| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
20-HETE
20-hete is a lipid of Fatty Acyls (FA) class. 20-hete is associated with abnormalities such as Cyst, Kidney Diseases, Kidney Failure, Chronic, Cystic Kidney Diseases and Simple renal cyst. The involved functions are known as Phosphorylation, inhibitors, Hypertrophy, Epithelial Cell Proliferation and Anabolism. 20-hete often locates in Mouse Kidney, Microsomes, Tissue membrane, Body tissue and Cytoplasmic matrix. The associated genes with 20-HETE are CYP4F3 gene, PKHD1 gene, Transgenes, P4HTM gene and CYP2E1 gene. The related lipids are Promega, enterodiol, Fatty Acids, hexanoic acid and U 73343. The related experimental models are Mouse Model, Knock-out, Streptozotocin Diabetes, Transgenic Model and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of 20-HETE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 20-HETE?
20-HETE is suspected in Hypertensive disease, Renal tubular disorder, endothelial dysfunction, Renal glomerular disease, Ischemia, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Hypertension (27)
- Am. J. Physiol. Heart Circ. Physiol. (19)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (16)
- Others (110)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 20-HETE
PubChem Associated disorders and diseases
What pathways are associated with 20-HETE
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 20-HETE through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
- Am. J. Physiol. Heart Circ. Physiol. (16)
- Hypertension (14)
- Am. J. Physiol. Renal Physiol. (10)
- Others (63)
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 20-HETE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- Hypertension (28)
- Am. J. Physiol. Heart Circ. Physiol. (26)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (18)
- Others (151)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 20-HETE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 20-HETE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 20-HETE?
Related references are published most in these journals:
- Hypertension (20)
- Am. J. Physiol. Heart Circ. Physiol. (19)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (12)
- Others (86)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 20-HETE?
Mouse Model
Mouse Model are used in the study '20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease.' (Park F et al., 2008), Mouse Model are used in the study 'Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth.' (Alexanian A et al., 2009) and Mouse Model are used in the study 'Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus.' (Harder DR and Roman RJ, 2006).
Knock-out
Knock-out are used in the study 'Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle.' (Yu M et al., 2007) and Knock-out are used in the study 'Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis.' (Williams JM et al., 2007).
Streptozotocin Diabetes
Streptozotocin Diabetes are used in the study 'Deficient renal 20-HETE release in the diabetic rat is not the result of oxidative stress.' (Chen YJ et al., 2008).
Related references are published most in these journals:
- J. Am. Soc. Nephrol. (2)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (2)
- Anticancer Res. (1)
- Others (4)
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 20-HETE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Botros FT et al. | Regulation of cyclooxygenase- and cytochrome p450-derived eicosanoids by heme oxygenase in the rat kidney. | 2002 | Hypertension | pmid:11882623 |
| Escalante BA et al. | Role of cytochrome P-450 arachidonate metabolites in endothelin signaling in rat proximal tubule. | 2002 | Am. J. Physiol. Renal Physiol. | pmid:11739122 |
| Roman RJ | P-450 metabolites of arachidonic acid in the control of cardiovascular function. | 2002 | Physiol. Rev. | pmid:11773611 |
| Yu M et al. | Nitric oxide contributes to 20-HETE-induced relaxation of pulmonary arteries. | 2002 | J. Appl. Physiol. | pmid:12235040 |
| Abraham NG et al. | Differential effect of cobalt protoporphyrin on distributions of heme oxygenase in renal structure and on blood pressure in SHR. | 2002 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:12699248 |
| Frisbee JC et al. | Relative contributions of cyclooxygenase- and cytochrome P450 omega-hydroxylase-dependent pathways to hypoxic dilation of skeletal muscle resistance arteries. | 2001 Jul-Aug | J. Vasc. Res. | pmid:11455201 |
| Carroll MA et al. | Regulation of preglomerular microvascular 20-hydroxyeicosatetraenoic acid levels by salt depletion. | 2001 Jul-Aug | Med. Sci. Monit. | pmid:11433178 |
| Kunert MP et al. | Cytochrome P-450 omega-hydroxylase: a potential O(2) sensor in rat arterioles and skeletal muscle cells. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11247799 |
| Kohagura K et al. | Involvement of cytochrome P450 metabolites in the vascular action of angiotensin II on the afferent arterioles. | 2001 | Hypertens. Res. | pmid:11675950 |
| Frisbee JC et al. | 20-HETE contributes to myogenic activation of skeletal muscle resistance arteries in Brown Norway and Sprague-Dawley rats. | 2001 | Microcirculation | pmid:11296852 |
| Frisbee JC et al. | Altered mechanisms underlying hypoxic dilation of skeletal muscle resistance arteries of hypertensive versus normotensive Dahl rats. | 2001 | Microcirculation | pmid:11379791 |
| Ito O et al. | Effects of converting enzyme inhibitors on renal P-450 metabolism of arachidonic acid. | 2001 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11171663 |
| Fleming I | Cytochrome p450 and vascular homeostasis. | 2001 | Circ. Res. | pmid:11679404 |
| Frisbee JC et al. | 20-HETE modulates myogenic response of skeletal muscle resistance arteries from hypertensive Dahl-SS rats. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11179048 |
| Frisbee JC et al. | Role of prostanoids and 20-HETE in mediating oxygen-induced constriction of skeletal muscle resistance arteries. | 2001 | Microvasc. Res. | pmid:11678630 |
| Sato M et al. | Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11714595 |
| Zhao X et al. | The CYP450 hydroxylase pathway contributes to P2X receptor-mediated afferent arteriolar vasoconstriction. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11668070 |
| Zhang F et al. | Modulation by 20-HETE of phenylephrine-induced mesenteric artery contraction in spontaneously hypertensive and Wistar-Kyoto rats. | 2001 | Hypertension | pmid:11751709 |
| Nithipatikom K et al. | Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs. | 2001 | Anal. Biochem. | pmid:11319825 |
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| Holla VR et al. | Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11320253 |
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| Parmentier JH et al. | Phospholipase D activation by norepinephrine is mediated by 12(s)-, 15(s)-, and 20-hydroxyeicosatetraenoic acids generated by stimulation of cytosolic phospholipase a2. tyrosine phosphorylation of phospholipase d2 in response to norepinephrine. | 2001 | J. Biol. Chem. | pmid:11278912 |
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| Watzer B et al. | Determination of free and glucuronide conjugated 20-hydroxyarachidonic acid (20-HETE) in urine by gas chromatography/negative ion chemical ionization mass spectrometry. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10841040 |
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| Sun CW et al. | Role of cGMP versus 20-HETE in the vasodilator response to nitric oxide in rat cerebral arteries. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10899074 |
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| Amlal H et al. | ANG II controls Na(+)-K+(NH4+)-2Cl- cotransport via 20-HETE and PKC in medullary thick ascending limb. | 1998 | Am. J. Physiol. | pmid:9575802 |
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| Alonso-Galicia M et al. | Inhibition of 20-HETE production contributes to the vascular responses to nitric oxide. | 1997 | Hypertension | pmid:9039122 |
| Kroetz DL et al. | Developmentally regulated expression of the CYP4A genes in the spontaneously hypertensive rat kidney. | 1997 | Mol. Pharmacol. | pmid:9281597 |
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| Grider JS et al. | P450 arachidonate metabolites mediate bradykinin-dependent inhibition of NaCl transport in the rat thick ascending limb. | 1997 | Can. J. Physiol. Pharmacol. | pmid:9114929 |
| Stec DE et al. | Renal cytochrome P4504A activity and salt sensitivity in spontaneously hypertensive rats. | 1996 | Hypertension | pmid:8641744 |
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| Harder DR et al. | Identification of a putative microvascular oxygen sensor. | 1996 | Circ. Res. | pmid:8925569 |
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