| MeSH term | MeSH ID | Detail |
|---|---|---|
| Coronary Disease | D003327 | 70 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Leukemia, Basophilic, Acute | D015471 | 9 associated lipids |
| Gastrointestinal Diseases | D005767 | 20 associated lipids |
| Vomiting | D014839 | 21 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Obstetric Labor, Premature | D007752 | 9 associated lipids |
5S-HETE
5s-hete is a lipid of Fatty Acyls (FA) class. 5s-hete often locates in Microsomes.
Cross Reference
Introduction
To understand associated biological information of 5S-HETE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 5S-HETE?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 5S-HETE
PubChem Associated disorders and diseases
What pathways are associated with 5S-HETE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 5S-HETE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 5S-HETE?
There are no associated biomedical information in the current reference collection.
What lipids are associated with 5S-HETE?
There are no associated biomedical information in the current reference collection.
What genes are associated with 5S-HETE?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with 5S-HETE?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 5S-HETE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kawada N et al. | Increased 5-lipoxygenase activity in massive hepatic cell necrosis in the rat correlates with neutrophil infiltration. | 1992 | Hepatology | pmid:1322350 |
| Rossi AG et al. | Enhancement of human neutrophil responses to platelet activating factor by 5(S)-hydroxy-eicosatetraenoate. | 1991 Sep-Oct | J Lipid Mediat | pmid:1659464 |
| Tanaka N et al. | Comparison of inhibitory actions of indomethacin and epostane on ovulation in rats. | 1991 | Am. J. Physiol. | pmid:1996619 |
| Mike I et al. | The differences in 12-hydroxyeicosatetraenoic acid and thromboxane B2 release from guinea pig platelets. | 1991 | Prostaglandins | pmid:1763200 |
| Henricks PA et al. | 9- and 13-hydroxy-linoleic acid possess chemotactic activity for bovine and human polymorphonuclear leukocytes. | 1991 | Prostaglandins | pmid:2020743 |
| Grimminger F et al. | Inhibition of cytoskeletal rearrangement by botulinum C2 toxin amplifies ligand-evoked lipid mediator generation in human neutrophils. | 1991 | Mol. Pharmacol. | pmid:1656192 |
| Dohi T et al. | Inhibition of lipoxygenase by phenolic compounds. | 1991 | Jpn. J. Pharmacol. | pmid:1909391 |
| Muller M and Sorrell TC | Production of leukotriene B4 and 5-hydroxyeicosatetraenoic acid by human neutrophils is inhibited by Pseudomonas aeruginosa phenazine derivatives. | 1991 | Infect. Immun. | pmid:1652564 |
| Jakobsson PJ et al. | Human B lymphocytes possess 5-lipoxygenase activity and convert arachidonic acid to leukotriene B4. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1648910 |
| Kirstein D et al. | Inhibition of leukotriene biosynthesis and polymorphonuclear leukocyte functions by orally active quinolylmethoxyphenylamines. | 1991 | Pharmacol. Toxicol. | pmid:1649466 |
| Engels F et al. | Production of arachidonic acid and linoleic acid metabolites by human bronchoalveolar lavage cells. | 1991 | Prostaglandins | pmid:1662406 |
| Badwey JA et al. | Products of inflammatory cells synergistically enhance superoxide production by phagocytic leukocytes. | 1991 | Adv. Exp. Med. Biol. | pmid:1667963 |
| Rossi AG and O'Flaherty JT | Bioactions of 5-hydroxyicosatetraenoate and its interaction with platelet-activating factor. | 1991 | Lipids | pmid:1668115 |
| Soter NA | The skin in mastocytosis. | 1991 | J. Invest. Dermatol. | pmid:1672136 |
| Brinkman HJ et al. | Selective conversion and esterification of monohydroxyeicosatetraenoic acids by human vascular smooth muscle cells: relevance to smooth muscle cell proliferation. | 1991 | Exp. Cell Res. | pmid:1984423 |
| Schulam PG et al. | Platelet-activating factor induces phospholipid turnover, calcium flux, arachidonic acid liberation, eicosanoid generation, and oncogene expression in a human B cell line. | 1991 | J. Immunol. | pmid:1847170 |
| Bukantz SC | Asthma: the molecular light at the end of the tracheal tunnel. | 1991 | Hosp. Pract. (Off. Ed.) | pmid:1899249 |
| Pasechnikov VD et al. | 5-Lipoxygenase products: their biosynthesis in human gastric mucosa and possible involvement in inflammatory response and oxygen saturation index reduction in gastric ulcer patients. | 1991 | Biochim. Biophys. Acta | pmid:1859850 |
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| Docherty JC and Wilson TW | Effect of indomethacin on arachidonic acid metabolism in human leukocytes stimulated ex vivo. | 1991 | Clin. Pharmacol. Ther. | pmid:1848800 |
| Walsh SW | Evidence for 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene C4(LTC4) in the onset of labor. | 1991 | Ann. N. Y. Acad. Sci. | pmid:2064194 |
| Sperling RI et al. | Inhibition of leukotriene B4 synthesis in neutrophils from patients with rheumatoid arthritis by a single oral dose of methotrexate. | 1990 | Arthritis Rheum. | pmid:2167685 |
| Grimminger F et al. | Influence of microvascular adherence on neutrophil leukotriene generation. Evidence for cooperative eicosanoid synthesis. | 1990 | J. Immunol. | pmid:2155266 |
| Jett M et al. | Staphylococcus aureus enterotoxin B challenge of monkeys: correlation of plasma levels of arachidonic acid cascade products with occurrence of illness. | 1990 | Infect. Immun. | pmid:2172165 |
| Rodriguez de Turco EB and Spitzer JA | Eicosanoid production in nonparenchymal liver cells isolated from rats infused with E. coli endotoxin. | 1990 | J. Leukoc. Biol. | pmid:2172432 |
| Yu CL et al. | Serum stimulation of NIH 3T3 cells induces the production of lipids able to inhibit GTPase-activating protein activity. | 1990 | Mol. Cell. Biol. | pmid:2174114 |
| Careaga-Houck M and Sprecher H | Effects of a fish oil diet on the metabolism of endogenous (n-6) and (n-3) fatty acids in rat neutrophils. | 1990 | Biochim. Biophys. Acta | pmid:2174263 |
| Ysrael MC and Croft KD | Inhibition of leukotriene and platelet activating factor synthesis in leukocytes by the sesquiterpene lactone scandenolide. | 1990 | Planta Med. | pmid:2168055 |
| Ikegami H et al. | 5-Hydroxyeicosatetraenoic acid and phorbol ester stimulate prolactin release from rat anterior pituitary cells by different mechanisms. | 1990 | Endocrinol. Jpn. | pmid:2129302 |
| Ichikawa F et al. | [Effects of 5-hydroxyeicosatetraenoic acid (5-HETE) on progesterone and prostaglandin production by human corpora lutea]. | 1990 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:2105363 |
| Ichikawa F et al. | The effects of lipoxygenase products on progesterone and prostaglandin production by human corpora lutea. | 1990 | J. Clin. Endocrinol. Metab. | pmid:2108184 |
| Schulam PG and Shearer WT | Evidence for 5-lipoxygenase activity in human B cell lines. A possible role for arachidonic acid metabolites during B cell signal transduction. | 1990 | J. Immunol. | pmid:2108210 |
| Vonakis BM and Vanderhoek JY | A calcium-independent 5-lipoxygenase system in mast/basophil PT-18 cells. | 1990 | Biochim. Biophys. Acta | pmid:2116176 |
| Postoak D et al. | 15-Lipoxygenase products of arachidonate play a role in proliferation of transformed erythroid cells. | 1990 | Am. J. Physiol. | pmid:2124416 |
| Graff G et al. | Preparation and purification of soybean lipoxygenase-derived unsaturated hydroperoxy and hydroxy fatty acids and determination of molar absorptivities of hydroxy fatty acids. | 1990 | Anal. Biochem. | pmid:2121063 |
| Huwyler J and Gut J | Single-step organic extraction of leukotrienes and related compounds and their simultaneous analysis by high-performance liquid chromatography. | 1990 | Anal. Biochem. | pmid:2171381 |
| Grimminger F et al. | Inflammatory lipid mediator generation elicited by viable hemolysin-forming Escherichia coli in lung vasculature. | 1990 | J. Exp. Med. | pmid:2120384 |
| Tegtmeier F et al. | Eicosanoids in rat brain during ischemia and reperfusion--correlation to DC depolarization. | 1990 | J. Cereb. Blood Flow Metab. | pmid:2329122 |
| Heidel JR et al. | Functional studies of bovine alveolar neutrophils elicited with recombinant bovine IL-1 beta. | 1990 | J. Immunol. | pmid:2153175 |
| König W et al. | Role of cloned virulence factors (mannose-resistant haemagglutination, mannose-resistant adhesions) from uropathogenic Escherichia coli strains in the release of inflammatory mediators from neutrophils and mast cells. | 1989 | Immunology | pmid:2569441 |
| Malo PE | Specific enhancement of LTD4-induced contractions of isolated guinea pig trachea by 5-hydroxyeicosatetraenoic acid (5-HETE). | 1989 | Prostaglandins | pmid:2740525 |
| Walsh SW | 5-Hydroxyeicosatetraenoic acid, leukotriene C4, and prostaglandin F2 alpha in amniotic fluid before and during term and preterm labor. | 1989 | Am. J. Obstet. Gynecol. | pmid:2589462 |
| Serhan CN | On the relationship between leukotriene and lipoxin production by human neutrophils: evidence for differential metabolism of 15-HETE and 5-HETE. | 1989 | Biochim. Biophys. Acta | pmid:2546590 |
| Eskew ML et al. | Effects of inadequate vitamin E and/or selenium nutrition on the release of arachidonic acid metabolites in rat alveolar macrophages. | 1989 | Prostaglandins | pmid:2546191 |
| Riendeau D et al. | Stimulation of 5-lipoxygenase activity under conditions which promote lipid peroxidation. | 1989 | Biochem. J. | pmid:2512907 |
| Richards CF and Campbell WB | Incorporation of hydroxyeicosatetraenoic acids into cellular lipids of adrenal glomerulosa cells: inhibition of aldosterone release by 5-HETE. | 1989 | Prostaglandins | pmid:2513620 |
| Hamasaki T et al. | Leukotriene B4 metabolism in neutrophils of patients with chronic granulomatous disease: phorbol myristate acetate decreases endogenous leukotriene B4 via NADPH oxidase-dependent mechanism. | 1989 | Eur. J. Clin. Invest. | pmid:2550242 |
| Bigby TD and Meslier N | Transcellular lipoxygenase metabolism between monocytes and platelets. | 1989 | J. Immunol. | pmid:2550547 |
| Gordon JA et al. | 5-HETE: uptake, distribution, and metabolism in MDCK cells. | 1989 | Am. J. Physiol. | pmid:2492150 |
| Burstein SH et al. | Antagonism to the actions of platelet activating factor by a nonpsychoactive cannabinoid. | 1989 | J. Pharmacol. Exp. Ther. | pmid:2553925 |
| Graff G and Anderson LA | 1-[4-[3-[4-[bis(4-fluorophenyl)hydroxymethyl]-1- piperidinyl]propoxy]-3-methoxyphenyl]ethanone(AHR-5333): a selective human blood neutrophil 5-lipoxygenase inhibitor. | 1989 | Prostaglandins | pmid:2554366 |
| Wang J et al. | Stimulation of progesterone and prostaglandin E2 production by lipoxygenase metabolites of arachidonic acid. | 1989 | FEBS Lett. | pmid:2494061 |
| Heyworth PG et al. | Protein phosphorylation associated with synergistic stimulation of neutrophils. | 1989 | J. Biol. Chem. | pmid:2549043 |
| Stern N et al. | Selective inhibition of angiotensin-II-mediated aldosterone secretion by 5-hydroxyeicosatetraenoic acid. | 1989 | Endocrinology | pmid:2555139 |
| Viggiano M et al. | The involvement of oxytocin in ovulation and in the outputs of cyclo-oxygenase and 5-lipoxygenase products from isolated rat ovaries. | 1989 | Prostaglandins | pmid:2501826 |
| Westcott JY et al. | Alveolar transfer and metabolism of eicosanoids in the rat. | 1989 | Am. Rev. Respir. Dis. | pmid:2536256 |
| Weitberg AB and Corvese D | Hydroxy- and hydroperoxy-6,8,11,14-eicosatetraenoic acids induce DNA strand breaks in human lymphocytes. | 1989 | Carcinogenesis | pmid:2497998 |
| Nishihira J et al. | Effect of azelastine on leukotriene synthesis in murine peritoneal cells and on thromboxane synthesis in human platelets. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2480337 |
| Heidel JR et al. | In vivo chemotaxis of bovine neutrophils induced by 5-lipoxygenase metabolites of arachidonic and eicosapentaenoic acid. | 1989 | Am. J. Pathol. | pmid:2538061 |
| Tessner TG et al. | Stimulation of platelet-activating factor synthesis by a nonmetabolizable bioactive analog of platelet-activating factor and influence of arachidonic acid metabolites. | 1989 | J. Biol. Chem. | pmid:2538461 |
| Romero R et al. | Amniotic fluid concentration of 5-hydroxyeicosatetraenoic acid is increased in human parturition at term. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2717653 |
| Cochran FR and Finch-Arietta MB | Optimization of cofactors which regulate RBL-1 arachidonate 5-lipoxygenase. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2742590 |
| Heidel JR et al. | Characterization of arachidonic acid metabolism, superoxide production, and bacterial killing in bovine circulating neutrophils and elicited alveolar neutrophils. | 1989 | J. Leukoc. Biol. | pmid:2543724 |
| Raza H et al. | Specific high affinity binding of lipoxygenase metabolites of arachidonic acid by liver fatty acid binding protein. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2500117 |
| Ku EC et al. | Characterization of CGS 8515 as a selective 5-lipoxygenase inhibitor using in vitro and in vivo models. | 1988 | Biochim. Biophys. Acta | pmid:2833314 |
| Watanabe T et al. | Participation of lipoxygenase products from arachidonic acid in the pathogenesis of cerebral vasospasm. | 1988 | J. Neurochem. | pmid:3126264 |
| Haas TA et al. | Binding of 13-HODE and 5-, 12- and 15-HETE to endothelial cells and subsequent platelet, neutrophil and tumor cell adhesion. | 1988 | Biochim. Biophys. Acta | pmid:3390452 |
| Balsinde J et al. | The interaction of ethanol and exogenous arachidonic acid in the generation of extracellular messengers by mouse peritoneal macrophages. | 1988 | Biochim. Biophys. Acta | pmid:2835991 |
| Bandyopadhyay GK et al. | Proliferative effects of insulin and epidermal growth factor on mouse mammary epithelial cells in primary culture. Enhancement by hydroxyeicosatetraenoic acids and synergism with prostaglandin E2. | 1988 | J. Biol. Chem. | pmid:3286636 |
| Sadler KL and Badwey JA | Second messengers involved in superoxide production by neutrophils. Function and metabolism. | 1988 | Hematol. Oncol. Clin. North Am. | pmid:2839455 |
| Bauldry SA et al. | Phospholipase A2 activation in human neutrophils. Differential actions of diacylglycerols and alkylacylglycerols in priming cells for stimulation by N-formyl-Met-Leu-Phe. | 1988 | J. Biol. Chem. | pmid:2846550 |
| Meghji S et al. | Stimulation of bone resorption by lipoxygenase metabolites of arachidonic acid. | 1988 | Prostaglandins | pmid:2847250 |
| Ueda N and Yamamoto S | The 6R-oxygenase activity of arachidonate 5-lipoxygenase purified from porcine leukocytes. | 1988 | J. Biol. Chem. | pmid:3338999 |
| Shimizu T et al. | Activation of the arachidonate 5-lipoxygenase pathway in the canine basilar artery after experimental subarachnoidal hemorrhage. | 1988 | J. Neurochem. | pmid:2843605 |
| Dahinden CA et al. | Leukotriene production in human neutrophils primed by recombinant human granulocyte/macrophage colony-stimulating factor and stimulated with the complement component C5A and FMLP as second signals. | 1988 | J. Exp. Med. | pmid:2833556 |
| Miyake A et al. | Possible involvement of lipoxygenase pathway of arachidonic acid in rat pituitary hormone release in vitro. | 1988 | J. Endocrinol. Invest. | pmid:2852195 |
| Romero R et al. | Amniotic fluid 5-hydroxyeicosatetraenoic acid in preterm labor. | 1988 | Prostaglandins | pmid:3187060 |
| Rossi AG et al. | Stereospecific bioactions of 5-hydroxyeicosatetraenoate. | 1988 | FEBS Lett. | pmid:3191990 |
| Wiseman JS and Nichols JS | Ketones as electrophilic substrates of lipoxygenase. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3135805 |
| O'Flaherty JT et al. | Mechanism involved in the mobilization of neutrophil calcium by 5-hydroxyeicosatetraenoate. | 1988 | J. Immunol. | pmid:2836511 |
| Moore SA et al. | Murine cerebral microvascular endothelium incorporate and metabolize 12-hydroxyeicosatetraenoic acid. | 1988 | J. Cell. Physiol. | pmid:3170659 |
| Burhop KE et al. | Monohydroxyeicosatetraenoic acids (5-HETE and 15-HETE) induce pulmonary vasoconstriction and edema. | 1988 | Circ. Res. | pmid:3349572 |
| Hwang DH et al. | Dietary linolenic acid and longer-chain n-3 fatty acids: comparison of effects on arachidonic acid metabolism in rats. | 1988 | J. Nutr. | pmid:2895804 |
| Chapkin RS et al. | Ability of 15-hydroxyeicosatrienoic acid (15-OH-20:3) to modulate macrophage arachidonic acid metabolism. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3132920 |
| Arm JP et al. | Enhanced generation of leukotriene B4 by neutrophils stimulated by unopsonized zymosan and by calcium ionophore after exercise-induced asthma. | 1988 | Am. Rev. Respir. Dis. | pmid:2849339 |
| Walenga RW et al. | Formation of hydroxyeicosatetraenoic acids (HETE) in blood from adults versus neonates: reduced production of 12-HETE in cord blood. | 1988 | Pediatr. Res. | pmid:3205606 |
| Shibata N et al. | Augmentation of eicosanoids in ischemic heart muscle in dogs: its role in the deterioration of the ischemic lesion. | 1988 | Jpn. Circ. J. | pmid:3141656 |
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| Warner JA et al. | Effects of a specific inhibitor of the 5-lipoxygenase pathway on mediator release from human basophils and mast cells. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3139865 |
| Badwey JA et al. | Synergistic stimulation of neutrophils. Possible involvement of 5-hydroxy-6,8,11,14-eicosatetraenoate in superoxide release. | 1988 | J. Biol. Chem. | pmid:2830263 |
| Bennett PR et al. | The effects of lipoxygenase metabolites of arachidonic acid on human myometrial contractility. | 1987 | Prostaglandins | pmid:2823315 |
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| Leis HJ et al. | Quantitative measurement of 5-, 12-, and 15-hydroxyeicosatetraenoic acid together with 12-hydroxyheptadecatrienoic acid by stable isotope dilution gas chromatography-negative ion chemical ionization-mass spectrometry. | 1987 | Anal. Biochem. | pmid:3300415 |
| Lawson LD and Powell DW | Bradykinin-stimulated eicosanoid synthesis and secretion by rabbit ileal components. | 1987 | Am. J. Physiol. | pmid:2438946 |
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| O'Flaherty JT and Nishihira J | Arachidonate metabolites, platelet-activating factor, and the mobilization of protein kinase C in human polymorphonuclear neutrophils. | 1987 | J. Immunol. | pmid:3029224 |
| Mobley A et al. | Selective inhibition of 5-lipoxygenase pathway in rat pulmonary alveolar macrophages by cigarette smoking. | 1987 | Biochim. Biophys. Acta | pmid:3030439 |
| Yamaoka A et al. | Inhibition of leukotriene formation in human leukocytes by halothane. | 1987 | Biochim. Biophys. Acta | pmid:3032266 |
| Gillespie MN et al. | Salutary effects of prostaglandin E1 in perfused rat lungs injured with hydrogen peroxide. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3033198 |
| Green FA et al. | Monohydroxyeicosatetraenoic acid and leukotriene production by the inflammatory cells of Xenopus laevis. | 1987 | J. Exp. Zool. | pmid:2821155 |