dynamic eicosanoid responses upon different inhibitor and combination treatments on the arachidonic acid metabolic network. |
2012 |
Mol Biosyst |
pmid:22446875
|
Fan SY et al. |
The anti-inflammatory activities of an extract and compounds isolated from Platycladus orientalis (Linnaeus) Franco in vitro and ex vivo. |
2012 |
J Ethnopharmacol |
pmid:21619922
|
Nielsen MS et al. |
The effect of low-dose marine n-3 fatty acids on the biosynthesis of pro-inflammatory 5-lipoxygenase pathway metabolites in overweight subjects: a randomized controlled trial. |
2012 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:22748976
|
Grant GE et al. |
Enhanced formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by cancer cells in response to oxidative stress, docosahexaenoic acid and neutrophil-derived 5-hydroxy-6,8,11,14-eicosatetraenoic acid. |
2011 |
Carcinogenesis |
pmid:21393477
|
Farias SE et al. |
Lipid mediators in cerebral spinal fluid of traumatic brain injured patients. |
2011 |
J Trauma |
pmid:21427623
|
Shureiqi I and Baron JA |
Curcumin chemoprevention: the long road to clinical translation. |
2011 |
Cancer Prev Res (Phila) |
pmid:21372027
|
Clark SR et al. |
Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. |
2011 |
Blood |
pmid:21177434
|
Chu J and Praticò D |
5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo. |
2011 |
Ann. Neurol. |
pmid:21280074
|
Dolegowska B et al. |
Lipoxygenase-derived hydroxyeicosatetraenoic acids--novel perioperative markers of early post-transplant allograft function? |
2010 |
Nephrol. Dial. Transplant. |
pmid:20530808
|
Kim DH et al. |
Epoxyeicosatrienoic acid agonist regulates human mesenchymal stem cell-derived adipocytes through activation of HO-1-pAKT signaling and a decrease in PPARγ. |
2010 |
Stem Cells Dev. |
pmid:20412023
|
Imaizumi S et al. |
L-4F differentially alters plasma levels of oxidized fatty acids resulting in more anti-inflammatory HDL in mice. |
2010 |
Drug Metab Lett |
pmid:20642447
|
Niknami M et al. |
Decrease in expression or activity of cytosolic phospholipase A2alpha increases cyclooxygenase-1 action: A cross-talk between key enzymes in arachidonic acid pathway in prostate cancer cells. |
2010 |
Biochim. Biophys. Acta |
pmid:20227521
|
Liu JY et al. |
Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model. |
2010 |
Biochem. Pharmacol. |
pmid:19896470
|
Jian W et al. |
5-Lipoxygenase-mediated endogenous DNA damage. |
2009 |
J. Biol. Chem. |
pmid:19390118
|
Graham FD et al. |
Oxidative stress-induced changes in pyridine nucleotides and chemoattractant 5-lipoxygenase products in aging neutrophils. |
2009 |
Free Radic. Biol. Med. |
pmid:19376220
|
Khan GN et al. |
Pomegranate fruit extract impairs invasion and motility in human breast cancer. |
2009 |
Integr Cancer Ther |
pmid:19815594
|
Patel P et al. |
Substrate selectivity of 5-hydroxyeicosanoid dehydrogenase and its inhibition by 5-hydroxy-Delta6-long-chain fatty acids. |
2009 |
J. Pharmacol. Exp. Ther. |
pmid:19164464
|
Paige M et al. |
HPLC quantification of 5-hydroxyeicosatetraenoic acid in human lung cancer tissues. |
2009 |
Biomed. Chromatogr. |
pmid:19353686
|
Radogna F et al. |
Lipoxygenase-mediated pro-radical effect of melatonin via stimulation of arachidonic acid metabolism. |
2009 |
Toxicol. Appl. Pharmacol. |
pmid:19460395
|
Dołegowska B et al. |
Platelets arachidonic acid metabolism in patients with essential hypertension. |
2009 |
Platelets |
pmid:19440924
|
Willey MB et al. |
The development of methodology for clinical measurement of 5-lipoxygenase pathway intermediates from human peripheral blood mononuclear cells. |
2008 |
J Pharm Biomed Anal |
pmid:18996667
|
Maier TJ et al. |
Celecoxib inhibits 5-lipoxygenase. |
2008 |
Biochem. Pharmacol. |
pmid:18692027
|
Tommasini I et al. |
Prostaglandin E2 signals monocyte/macrophage survival to peroxynitrite via protein kinase A converging in bad phosphorylation with the protein kinase C alpha-dependent pathway driven by 5-hydroxyeicosatetraenoic acid. |
2008 |
J. Immunol. |
pmid:18832722
|
Patel P et al. |
Structural requirements for activation of the 5-oxo-6E,8Z, 11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) receptor: identification of a mead acid metabolite with potent agonist activity. |
2008 |
J. Pharmacol. Exp. Ther. |
pmid:18292294
|
Cossette C et al. |
Human neutrophils convert the sebum-derived polyunsaturated fatty acid Sebaleic acid to a potent granulocyte chemoattractant. |
2008 |
J. Biol. Chem. |
pmid:18287092
|
Zweifel BS et al. |
A rat air pouch model for evaluating the efficacy and selectivity of 5-lipoxygenase inhibitors. |
2008 |
Eur. J. Pharmacol. |
pmid:18295198
|
Gillis RC et al. |
Regulation of apoptosis in eicosapentaenoic acid-treated HL-60 cells. |
2007 |
J. Surg. Res. |
pmid:17084410
|
Park S et al. |
Inhibitory activities and attenuated expressions of 5-LOX with red ginseng in Helicobacter pylori-infected gastric epithelial cells. |
2007 |
Dig. Dis. Sci. |
pmid:17333352
|
Sanna F et al. |
Production of inflammatory molecules in peripheral blood mononuclear cells from severely glucose-6-phosphate dehydrogenase-deficient subjects. |
2007 |
J. Vasc. Res. |
pmid:17361089
|
Cerioni L and Cantoni O |
ERK1/2 regulates two sequential steps promoting monocyte survival to peroxynitrite. |
2007 |
J. Cell. Physiol. |
pmid:16998804
|
Altmann R et al. |
13-Oxo-ODE is an endogenous ligand for PPARgamma in human colonic epithelial cells. |
2007 |
Biochem. Pharmacol. |
pmid:17604003
|
Dołegowska B et al. |
Metabolism of eicosanoids and their action on renal function during ischaemia and reperfusion: the effect of alprostadil. |
2006 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:17011760
|
Hassan S and Carraway RE |
Involvement of arachidonic acid metabolism and EGF receptor in neurotensin-induced prostate cancer PC3 cell growth. |
2006 |
Regul. Pept. |
pmid:16330112
|
Hayashi T et al. |
Inhibition of 5-lipoxygenase pathway suppresses the growth of bladder cancer cells. |
2006 |
Int. J. Urol. |
pmid:16903934
|
Erlemann KR et al. |
Metabolism of 5-hydroxy-6,8,11,14-eicosatetraenoic acid by human endothelial cells. |
2006 |
Biochem. Biophys. Res. Commun. |
pmid:16997273
|
Tommasini I et al. |
5-Hydroxyeicosatetraenoic acid is a key intermediate of the arachidonate-dependent protective signaling in monocytes/macrophages exposed to peroxynitrite. |
2006 |
J. Leukoc. Biol. |
pmid:16885503
|
Zarini S et al. |
Effect of arachidonic acid reacylation on leukotriene biosynthesis in human neutrophils stimulated with granulocyte-macrophage colony-stimulating factor and formyl-methionyl-leucyl-phenylalanine. |
2006 |
J. Biol. Chem. |
pmid:16495221
|
Berg C et al. |
Platelet-induced growth of human fibroblasts is associated with an increased expression of 5-lipoxygenase. |
2006 |
Thromb. Haemost. |
pmid:17080223
|
Shashkin PN et al. |
Insulin and glucose play a role in foam cell formation and function. |
2006 |
Cardiovasc Diabetol |
pmid:16787541
|
Chouinard S et al. |
Isoform-specific regulation of uridine diphosphate-glucuronosyltransferase 2B enzymes in the human prostate: differential consequences for androgen and bioactive lipid inactivation. |
2006 |
Endocrinology |
pmid:16887906
|
Powell WS and Rokach J |
Biochemistry, biology and chemistry of the 5-lipoxygenase product 5-oxo-ETE. |
2005 Mar-May |
Prog. Lipid Res. |
pmid:15893379
|
Draganov DI et al. |
Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. |
2005 |
J. Lipid Res. |
pmid:15772423
|
Kudryavtsev IA et al. |
Lipoxygenase pathway of arachidonic acid metabolism in growth control of tumor cells of different type. |
2005 |
Biochemistry Mosc. |
pmid:16417464
|
O'Flaherty JT et al. |
5-Oxo-ETE analogs and the proliferation of cancer cells. |
2005 |
Biochim. Biophys. Acta |
pmid:16154383
|
Hosoi T et al. |
TG1019/OXE, a Galpha(i/o)-protein-coupled receptor, mediates 5-oxo-eicosatetraenoic acid-induced chemotaxis. |
2005 |
Biochem. Biophys. Res. Commun. |
pmid:16039985
|
Kim JH et al. |
Conjugated linoleic acid reduction of murine mammary tumor cell growth through 5-hydroxyeicosatetraenoic acid. |
2005 |
Biochim. Biophys. Acta |
pmid:15708358
|
Kim JH et al. |
Attenuation of breast tumor cell growth by conjugated linoleic acid via inhibition of 5-lipoxygenase activating protein. |
2005 |
Biochim. Biophys. Acta |
pmid:16185917
|
Moretti RM et al. |
Activation of the orphan nuclear receptor RORalpha counteracts the proliferative effect of fatty acids on prostate cancer cells: crucial role of 5-lipoxygenase. |
2004 |
Int. J. Cancer |
pmid:15305379
|
Prasad NS et al. |
Spice phenolics inhibit human PMNL 5-lipoxygenase. |
2004 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:15120715
|
Zimmer JS et al. |
Fatty acid binding proteins stabilize leukotriene A4: competition with arachidonic acid but not other lipoxygenase products. |
2004 |
J. Lipid Res. |
pmid:15342681
|
David KC et al. |
Characterization of the in vitro anti-inflammatory activity of AL-5898 and related benzopyranyl esters and amides. |
2003 |
Inflammation |
pmid:12772775
|
Chabannes B et al. |
Platelets may inhibit leucotriene biosynthesis by human neutrophils at the integrin level. |
2003 |
Br. J. Haematol. |
pmid:12694258
|
Canetti C et al. |
Syk activation is a leukotriene B4-regulated event involved in macrophage phagocytosis of IgG-coated targets but not apoptotic cells. |
2003 |
Blood |
pmid:12730109
|
Yang P et al. |
Inhibition of proliferation of PC3 cells by the branched-chain fatty acid, 12-methyltetradecanoic acid, is associated with inhibition of 5-lipoxygenase. |
2003 |
Prostate |
pmid:12712407
|
Brock TG et al. |
Prolonged lipopolysaccharide inhibits leukotriene synthesis in peritoneal macrophages: mediation by nitric oxide and prostaglandins. |
2003 |
Prostaglandins Other Lipid Mediat. |
pmid:14518557
|
Robinson BS et al. |
Inhibition of neutrophil leukotriene B4 production by a novel synthetic N-3 polyunsaturated fatty acid analogue, beta-oxa 21:3n-3. |
2003 |
J. Immunol. |
pmid:14568954
|
Wang XJ et al. |
Involvement of 5-lipoxygenase metabolites of arachidonic acid in cyclic AMP-stimulated steroidogenesis and steroidogenic acute regulatory protein gene expression. |
2003 |
J. Steroid Biochem. Mol. Biol. |
pmid:12943700
|
Jones CE et al. |
Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils. |
2003 |
Mol. Pharmacol. |
pmid:12606753
|
Rose F et al. |
Increased neutrophil mediator release in patients with pulmonary hypertension--suppression by inhaled iloprost. |
2003 |
Thromb. Haemost. |
pmid:14652649
|
Beck-Speier I et al. |
Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2. |
2003 |
Prostaglandins Other Lipid Mediat. |
pmid:14518563
|
Chen X et al. |
Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model. |
2002 |
Carcinogenesis |
pmid:12507933
|
Zeng ZZ et al. |
5(S)-hydroxyeicosatetraenoic acid stimulates DNA synthesis in human microvascular endothelial cells via activation of Jak/STAT and phosphatidylinositol 3-kinase/Akt signaling, leading to induction of expression of basic fibroblast growth factor 2. |
2002 |
J. Biol. Chem. |
pmid:12193593
|
Tong WG et al. |
The mechanisms of lipoxygenase inhibitor-induced apoptosis in human breast cancer cells. |
2002 |
Biochem. Biophys. Res. Commun. |
pmid:12200139
|
Hosoi T et al. |
Identification of a novel human eicosanoid receptor coupled to G(i/o). |
2002 |
J. Biol. Chem. |
pmid:12065583
|
Powell WS et al. |
Interactions between 5-oxo-ETE and chemokines in stimulating eosinophils. |
2002 |
Adv. Exp. Med. Biol. |
pmid:12664591
|
O'Flaherty JT et al. |
5(S)-Hydroxy-6,8,11,14-E,Z,Z,Z-eicosatetraenoate stimulates PC3 cell signaling and growth by a receptor-dependent mechanism. |
2002 |
Cancer Res. |
pmid:12460891
|
Taniguchi H et al. |
The lipoxygenase pathways are involved in LH-stimulated progesterone production in bovine corpus luteum. |
2002 |
Prostaglandins Other Lipid Mediat. |
pmid:11789897
|
Tavakoli S et al. |
Prostaglandin E(2)-induced interleukin-6 release by a human airway epithelial cell line. |
2001 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:11133502
|
Gupta S et al. |
Lipoxygenase-5 is overexpressed in prostate adenocarcinoma. |
2001 |
Cancer |
pmid:11241241
|
Hevko JM et al. |
Synthesis of 5-oxo-6,8,11,14-eicosatetraenoic acid and identification of novel omega-oxidized metabolites in the mouse macrophage. |
2001 |
J. Pharmacol. Exp. Ther. |
pmid:11160610
|
Velardez MO et al. |
Role of nitric oxide in the metabolism of arachidonic acid in the rat anterior pituitary gland. |
2001 |
Mol. Cell. Endocrinol. |
pmid:11165034
|
Kempen EC et al. |
Simultaneous quantification of arachidonic acid metabolites in cultured tumor cells using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. |
2001 |
Anal. Biochem. |
pmid:11673886
|
Di Girolamo G et al. |
[Effect of nonsteroidal antiinflammatory drugs on colonic lipoxygenase and cyclooxygenase activities from patients with colonic neoplasia]. |
2001 |
Medicina (B Aires) |
pmid:11721323
|
Werz O et al. |
p38 MAP kinase mediates stress-induced leukotriene synthesis in a human B-lymphocyte cell line. |
2001 |
J. Leukoc. Biol. |
pmid:11698504
|
Avis I et al. |
Five-lipoxygenase inhibitors can mediate apoptosis in human breast cancer cell lines through complex eicosanoid interactions. |
2001 |
FASEB J. |
pmid:11511519
|
Spanbroek R et al. |
IL-4 determines eicosanoid formation in dendritic cells by down-regulation of 5-lipoxygenase and up-regulation of 15-lipoxygenase 1 expression. |
2001 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:11320251
|
O'Flaherty JT et al. |
Protein kinases C translocation responses to low concentrations of arachidonic acid. |
2001 |
J. Biol. Chem. |
pmid:11328812
|
Hwang SW et al. |
Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. |
2000 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:10823958
|
Grimminger F et al. |
PAF-induced synthesis of tetraenoic and pentaenoic leukotrienes in the isolated rabbit lung. |
2000 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:10666110
|
Zimpfer U et al. |
Human dendritic cells are a physiological source of the chemotactic arachidonic acid metabolite 5-oxo-eicosatetraenoic acid. |
2000 |
Inflamm. Res. |
pmid:11131304
|
Franchi A et al. |
[Differential action of non-steroidal antiinflammatory drugs on human gallbladder cyclooxygenase and lipoxygenase]. |
2000 |
Medicina (B Aires) |
pmid:11188896
|
Wächtershäuser A et al. |
Expression of 5-lipoxygenase by human colorectal carcinoma Caco-2 cells during butyrate-induced cell differentiation. |
2000 |
Biochem. Biophys. Res. Commun. |
pmid:10679282
|
Halpern GM |
Anti-inflammatory effects of a stabilized lipid extract of Perna canaliculus (Lyprinol). |
2000 |
Allerg Immunol (Paris) |
pmid:11094640
|
Miller TA et al. |
5-HETE congeners as modulators of cell proliferation. |
2000 |
Bioorg. Med. Chem. Lett. |
pmid:10987416
|
Wegmann M et al. |
Effect of hydroxyeicosatetraenoic acids on furosemide-sensitive chloride secretion in rat distal colon. |
2000 |
J. Pharmacol. Exp. Ther. |
pmid:10991970
|
Spanbroek R et al. |
5-lipoxygenase expression in dendritic cells generated from CD34(+) hematopoietic progenitors and in lymphoid organs. |
2000 |
Blood |
pmid:11090070
|
Powell WS et al. |
Biological inactivation of 5-oxo-6,8,11,14-eicosatetraenoic acid by human platelets. |
1999 |
Blood |
pmid:9920859
|
Myers CE and Ghosh J |
Lipoxygenase inhibition in prostate cancer. |
1999 |
Eur. Urol. |
pmid:10325495
|
Chavis C et al. |
A method for the measurement of plasma hydroxyeicosatetraenoic acid levels. |
1999 |
Anal. Biochem. |
pmid:10361015
|