| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
20-HETE
20-hete is a lipid of Fatty Acyls (FA) class. 20-hete is associated with abnormalities such as Cyst, Kidney Diseases, Kidney Failure, Chronic, Cystic Kidney Diseases and Simple renal cyst. The involved functions are known as Phosphorylation, inhibitors, Hypertrophy, Epithelial Cell Proliferation and Anabolism. 20-hete often locates in Mouse Kidney, Microsomes, Tissue membrane, Body tissue and Cytoplasmic matrix. The associated genes with 20-HETE are CYP4F3 gene, PKHD1 gene, Transgenes, P4HTM gene and CYP2E1 gene. The related lipids are Promega, enterodiol, Fatty Acids, hexanoic acid and U 73343. The related experimental models are Mouse Model, Knock-out, Streptozotocin Diabetes, Transgenic Model and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of 20-HETE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 20-HETE?
20-HETE is suspected in Hypertensive disease, Renal tubular disorder, endothelial dysfunction, Renal glomerular disease, Ischemia, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Hypertension (27)
- Am. J. Physiol. Heart Circ. Physiol. (19)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (16)
- Others (110)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 20-HETE
PubChem Associated disorders and diseases
What pathways are associated with 20-HETE
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 20-HETE through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
- Am. J. Physiol. Heart Circ. Physiol. (16)
- Hypertension (14)
- Am. J. Physiol. Renal Physiol. (10)
- Others (63)
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 20-HETE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- Hypertension (28)
- Am. J. Physiol. Heart Circ. Physiol. (26)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (18)
- Others (151)
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 20-HETE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 20-HETE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 20-HETE?
Related references are published most in these journals:
- Hypertension (20)
- Am. J. Physiol. Heart Circ. Physiol. (19)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (12)
- Others (86)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 20-HETE?
Mouse Model
Mouse Model are used in the study '20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease.' (Park F et al., 2008), Mouse Model are used in the study 'Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth.' (Alexanian A et al., 2009) and Mouse Model are used in the study 'Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus.' (Harder DR and Roman RJ, 2006).
Knock-out
Knock-out are used in the study 'Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle.' (Yu M et al., 2007) and Knock-out are used in the study 'Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis.' (Williams JM et al., 2007).
Streptozotocin Diabetes
Streptozotocin Diabetes are used in the study 'Deficient renal 20-HETE release in the diabetic rat is not the result of oxidative stress.' (Chen YJ et al., 2008).
Related references are published most in these journals:
- J. Am. Soc. Nephrol. (2)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (2)
- Anticancer Res. (1)
- Others (4)
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with 20-HETE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang MH et al. | Contribution of cytochrome P-450 4A1 and 4A2 to vascular 20-hydroxyeicosatetraenoic acid synthesis in rat kidneys. | 1999 | Am. J. Physiol. | pmid:9950955 |
| Jacobs ER et al. | Airway synthesis of 20-hydroxyeicosatetraenoic acid: metabolism by cyclooxygenase to a bronchodilator. | 1999 | Am. J. Physiol. | pmid:9950890 |
| Ito O and Roman RJ | Role of 20-HETE in elevating chloride transport in the thick ascending limb of Dahl SS/Jr rats. | 1999 | Hypertension | pmid:9931140 |
| Sun CW et al. | Role of tyrosine kinase and PKC in the vasoconstrictor response to 20-HETE in renal arterioles. | 1999 | Hypertension | pmid:9931139 |
| Oyekan AO and McGiff JC | Functional response of the rat kidney to inhibition of nitric oxide synthesis: role of cytochrome p450-derived arachidonate metabolites. | 1998 | Br. J. Pharmacol. | pmid:9846646 |
| Sun CW et al. | Nitric oxide-20-hydroxyeicosatetraenoic acid interaction in the regulation of K+ channel activity and vascular tone in renal arterioles. | 1998 | Circ. Res. | pmid:9831701 |
| Oyekan AO et al. | Renal functional effects of endothelins: dependency on cytochrome P450-derived arachidonate metabolites. | 1998 | Biol. Res. | pmid:9830508 |
| Muthalif MM et al. | 20-Hydroxyeicosatetraenoic acid mediates calcium/calmodulin-dependent protein kinase II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9770549 |
| Imaoka S and Funae Y | [The physiological role of P450-derived arachidonic acid metabolites]. | 1998 | Nippon Yakurigaku Zasshi | pmid:9755459 |
| Alonso-Galicia M et al. | Contribution of 20-HETE to the vasodilator actions of nitric oxide in renal arteries. | 1998 | Am. J. Physiol. | pmid:9729509 |
| Fulton D et al. | A method for the determination of 5,6-EET using the lactone as an intermediate in the formation of the diol. | 1998 | J. Lipid Res. | pmid:9717733 |
| Su P et al. | Inhibition of renal arachidonic acid omega-hydroxylase activity with ABT reduces blood pressure in the SHR. | 1998 | Am. J. Physiol. | pmid:9688677 |
| Zhu D et al. | Tissue sources of cytochrome P450 4A and 20-HETE synthesis in rabbit lungs. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9651188 |
| Powell PK et al. | Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9618440 |
| Silverstein DM et al. | 20-HETE mediates the effect of parathyroid hormone and protein kinase C on renal phosphate transport. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610844 |
| Amlal H et al. | ANG II controls Na(+)-K+(NH4+)-2Cl- cotransport via 20-HETE and PKC in medullary thick ascending limb. | 1998 | Am. J. Physiol. | pmid:9575802 |
| Mao K et al. | New group of lipid mediators containing omega-hydroxyarachadonic acid (20-HETE). | 1997 | Adv. Exp. Med. Biol. | pmid:9561103 |
| Moore K | Cytochrome P450 products and renal function in cirrhosis: the HETE is on. | 1998 | Hepatology | pmid:9537461 |
| Gebremedhin D et al. | Cat cerebral arterial smooth muscle cells express cytochrome P450 4A2 enzyme and produce the vasoconstrictor 20-HETE which enhances L-type Ca2+ current. | 1998 | J. Physiol. (Lond.) | pmid:9508838 |
| Pratt PF et al. | 20-HETE relaxes bovine coronary arteries through the release of prostacyclin. | 1998 | Hypertension | pmid:9453309 |
| Bednar MM et al. | Antineutrophil strategies. | 1997 | Neurology | pmid:9371144 |
| Lange A et al. | 20-Hydroxyeicosatetraenoic acid-induced vasoconstriction and inhibition of potassium current in cerebral vascular smooth muscle is dependent on activation of protein kinase C. | 1997 | J. Biol. Chem. | pmid:9341185 |
| Wang W et al. | Phospholipase A2 is involved in mediating the effect of extracellular Ca2+ on apical K+ channels in rat TAL. | 1997 | Am. J. Physiol. | pmid:9321915 |
| Kroetz DL et al. | Developmentally regulated expression of the CYP4A genes in the spontaneously hypertensive rat kidney. | 1997 | Mol. Pharmacol. | pmid:9281597 |
| Sacerdoti D et al. | Eicosanoid excretion in hepatic cirrhosis. Predominance of 20-HETE. | 1997 | J. Clin. Invest. | pmid:9276745 |
| Askari B et al. | Analysis of eicosanoid mediation of the renal functional effects of hyperchloremia. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9223545 |
| Birks EK et al. | Human pulmonary arteries dilate to 20-HETE, an endogenous eicosanoid of lung tissue. | 1997 | Am. J. Physiol. | pmid:9176244 |
| Roman RJ et al. | Renal P450 metabolites of arachidonic acid and the development of hypertension in Dahl salt-sensitive rats. | 1997 | Am. J. Hypertens. | pmid:9160783 |
| Grider JS et al. | P450 arachidonate metabolites mediate bradykinin-dependent inhibition of NaCl transport in the rat thick ascending limb. | 1997 | Can. J. Physiol. Pharmacol. | pmid:9114929 |
| Nowicki S et al. | 20-Hydroxyeicosa-tetraenoic acid (20 HETE) activates protein kinase C. Role in regulation of rat renal Na+,K+-ATPase. | 1997 | J. Clin. Invest. | pmid:9077530 |
| Alonso-Galicia M et al. | Inhibition of 20-HETE production contributes to the vascular responses to nitric oxide. | 1997 | Hypertension | pmid:9039122 |
| Stec DE et al. | Inhibition of renal outer medullary 20-HETE production produces hypertension in Lewis rats. | 1997 | Hypertension | pmid:9039121 |
| Goodman AI et al. | Overexpression of the heme oxygenase gene in renal cell carcinoma. | 1997 | Proc. Soc. Exp. Biol. Med. | pmid:9012361 |
| Lu M et al. | Effect of angiotensin II on the apical K+ channel in the thick ascending limb of the rat kidney. | 1996 | J. Gen. Physiol. | pmid:8972391 |
| Wang MH et al. | Cloning, sequencing, and cDNA-directed expression of the rat renal CYP4A2: arachidonic acid omega-hydroxylation and 11,12-epoxidation by CYP4A2 protein. | 1996 | Arch. Biochem. Biophys. | pmid:8954571 |
| Harder DR et al. | Identification of a putative microvascular oxygen sensor. | 1996 | Circ. Res. | pmid:8925569 |
| Amlal H et al. | Na(+)-K+(NH4+)-2Cl- cotransport in medullary thick ascending limb: control by PKA, PKC, and 20-HETE. | 1996 | Am. J. Physiol. | pmid:8769983 |
| Zou AP et al. | 20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles. | 1996 | Am. J. Physiol. | pmid:8769806 |
| Imig JD et al. | Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles. | 1996 | Am. J. Physiol. | pmid:8769805 |
| Stec DE et al. | Renal cytochrome P4504A activity and salt sensitivity in spontaneously hypertensive rats. | 1996 | Hypertension | pmid:8641744 |
| Arima S et al. | 20-HETE requires increased vascular tone to constrict rabbit afferent arterioles. | 1996 | Hypertension | pmid:8613240 |
| Zou AP et al. | Role of 20-HETE in elevating loop chloride reabsorption in Dahl SS/Jr rats. | 1996 | Hypertension | pmid:8613215 |
| Lin F et al. | 20-Hydroxyeicosatetraenoic acid is formed in response to EGF and is a mitogen in rat proximal tubule. | 1995 | Am. J. Physiol. | pmid:8594874 |
| Wang W and Lu M | Effect of arachidonic acid on activity of the apical K+ channel in the thick ascending limb of the rat kidney. | 1995 | J. Gen. Physiol. | pmid:8576704 |
| Escalante B et al. | 20-hydroxyeicosatetraenoic acid is an endothelium-dependent vasoconstrictor in rabbit arteries. | 1993 | Eur. J. Pharmacol. | pmid:8519270 |
| Roman RJ et al. | Clofibrate prevents the development of hypertension in Dahl salt-sensitive rats. | 1993 | Hypertension | pmid:8505111 |
| Gebremedhin D et al. | Role of cytochrome P-450 in elevating renal vascular tone in spontaneously hypertensive rats. | 1993 Jan-Feb | J. Vasc. Res. | pmid:8435472 |
| Ma YH et al. | 20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries. | 1993 | Circ. Res. | pmid:8417836 |
| Masters BS et al. | Functional aspects of eicosanoid hydroxylation by lung and kidney cytochromes P450. Expression of cDNAs in mammalian cells and E. coli. | 1993 Mar-Apr | J Lipid Mediat | pmid:8357994 |
| Harder DR et al. | Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels. | 1994 | Am. J. Physiol. | pmid:8203608 |
| Imig JD et al. | Cytochrome P-450 inhibitors alter afferent arteriolar responses to elevations in pressure. | 1994 | Am. J. Physiol. | pmid:8203587 |
| Da Silva JL et al. | Tin-mediated heme oxygenase gene activation and cytochrome P450 arachidonate hydroxylase inhibition in spontaneously hypertensive rats. | 1994 | Am. J. Med. Sci. | pmid:8160707 |
| Zou AP et al. | Inhibition of renal vascular 20-HETE production impairs autoregulation of renal blood flow. | 1994 | Am. J. Physiol. | pmid:8141328 |
| Ma YH et al. | Altered renal P-450 metabolism of arachidonic acid in Dahl salt-sensitive rats. | 1994 | Am. J. Physiol. | pmid:8067471 |
| Zou AP et al. | Effect of P-450 omega-hydroxylase metabolites of arachidonic acid on tubuloglomerular feedback. | 1994 | Am. J. Physiol. | pmid:8023972 |
| McGiff JC et al. | Pieces in the puzzle: novel arachidonate metabolites. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7732832 |
| Zhu Y et al. | Identification of arachidonate P-450 metabolites in human platelet phospholipids. | 1995 | Hypertension | pmid:7721444 |
| Sohlenius AK et al. | Synergistic induction of acyl-CoA oxidase activity, an indicator of peroxisome proliferation, by arachidonic acid and retinoic acid in Morris hepatoma 7800C1 cells. | 1995 | Biochim. Biophys. Acta | pmid:7548195 |
| Escalante B et al. | Cytochrome P450-dependent arachidonate metabolites affect renal transport in the rabbit. | 1993 | J. Cardiovasc. Pharmacol. | pmid:7508012 |
| Roman RJ and Harder DR | Cellular and ionic signal transduction mechanisms for the mechanical activation of renal arterial vascular smooth muscle. | 1993 | J. Am. Soc. Nephrol. | pmid:7506944 |
| Levine L et al. | The development of a radioimmunoassay for 12-L-hydroxyeicosatetraenoic acid. | 1980 | Prostaglandins | pmid:7465871 |
| Rigas B and Levine L | Concentrations of arachidonic-acid metabolites in human mixed saliva are independent of flow rate. | 1983 | Arch. Oral Biol. | pmid:6582819 |
| pmid:29330456 | ||||
| pmid:29206843 | ||||
| pmid:28912346 | ||||
| pmid:28641720 | ||||
| pmid:28639228 | ||||
| pmid:28602979 | ||||
| pmid:28533430 | ||||
| Escalante B et al. | 19(S)-hydroxyeicosatetraenoic acid is a potent stimulator of renal Na+-K+-ATPase. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2837181 |
| Yi M et al. | Functional characterization of a common CYP4F11 genetic variant and identification of functionally defective CYP4F11 variants in erythromycin metabolism and 20-HETE synthesis. | 2017 | Arch. Biochem. Biophys. | pmid:28347661 |
| pmid:28325781 | ||||
| pmid:28287282 | ||||
| pmid:28249552 | ||||
| Mapelli L et al. | Granular Layer Neurons Control Cerebellar Neurovascular Coupling Through an NMDA Receptor/NO-Dependent System. | 2017 | J. Neurosci. | pmid:28039371 |
| pmid:28025003 | ||||
| pmid:28011587 | ||||
| Steuck M et al. | Food Polyphenol Apigenin Inhibits the Cytochrome P450 Monoxygenase Branch of the Arachidonic Acid Cascade. | 2016 | J. Agric. Food Chem. | pmid:27933871 |
| pmid:27916259 | ||||
| pmid:27906746 | ||||
| pmid:27834744 | ||||
| pmid:27580276 | ||||
| pmid:27568038 | ||||
| Ziegler N et al. | β-Catenin Is Required for Endothelial Cyp1b1 Regulation Influencing Metabolic Barrier Function. | 2016 | J. Neurosci. | pmid:27559173 |
| Garbacz WG et al. | Hepatic Overexpression of CD36 Improves Glycogen Homeostasis and Attenuates High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance. | 2016 | Mol. Cell. Biol. | pmid:27528620 |
| pmid:27451096 | ||||
| pmid:27393924 | ||||
| Jackson WF | Arteriolar oxygen reactivity: where is the sensor and what is the mechanism of action? | 2016 | J. Physiol. (Lond.) | pmid:27324312 |
| pmid:27287720 | ||||
| pmid:27241246 | ||||
| Dordea AC et al. | Androgen-sensitive hypertension associated with soluble guanylate cyclase-α1 deficiency is mediated by 20-HETE. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:27199131 |
| Dalmasso C et al. | 20-HETE and CYP4A2 ω-hydroxylase contribute to the elevated blood pressure in hyperandrogenemic female rats. | 2016 | Am. J. Physiol. Renal Physiol. | pmid:27194719 |
| pmid:27179555 | ||||
| Gebremedhin D et al. | Expression of CYP 4A ω-hydroxylase and formation of 20-hydroxyeicosatetreanoic acid (20-HETE) in cultured rat brain astrocytes. | 2016 | Prostaglandins Other Lipid Mediat. | pmid:27174801 |
| pmid:27100515 | ||||
| Yi X et al. | Interactions Among CYP2C8, EPHX2, and CYP4A11 Variants and CYP Plasma Metabolite Levels in Ischemic Stroke. | 2016 | J. Atheroscler. Thromb. | pmid:27087514 |
| Chen L et al. | 20-HETE contributes to ischemia-induced angiogenesis. | 2016 | Vascul. Pharmacol. | pmid:27084395 |
| Froogh G et al. | Female-favorable attenuation of coronary myogenic constriction via reciprocal activations of epoxyeicosatrienoic acids and nitric oxide. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:27016584 |
| Liao D et al. | Interaction Between CYP4F2 rs2108622 and CPY4A11 rs9333025 Variants Is Significantly Correlated with Susceptibility to Ischemic Stroke and 20-Hydroxyeicosatetraenoic Acid Level. | 2016 | Genet Test Mol Biomarkers | pmid:26959478 |
| Lakhkar A et al. | 20-HETE-induced mitochondrial superoxide production and inflammatory phenotype in vascular smooth muscle is prevented by glucose-6-phosphate dehydrogenase inhibition. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:26921441 |