| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
20-HETE
20-hete is a lipid of Fatty Acyls (FA) class. 20-hete is associated with abnormalities such as Cyst, Kidney Diseases, Kidney Failure, Chronic, Cystic Kidney Diseases and Simple renal cyst. The involved functions are known as Phosphorylation, inhibitors, Hypertrophy, Epithelial Cell Proliferation and Anabolism. 20-hete often locates in Mouse Kidney, Microsomes, Tissue membrane, Body tissue and Cytoplasmic matrix. The associated genes with 20-HETE are CYP4F3 gene, PKHD1 gene, Transgenes, P4HTM gene and CYP2E1 gene. The related lipids are Promega, enterodiol, Fatty Acids, hexanoic acid and U 73343. The related experimental models are Mouse Model, Knock-out, Streptozotocin Diabetes, Transgenic Model and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of 20-HETE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 20-HETE?
20-HETE is suspected in Hypertensive disease, Renal tubular disorder, endothelial dysfunction, Renal glomerular disease, Ischemia, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Hypertension (27)
- Am. J. Physiol. Heart Circ. Physiol. (19)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (16)
- Others (110)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 20-HETE
PubChem Associated disorders and diseases
What pathways are associated with 20-HETE
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 20-HETE through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
- Am. J. Physiol. Heart Circ. Physiol. (16)
- Hypertension (14)
- Am. J. Physiol. Renal Physiol. (10)
- Others (63)
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 20-HETE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- Hypertension (28)
- Am. J. Physiol. Heart Circ. Physiol. (26)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (18)
- Others (151)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 20-HETE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 20-HETE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 20-HETE?
Related references are published most in these journals:
- Hypertension (20)
- Am. J. Physiol. Heart Circ. Physiol. (19)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (12)
- Others (86)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 20-HETE?
Mouse Model
Mouse Model are used in the study '20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease.' (Park F et al., 2008), Mouse Model are used in the study 'Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth.' (Alexanian A et al., 2009) and Mouse Model are used in the study 'Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus.' (Harder DR and Roman RJ, 2006).
Knock-out
Knock-out are used in the study 'Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle.' (Yu M et al., 2007) and Knock-out are used in the study 'Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis.' (Williams JM et al., 2007).
Streptozotocin Diabetes
Streptozotocin Diabetes are used in the study 'Deficient renal 20-HETE release in the diabetic rat is not the result of oxidative stress.' (Chen YJ et al., 2008).
Related references are published most in these journals:
- J. Am. Soc. Nephrol. (2)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (2)
- Circ. Res. (1)
- Others (4)
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 20-HETE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bodiga S et al. | 20-HETE-induced nitric oxide production in pulmonary artery endothelial cells is mediated by NADPH oxidase, H2O2, and PI3-kinase/Akt. | 2010 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:20061439 |
| Anwar-mohamed A et al. | Alteration of cardiac cytochrome P450-mediated arachidonic acid metabolism in response to lipopolysaccharide-induced acute systemic inflammation. | 2010 | Pharmacol. Res. | pmid:20045729 |
| Cooper PR et al. | 20-HETE mediates ozone-induced, neutrophil-independent airway hyper-responsiveness in mice. | 2010 | PLoS ONE | pmid:20422032 |
| Raffai G et al. | Modulation by cytochrome P450-4A ω-hydroxylase enzymes of adrenergic vasoconstriction and response to reduced PO₂ in mesenteric resistance arteries of Dahl salt-sensitive rats. | 2010 | Microcirculation | pmid:21040118 |
| Zeng Q et al. | 20-HETE increases NADPH oxidase-derived ROS production and stimulates the L-type Ca2+ channel via a PKC-dependent mechanism in cardiomyocytes. | 2010 | Am. J. Physiol. Heart Circ. Physiol. | pmid:20675568 |
| Ljuca F and Drevensek G | Endothelin-1 induced vascular smooth muscle cell proliferation is mediated by cytochrome p-450 arachidonic acid metabolites. | 2010 | Bosn J Basic Med Sci | pmid:20846129 |
| Sahan-Firat S et al. | 2,3',4,5'-Tetramethoxystilbene prevents deoxycorticosterone-salt-induced hypertension: contribution of cytochrome P-450 1B1. | 2010 | Am. J. Physiol. Heart Circ. Physiol. | pmid:20852048 |
| CertÃková Chábová V et al. | Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats. | 2010 | Clin. Sci. | pmid:20050826 |
| Sodhi K et al. | CYP4A2-induced hypertension is 20-hydroxyeicosatetraenoic acid- and angiotensin II-dependent. | 2010 | Hypertension | pmid:20837888 |
| Liu JY et al. | Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20837537 |
| Imig JD | 20-hydroxyeicosatetraenoic acid and angiotensin: a positive feedback system to cause hypertension. | 2010 | Hypertension | pmid:20837886 |
| Bardowell SA et al. | Common variants of cytochrome P450 4F2 exhibit altered vitamin E-{omega}-hydroxylase specific activity. | 2010 | J. Nutr. | pmid:20861217 |
| Liu X et al. | Overexpression of cytochrome P450 4F2 in mice increases 20-hydroxyeicosatetraenoic acid production and arterial blood pressure. | 2009 | Kidney Int. | pmid:19279555 |
| Yousif MH et al. | Role of 20-hydroxyeicosatetraenoic acid in altering vascular reactivity in diabetes. | 2009 | Auton Autacoid Pharmacol | pmid:19302551 |
| Hilgers RH and De Mey JG | Myoendothelial coupling in the mesenteric arterial bed; segmental differences and interplay between nitric oxide and endothelin-1. | 2009 | Br. J. Pharmacol. | pmid:19302591 |
| Inoue R et al. | Chemical-mechanical synergism for cardiovascular TRPC6 channel activation via PLC/diacylglycerol and PLA2/omega-hydroxylase/20-HETE pathways. | 2009 | Nippon Yakurigaku Zasshi | pmid:19749481 |
| Kunert MP et al. | CYP450 4A inhibition attenuates O2 induced arteriolar constriction in chronic but not acute Goldblatt hypertension. | 2009 | Microvasc. Res. | pmid:19761780 |
| Tsai IJ et al. | 20-HETE and F2-isoprostanes in the metabolic syndrome: the effect of weight reduction. | 2009 | Free Radic. Biol. Med. | pmid:19013235 |
| Regner KR et al. | Protective effect of 20-HETE analogues in experimental renal ischemia reperfusion injury. | 2009 | Kidney Int. | pmid:19052533 |
| Dhanasekaran A et al. | 20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells. | 2009 | Am. J. Physiol. Heart Circ. Physiol. | pmid:19136601 |
| Nayeem MA et al. | High-salt diet enhances mouse aortic relaxation through adenosine A2A receptor via CYP epoxygenases. | 2009 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:19109366 |
| Renic M et al. | Effect of 20-HETE inhibition on infarct volume and cerebral blood flow after transient middle cerebral artery occlusion. | 2009 | J. Cereb. Blood Flow Metab. | pmid:19107134 |
| Inoue R et al. | Synergistic activation of vascular TRPC6 channel by receptor and mechanical stimulation via phospholipase C/diacylglycerol and phospholipase A2/omega-hydroxylase/20-HETE pathways. | 2009 | Circ. Res. | pmid:19443836 |
| Cai Y | Arachidonic acid cytochrome P450 4F2 in hypertension: what can we learn from a transgenic mouse model?? | 2009 | Kidney Int. | pmid:19483747 |
| Zhang Y et al. | The role of 20-hydroxyeicosatetraenoic acid in adrenocorticotrophic hormone and dexamethasone-induced hypertension. | 2009 | J. Hypertens. | pmid:19458537 |
| Guo AM et al. | 20-HETE can act as a nonhypoxic regulator of HIF-1alpha in human microvascular endothelial cells. | 2009 | Am. J. Physiol. Heart Circ. Physiol. | pmid:19502554 |
| Akbulut T et al. | 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism. | 2009 | Am. J. Physiol. Renal Physiol. | pmid:19570883 |
| Inoue K et al. | Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE. | 2009 | Am. J. Physiol. Renal Physiol. | pmid:19675180 |
| Liclican EL et al. | Inhibition of the adenosine2A receptor-epoxyeicosatrienoic acid pathway renders Dahl salt-resistant rats hypertensive. | 2009 | Hypertension | pmid:19822802 |
| Hama-Tomioka K et al. | The role of 20-hydroxyeicosatetraenoic acid in cerebral arteriolar constriction and the inhibitory effect of propofol. | 2009 | Anesth. Analg. | pmid:19923524 |
| Alexanian A et al. | Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth. | 2009 | Anticancer Res. | pmid:19846914 |
| Wu JH et al. | Inhibition of 20-hydroxyeicosatetraenoic acid synthesis using specific plant lignans: in vitro and human studies. | 2009 | Hypertension | pmid:19786646 |
| Fava C et al. | Overexpression of cytochrome P450 4F2 in mice increases 20-hydroxyeicosatetraenoic acid production and arterial blood pressure. | 2009 | Kidney Int. | pmid:19789547 |
| Yousif MH et al. | Cytochrome P450 metabolites of arachidonic acid play a role in the enhanced cardiac dysfunction in diabetic rats following ischaemic reperfusion injury. | 2009 | Auton Autacoid Pharmacol | pmid:19302554 |
| Gu RM et al. | CYP-omega-hydroxylation-dependent metabolites of arachidonic acid inhibit the basolateral 10 pS chloride channel in the rat thick ascending limb. | 2009 | Kidney Int. | pmid:19641481 |
| Park F et al. | Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD. | 2009 | Am. J. Physiol. Renal Physiol. | pmid:19129252 |
| Luo P et al. | Glomerular 20-HETE, EETs, and TGF-beta1 in diabetic nephropathy. | 2009 | Am. J. Physiol. Renal Physiol. | pmid:19129258 |
| Miller TM et al. | Rapid, simultaneous quantitation of mono and dioxygenated metabolites of arachidonic acid in human CSF and rat brain. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19892608 |
| Rimmerman N et al. | Microsomal omega-hydroxylated metabolites of N-arachidonoyl dopamine are active at recombinant human TRPV1 receptors. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:18812233 |
| Wang J et al. | Modulation of vascular O2 responses by cytochrome 450-4A omega-hydroxylase metabolites in Dahl salt-sensitive rats. | 2009 | Microcirculation | pmid:19225982 |
| Hamilton SJ et al. | Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients. | 2009 | Diabetes Care | pmid:19228872 |
| Eid AA et al. | Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases. | 2009 | Diabetes | pmid:19208908 |
| Dołegowska B et al. | Is it possible to predict the early post-transplant allograft function using 20-HETE measurements? A preliminary report. | 2009 | Transpl. Int. | pmid:19175563 |
| Cao S et al. | Endothelin rather than 20-HETE contributes to loss of pial arteriolar dilation during focal cerebral ischemia with and without polymeric hemoglobin transfusion. | 2009 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:19261918 |
| Singh H and Schwartzman ML | Renal vascular cytochrome P450-derived eicosanoids in androgen-induced hypertension. | 2008 Jan-Feb | Pharmacol Rep | pmid:18276983 |
| Yang HY and Chen JR | Renoprotective effects of soy protein hydrolysates in N(omega)-nitro-L-arginine methyl ester hydrochloride-induced hypertensive rats. | 2008 | Hypertens. Res. | pmid:18957819 |
| Antoun J et al. | CYP4F3B is induced by PGA1 in human liver cells: a regulation of the 20-HETE synthesis. | 2008 | J. Lipid Res. | pmid:18566475 |
| Fava C et al. | The V433M variant of the CYP4F2 is associated with ischemic stroke in male Swedes beyond its effect on blood pressure. | 2008 | Hypertension | pmid:18574070 |
| Guo AM et al. | Expression of CYP4A1 in U251 human glioma cell induces hyperproliferative phenotype in vitro and rapidly growing tumors in vivo. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18591218 |
| Fu Z et al. | Haplotype-based case study of human CYP4A11 gene and cerebral infarction in Japanese subject. | 2008 | Endocrine | pmid:18484194 |