| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
20-HETE
20-hete is a lipid of Fatty Acyls (FA) class. 20-hete is associated with abnormalities such as Cyst, Kidney Diseases, Kidney Failure, Chronic, Cystic Kidney Diseases and Simple renal cyst. The involved functions are known as Phosphorylation, inhibitors, Hypertrophy, Epithelial Cell Proliferation and Anabolism. 20-hete often locates in Mouse Kidney, Microsomes, Tissue membrane, Body tissue and Cytoplasmic matrix. The associated genes with 20-HETE are CYP4F3 gene, PKHD1 gene, Transgenes, P4HTM gene and CYP2E1 gene. The related lipids are Promega, enterodiol, Fatty Acids, hexanoic acid and U 73343. The related experimental models are Mouse Model, Knock-out, Streptozotocin Diabetes, Transgenic Model and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of 20-HETE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 20-HETE?
20-HETE is suspected in Hypertensive disease, Renal tubular disorder, endothelial dysfunction, Renal glomerular disease, Ischemia, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Hypertension (27)
- Am. J. Physiol. Heart Circ. Physiol. (19)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (16)
- Others (110)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 20-HETE
PubChem Associated disorders and diseases
What pathways are associated with 20-HETE
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 20-HETE through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
- Am. J. Physiol. Heart Circ. Physiol. (16)
- Hypertension (14)
- Am. J. Physiol. Renal Physiol. (10)
- Others (63)
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 20-HETE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- Hypertension (28)
- Am. J. Physiol. Heart Circ. Physiol. (26)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (18)
- Others (151)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 20-HETE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 20-HETE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 20-HETE?
Related references are published most in these journals:
- Hypertension (20)
- Am. J. Physiol. Heart Circ. Physiol. (19)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (12)
- Others (86)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 20-HETE?
Mouse Model
Mouse Model are used in the study '20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease.' (Park F et al., 2008), Mouse Model are used in the study 'Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth.' (Alexanian A et al., 2009) and Mouse Model are used in the study 'Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus.' (Harder DR and Roman RJ, 2006).
Knock-out
Knock-out are used in the study 'Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle.' (Yu M et al., 2007) and Knock-out are used in the study 'Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis.' (Williams JM et al., 2007).
Streptozotocin Diabetes
Streptozotocin Diabetes are used in the study 'Deficient renal 20-HETE release in the diabetic rat is not the result of oxidative stress.' (Chen YJ et al., 2008).
Related references are published most in these journals:
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (2)
- J. Am. Soc. Nephrol. (2)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Others (4)
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 20-HETE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Seki T et al. | Cytochrome P450 4A isoform inhibitory profile of N-hydroxy-N'-(4-butyl-2-methylphenyl)-formamidine (HET0016), a selective inhibitor of 20-HETE synthesis. | 2005 | Biol. Pharm. Bull. | pmid:16141533 |
| Ward NC et al. | Urinary 20-hydroxyeicosatetraenoic acid excretion is associated with oxidative stress in hypertensive subjects. | 2005 | Free Radic. Biol. Med. | pmid:15780761 |
| Miyata N et al. | Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide], on hemorrhagic and ischemic stroke. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15831442 |
| Silverstein DM et al. | Parathormone sensitivity and responses to protein kinases in subclones of opossum kidney cells. | 2005 | Pediatr. Nephrol. | pmid:15834620 |
| Randriamboavonjy V et al. | The synthesis of 20-HETE in small porcine coronary arteries antagonizes EDHF-mediated relaxation. | 2005 | Cardiovasc. Res. | pmid:15639488 |
| Zhang F et al. | Decreased levels of cytochrome P450 2E1-derived eicosanoids sensitize renal arteries to constrictor agonists in spontaneously hypertensive rats. | 2005 | Hypertension | pmid:15569854 |
| McCarthy ET et al. | Protective effect of 20-hydroxyeicosatetraenoic acid (20-HETE) on glomerular protein permeability barrier. | 2005 | Kidney Int. | pmid:15610238 |
| Wang J et al. | Effects of high-salt diet on CYP450-4A omega-hydroxylase expression and active tone in mesenteric resistance arteries. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15576442 |
| Zhang F et al. | Long-term modifications of blood pressure in normotensive and spontaneously hypertensive rats by gene delivery of rAAV-mediated cytochrome P450 arachidonic acid hydroxylase. | 2005 | Cell Res. | pmid:16212878 |
| Miyata N and Roman RJ | Role of 20-hydroxyeicosatetraenoic acid (20-HETE) in vascular system. | 2005 | J Smooth Muscle Res | pmid:16258232 |
| Yaghini FA et al. | Contribution of arachidonic acid metabolites derived via cytochrome P4504A to angiotensin II-induced neointimal growth. | 2005 | Hypertension | pmid:15897359 |
| Huang H et al. | Renal 20-HETE inhibition attenuates changes in renal hemodynamics induced by L-NAME treatment in pregnant rats. | 2005 | Am. J. Physiol. Renal Physiol. | pmid:15998843 |
| Takeuchi K et al. | Reversal of delayed vasospasm by an inhibitor of the synthesis of 20-HETE. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15964920 |
| Bolad I and Delafontaine P | Endothelial dysfunction: its role in hypertensive coronary disease. | 2005 | Curr. Opin. Cardiol. | pmid:15956822 |
| Dahly-Vernon AJ et al. | Transforming growth factor-beta, 20-HETE interaction, and glomerular injury in Dahl salt-sensitive rats. | 2005 | Hypertension | pmid:15723968 |
| Wang H et al. | Glomerular cytochrome P-450 and cyclooxygenase metabolites regulate efferent arteriole resistance. | 2005 | Hypertension | pmid:16230518 |
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| Li D et al. | Dietary K intake regulates the response of apical K channels to adenosine in the thick ascending limb. | 2004 | Am. J. Physiol. Renal Physiol. | pmid:15265768 |
| Kaide J et al. | Vascular CO counterbalances the sensitizing influence of 20-HETE on agonist-induced vasoconstriction. | 2004 | Hypertension | pmid:15226275 |
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| Cheng MK et al. | Renal arterial 20-hydroxyeicosatetraenoic acid levels: regulation by cyclooxygenase. | 2003 | Am. J. Physiol. Renal Physiol. | pmid:12419775 |
| Laffer CL et al. | 20-HETE and furosemide-induced natriuresis in salt-sensitive essential hypertension. | 2003 | Hypertension | pmid:12623983 |
| Randriamboavonjy V et al. | 20-HETE-induced contraction of small coronary arteries depends on the activation of Rho-kinase. | 2003 | Hypertension | pmid:12623999 |
| Skott O | Androgen-induced activation of 20-HETE production may contribute to gender differences in blood pressure regulation. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12626366 |
| Ren Y et al. | Glomerular autacoids stimulated by bradykinin regulate efferent arteriole tone. | 2003 | Kidney Int. | pmid:12631079 |
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| Marji JS et al. | Cytochrome P-450 4A isoform expression and 20-HETE synthesis in renal preglomerular arteries. | 2002 | Am. J. Physiol. Renal Physiol. | pmid:12060587 |
| Obara K et al. | 20-Hydroxyeicosatetraenoic acid potentiates stretch-induced contraction of canine basilar artery via PKC alpha-mediated inhibition of KCa channel. | 2002 | Br. J. Pharmacol. | pmid:12466247 |
| Li PL et al. | Role of ADP-ribose in 11,12-EET-induced activation of K(Ca) channels in coronary arterial smooth muscle cells. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11893556 |