| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
20-HETE
20-hete is a lipid of Fatty Acyls (FA) class. 20-hete is associated with abnormalities such as Cyst, Kidney Diseases, Kidney Failure, Chronic, Cystic Kidney Diseases and Simple renal cyst. The involved functions are known as Phosphorylation, inhibitors, Hypertrophy, Epithelial Cell Proliferation and Anabolism. 20-hete often locates in Mouse Kidney, Microsomes, Tissue membrane, Body tissue and Cytoplasmic matrix. The associated genes with 20-HETE are CYP4F3 gene, PKHD1 gene, Transgenes, P4HTM gene and CYP2E1 gene. The related lipids are Promega, enterodiol, Fatty Acids, hexanoic acid and U 73343. The related experimental models are Mouse Model, Knock-out, Streptozotocin Diabetes, Transgenic Model and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of 20-HETE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 20-HETE?
20-HETE is suspected in Hypertensive disease, Renal tubular disorder, endothelial dysfunction, Renal glomerular disease, Ischemia, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Hypertension (27)
- Am. J. Physiol. Heart Circ. Physiol. (19)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (16)
- Others (110)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 20-HETE
PubChem Associated disorders and diseases
What pathways are associated with 20-HETE
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 20-HETE through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
- Am. J. Physiol. Heart Circ. Physiol. (16)
- Hypertension (14)
- Am. J. Physiol. Renal Physiol. (10)
- Others (63)
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 20-HETE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- Hypertension (28)
- Am. J. Physiol. Heart Circ. Physiol. (26)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (18)
- Others (151)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 20-HETE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 20-HETE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 20-HETE?
Related references are published most in these journals:
- Hypertension (20)
- Am. J. Physiol. Heart Circ. Physiol. (19)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (12)
- Others (86)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 20-HETE?
Mouse Model
Mouse Model are used in the study '20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease.' (Park F et al., 2008), Mouse Model are used in the study 'Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth.' (Alexanian A et al., 2009) and Mouse Model are used in the study 'Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus.' (Harder DR and Roman RJ, 2006).
Knock-out
Knock-out are used in the study 'Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle.' (Yu M et al., 2007) and Knock-out are used in the study 'Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis.' (Williams JM et al., 2007).
Streptozotocin Diabetes
Streptozotocin Diabetes are used in the study 'Deficient renal 20-HETE release in the diabetic rat is not the result of oxidative stress.' (Chen YJ et al., 2008).
Related references are published most in these journals:
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (2)
- J. Am. Soc. Nephrol. (2)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Others (4)
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 20-HETE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Williams JM et al. | Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury. | 2008 | Am. J. Physiol. Renal Physiol. | pmid:18842817 |
| Dunn KM et al. | Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18952718 |
| Yang HY and Chen JR | Renoprotective effects of soy protein hydrolysates in N(omega)-nitro-L-arginine methyl ester hydrochloride-induced hypertensive rats. | 2008 | Hypertens. Res. | pmid:18957819 |
| Liu X et al. | Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18502903 |
| Schubert GA and Thome C | Cerebral blood flow changes in acute subarachnoid hemorrhage. | 2008 | Front. Biosci. | pmid:17981651 |
| Wang Z et al. | 20-Hydroxyeicosatetraenoic acid inhibits the apoptotic responses in pulmonary artery smooth muscle cells. | 2008 | Eur. J. Pharmacol. | pmid:18455723 |
| Lv X et al. | Cytochrome P450 omega-hydroxylase inhibition reduces cardiomyocyte apoptosis via activation of ERK1/2 signaling in rat myocardial ischemia-reperfusion. | 2008 | Eur. J. Pharmacol. | pmid:18771665 |
| Gebremedhin D et al. | Role of 20-HETE in the hypoxia-induced activation of Ca2+-activated K+ channel currents in rat cerebral arterial muscle cells. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17906097 |
| Koehler RC et al. | Insensitivity of cerebral oxygen transport to oxygen affinity of hemoglobin-based oxygen carriers. | 2008 | Biochim. Biophys. Acta | pmid:18230370 |
| Morin C et al. | Effects of omega-hydroxylase product on distal human pulmonary arteries. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18203846 |
| Nilakantan V et al. | 20-HETE-mediated cytotoxicity and apoptosis in ischemic kidney epithelial cells. | 2008 | Am. J. Physiol. Renal Physiol. | pmid:18171997 |
| Liu H et al. | Association of a functional cytochrome P450 4F2 haplotype with urinary 20-HETE and hypertension. | 2008 | J. Am. Soc. Nephrol. | pmid:18235092 |
| Berezan DJ et al. | Aging increases cytochrome P450 4A modulation of alpha1-adrenergic vasoconstriction in mesenteric arteries. | 2008 | J. Cardiovasc. Pharmacol. | pmid:18356699 |
| Chen YJ et al. | Deficient renal 20-HETE release in the diabetic rat is not the result of oxidative stress. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18326808 |
| Tunctan B et al. | A 20-hydroxyeicosatetraenoic acid agonist, N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine, opposes the fall in blood pressure and vascular reactivity in endotoxin-treated rats. | 2008 | Shock | pmid:18323740 |
| Gao Z et al. | 20-HETE increases renal sympathetic nerve activity via activation of chemically and mechanically sensitive muscle afferents. | 2008 | J. Physiol. (Lond.) | pmid:18372304 |
| Ward NC et al. | A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure. | 2008 | Hypertension | pmid:18391101 |
| Ishizuka T et al. | 20-Hydroxyeicosatetraenoic acid stimulates nuclear factor-kappaB activation and the production of inflammatory cytokines in human endothelial cells. | 2008 | J. Pharmacol. Exp. Ther. | pmid:17947496 |
| Medhora M et al. | 20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells. | 2008 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:18296498 |
| Park F et al. | 20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease. | 2008 | J. Am. Soc. Nephrol. | pmid:18596124 |
| Zhou Y et al. | Colfibrate attenuates blood pressure and sodium retention in DOCA-salt hypertension. | 2008 | Kidney Int. | pmid:18596730 |
| Fava C et al. | The V433M variant of the CYP4F2 is associated with ischemic stroke in male Swedes beyond its effect on blood pressure. | 2008 | Hypertension | pmid:18574070 |
| Guo AM et al. | Expression of CYP4A1 in U251 human glioma cell induces hyperproliferative phenotype in vitro and rapidly growing tumors in vivo. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18591218 |
| Fu Z et al. | Haplotype-based case study of human CYP4A11 gene and cerebral infarction in Japanese subject. | 2008 | Endocrine | pmid:18484194 |
| Mu Y et al. | Intravenous formulation of N-hydroxy-N'-(4-n-butyl-2-methylphenyl)formamidine (HET0016) for inhibition of rat brain 20-hydroxyeicosatetraenoic acid formation. | 2008 | Drug Metab. Dispos. | pmid:18725506 |
| Cheng J et al. | 20-hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18156192 |
| Liang CJ et al. | 20-HETE inhibits the proliferation of vascular smooth muscle cells via transforming growth factor-beta. | 2008 | J. Lipid Res. | pmid:17916879 |
| Minuz P et al. | Altered release of cytochrome p450 metabolites of arachidonic acid in renovascular disease. | 2008 | Hypertension | pmid:18378855 |
| Yousif MH and Benter IF | Role of cytochrome P450 metabolites of arachidonic acid in regulation of corporal smooth muscle tone in diabetic and older rats. | 2007 Nov-Dec | Vascul. Pharmacol. | pmid:17855173 |
| Chábová VC et al. | Effects of chronic cytochrome P-450 inhibition on the course of hypertension and end-organ damage in Ren-2 transgenic rats. | 2007 Aug-Sep | Vascul. Pharmacol. | pmid:17604232 |
| Capdevila JH | Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases. | 2007 | Curr. Opin. Nephrol. Hypertens. | pmid:17693763 |
| Tanaka Y et al. | Continuous inhibition of 20-HETE synthesis by TS-011 improves neurological and functional outcomes after transient focal cerebral ischemia in rats. | 2007 | Neurosci. Res. | pmid:17933409 |
| Kirchheimer C et al. | Role of 20-HETE in D1/D2 dopamine receptor synergism resulting in the inhibition of Na+-K+-ATPase activity in the proximal tubule. | 2007 | Am. J. Physiol. Renal Physiol. | pmid:17264308 |
| Wang MZ et al. | Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine. | 2007 | Drug Metab. Dispos. | pmid:17709372 |
| Yu M et al. | Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle. | 2007 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:17303679 |
| Roman RJ and Lombard JH | Does 20-hydroxyeicosatetraenoic acid contribute to sex differences in cardiovascular risk by increasing oxidative stress? | 2007 | Hypertension | pmid:17548717 |
| Singh H et al. | Vascular cytochrome P450 4A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertension. | 2007 | Hypertension | pmid:17548721 |
| Williams JM et al. | Role of endogenous CYP450 metabolites of arachidonic acid in maintaining the glomerular protein permeability barrier. | 2007 | Am. J. Physiol. Renal Physiol. | pmid:17507602 |
| Barden A et al. | A reduction in alcohol consumption is associated with reduced plasma F2-isoprostanes and urinary 20-HETE excretion in men. | 2007 | Free Radic. Biol. Med. | pmid:17462541 |
| Stec DE et al. | 20-Hydroxyeicosatetraenoic acid (20-HETE) stimulates migration of vascular smooth muscle cells. | 2007 | Cell. Physiol. Biochem. | pmid:17310106 |
| Zhang D et al. | [Roles of 20-HETE on physiologic and pathologic regulation in organism]. | 2007 | Sheng Li Ke Xue Jin Zhan | pmid:17633224 |
| Morin C et al. | Functional effects of 20-HETE on human bronchi: hyperpolarization and relaxation due to BKCa channel activation. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:17660330 |
| CertÃková Chábová V et al. | The roles of intrarenal 20-hydroxyeicosatetraenoic and epoxyeicosatrienoic acids in the regulation of renal function in hypertensive Ren-2 transgenic rats. | 2007 | Kidney Blood Press. Res. | pmid:17785988 |
| Fang X et al. | 20-carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors alpha and gamma. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17164145 |
| Snider NT et al. | Anandamide metabolism by human liver and kidney microsomal cytochrome p450 enzymes to form hydroxyeicosatetraenoic and epoxyeicosatrienoic acid ethanolamides. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17272674 |
| Marvar PJ et al. | High dietary salt reduces the contribution of 20-HETE to arteriolar oxygen responsiveness in skeletal muscle. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17114243 |
| Guo AM et al. | Activation of vascular endothelial growth factor through reactive oxygen species mediates 20-hydroxyeicosatetraenoic acid-induced endothelial cell proliferation. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17210799 |
| Williams JM et al. | Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis. | 2007 | Hypertension | pmid:17210834 |
| Ng VY et al. | Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha. | 2007 | Drug Metab. Dispos. | pmid:17431031 |
| Stec DE et al. | Functional polymorphism in human CYP4F2 decreases 20-HETE production. | 2007 | Physiol. Genomics | pmid:17341693 |
| Hacein-Bey L et al. | Reversal of delayed vasospasm by TS-011 in the dual hemorrhage dog model of subarachnoid hemorrhage. | 2006 Jun-Jul | AJNR Am J Neuroradiol | pmid:16775295 |
| Nithipatikom K et al. | Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16473964 |
| Metea MR and Newman EA | Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling. | 2006 | J. Neurosci. | pmid:16540563 |
| Roman RJ et al. | Characterization of blood pressure and renal function in chromosome 5 congenic strains of Dahl S rats. | 2006 | Am. J. Physiol. Renal Physiol. | pmid:16396943 |
| Zhou Y et al. | Induction of renal 20-hydroxyeicosatetraenoic acid by clofibrate attenuates high-fat diet-induced hypertension in rats. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16339392 |
| Nithipatikom K et al. | Elevated 12- and 20-hydroxyeicosatetraenoic acid in urine of patients with prostatic diseases. | 2006 | Cancer Lett. | pmid:15882928 |
| Poloyac SM et al. | Protective effect of the 20-HETE inhibitor HET0016 on brain damage after temporary focal ischemia. | 2006 | J. Cereb. Blood Flow Metab. | pmid:16570075 |
| Satarug S et al. | Kidney dysfunction and hypertension: role for cadmium, p450 and heme oxygenases? | 2006 | Tohoku J. Exp. Med. | pmid:16498227 |
| Cowpland C et al. | Effect of alcohol on cytochrome p450 arachidonic acid metabolism and blood pressure in rats and its modulation by red wine polyphenolics. | 2006 | Clin. Exp. Pharmacol. Physiol. | pmid:16487260 |
| Blanton A et al. | Nitric oxide/cytochrome P450 interactions in cyclosporin A-induced effects in the rat. | 2006 | J. Hypertens. | pmid:16915037 |
| Sankaralingam S et al. | Inability to upregulate cytochrome P450 4A and 2C causes salt sensitivity in young Sprague-Dawley rats. | 2006 | Am. J. Hypertens. | pmid:17070431 |
| Elijovich F | 20-HETE and salt-sensitivity of blood pressure a novel emerging concept. | 2006 | Am. J. Hypertens. | pmid:17070432 |
| Zhang JH | Editorial: experimental subarachnoid hemorrhage second issue: cerebral vasospasm. | 2006 | Neurol. Res. | pmid:17164031 |
| Roman RJ et al. | Evidence that 20-HETE contributes to the development of acute and delayed cerebral vasospasm. | 2006 | Neurol. Res. | pmid:17164037 |
| Nithipatikom K et al. | Effects of selective inhibition of cytochrome P-450 omega-hydroxylases and ischemic preconditioning in myocardial protection. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16214838 |
| Wang JS et al. | Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus. | 2006 | Circ. Res. | pmid:16543501 |
| Harder DR and Roman RJ | Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus. | 2006 | Circ. Res. | pmid:16614311 |
| Ito O et al. | Expression of cytochrome P-450 4 enzymes in the kidney and liver: regulation by PPAR and species-difference between rat and human. | 2006 | Mol. Cell. Biochem. | pmid:16552476 |
| Fang X et al. | 20-Hydroxyeicosatetraenoic acid is a potent dilator of mouse basilar artery: role of cyclooxygenase. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16782846 |
| Ward NC et al. | 20-Hydroxyeicosatetraenoic acid is not associated with circulating insulin in lean to overweight humans. | 2006 | Diabetes Res. Clin. Pract. | pmid:16713008 |
| Joly E et al. | Increased renal vascular reactivity to ANG II after unilateral nephrectomy in the rat involves 20-HETE. | 2006 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:16675634 |
| Chen Y et al. | Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells. | 2006 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16679377 |
| Jacobs ER et al. | VEGF-induced relaxation of pulmonary arteries is mediated by endothelial cytochrome P-450 hydroxylase. | 2006 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16679379 |
| Omura T et al. | Effect of a new inhibitor of the synthesis of 20-HETE on cerebral ischemia reperfusion injury. | 2006 | Stroke | pmid:16601220 |
| Takeuchi K et al. | Hemoglobin, NO, and 20-HETE interactions in mediating cerebral vasoconstriction following SAH. | 2006 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:16166205 |
| Qin X et al. | Role of 20-HETE in the pial arteriolar constrictor response to decreased hematocrit after exchange transfusion of cell-free polymeric hemoglobin. | 2006 | J. Appl. Physiol. | pmid:16166237 |
| Kuczeriszka M et al. | Cytochrome P-450 monooxygenases in control of renal haemodynamics and arterial pressure in anaesthetized rats. | 2006 | J. Physiol. Pharmacol. | pmid:17244949 |
| Harmon SD et al. | Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16820285 |
| Parker TA et al. | Inhibition of 20-HETE abolishes the myogenic response during NOS antagonism in the ovine fetal pulmonary circulation. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15821014 |
| Kroetz DL and Xu F | Regulation and inhibition of arachidonic acid omega-hydroxylases and 20-HETE formation. | 2005 | Annu. Rev. Pharmacol. Toxicol. | pmid:15822183 |
| Wang J et al. | Effects of high-salt diet on CYP450-4A omega-hydroxylase expression and active tone in mesenteric resistance arteries. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15576442 |
| Zhang F et al. | Long-term modifications of blood pressure in normotensive and spontaneously hypertensive rats by gene delivery of rAAV-mediated cytochrome P450 arachidonic acid hydroxylase. | 2005 | Cell Res. | pmid:16212878 |
| Miyata N and Roman RJ | Role of 20-hydroxyeicosatetraenoic acid (20-HETE) in vascular system. | 2005 | J Smooth Muscle Res | pmid:16258232 |
| Doggrell SA | Taking the 20-HETE out of the cardiovascular system: the potential of 20-HETE synthesis inhibitors. | 2005 | Curr Opin Investig Drugs | pmid:16187690 |
| Baines AD and Ho P | 20-HETE-mediated vasoconstriction by hemoglobin-O2 carrier in Sprague-Dawley but not Wistar rats. | 2005 | J. Appl. Physiol. | pmid:15531567 |
| Collins XH et al. | Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4. | 2005 | J. Biol. Chem. | pmid:16081420 |
| Guo M et al. | Human U251 glioma cell proliferation is suppressed by HET0016 [N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine], a selective inhibitor of CYP4A. | 2005 | J. Pharmacol. Exp. Ther. | pmid:16081682 |
| Huang A et al. | Contribution of 20-HETE to augmented myogenic constriction in coronary arteries of endothelial NO synthase knockout mice. | 2005 | Hypertension | pmid:16043660 |
| Yaghi A and Sims SM | Constrictor-induced translocation of NFAT3 in human and rat pulmonary artery smooth muscle. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16055480 |
| Seki T et al. | Increased excretion of urinary 20-HETE in rats with cyclosporine-induced nephrotoxicity. | 2005 | J. Pharmacol. Sci. | pmid:15655287 |
| Jung O et al. | Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension. | 2005 | Hypertension | pmid:15699457 |
| Vera T et al. | Fenofibrate prevents the development of angiotensin II-dependent hypertension in mice. | 2005 | Hypertension | pmid:15699464 |
| Kamata K | Pathophysiological role of 20-HETE a cytochrome P450 metabolite of arachidonic acid. | 2005 | J. Pharmacol. Sci. | pmid:15725698 |
| Ljubimov AV and Grant MB | P450 in the angiogenesis affair: the unusual suspect. | 2005 | Am. J. Pathol. | pmid:15681818 |
| Chen P et al. | Inhibitors of cytochrome P450 4A suppress angiogenic responses. | 2005 | Am. J. Pathol. | pmid:15681843 |
| Benter IF et al. | Inhibition of Ca2+/calmodulin-dependent protein kinase II, RAS-GTPase and 20-hydroxyeicosatetraenoic acid attenuates the development of diabetes-induced vascular dysfunction in the rat carotid artery. | 2005 | Pharmacol. Res. | pmid:15886012 |
| Poloyac SM et al. | Identification and quantification of the hydroxyeicosatetraenoic acids, 20-HETE and 12-HETE, in the cerebrospinal fluid after subarachnoid hemorrhage. | 2005 | J. Neurosci. Methods | pmid:15910986 |
| Parmentier JH et al. | Evaluation of cytochrome P450 4 family as mediator of phospholipase D activation in aortic vascular smooth muscle cells. | 2005 | Life Sci. | pmid:15964316 |
| Wang H et al. | Glomerular cytochrome P-450 and cyclooxygenase metabolites regulate efferent arteriole resistance. | 2005 | Hypertension | pmid:16230518 |
| Gross GJ et al. | Cytochrome P450 and arachidonic acid metabolites: role in myocardial ischemia/reperfusion injury revisited. | 2005 | Cardiovasc. Res. | pmid:15993870 |