| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
20-HETE
20-hete is a lipid of Fatty Acyls (FA) class. 20-hete is associated with abnormalities such as Cyst, Kidney Diseases, Kidney Failure, Chronic, Cystic Kidney Diseases and Simple renal cyst. The involved functions are known as Phosphorylation, inhibitors, Hypertrophy, Epithelial Cell Proliferation and Anabolism. 20-hete often locates in Mouse Kidney, Microsomes, Tissue membrane, Body tissue and Cytoplasmic matrix. The associated genes with 20-HETE are CYP4F3 gene, PKHD1 gene, Transgenes, P4HTM gene and CYP2E1 gene. The related lipids are Promega, enterodiol, Fatty Acids, hexanoic acid and U 73343. The related experimental models are Mouse Model, Knock-out, Streptozotocin Diabetes, Transgenic Model and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of 20-HETE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 20-HETE?
20-HETE is suspected in Hypertensive disease, Renal tubular disorder, endothelial dysfunction, Renal glomerular disease, Ischemia, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Hypertension (27)
- Am. J. Physiol. Heart Circ. Physiol. (19)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (16)
- Others (110)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 20-HETE
PubChem Associated disorders and diseases
What pathways are associated with 20-HETE
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 20-HETE through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
- Am. J. Physiol. Heart Circ. Physiol. (16)
- Hypertension (14)
- Am. J. Physiol. Renal Physiol. (10)
- Others (63)
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 20-HETE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- Hypertension (28)
- Am. J. Physiol. Heart Circ. Physiol. (26)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (18)
- Others (151)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 20-HETE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 20-HETE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 20-HETE?
Related references are published most in these journals:
- Hypertension (20)
- Am. J. Physiol. Heart Circ. Physiol. (19)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (12)
- Others (86)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 20-HETE?
Mouse Model
Mouse Model are used in the study '20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease.' (Park F et al., 2008), Mouse Model are used in the study 'Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth.' (Alexanian A et al., 2009) and Mouse Model are used in the study 'Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus.' (Harder DR and Roman RJ, 2006).
Knock-out
Knock-out are used in the study 'Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle.' (Yu M et al., 2007) and Knock-out are used in the study 'Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis.' (Williams JM et al., 2007).
Streptozotocin Diabetes
Streptozotocin Diabetes are used in the study 'Deficient renal 20-HETE release in the diabetic rat is not the result of oxidative stress.' (Chen YJ et al., 2008).
Related references are published most in these journals:
- J. Am. Soc. Nephrol. (2)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (2)
- Circ. Res. (1)
- Others (4)
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 20-HETE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Regner KR and Roman RJ | Role of medullary blood flow in the pathogenesis of renal ischemia-reperfusion injury. | 2012 | Curr. Opin. Nephrol. Hypertens. | pmid:22080855 |
| Lai G et al. | Evaluation of CMV and KAP promoters for driving the expression of human CYP4F2 in transgenic mice. | 2012 | Int. J. Mol. Med. | pmid:21887457 |
| Vasudevan H et al. | Testosterone-dependent increase in blood pressure is mediated by elevated Cyp4A expression in fructose-fed rats. | 2012 | Mol. Cell. Biochem. | pmid:21894443 |
| Theken KN et al. | Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease. | 2012 | Atherosclerosis | pmid:22503544 |
| Renic M et al. | Protective effect of 20-HETE inhibition in a model of oxygen-glucose deprivation in hippocampal slice cultures. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22245774 |
| Plée-Gautier E et al. | Statins increase cytochrome P450 4F3-mediated eicosanoids production in human liver cells: a PXR dependent mechanism. | 2012 | Biochem. Pharmacol. | pmid:22634049 |
| Fernandez MM et al. | Inhibitors of 20-hydroxyeicosatetraenoic acid (20-HETE) formation attenuate the natriuretic effect of dopamine. | 2012 | Eur. J. Pharmacol. | pmid:22575524 |
| Kawasaki T et al. | Increase of 20-HETE synthase after brain ischemia in rats revealed by PET study with 11C-labeled 20-HETE synthase-specific inhibitor. | 2012 | J. Cereb. Blood Flow Metab. | pmid:22669478 |
| Wen H et al. | 20-Hydroxyeicosatetraenoic acid (20-HETE) is a novel activator of transient receptor potential vanilloid 1 (TRPV1) channel. | 2012 | J. Biol. Chem. | pmid:22389490 |
| Tunctan B et al. | A novel treatment strategy for sepsis and septic shock based on the interactions between prostanoids, nitric oxide, and 20-hydroxyeicosatetraenoic acid. | 2012 | Antiinflamm Antiallergy Agents Med Chem | pmid:23013331 |
| Ward NC et al. | Cytochrome P450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controls. | 2011 | Clin. Sci. | pmid:21689071 |
| Sridar C et al. | Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6. | 2011 | Drug Metab. Dispos. | pmid:21289075 |
| Liu X et al. | Epoxyeicosatrienoic acid-dependent cerebral vasodilation evoked by metabotropic glutamate receptor activation in vivo. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21602473 |
| Liang CJ et al. | 20-Hydroxyeicosatetraenoic acid inhibits ATP-induced COX-2 expression via peroxisome proliferator activator receptor-α in vascular smooth muscle cells. | 2011 | Br. J. Pharmacol. | pmid:21323895 |
| Xie XN et al. | [Progress in research of arachidonic acid-cytochrome P450 pathway in diabetes]. | 2011 | Sheng Li Ke Xue Jin Zhan | pmid:22066421 |
| Boonprasert K et al. | Study on the association between environmental cadmium exposure, cytochrome P450-mediated 20-HETE, heme-oxygenase-1 polymorphism and hypertension in Thai population residing in a malaria endemic areas with cadmium pollution. | 2011 | Environ. Toxicol. Pharmacol. | pmid:21787712 |
| Pat Kunert M and Drenjancević I | 20-hydroxyeicosatetraenoic acid, endothelial dysfunction and hypertension. | 2011 | Med Glas (Zenica) | pmid:21849935 |
| Wu CC and Schwartzman ML | The role of 20-HETE in androgen-mediated hypertension. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21722750 |
| Imig JD et al. | Cytochrome P450 eicosanoids and cerebral vascular function. | 2011 | Expert Rev Mol Med | pmid:21356152 |
| Sacerdoti D et al. | 11,12-EET increases porto-sinusoidal resistance and may play a role in endothelial dysfunction of portal hypertension. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21856435 |
| Hoff U et al. | Inhibition of 20-HETE synthesis and action protects the kidney from ischemia/reperfusion injury. | 2011 | Kidney Int. | pmid:20962739 |
| Roman RJ et al. | 20-HETE in acute kidney injury. | 2011 | Kidney Int. | pmid:21157458 |
| Speed JS et al. | Role of 20-hydroxyeicosatetraenoic acid in mediating hypertension in response to chronic renal medullary endothelin type B receptor blockade. | 2011 | PLoS ONE | pmid:22016812 |
| Kuczeriszka M et al. | Interaction of nitric oxide and the cytochrome P-450 system on blood pressure and renal function in the rat: dependence on sodium intake. | 2011 | Acta Physiol (Oxf) | pmid:21073660 |
| Hu BC et al. | Peripheral and central augmentation indexes in relation to the CYP4F2 polymorphisms in Chinese. | 2011 | J. Hypertens. | pmid:21150635 |
| Baragatti B and Coceani F | Arachidonic acid epoxygenase and 12(S)-lipoxygenase: evidence of their concerted involvement in ductus arteriosus constriction to oxygen. | 2011 | Can. J. Physiol. Pharmacol. | pmid:21619415 |
| Wang Z et al. | Inhibition of 20-HETE attenuates diabetes-induced decreases in retinal hemodynamics. | 2011 | Exp. Eye Res. | pmid:21658386 |
| Ward NC et al. | Chronic activation of AMP-activated protein kinase prevents 20-hydroxyeicosatetraenoic acid-induced endothelial dysfunction. | 2011 | Clin. Exp. Pharmacol. Physiol. | pmid:21388435 |
| Wu CC et al. | Androgen-dependent hypertension is mediated by 20-hydroxy-5,8,11,14-eicosatetraenoic acid-induced vascular dysfunction: role of inhibitor of kappaB Kinase. | 2011 | Hypertension | pmid:21321301 |
| Sporková A et al. | Role of cytochrome P-450 metabolites in the regulation of renal function and blood pressure in 2-kidney 1-clip hypertensive rats. | 2011 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:21411763 |
| Yanes LL et al. | Postmenopausal hypertension: role of 20-HETE. | 2011 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:21474427 |
| Guo AM et al. | The cytochrome P450 4A/F-20-hydroxyeicosatetraenoic acid system: a regulator of endothelial precursor cells derived from human umbilical cord blood. | 2011 | J. Pharmacol. Exp. Ther. | pmid:21527533 |
| Buharalioglu CK et al. | Piroxicam reverses endotoxin-induced hypotension in rats: contribution of vasoactive eicosanoids and nitric oxide. | 2011 | Basic Clin. Pharmacol. Toxicol. | pmid:21463481 |
| Bao Y et al. | 20-Hydroxyeicosatetraenoic acid induces apoptosis in neonatal rat cardiomyocytes through mitochondrial-dependent pathways. | 2011 | J. Cardiovasc. Pharmacol. | pmid:21266918 |
| Harder DR et al. | Pressure-induced myogenic tone and role of 20-HETE in mediating autoregulation of cerebral blood flow. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21257913 |
| Tsai IJ et al. | 20-Hydroxyeicosatetraenoic acid synthesis is increased in human neutrophils and platelets by angiotensin II and endothelin-1. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21239640 |
| Toth P et al. | Isolated human and rat cerebral arteries constrict to increases in flow: role of 20-HETE and TP receptors. | 2011 | J. Cereb. Blood Flow Metab. | pmid:21610722 |
| Crago EA et al. | Cerebrospinal fluid 20-HETE is associated with delayed cerebral ischemia and poor outcomes after aneurysmal subarachnoid hemorrhage. | 2011 | Stroke | pmid:21617146 |
| Arnold C et al. | Cytochrome P450-dependent metabolism of omega-6 and omega-3 long-chain polyunsaturated fatty acids. | 2010 May-Jun | Pharmacol Rep | pmid:20631419 |
| Yang X et al. | The effects of a lupin-enriched diet on oxidative stress and factors influencing vascular function in overweight subjects. | 2010 | Antioxid. Redox Signal. | pmid:20214496 |
| Cheng J et al. | 20-hydroxy-5,8,11,14-eicosatetraenoic acid mediates endothelial dysfunction via IkappaB kinase-dependent endothelial nitric-oxide synthase uncoupling. | 2010 | J. Pharmacol. Exp. Ther. | pmid:19841472 |
| Zordoky BN et al. | Acute doxorubicin cardiotoxicity alters cardiac cytochrome P450 expression and arachidonic acid metabolism in rats. | 2010 | Toxicol. Appl. Pharmacol. | pmid:19796650 |
| Cuez T et al. | A synthetic analogue of 20-HETE, 5,14-HEDGE, reverses endotoxin-induced hypotension via increased 20-HETE levels associated with decreased iNOS protein expression and vasodilator prostanoid production in rats. | 2010 | Basic Clin. Pharmacol. Toxicol. | pmid:20002062 |
| Devos A et al. | Genetic polymorphism of CYP2U1, a cytochrome P450 involved in fatty acids hydroxylation. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20630735 |
| Schäfer A et al. | Increased cytochrome P4502E1 expression and altered hydroxyeicosatetraenoic acid formation mediate diabetic vascular dysfunction: rescue by guanylyl-cyclase activation. | 2010 | Diabetes | pmid:20522591 |
| Bodiga S et al. | 20-HETE-induced nitric oxide production in pulmonary artery endothelial cells is mediated by NADPH oxidase, H2O2, and PI3-kinase/Akt. | 2010 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:20061439 |
| CertÃková Chábová V et al. | Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats. | 2010 | Clin. Sci. | pmid:20050826 |
| Sodhi K et al. | CYP4A2-induced hypertension is 20-hydroxyeicosatetraenoic acid- and angiotensin II-dependent. | 2010 | Hypertension | pmid:20837888 |
| Marumo T et al. | The inhibitor of 20-HETE synthesis, TS-011, improves cerebral microcirculatory autoregulation impaired by middle cerebral artery occlusion in mice. | 2010 | Br. J. Pharmacol. | pmid:20735406 |
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