| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
20-HETE
20-hete is a lipid of Fatty Acyls (FA) class. 20-hete is associated with abnormalities such as Cyst, Kidney Diseases, Kidney Failure, Chronic, Cystic Kidney Diseases and Simple renal cyst. The involved functions are known as Phosphorylation, inhibitors, Hypertrophy, Epithelial Cell Proliferation and Anabolism. 20-hete often locates in Mouse Kidney, Microsomes, Tissue membrane, Body tissue and Cytoplasmic matrix. The associated genes with 20-HETE are CYP4F3 gene, PKHD1 gene, Transgenes, P4HTM gene and CYP2E1 gene. The related lipids are Promega, enterodiol, Fatty Acids, hexanoic acid and U 73343. The related experimental models are Mouse Model, Knock-out, Streptozotocin Diabetes, Transgenic Model and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of 20-HETE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 20-HETE?
20-HETE is suspected in Hypertensive disease, Renal tubular disorder, endothelial dysfunction, Renal glomerular disease, Ischemia, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Hypertension (27)
- Am. J. Physiol. Heart Circ. Physiol. (19)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (16)
- Others (110)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 20-HETE
PubChem Associated disorders and diseases
What pathways are associated with 20-HETE
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 20-HETE through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
- Am. J. Physiol. Heart Circ. Physiol. (16)
- Hypertension (14)
- Am. J. Physiol. Renal Physiol. (10)
- Others (63)
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 20-HETE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- Hypertension (28)
- Am. J. Physiol. Heart Circ. Physiol. (26)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (18)
- Others (151)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 20-HETE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 20-HETE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 20-HETE?
Related references are published most in these journals:
- Hypertension (20)
- Am. J. Physiol. Heart Circ. Physiol. (19)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (12)
- Others (86)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 20-HETE?
Mouse Model
Mouse Model are used in the study '20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease.' (Park F et al., 2008), Mouse Model are used in the study 'Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth.' (Alexanian A et al., 2009) and Mouse Model are used in the study 'Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus.' (Harder DR and Roman RJ, 2006).
Knock-out
Knock-out are used in the study 'Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle.' (Yu M et al., 2007) and Knock-out are used in the study 'Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis.' (Williams JM et al., 2007).
Streptozotocin Diabetes
Streptozotocin Diabetes are used in the study 'Deficient renal 20-HETE release in the diabetic rat is not the result of oxidative stress.' (Chen YJ et al., 2008).
Related references are published most in these journals:
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (2)
- J. Am. Soc. Nephrol. (2)
- Anticancer Res. (1)
- Others (4)
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 20-HETE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mapelli L et al. | Granular Layer Neurons Control Cerebellar Neurovascular Coupling Through an NMDA Receptor/NO-Dependent System. | 2017 | J. Neurosci. | pmid:28039371 |
| Yi M et al. | Functional characterization of a common CYP4F11 genetic variant and identification of functionally defective CYP4F11 variants in erythromycin metabolism and 20-HETE synthesis. | 2017 | Arch. Biochem. Biophys. | pmid:28347661 |
| Kizub IV et al. | Involvement of gap junctions between smooth muscle cells in sustained hypoxic pulmonary vasoconstriction development: a potential role for 15-HETE and 20-HETE. | 2016 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26895643 |
| Froogh G et al. | Female-favorable attenuation of coronary myogenic constriction via reciprocal activations of epoxyeicosatrienoic acids and nitric oxide. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:27016584 |
| Yi X et al. | Interactions Among CYP2C8, EPHX2, and CYP4A11 Variants and CYP Plasma Metabolite Levels in Ischemic Stroke. | 2016 | J. Atheroscler. Thromb. | pmid:27087514 |
| Ziegler N et al. | β-Catenin Is Required for Endothelial Cyp1b1 Regulation Influencing Metabolic Barrier Function. | 2016 | J. Neurosci. | pmid:27559173 |
| Garbacz WG et al. | Hepatic Overexpression of CD36 Improves Glycogen Homeostasis and Attenuates High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance. | 2016 | Mol. Cell. Biol. | pmid:27528620 |
| Jackson WF | Arteriolar oxygen reactivity: where is the sensor and what is the mechanism of action? | 2016 | J. Physiol. (Lond.) | pmid:27324312 |
| Dordea AC et al. | Androgen-sensitive hypertension associated with soluble guanylate cyclase-α1 deficiency is mediated by 20-HETE. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:27199131 |
| Dalmasso C et al. | 20-HETE and CYP4A2 ω-hydroxylase contribute to the elevated blood pressure in hyperandrogenemic female rats. | 2016 | Am. J. Physiol. Renal Physiol. | pmid:27194719 |
| Gebremedhin D et al. | Expression of CYP 4A ω-hydroxylase and formation of 20-hydroxyeicosatetreanoic acid (20-HETE) in cultured rat brain astrocytes. | 2016 | Prostaglandins Other Lipid Mediat. | pmid:27174801 |
| Chen L et al. | 20-HETE contributes to ischemia-induced angiogenesis. | 2016 | Vascul. Pharmacol. | pmid:27084395 |
| Liao D et al. | Interaction Between CYP4F2 rs2108622 and CPY4A11 rs9333025 Variants Is Significantly Correlated with Susceptibility to Ischemic Stroke and 20-Hydroxyeicosatetraenoic Acid Level. | 2016 | Genet Test Mol Biomarkers | pmid:26959478 |
| Lakhkar A et al. | 20-HETE-induced mitochondrial superoxide production and inflammatory phenotype in vascular smooth muscle is prevented by glucose-6-phosphate dehydrogenase inhibition. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:26921441 |
| Huang H et al. | Cyclooxygenase- and cytochrome P450-derived eicosanoids in stroke. | 2016 | Prostaglandins Other Lipid Mediat. | pmid:26747234 |
| Zhu Y et al. | Renal Ischemia/Reperfusion Injury in Soluble Epoxide Hydrolase-Deficient Mice. | 2016 | PLoS ONE | pmid:26727266 |
| Garcia V et al. | 20-HETE Activates the Transcription of Angiotensin-Converting Enzyme via Nuclear Factor-κB Translocation and Promoter Binding. | 2016 | J. Pharmacol. Exp. Ther. | pmid:26699146 |
| Yi X et al. | CYP Genetic Variants, CYP Metabolite Levels, and Symptomatic Carotid Stenosis in Ischemic Stroke Patients. | 2016 | J. Atheroscler. Thromb. | pmid:26686738 |
| Steuck M et al. | Food Polyphenol Apigenin Inhibits the Cytochrome P450 Monoxygenase Branch of the Arachidonic Acid Cascade. | 2016 | J. Agric. Food Chem. | pmid:27933871 |
| McCarthy ET et al. | Ethanol at low concentrations protects glomerular podocytes through alcohol dehydrogenase and 20-HETE. | 2015 Jan-Mar | Prostaglandins Other Lipid Mediat. | pmid:25447342 |
| Garcia V et al. | Androgen-induced hypertension in angiotensinogen deficient mice: role of 20-HETE and EETS. | 2015 Jan-Mar | Prostaglandins Other Lipid Mediat. | pmid:25526688 |
| Yuan ZX and Rapoport SI | Transient postnatal fluoxetine decreases brain concentrations of 20-HETE and 15-epi-LXA4, arachidonic acid metabolites in adult mice. | 2015 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:26234927 |
| Liu X et al. | Contribution of epoxyeicosatrienoic acids to the cerebral blood flow response to hypoxemia. | 2015 | J. Appl. Physiol. | pmid:25792716 |
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| Shaik JS et al. | 20-Hydroxyeicosatetraenoic Acid Inhibition by HET0016 Offers Neuroprotection, Decreases Edema, and Increases Cortical Cerebral Blood Flow in a Pediatric Asphyxial Cardiac Arrest Model in Rats. | 2015 | J. Cereb. Blood Flow Metab. | pmid:26058691 |
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| Garcia V et al. | Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension. | 2015 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:25924878 |
| Donnelly MK et al. | 20-HETE is associated with unfavorable outcomes in subarachnoid hemorrhage patients. | 2015 | J. Cereb. Blood Flow Metab. | pmid:25920956 |
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| Wang J et al. | 20-Hydroxyeicosatetraenoic acid involved in endothelial activation and thrombosis. | 2015 | Am. J. Physiol. Heart Circ. Physiol. | pmid:25820395 |
| Hoopes SL et al. | Vascular actions of 20-HETE. | 2015 | Prostaglandins Other Lipid Mediat. | pmid:25813407 |
| Zhu J et al. | Additive Neuroprotection of a 20-HETE Inhibitor with Delayed Therapeutic Hypothermia after Hypoxia-Ischemia in Neonatal Piglets. | 2015 | Dev. Neurosci. | pmid:25721266 |
| Muroya Y et al. | Deficiency in the Formation of 20-Hydroxyeicosatetraenoic Acid Enhances Renal Ischemia-Reperfusion Injury. | 2015 | J. Am. Soc. Nephrol. | pmid:25644108 |
| Fan F et al. | Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat. | 2015 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:25540098 |
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| Gangadhariah MH et al. | Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy. | 2015 | J. Am. Soc. Nephrol. | pmid:25071086 |
| Alvarellos ML et al. | PharmGKB summary: very important pharmacogene information for CYP4F2. | 2015 | Pharmacogenet. Genomics | pmid:25370453 |
| Wu CC et al. | 20-HETE and blood pressure regulation: clinical implications. | 2014 Jan-Feb | Cardiol Rev | pmid:23584425 |
| Bajpai P et al. | Targeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction. | 2014 | J. Biol. Chem. | pmid:25160618 |
| Chen L et al. | Role of TRPV1 channels in ischemia/reperfusion-induced acute kidney injury. | 2014 | PLoS ONE | pmid:25330307 |
| Jarrar YB et al. | Determination of major UDP-glucuronosyltransferase enzymes and their genotypes responsible for 20-HETE glucuronidation. | 2014 | J. Lipid Res. | pmid:25249502 |
| Ge Y et al. | Role of 20-HETE in the impaired myogenic and TGF responses of the Af-Art of Dahl salt-sensitive rats. | 2014 | Am. J. Physiol. Renal Physiol. | pmid:25007877 |
| Sari AN et al. | Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKKβ/IκB-α/NF-κB pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock. | 2014 | Inflamm. Res. | pmid:24915805 |
| Li X et al. | 20-Hydroxyeicosatetraenoic acid impairs endothelial insulin signaling by inducing phosphorylation of the insulin receptor substrate-1 at Ser616. | 2014 | PLoS ONE | pmid:24763529 |
| Althurwi HN et al. | Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy. | 2014 | J. Cardiovasc. Pharmacol. | pmid:24157956 |
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| Zhang Y et al. | Combined therapy with COX-2 inhibitor and 20-HETE inhibitor reduces colon tumor growth and the adverse effects of ischemic stroke associated with COX-2 inhibition. | 2014 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:24990856 |
| Hall CN et al. | Capillary pericytes regulate cerebral blood flow in health and disease. | 2014 | Nature | pmid:24670647 |
| Chen L et al. | 20-HETE regulates the angiogenic functions of human endothelial progenitor cells and contributes to angiogenesis in vivo. | 2014 | J. Pharmacol. Exp. Ther. | pmid:24403517 |
| Lu S et al. | Effect of 20-hydroxyeicosatetraenoic acid on biological behavior of human villous trophoblasts and uterine vascular smooth muscle cells. | 2014 | Mol Med Rep | pmid:24604088 |
| Tse MM et al. | Cytochrome P450 epoxygenase metabolite, 14,15-EET, protects against isoproterenol-induced cellular hypertrophy in H9c2 rat cell line. | 2013 May-Jun | Vascul. Pharmacol. | pmid:23466634 |
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| Tunctan B et al. | 5,14-HEDGE, a 20-HETE mimetic, reverses hypotension and improves survival in a rodent model of septic shock: contribution of soluble epoxide hydrolase, CYP2C23, MEK1/ERK1/2/IKKβ/IκB-α/NF-κB pathway, and proinflammatory cytokine formation. | 2013 Apr-May | Prostaglandins Other Lipid Mediat. | pmid:23454652 |
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| Issan Y et al. | Elevated level of pro-inflammatory eicosanoids and EPC dysfunction in diabetic patients with cardiac ischemia. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:23291334 |
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| Toth P et al. | Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:24097425 |
| Bubb KJ et al. | Activation of neuronal transient receptor potential vanilloid 1 channel underlies 20-hydroxyeicosatetraenoic acid-induced vasoactivity: role for protein kinase A. | 2013 | Hypertension | pmid:23753406 |
| Fan F et al. | 20-Hydroxyeicosatetraenoic acid contributes to the inhibition of K+ channel activity and vasoconstrictor response to angiotensin II in rat renal microvessels. | 2013 | PLoS ONE | pmid:24324797 |
| Van Bogaert I et al. | Preparation of 20-HETE using multifunctional enzyme type 2-negative Starmerella bombicola. | 2013 | J. Lipid Res. | pmid:23966667 |
| Toth P et al. | Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin II-induced hypertension. | 2013 | J. Cereb. Blood Flow Metab. | pmid:23942363 |
| Alexanian A et al. | 20-HETE-producing enzymes are up-regulated in human cancers. | 2012 Jul-Aug | Cancer Genomics Proteomics | pmid:22798501 |
| Singh TU et al. | Arachidonic acid inhibits Naâº-Kâº-ATPase via cytochrome P-450, lipoxygenase and protein kinase C-dependent pathways in sheep pulmonary artery. | 2012 Jan-Feb | Vascul. Pharmacol. | pmid:22155164 |
| Regner KR and Roman RJ | Role of medullary blood flow in the pathogenesis of renal ischemia-reperfusion injury. | 2012 | Curr. Opin. Nephrol. Hypertens. | pmid:22080855 |
| Lai G et al. | Evaluation of CMV and KAP promoters for driving the expression of human CYP4F2 in transgenic mice. | 2012 | Int. J. Mol. Med. | pmid:21887457 |
| Vasudevan H et al. | Testosterone-dependent increase in blood pressure is mediated by elevated Cyp4A expression in fructose-fed rats. | 2012 | Mol. Cell. Biochem. | pmid:21894443 |
| Liu X et al. | Disturbed ratio of renal 20-HETE/EETs is involved in androgen-induced hypertension in cytochrome P450 4F2 transgenic mice. | 2012 | Gene | pmid:22387726 |
| Yu W et al. | Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22841774 |
| Plée-Gautier E et al. | Statins increase cytochrome P450 4F3-mediated eicosanoids production in human liver cells: a PXR dependent mechanism. | 2012 | Biochem. Pharmacol. | pmid:22634049 |
| Fernandez MM et al. | Inhibitors of 20-hydroxyeicosatetraenoic acid (20-HETE) formation attenuate the natriuretic effect of dopamine. | 2012 | Eur. J. Pharmacol. | pmid:22575524 |
| Yang ZJ et al. | Attenuation of neonatal ischemic brain damage using a 20-HETE synthesis inhibitor. | 2012 | J. Neurochem. | pmid:22251169 |
| Wen H et al. | 20-Hydroxyeicosatetraenoic acid (20-HETE) is a novel activator of transient receptor potential vanilloid 1 (TRPV1) channel. | 2012 | J. Biol. Chem. | pmid:22389490 |
| Tunctan B et al. | A novel treatment strategy for sepsis and septic shock based on the interactions between prostanoids, nitric oxide, and 20-hydroxyeicosatetraenoic acid. | 2012 | Antiinflamm Antiallergy Agents Med Chem | pmid:23013331 |