| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
20-HETE
20-hete is a lipid of Fatty Acyls (FA) class. 20-hete is associated with abnormalities such as Cyst, Kidney Diseases, Kidney Failure, Chronic, Cystic Kidney Diseases and Simple renal cyst. The involved functions are known as Phosphorylation, inhibitors, Hypertrophy, Epithelial Cell Proliferation and Anabolism. 20-hete often locates in Mouse Kidney, Microsomes, Tissue membrane, Body tissue and Cytoplasmic matrix. The associated genes with 20-HETE are CYP4F3 gene, PKHD1 gene, Transgenes, P4HTM gene and CYP2E1 gene. The related lipids are Promega, enterodiol, Fatty Acids, hexanoic acid and U 73343. The related experimental models are Mouse Model, Knock-out, Streptozotocin Diabetes, Transgenic Model and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of 20-HETE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 20-HETE?
20-HETE is suspected in Hypertensive disease, Renal tubular disorder, endothelial dysfunction, Renal glomerular disease, Ischemia, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Hypertension (27)
- Am. J. Physiol. Heart Circ. Physiol. (19)
- Am. J. Physiol. Renal Physiol. (16)
- Others (110)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 20-HETE
PubChem Associated disorders and diseases
What pathways are associated with 20-HETE
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 20-HETE through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
- Am. J. Physiol. Heart Circ. Physiol. (16)
- Hypertension (14)
- Am. J. Physiol. Renal Physiol. (10)
- Others (63)
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 20-HETE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- Hypertension (28)
- Am. J. Physiol. Heart Circ. Physiol. (26)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (18)
- Others (151)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 20-HETE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 20-HETE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 20-HETE?
Related references are published most in these journals:
- Hypertension (20)
- Am. J. Physiol. Heart Circ. Physiol. (19)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (12)
- Others (86)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 20-HETE?
Mouse Model
Mouse Model are used in the study '20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease.' (Park F et al., 2008), Mouse Model are used in the study 'Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth.' (Alexanian A et al., 2009) and Mouse Model are used in the study 'Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus.' (Harder DR and Roman RJ, 2006).
Knock-out
Knock-out are used in the study 'Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle.' (Yu M et al., 2007) and Knock-out are used in the study 'Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis.' (Williams JM et al., 2007).
Streptozotocin Diabetes
Streptozotocin Diabetes are used in the study 'Deficient renal 20-HETE release in the diabetic rat is not the result of oxidative stress.' (Chen YJ et al., 2008).
Related references are published most in these journals:
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (2)
- J. Am. Soc. Nephrol. (2)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Others (4)
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 20-HETE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li X et al. | 20-Hydroxyeicosatetraenoic acid impairs endothelial insulin signaling by inducing phosphorylation of the insulin receptor substrate-1 at Ser616. | 2014 | PLoS ONE | pmid:24763529 |
| Tse MM et al. | Cytochrome P450 epoxygenase metabolite, 14,15-EET, protects against isoproterenol-induced cellular hypertrophy in H9c2 rat cell line. | 2013 May-Jun | Vascul. Pharmacol. | pmid:23466634 |
| Eid S et al. | Involvement of renal cytochromes P450 and arachidonic acid metabolites in diabetic nephropathy. | 2013 Jul-Sep | J. Biol. Regul. Homeost. Agents | pmid:24152838 |
| Imig JD | Epoxyeicosatrienoic acids, 20-hydroxyeicosatetraenoic acid, and renal microvascular function. | 2013 Jul-Aug | Prostaglandins Other Lipid Mediat. | pmid:23333581 |
| Tunctan B et al. | NS-398 reverses hypotension in endotoxemic rats: contribution of eicosanoids, NO, and peroxynitrite. | 2013 Jul-Aug | Prostaglandins Other Lipid Mediat. | pmid:22975359 |
| Tunctan B et al. | 5,14-HEDGE, a 20-HETE mimetic, reverses hypotension and improves survival in a rodent model of septic shock: contribution of soluble epoxide hydrolase, CYP2C23, MEK1/ERK1/2/IKKβ/IκB-α/NF-κB pathway, and proinflammatory cytokine formation. | 2013 Apr-May | Prostaglandins Other Lipid Mediat. | pmid:23454652 |
| Ge Y et al. | Endogenously produced 20-HETE modulates myogenic and TGF response in microperfused afferent arterioles. | 2013 Apr-May | Prostaglandins Other Lipid Mediat. | pmid:23500064 |
| Toth P et al. | Treatment with the cytochrome P450 ω-hydroxylase inhibitor HET0016 attenuates cerebrovascular inflammation, oxidative stress and improves vasomotor function in spontaneously hypertensive rats. | 2013 | Br. J. Pharmacol. | pmid:23194285 |
| Eid S et al. | 20-HETE and EETs in diabetic nephropathy: a novel mechanistic pathway. | 2013 | PLoS ONE | pmid:23936373 |
| Ding Y et al. | 20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension. | 2013 | Am. J. Physiol. Renal Physiol. | pmid:23825080 |
| Lukaszewicz KM et al. | Introgression of Brown Norway CYP4A genes on to the Dahl salt-sensitive background restores vascular function in SS-5(BN) consomic rats. | 2013 | Clin. Sci. | pmid:22938512 |
| Schuck RN et al. | Cytochrome P450-derived eicosanoids and vascular dysfunction in coronary artery disease patients. | 2013 | Atherosclerosis | pmid:23466098 |
| Anwar-Mohamed A et al. | Acute arsenic treatment alters cytochrome P450 expression and arachidonic acid metabolism in lung, liver and kidney of C57Bl/6 mice. | 2013 | Xenobiotica | pmid:23409951 |
| Lukaszewicz KM and Lombard JH | Role of the CYP4A/20-HETE pathway in vascular dysfunction of the Dahl salt-sensitive rat. | 2013 | Clin. Sci. | pmid:23438293 |
| Filosa JA and Iddings JA | Astrocyte regulation of cerebral vascular tone. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:23792684 |
| Edson KZ and Rettie AE | CYP4 enzymes as potential drug targets: focus on enzyme multiplicity, inducers and inhibitors, and therapeutic modulation of 20-hydroxyeicosatetraenoic acid (20-HETE) synthase and fatty acid ω-hydroxylase activities. | 2013 | Curr Top Med Chem | pmid:23688133 |
| Alsaad AM et al. | Role of cytochrome P450-mediated arachidonic acid metabolites in the pathogenesis of cardiac hypertrophy. | 2013 | Drug Metab. Rev. | pmid:23600686 |
| Wu CC et al. | Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase. | 2013 | J. Am. Soc. Nephrol. | pmid:23641057 |
| Orozco LD et al. | 20-Hydroxyeicosatetraenoic acid inhibition attenuates balloon injury-induced neointima formation and vascular remodeling in rat carotid arteries. | 2013 | J. Pharmacol. Exp. Ther. | pmid:23658377 |
| Ngo AT et al. | Significance of K(ATP) channels, L-type Ca²⺠channels and CYP450-4A enzymes in oxygen sensing in mouse cremaster muscle arterioles in vivo. | 2013 | BMC Physiol. | pmid:23663730 |
| Li H and Zhu Y | [Progress of studies in 20-hydroxyeicosatetraenoic acid on vascular endothelium]. | 2013 | Sheng Li Ke Xue Jin Zhan | pmid:23671992 |
| Li Y et al. | Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23747687 |
| Kim DH et al. | Cyclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes. | 2013 | J. Lipid Res. | pmid:23293373 |
| Lima R et al. | Roles played by 20-HETE, angiotensin II and endothelin in mediating the hypertension in aging female spontaneously hypertensive rats. | 2013 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:23220478 |
| Fordsmann JC et al. | Increased 20-HETE synthesis explains reduced cerebral blood flow but not impaired neurovascular coupling after cortical spreading depression in rat cerebral cortex. | 2013 | J. Neurosci. | pmid:23392684 |
| Issan Y et al. | Elevated level of pro-inflammatory eicosanoids and EPC dysfunction in diabetic patients with cardiac ischemia. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:23291334 |
| Jiang H et al. | Maternal and fetal epoxyeicosatrienoic acids in normotensive and preeclamptic pregnancies. | 2013 | Am. J. Hypertens. | pmid:23382413 |
| Hadfield J et al. | Modeling secondary messenger pathways in neurovascular coupling. | 2013 | Bull. Math. Biol. | pmid:23358799 |
| Wu J et al. | Synergistical effect of 20-HETE and high salt on NKCC2 protein and blood pressure via ubiquitin-proteasome pathway. | 2013 | Hum. Genet. | pmid:23104236 |
| Han Y et al. | 20-Hydroxyeicosatetraenoic acid mediates isolated heart ischemia/reperfusion injury by increasing NADPH oxidase-derived reactive oxygen species production. | 2013 | Circ. J. | pmid:23585488 |
| Kunduri SS et al. | Adenosine A1 receptors link to smooth muscle contraction via CYP4a, protein kinase C-α, and ERK1/2. | 2013 | J. Cardiovasc. Pharmacol. | pmid:23519140 |
| Elshenawy OH et al. | 20-Hydroxyeicosatetraenoic acid is a potential therapeutic target in cardiovascular diseases. | 2013 | Curr. Drug Metab. | pmid:23701160 |
| Ma F et al. | Indapamide lowers blood pressure by increasing production of epoxyeicosatrienoic acids in the kidney. | 2013 | Mol. Pharmacol. | pmid:23729436 |
| Toth P et al. | Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:24097425 |
| Bubb KJ et al. | Activation of neuronal transient receptor potential vanilloid 1 channel underlies 20-hydroxyeicosatetraenoic acid-induced vasoactivity: role for protein kinase A. | 2013 | Hypertension | pmid:23753406 |
| Fan F et al. | 20-Hydroxyeicosatetraenoic acid contributes to the inhibition of K+ channel activity and vasoconstrictor response to angiotensin II in rat renal microvessels. | 2013 | PLoS ONE | pmid:24324797 |
| Van Bogaert I et al. | Preparation of 20-HETE using multifunctional enzyme type 2-negative Starmerella bombicola. | 2013 | J. Lipid Res. | pmid:23966667 |
| Toth P et al. | Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin II-induced hypertension. | 2013 | J. Cereb. Blood Flow Metab. | pmid:23942363 |
| Alexanian A et al. | 20-HETE-producing enzymes are up-regulated in human cancers. | 2012 Jul-Aug | Cancer Genomics Proteomics | pmid:22798501 |
| Singh TU et al. | Arachidonic acid inhibits Naâº-Kâº-ATPase via cytochrome P-450, lipoxygenase and protein kinase C-dependent pathways in sheep pulmonary artery. | 2012 Jan-Feb | Vascul. Pharmacol. | pmid:22155164 |
| Theken KN et al. | Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease. | 2012 | Atherosclerosis | pmid:22503544 |
| Renic M et al. | Protective effect of 20-HETE inhibition in a model of oxygen-glucose deprivation in hippocampal slice cultures. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22245774 |
| Yang ZJ et al. | Attenuation of neonatal ischemic brain damage using a 20-HETE synthesis inhibitor. | 2012 | J. Neurochem. | pmid:22251169 |
| Lai G et al. | 20-HETE induces hyperglycemia through the cAMP/PKA-PhK-GP pathway. | 2012 | Mol. Endocrinol. | pmid:22918876 |
| Chen L et al. | 20-HETE in neovascularization. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22227460 |
| Cheng J et al. | Induction of angiotensin-converting enzyme and activation of the renin-angiotensin system contribute to 20-hydroxyeicosatetraenoic acid-mediated endothelial dysfunction. | 2012 | Arterioscler. Thromb. Vasc. Biol. | pmid:22723444 |
| Tian T et al. | Protective effect of 20-hydroxyeicosatetraenoic acid (20-HETE) on adriamycin-induced toxicity of human renal tubular epithelial cell (HK-2). | 2012 | Eur. J. Pharmacol. | pmid:22421401 |
| Nikolaeva S et al. | The circadian clock modulates renal sodium handling. | 2012 | J. Am. Soc. Nephrol. | pmid:22440902 |
| Williams JM et al. | Role of 20-HETE in the antihypertensive effect of transfer of chromosome 5 from Brown Norway to Dahl salt-sensitive rats. | 2012 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:22442195 |
| Tunctan B et al. | A novel treatment strategy for sepsis and septic shock based on the interactions between prostanoids, nitric oxide, and 20-hydroxyeicosatetraenoic acid. | 2012 | Antiinflamm Antiallergy Agents Med Chem | pmid:23013331 |