| MeSH term | MeSH ID | Detail |
|---|---|---|
| Polycystic Kidney, Autosomal Recessive | D017044 | 2 associated lipids |
| Neointima | D058426 | 3 associated lipids |
| Diabetes Insipidus | D003919 | 5 associated lipids |
| Hypokalemia | D007008 | 6 associated lipids |
| Carotid Artery Injuries | D020212 | 8 associated lipids |
| Hypertension, Renal | D006977 | 9 associated lipids |
| Hypertension, Renovascular | D006978 | 10 associated lipids |
| Dehydration | D003681 | 11 associated lipids |
| Polycystic Kidney Diseases | D007690 | 12 associated lipids |
| Carcinoma, Renal Cell | D002292 | 12 associated lipids |
20-HETE
20-hete is a lipid of Fatty Acyls (FA) class. 20-hete is associated with abnormalities such as Cyst, Kidney Diseases, Kidney Failure, Chronic, Cystic Kidney Diseases and Simple renal cyst. The involved functions are known as Phosphorylation, inhibitors, Hypertrophy, Epithelial Cell Proliferation and Anabolism. 20-hete often locates in Mouse Kidney, Microsomes, Tissue membrane, Body tissue and Cytoplasmic matrix. The associated genes with 20-HETE are CYP4F3 gene, PKHD1 gene, Transgenes, P4HTM gene and CYP2E1 gene. The related lipids are Promega, enterodiol, Fatty Acids, hexanoic acid and U 73343. The related experimental models are Mouse Model, Knock-out, Streptozotocin Diabetes, Transgenic Model and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of 20-HETE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 20-HETE?
20-HETE is suspected in Hypertensive disease, Renal tubular disorder, endothelial dysfunction, Renal glomerular disease, Ischemia, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Hypertension (27)
- Am. J. Physiol. Heart Circ. Physiol. (19)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (16)
- Others (110)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 20-HETE
PubChem Associated disorders and diseases
What pathways are associated with 20-HETE
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 20-HETE through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
- Am. J. Physiol. Heart Circ. Physiol. (16)
- Hypertension (14)
- Am. J. Physiol. Renal Physiol. (10)
- Others (63)
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 20-HETE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- Hypertension (28)
- Am. J. Physiol. Heart Circ. Physiol. (26)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (18)
- Others (151)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 20-HETE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 20-HETE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 20-HETE?
Related references are published most in these journals:
- Hypertension (20)
- Am. J. Physiol. Heart Circ. Physiol. (19)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (12)
- Others (86)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 20-HETE?
Mouse Model
Mouse Model are used in the study '20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease.' (Park F et al., 2008), Mouse Model are used in the study 'Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth.' (Alexanian A et al., 2009) and Mouse Model are used in the study 'Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus.' (Harder DR and Roman RJ, 2006).
Knock-out
Knock-out are used in the study 'Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle.' (Yu M et al., 2007) and Knock-out are used in the study 'Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis.' (Williams JM et al., 2007).
Streptozotocin Diabetes
Streptozotocin Diabetes are used in the study 'Deficient renal 20-HETE release in the diabetic rat is not the result of oxidative stress.' (Chen YJ et al., 2008).
Related references are published most in these journals:
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (2)
- J. Am. Soc. Nephrol. (2)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Others (4)
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 20-HETE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mapelli L et al. | Granular Layer Neurons Control Cerebellar Neurovascular Coupling Through an NMDA Receptor/NO-Dependent System. | 2017 | J. Neurosci. | pmid:28039371 |
| Yi M et al. | Functional characterization of a common CYP4F11 genetic variant and identification of functionally defective CYP4F11 variants in erythromycin metabolism and 20-HETE synthesis. | 2017 | Arch. Biochem. Biophys. | pmid:28347661 |
| Kizub IV et al. | Involvement of gap junctions between smooth muscle cells in sustained hypoxic pulmonary vasoconstriction development: a potential role for 15-HETE and 20-HETE. | 2016 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26895643 |
| Yi X et al. | Interactions Among CYP2C8, EPHX2, and CYP4A11 Variants and CYP Plasma Metabolite Levels in Ischemic Stroke. | 2016 | J. Atheroscler. Thromb. | pmid:27087514 |
| Ziegler N et al. | β-Catenin Is Required for Endothelial Cyp1b1 Regulation Influencing Metabolic Barrier Function. | 2016 | J. Neurosci. | pmid:27559173 |
| Lakhkar A et al. | 20-HETE-induced mitochondrial superoxide production and inflammatory phenotype in vascular smooth muscle is prevented by glucose-6-phosphate dehydrogenase inhibition. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:26921441 |
| Huang H et al. | Cyclooxygenase- and cytochrome P450-derived eicosanoids in stroke. | 2016 | Prostaglandins Other Lipid Mediat. | pmid:26747234 |
| Zhu Y et al. | Renal Ischemia/Reperfusion Injury in Soluble Epoxide Hydrolase-Deficient Mice. | 2016 | PLoS ONE | pmid:26727266 |
| Garcia V et al. | 20-HETE Activates the Transcription of Angiotensin-Converting Enzyme via Nuclear Factor-κB Translocation and Promoter Binding. | 2016 | J. Pharmacol. Exp. Ther. | pmid:26699146 |
| Yi X et al. | CYP Genetic Variants, CYP Metabolite Levels, and Symptomatic Carotid Stenosis in Ischemic Stroke Patients. | 2016 | J. Atheroscler. Thromb. | pmid:26686738 |