| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
20-HETE
20-hete is a lipid of Fatty Acyls (FA) class. 20-hete is associated with abnormalities such as Cyst, Kidney Diseases, Kidney Failure, Chronic, Cystic Kidney Diseases and Simple renal cyst. The involved functions are known as Phosphorylation, inhibitors, Hypertrophy, Epithelial Cell Proliferation and Anabolism. 20-hete often locates in Mouse Kidney, Microsomes, Tissue membrane, Body tissue and Cytoplasmic matrix. The associated genes with 20-HETE are CYP4F3 gene, PKHD1 gene, Transgenes, P4HTM gene and CYP2E1 gene. The related lipids are Promega, enterodiol, Fatty Acids, hexanoic acid and U 73343. The related experimental models are Mouse Model, Knock-out, Streptozotocin Diabetes, Transgenic Model and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of 20-HETE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 20-HETE?
20-HETE is suspected in Hypertensive disease, Renal tubular disorder, endothelial dysfunction, Renal glomerular disease, Ischemia, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Hypertension (27)
- Am. J. Physiol. Heart Circ. Physiol. (19)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (16)
- Others (110)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 20-HETE
PubChem Associated disorders and diseases
What pathways are associated with 20-HETE
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 20-HETE through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
- Am. J. Physiol. Heart Circ. Physiol. (16)
- Hypertension (14)
- Am. J. Physiol. Renal Physiol. (10)
- Others (63)
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 20-HETE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- Hypertension (28)
- Am. J. Physiol. Heart Circ. Physiol. (26)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (18)
- Others (151)
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 20-HETE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 20-HETE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 20-HETE?
Related references are published most in these journals:
- Hypertension (20)
- Am. J. Physiol. Heart Circ. Physiol. (19)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (12)
- Others (86)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 20-HETE?
Mouse Model
Mouse Model are used in the study '20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease.' (Park F et al., 2008), Mouse Model are used in the study 'Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth.' (Alexanian A et al., 2009) and Mouse Model are used in the study 'Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus.' (Harder DR and Roman RJ, 2006).
Knock-out
Knock-out are used in the study 'Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle.' (Yu M et al., 2007) and Knock-out are used in the study 'Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis.' (Williams JM et al., 2007).
Streptozotocin Diabetes
Streptozotocin Diabetes are used in the study 'Deficient renal 20-HETE release in the diabetic rat is not the result of oxidative stress.' (Chen YJ et al., 2008).
Related references are published most in these journals:
- J. Am. Soc. Nephrol. (2)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (2)
- Anticancer Res. (1)
- Others (4)
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with 20-HETE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Faraci FM and Sobey CG | Role of soluble guanylate cyclase in dilator responses of the cerebral microcirculation. | 1999 | Brain Res. | pmid:10064823 |
| Oyekan AO et al. | Endothelin-1 and CYP450 arachidonate metabolites interact to promote tissue injury in DOCA-salt hypertension. | 1999 | Am. J. Physiol. | pmid:10070137 |
| Good DW et al. | Angiotensin II inhibits HCO-3 absorption via a cytochrome P-450-dependent pathway in MTAL. | 1999 | Am. J. Physiol. | pmid:10330055 |
| Nguyen X et al. | Kinetic profile of the rat CYP4A isoforms: arachidonic acid metabolism and isoform-specific inhibitors. | 1999 | Am. J. Physiol. | pmid:10362749 |
| Ito O and Roman RJ | Regulation of P-450 4A activity in the glomerulus of the rat. | 1999 | Am. J. Physiol. | pmid:10362756 |
| McGiff JC and Quilley J | 20-HETE and the kidney: resolution of old problems and new beginnings. | 1999 | Am. J. Physiol. | pmid:10484476 |
| Messer-Létienne I et al. | 20-Hydroxyeicosatetraenoic acid and renal function in Lyon hypertensive rats. | 1999 | Eur. J. Pharmacol. | pmid:10493105 |
| Oyekan AO et al. | Renal cytochrome P450 omega-hydroxylase and epoxygenase activity are differentially modified by nitric oxide and sodium chloride. | 1999 | J. Clin. Invest. | pmid:10525052 |
| Alonso-Galicia M et al. | 20-HETE agonists and antagonists in the renal circulation. | 1999 | Am. J. Physiol. | pmid:10564244 |
| Silverstein DM et al. | Multiple arachidonic acid metabolites inhibit sodium-dependent phosphate transport in OK cells. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10582656 |
| Alonso-Galicia M et al. | Contribution of 20-HETE to vasodilator actions of nitric oxide in the cerebral microcirculation. | 1999 | Stroke | pmid:10583004 |
| Lasker JM et al. | Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11. | 2000 | J. Biol. Chem. | pmid:10660572 |
| Hercule HC and Oyekan AO | Cytochrome P450 omega/omega-1 hydroxylase-derived eicosanoids contribute to endothelin(A) and endothelin(B) receptor-mediated vasoconstriction to endothelin-1 in the rat preglomerular arteriole. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10688635 |
| Frisbee JC et al. | Contribution of cytochrome P-450 omega-hydroxylase to altered arteriolar reactivity with high-salt diet and hypertension. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10775129 |
| Sánchez-Mendoza A et al. | Angiotensin II modulates ion transport in rat proximal tubules through CYP metabolites. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10833430 |
| Quigley R et al. | Effects of 20-HETE and 19(S)-HETE on rabbit proximal straight tubule volume transport. | 2000 | Am. J. Physiol. Renal Physiol. | pmid:10836982 |
| Watzer B et al. | Determination of free and glucuronide conjugated 20-hydroxyarachidonic acid (20-HETE) in urine by gas chromatography/negative ion chemical ionization mass spectrometry. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10841040 |
| Bednar MM et al. | 16(R)-hydroxy-5,8,11,14-eicosatetraenoic acid, a new arachidonate metabolite in human polymorphonuclear leukocytes. | 2000 | Biochem. Pharmacol. | pmid:10856441 |
| Frisbee JC et al. | Impairment of flow-induced dilation of skeletal muscle arterioles with elevated oxygen in normotensive and hypertensive rats. | 2000 | Microvasc. Res. | pmid:10873513 |
| Kaley G | Regulation of vascular tone: role of 20-HETE in the modulation of myogenic reactivity. | 2000 | Circ. Res. | pmid:10884363 |
| Gebremedhin D et al. | Production of 20-HETE and its role in autoregulation of cerebral blood flow. | 2000 | Circ. Res. | pmid:10884373 |
| Sun CW et al. | Role of cGMP versus 20-HETE in the vasodilator response to nitric oxide in rat cerebral arteries. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10899074 |
| Oyekan AO | Cytochrome p450-dependent metabolites of arachidonic acid and renal function in the rat. | 2000 | Clin. Exp. Pharmacol. Physiol. | pmid:10901386 |
| Maier KG et al. | Fluorescent HPLC assay for 20-HETE and other P-450 metabolites of arachidonic acid. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10924088 |
| Croft KD et al. | Angiotensin II releases 20-HETE from rat renal microvessels. | 2000 | Am. J. Physiol. Renal Physiol. | pmid:10966934 |
| Wegmann M et al. | Effect of hydroxyeicosatetraenoic acids on furosemide-sensitive chloride secretion in rat distal colon. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10991970 |
| Carroll MA and McGiff JC | A new class of lipid mediators: cytochrome P450 arachidonate metabolites. | 2000 | Thorax | pmid:10992547 |
| Zhu D et al. | Hypoxic pulmonary vasoconstriction is modified by P-450 metabolites. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11009437 |
| Honeck H et al. | Cytochrome P450-dependent renal arachidonic acid metabolism in desoxycorticosterone acetate-salt hypertensive mice. | 2000 | Hypertension | pmid:11040244 |
| Roman RJ et al. | Renal and cardiovascular actions of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids. | 2000 | Clin. Exp. Pharmacol. Physiol. | pmid:11071299 |
| Hercule HC and Oyekan AO | Role of NO and cytochrome P-450-derived eicosanoids in ET-1-induced changes in intrarenal hemodynamics in rats. | 2000 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11080078 |
| Wang MH et al. | CYP4A1 antisense oligonucleotide reduces mesenteric vascular reactivity and blood pressure in SHR. | 2001 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11124159 |
| Widstrom RL et al. | Binding of cytochrome P450 monooxygenase and lipoxygenase pathway products by heart fatty acid-binding protein. | 2001 | Biochemistry | pmid:11170430 |
| Ito O et al. | Effects of converting enzyme inhibitors on renal P-450 metabolism of arachidonic acid. | 2001 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11171663 |
| Frisbee JC et al. | 20-HETE modulates myogenic response of skeletal muscle resistance arteries from hypertensive Dahl-SS rats. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11179048 |
| Silverstein DM et al. | Hormonal regulation of sodium-dependent phosphate transport in opossum kidney cells. | 2000 | Horm. Res. | pmid:11182634 |
| Gu R et al. | Role of 20-HETE in mediating the effect of dietary K intake on the apical K channels in the mTAL. | 2001 | Am. J. Physiol. Renal Physiol. | pmid:11208597 |
| McGiff JC and Quilley J | 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids and blood pressure. | 2001 | Curr. Opin. Nephrol. Hypertens. | pmid:11224699 |
| Parmentier JH et al. | 20-Hydroxyeicosatetraenoic acid mediates angiotensin ii-induced phospholipase d activation in vascular smooth muscle cells. | 2001 | Hypertension | pmid:11230346 |
| Kunert MP et al. | Cytochrome P-450 omega-hydroxylase: a potential O(2) sensor in rat arterioles and skeletal muscle cells. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11247799 |
| Parmentier JH et al. | Phospholipase D activation by norepinephrine is mediated by 12(s)-, 15(s)-, and 20-hydroxyeicosatetraenoic acids generated by stimulation of cytosolic phospholipase a2. tyrosine phosphorylation of phospholipase d2 in response to norepinephrine. | 2001 | J. Biol. Chem. | pmid:11278912 |
| Frisbee JC et al. | 20-HETE contributes to myogenic activation of skeletal muscle resistance arteries in Brown Norway and Sprague-Dawley rats. | 2001 | Microcirculation | pmid:11296852 |
| Yaghi A et al. | Cytochrome P450 metabolites of arachidonic acid but not cyclooxygenase-2 metabolites contribute to the pulmonary vascular hyporeactivity in rats with acute Pseudomonas pneumonia. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11303033 |
| Nithipatikom K et al. | Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs. | 2001 | Anal. Biochem. | pmid:11319825 |
| Holla VR et al. | Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11320253 |
| Miyata N et al. | HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme. | 2001 | Br. J. Pharmacol. | pmid:11375247 |
| Frisbee JC et al. | Altered mechanisms underlying hypoxic dilation of skeletal muscle resistance arteries of hypertensive versus normotensive Dahl rats. | 2001 | Microcirculation | pmid:11379791 |
| Carroll MA et al. | Regulation of preglomerular microvascular 20-hydroxyeicosatetraenoic acid levels by salt depletion. | 2001 Jul-Aug | Med. Sci. Monit. | pmid:11433178 |
| Frisbee JC et al. | Relative contributions of cyclooxygenase- and cytochrome P450 omega-hydroxylase-dependent pathways to hypoxic dilation of skeletal muscle resistance arteries. | 2001 Jul-Aug | J. Vasc. Res. | pmid:11455201 |