20-HETE

20-hete is a lipid of Fatty Acyls (FA) class. 20-hete is associated with abnormalities such as Cyst, Kidney Diseases, Kidney Failure, Chronic, Cystic Kidney Diseases and Simple renal cyst. The involved functions are known as Phosphorylation, inhibitors, Hypertrophy, Epithelial Cell Proliferation and Anabolism. 20-hete often locates in Mouse Kidney, Microsomes, Tissue membrane, Body tissue and Cytoplasmic matrix. The associated genes with 20-HETE are CYP4F3 gene, PKHD1 gene, Transgenes, P4HTM gene and CYP2E1 gene. The related lipids are Promega, enterodiol, Fatty Acids, hexanoic acid and U 73343. The related experimental models are Mouse Model, Knock-out, Streptozotocin Diabetes, Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of 20-HETE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 20-HETE?

20-HETE is suspected in Hypertensive disease, Renal tubular disorder, endothelial dysfunction, Renal glomerular disease, Ischemia, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 20-HETE

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Reperfusion Injury D015427 65 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Hypotension D007022 41 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Per page 10 20 50 | Total 33

PubChem Associated disorders and diseases

What pathways are associated with 20-HETE

Lipid pathways are not clear in current pathway databases. We organized associated pathways with 20-HETE through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 20-HETE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 20-HETE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 20-HETE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 20-HETE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 20-HETE?

Mouse Model

Mouse Model are used in the study '20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease.' (Park F et al., 2008), Mouse Model are used in the study 'Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth.' (Alexanian A et al., 2009) and Mouse Model are used in the study 'Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus.' (Harder DR and Roman RJ, 2006).

Knock-out

Knock-out are used in the study 'Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle.' (Yu M et al., 2007) and Knock-out are used in the study 'Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis.' (Williams JM et al., 2007).

Streptozotocin Diabetes

Streptozotocin Diabetes are used in the study 'Deficient renal 20-HETE release in the diabetic rat is not the result of oxidative stress.' (Chen YJ et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with 20-HETE

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Per page 10 20 50 100 | Total 571
Authors Title Published Journal PubMed Link
Gu RM et al. Effects of protein tyrosine kinase and protein tyrosine phosphatase on apical K(+) channels in the TAL. 2001 Am. J. Physiol., Cell Physiol. pmid:11546655
Zhao X et al. The CYP450 hydroxylase pathway contributes to P2X receptor-mediated afferent arteriolar vasoconstriction. 2001 Am. J. Physiol. Heart Circ. Physiol. pmid:11668070
Kohagura K et al. Involvement of cytochrome P450 metabolites in the vascular action of angiotensin II on the afferent arterioles. 2001 Hypertens. Res. pmid:11675950
Frisbee JC et al. Role of prostanoids and 20-HETE in mediating oxygen-induced constriction of skeletal muscle resistance arteries. 2001 Microvasc. Res. pmid:11678630
Fleming I Cytochrome p450 and vascular homeostasis. 2001 Circ. Res. pmid:11679404
Sato M et al. Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor. 2001 Bioorg. Med. Chem. Lett. pmid:11714595
Escalante BA et al. Role of cytochrome P-450 arachidonate metabolites in endothelin signaling in rat proximal tubule. 2002 Am. J. Physiol. Renal Physiol. pmid:11739122
Zhang F et al. Modulation by 20-HETE of phenylephrine-induced mesenteric artery contraction in spontaneously hypertensive and Wistar-Kyoto rats. 2001 Hypertension pmid:11751709
Roman RJ P-450 metabolites of arachidonic acid in the control of cardiovascular function. 2002 Physiol. Rev. pmid:11773611
Wang MH et al. Renal 20-hydroxyeicosatetraenoic acid synthesis during pregnancy. 2002 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:11792647
Botros FT et al. Regulation of cyclooxygenase- and cytochrome p450-derived eicosanoids by heme oxygenase in the rat kidney. 2002 Hypertension pmid:11882623
Li PL et al. Role of ADP-ribose in 11,12-EET-induced activation of K(Ca) channels in coronary arterial smooth muscle cells. 2002 Am. J. Physiol. Heart Circ. Physiol. pmid:11893556
Kehl F et al. 20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat. 2002 Am. J. Physiol. Heart Circ. Physiol. pmid:11893593
Frisbee JC and Lombard JH Parenchymal tissue cytochrome P450 4A enzymes contribute to oxygen-induced alterations in skeletal muscle arteriolar tone. 2002 Microvasc. Res. pmid:11969311
Kroetz DL and Zeldin DC Cytochrome P450 pathways of arachidonic acid metabolism. 2002 Curr. Opin. Lipidol. pmid:12045397
Zhang F et al. Arachidonate CYP hydroxylases of kidney contribute to formation of hypertension and maintenance of blood pressure. 2002 Acta Pharmacol. Sin. pmid:12060522
Marji JS et al. Cytochrome P-450 4A isoform expression and 20-HETE synthesis in renal preglomerular arteries. 2002 Am. J. Physiol. Renal Physiol. pmid:12060587
Alonso-Galicia M et al. Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II. 2002 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:12069931
Zhu D et al. CYP4A mRNA, protein, and product in rat lungs: novel localization in vascular endothelium. 2002 J. Appl. Physiol. pmid:12070222
Nie D et al. Role of eicosanoids in prostate cancer progression. 2001 Cancer Metastasis Rev. pmid:12085962
Bełtowski J et al. The opposite effects of cyclic AMP-protein kinase a signal transduction pathway on renal cortical and medullary Na+,K+-ATPase activity. 2002 J. Physiol. Pharmacol. pmid:12120897
Frisbee JC et al. Integration of hypoxic dilation signaling pathways for skeletal muscle resistance arteries. 2002 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:12121842
Zemaitis M et al. Identification of omega hydroxy fatty acids in biological samples as their pentafluoropropyl derivatives by gas chromatography/mass spectrometry with positive and negative ion detection. 2002 Rapid Commun. Mass Spectrom. pmid:12125016
Hercule H and Oyekan A Renal cytochrome p450 oxygenases and preglomerular vascular response to arachidonic acid and endothelin-1 following ischemia/reperfusion. 2002 J. Pharmacol. Exp. Ther. pmid:12130736
Gu RM and Wang WH Arachidonic acid inhibits K channels in basolateral membrane of the thick ascending limb. 2002 Am. J. Physiol. Renal Physiol. pmid:12167590
Xu F et al. Antihypertensive effect of mechanism-based inhibition of renal arachidonic acid omega-hydroxylase activity. 2002 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:12185006
Looft-Wilson RC et al. 20-HETE pathway antagonists inhibit rat small mesenteric artery tone. 2002 Microvasc. Res. pmid:12204659
Yu M et al. Nitric oxide contributes to 20-HETE-induced relaxation of pulmonary arteries. 2002 J. Appl. Physiol. pmid:12235040
Kaide J et al. Transfection of CYP4A1 cDNA increases vascular reactivity in renal interlobar arteries. 2003 Am. J. Physiol. Renal Physiol. pmid:12388396
Cheng MK et al. Renal arterial 20-hydroxyeicosatetraenoic acid levels: regulation by cyclooxygenase. 2003 Am. J. Physiol. Renal Physiol. pmid:12419775
Bellamine A et al. Characterization of the CYP4A11 gene, a second CYP4A gene in humans. 2003 Arch. Biochem. Biophys. pmid:12464262
Obara K et al. 20-Hydroxyeicosatetraenoic acid potentiates stretch-induced contraction of canine basilar artery via PKC alpha-mediated inhibition of KCa channel. 2002 Br. J. Pharmacol. pmid:12466247
Amaral SL et al. CYP4A metabolites of arachidonic acid and VEGF are mediators of skeletal muscle angiogenesis. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12521947
Nakagawa K et al. Androgen-mediated induction of the kidney arachidonate hydroxylases is associated with the development of hypertension. 2003 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:12531784
Laffer CL et al. Differential regulation of natriuresis by 20-hydroxyeicosatetraenoic Acid in human salt-sensitive versus salt-resistant hypertension. 2003 Circulation pmid:12566369
Moreno JJ Cyclooxygenase and cytochrome P-450 pathways induced by fetal calf serum regulate wound closure in 3T6 fibroblast cultures through the effect of prostaglandin E2 and 12 and 20 hydroxyeicosatetraenoic acids. 2003 J. Cell. Physiol. pmid:12599212
Hoagland KM et al. Contributions of 20-HETE to the antihypertensive effects of Tempol in Dahl salt-sensitive rats. 2003 Hypertension pmid:12623982
Laffer CL et al. 20-HETE and furosemide-induced natriuresis in salt-sensitive essential hypertension. 2003 Hypertension pmid:12623983
Randriamboavonjy V et al. 20-HETE-induced contraction of small coronary arteries depends on the activation of Rho-kinase. 2003 Hypertension pmid:12623999
Skott O Androgen-induced activation of 20-HETE production may contribute to gender differences in blood pressure regulation. 2003 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:12626366
Ren Y et al. Glomerular autacoids stimulated by bradykinin regulate efferent arteriole tone. 2003 Kidney Int. pmid:12631079
Cambj-Sapunar L et al. Contribution of 5-hydroxytryptamine1B receptors and 20-hydroxyeiscosatetraenoic acid to fall in cerebral blood flow after subarachnoid hemorrhage. 2003 Stroke pmid:12677022
Grates HE et al. Quantification of 20-hydroxyeicosatetraenoic acid by colorimetric competitive enzyme linked immunosorbent assay. 2003 J. Biosci. pmid:12682433
Wang MH et al. Regulation of renal CYP4A expression and 20-HETE synthesis by nitric oxide in pregnant rats. 2003 Am. J. Physiol. Renal Physiol. pmid:12684227
Abraham NG et al. Differential effect of cobalt protoporphyrin on distributions of heme oxygenase in renal structure and on blood pressure in SHR. 2002 Cell. Mol. Biol. (Noisy-le-grand) pmid:12699248
Goodman AI et al. Functional expression of human heme oxygenase-1 gene in renal structure of spontaneously hypertensive rats. 2003 Exp. Biol. Med. (Maywood) pmid:12709568
Carroll MA et al. Regulation of renal microvascular 20-hydroxyeicosatetraenoic acid (20-HETE) levels. 2003 Adv. Exp. Med. Biol. pmid:12751736
Carroll MA et al. Cytochrome P450 arachidonic acid metabolites modulate renal tubular function. 2003 Adv. Exp. Med. Biol. pmid:12751738
Cloutier M et al. 20-HETE inotropic effects involve the activation of a nonselective cationic current in airway smooth muscle. 2003 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12754190
Yu M et al. 20-hydroxyeicosatetraenoic acid (20-HETE): structural determinants for renal vasoconstriction. 2003 Bioorg. Med. Chem. pmid:12788354