20-HETE

20-hete is a lipid of Fatty Acyls (FA) class. 20-hete is associated with abnormalities such as Cyst, Kidney Diseases, Kidney Failure, Chronic, Cystic Kidney Diseases and Simple renal cyst. The involved functions are known as Phosphorylation, inhibitors, Hypertrophy, Epithelial Cell Proliferation and Anabolism. 20-hete often locates in Mouse Kidney, Microsomes, Tissue membrane, Body tissue and Cytoplasmic matrix. The associated genes with 20-HETE are CYP4F3 gene, PKHD1 gene, Transgenes, P4HTM gene and CYP2E1 gene. The related lipids are Promega, enterodiol, Fatty Acids, hexanoic acid and U 73343. The related experimental models are Mouse Model, Knock-out, Streptozotocin Diabetes, Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of 20-HETE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 20-HETE?

20-HETE is suspected in Hypertensive disease, Renal tubular disorder, endothelial dysfunction, Renal glomerular disease, Ischemia, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 20-HETE

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Reperfusion Injury D015427 65 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Hypotension D007022 41 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Per page 10 20 50 | Total 33

PubChem Associated disorders and diseases

What pathways are associated with 20-HETE

Lipid pathways are not clear in current pathway databases. We organized associated pathways with 20-HETE through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 20-HETE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 20-HETE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 20-HETE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 20-HETE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 20-HETE?

Mouse Model

Mouse Model are used in the study '20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease.' (Park F et al., 2008), Mouse Model are used in the study 'Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth.' (Alexanian A et al., 2009) and Mouse Model are used in the study 'Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus.' (Harder DR and Roman RJ, 2006).

Knock-out

Knock-out are used in the study 'Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle.' (Yu M et al., 2007) and Knock-out are used in the study 'Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis.' (Williams JM et al., 2007).

Streptozotocin Diabetes

Streptozotocin Diabetes are used in the study 'Deficient renal 20-HETE release in the diabetic rat is not the result of oxidative stress.' (Chen YJ et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with 20-HETE

Download all related citations
Per page 10 20 50 100 | Total 571
Authors Title Published Journal PubMed Link
Oyekan AO and McGiff JC Functional response of the rat kidney to inhibition of nitric oxide synthesis: role of cytochrome p450-derived arachidonate metabolites. 1998 Br. J. Pharmacol. pmid:9846646
Birks EK et al. Human pulmonary arteries dilate to 20-HETE, an endogenous eicosanoid of lung tissue. 1997 Am. J. Physiol. pmid:9176244
Lange A et al. 20-Hydroxyeicosatetraenoic acid-induced vasoconstriction and inhibition of potassium current in cerebral vascular smooth muscle is dependent on activation of protein kinase C. 1997 J. Biol. Chem. pmid:9341185
Wang W et al. Phospholipase A2 is involved in mediating the effect of extracellular Ca2+ on apical K+ channels in rat TAL. 1997 Am. J. Physiol. pmid:9321915
Sacerdoti D et al. Eicosanoid excretion in hepatic cirrhosis. Predominance of 20-HETE. 1997 J. Clin. Invest. pmid:9276745
Askari B et al. Analysis of eicosanoid mediation of the renal functional effects of hyperchloremia. 1997 J. Pharmacol. Exp. Ther. pmid:9223545
Nowicki S et al. 20-Hydroxyeicosa-tetraenoic acid (20 HETE) activates protein kinase C. Role in regulation of rat renal Na+,K+-ATPase. 1997 J. Clin. Invest. pmid:9077530
Stec DE et al. Inhibition of renal outer medullary 20-HETE production produces hypertension in Lewis rats. 1997 Hypertension pmid:9039121
Goodman AI et al. Overexpression of the heme oxygenase gene in renal cell carcinoma. 1997 Proc. Soc. Exp. Biol. Med. pmid:9012361
Mao K et al. New group of lipid mediators containing omega-hydroxyarachadonic acid (20-HETE). 1997 Adv. Exp. Med. Biol. pmid:9561103
Roman RJ et al. Renal P450 metabolites of arachidonic acid and the development of hypertension in Dahl salt-sensitive rats. 1997 Am. J. Hypertens. pmid:9160783
Alonso-Galicia M et al. Inhibition of 20-HETE production contributes to the vascular responses to nitric oxide. 1997 Hypertension pmid:9039122
Kroetz DL et al. Developmentally regulated expression of the CYP4A genes in the spontaneously hypertensive rat kidney. 1997 Mol. Pharmacol. pmid:9281597
Bednar MM et al. Antineutrophil strategies. 1997 Neurology pmid:9371144
Grider JS et al. P450 arachidonate metabolites mediate bradykinin-dependent inhibition of NaCl transport in the rat thick ascending limb. 1997 Can. J. Physiol. Pharmacol. pmid:9114929
Zou AP et al. Role of 20-HETE in elevating loop chloride reabsorption in Dahl SS/Jr rats. 1996 Hypertension pmid:8613215
Imig JD et al. Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles. 1996 Am. J. Physiol. pmid:8769805
Zou AP et al. 20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles. 1996 Am. J. Physiol. pmid:8769806
Amlal H et al. Na(+)-K+(NH4+)-2Cl- cotransport in medullary thick ascending limb: control by PKA, PKC, and 20-HETE. 1996 Am. J. Physiol. pmid:8769983
Wang MH et al. Cloning, sequencing, and cDNA-directed expression of the rat renal CYP4A2: arachidonic acid omega-hydroxylation and 11,12-epoxidation by CYP4A2 protein. 1996 Arch. Biochem. Biophys. pmid:8954571