| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
isoliquiritigenin
Isoliquiritigenin is a lipid of Polyketides (PK) class. Isoliquiritigenin is associated with abnormalities such as abnormal fragmented structure, Gastric ulcer, Gastric mucosa lesion, Peptic Ulcer and Wiskott-Aldrich Syndrome. The involved functions are known as Mass-to-Charge Ratio, Anabolism, Oxidation, inhibitors and Energy Absorption. Isoliquiritigenin often locates in Microsomes, Liver, Hepatic, Microsomes, Immune system and Vacuole. The associated genes with Isoliquiritigenin are P4HTM gene, BCL2 gene, AP1AR gene, oxytocin, 1-desamino-(O-Et-Tyr)(2)- and ODAM gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of isoliquiritigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with isoliquiritigenin?
isoliquiritigenin is suspected in Gastric mucosa lesion, Gastric ulcer, Peptic Ulcer, Nodule, Infertility and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with isoliquiritigenin
PubChem Associated disorders and diseases
What pathways are associated with isoliquiritigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with isoliquiritigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with isoliquiritigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with isoliquiritigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with isoliquiritigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with isoliquiritigenin?
Knock-out
Knock-out are used in the study 'Two activators of in vitro fertilization in mice from licorice.' (Tung NH et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with isoliquiritigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sun ZJ et al. | Mammalian target of rapamycin pathway promotes tumor-induced angiogenesis in adenoid cystic carcinoma: its suppression by isoliquiritigenin through dual activation of c-Jun NH2-terminal kinase and inhibition of extracellular signal-regulated kinase. | 2010 | J. Pharmacol. Exp. Ther. | pmid:20484154 |
| Youns M et al. | Sensitivity and resistance towards isoliquiritigenin, doxorubicin and methotrexate in T cell acute lymphoblastic leukaemia cell lines by pharmacogenomics. | 2010 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:20668838 |
| Cao L et al. | In vitro screening for angiostatic potential of herbal chemicals. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20671276 |
| Park SJ and Youn HS | Suppression of homodimerization of toll-like receptor 4 by isoliquiritigenin. | 2010 | Phytochemistry | pmid:20701936 |
| Gaur R et al. | Liquiritigenin derivatives and their hepatotoprotective activity. | 2010 | Nat Prod Commun | pmid:20839627 |
| Kim YM et al. | Inhibition of liver X receptor-α-dependent hepatic steatosis by isoliquiritigenin, a licorice antioxidant flavonoid, as mediated by JNK1 inhibition. | 2010 | Free Radic. Biol. Med. | pmid:20840863 |
| Chandrasekaran CV et al. | Dual inhibitory effect of Glycyrrhiza glabra (GutGardâ„¢) on COX and LOX products. | 2011 | Phytomedicine | pmid:20864324 |
| Zorko BA et al. | Effects of ILTG on DAPK1 promoter methylation in colon and leukemia cancer cell lines. | 2010 | Anticancer Res. | pmid:21036707 |
| Srinivasan B et al. | Chalcone-based inhibitors against hypoxia-inducible factor 1--structure activity relationship studies. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21112783 |
| Aida K et al. | Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix. | 1990 | Planta Med. | pmid:2118267 |
| Birari RB et al. | Antiobesity and lipid lowering effects of Glycyrrhiza chalcones: experimental and computational studies. | 2011 | Phytomedicine | pmid:21315569 |
| Thiyagarajan P et al. | Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents. | 2011 | Inflammopharmacology | pmid:21328091 |
| Kawakami Z et al. | Isoliquiritigenin is a novel NMDA receptor antagonist in kampo medicine yokukansan. | 2011 | Cell. Mol. Neurobiol. | pmid:21691759 |
| Jhanji V et al. | Isoliquiritigenin from licorice root suppressed neovascularisation in experimental ocular angiogenesis models. | 2011 | Br J Ophthalmol | pmid:21719569 |
| Sano S et al. | Reinvestigation of the synthesis of isoliquiritigenin: application of Horner-Wadsworth-Emmons reaction and Claisen-Schmidt condensation. | 2011 | Chem. Pharm. Bull. | pmid:21720042 |
| Yang H et al. | Isoliquiritigenin (4,2',4'-trihydroxychalcone): a new matrix-assisted laser desorption/ionization matrix with outstanding properties for the analysis of neutral oligosaccharides. | 2011 | Anal. Chim. Acta | pmid:21763807 |
| Cui FC et al. | Elucidation of the methyl transfer mechanism catalyzed by chalcone O-methyltransferase: a density functional study. | 2011 | J Comput Chem | pmid:21815175 |
| Feldman M et al. | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. | 2011 | J. Nat. Prod. | pmid:21866899 |
| Cho S et al. | Isoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABAA receptors and shows hypnotic effects. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21945440 |
| Chen G et al. | Mammalian target of rapamycin regulates isoliquiritigenin-induced autophagic and apoptotic cell death in adenoid cystic carcinoma cells. | 2012 | Apoptosis | pmid:21956714 |
| Han B et al. | Determination of isoliquiritigenin and its distribution in mice by synchronous fluorescence spectrometry. | 2011 | Anal Sci | pmid:22076338 |
| Muanprasat C et al. | Novel action of the chalcone isoliquiritigenin as a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor: potential therapy for cholera and polycystic kidney disease. | 2012 | J. Pharmacol. Sci. | pmid:22186622 |
| Shi Y et al. | Analgesic and uterine relaxant effects of isoliquiritigenin, a flavone from Glycyrrhiza glabra. | 2012 | Phytother Res | pmid:22389128 |
| Honda H et al. | Glycyrrhizin and isoliquiritigenin suppress the LPS sensor toll-like receptor 4/MD-2 complex signaling in a different manner. | 2012 | J. Leukoc. Biol. | pmid:22422925 |
| Liu MM et al. | Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy. | 2012 | Eur J Med Chem | pmid:22445328 |
| Hwang CK and Chun HS | Isoliquiritigenin isolated from licorice Glycyrrhiza uralensis prevents 6-hydroxydopamine-induced apoptosis in dopaminergic neurons. | 2012 | Biosci. Biotechnol. Biochem. | pmid:22451397 |
| Li X et al. | A new flavonol from Oxytropis ochrocephala Bunge. | 2013 | Nat. Prod. Res. | pmid:22494026 |
| Zhu L et al. | Licorice isoliquiritigenin suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo. | 2012 | Int. J. Biochem. Cell Biol. | pmid:22521613 |
| Yang EJ et al. | Isoliquiritigenin isolated from Glycyrrhiza uralensis protects neuronal cells against glutamate-induced mitochondrial dysfunction. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22538371 |
| Lee HK et al. | Inhibitory effects of Glycyrrhizae radix and its active component, isoliquiritigenin, on Aβ(25-35)-induced neurotoxicity in cultured rat cortical neurons. | 2012 | Arch. Pharm. Res. | pmid:22644857 |
| Chen X et al. | Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. | 2012 | J. Mol. Med. | pmid:22648519 |
| Yuan X et al. | Isoliquiritigenin treatment induces apoptosis by increasing intracellular ROS levels in HeLa cells. | 2012 | J Asian Nat Prod Res | pmid:22694287 |
| Fioravanti R et al. | Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action. | 2012 | Bioorg. Med. Chem. | pmid:22743086 |
| Khamsan S et al. | The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry. | 2012 | Acta Pharm | pmid:22750816 |
| Yang YM et al. | Decrease of microRNA-122 causes hepatic insulin resistance by inducing protein tyrosine phosphatase 1B, which is reversed by licorice flavonoid. | 2012 | Hepatology | pmid:22807119 |
| Yuan X et al. | Involvement of endoplasmic reticulum stress in isoliquiritigenin-induced SKOV-3 cell apoptosis. | 2013 | Recent Pat Anticancer Drug Discov | pmid:22963151 |
| Lee JE et al. | Molecular signatures in response to Isoliquiritigenin in lymphoblastoid cell lines. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22995316 |
| Hong H et al. | Rat α-Fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities. | 2012 | Chem. Res. Toxicol. | pmid:23013281 |
| Sun C et al. | Isoliquiritigenin enhances radiosensitivity of HepG2 cells via disturbance of redox status. | 2013 | Cell Biochem. Biophys. | pmid:23086355 |
| Chen H et al. | NADPH oxidase-derived reactive oxygen species are involved in the HL-60 cell monocytic differentiation induced by isoliquiritigenin. | 2012 | Molecules | pmid:23147401 |
| Lee KK et al. | Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix. | 2013 | J Ethnopharmacol | pmid:23164761 |
| Yang N et al. | Glycyrrhiza uralensis flavonoids present in anti-asthma formula, ASHMIâ„¢, inhibit memory Th2 responses in vitro and in vivo. | 2013 | Phytother Res | pmid:23165939 |
| Zhou GS et al. | Isoliquiritigenin inhibits proliferation and induces apoptosis of U87 human glioma cells in vitro. | 2013 | Mol Med Rep | pmid:23229626 |
| Lu H et al. | Isoliquiritigenin showed strong inhibitory effects towards multiple UDP-glucuronosyltransferase (UGT) isoform-catalyzed 4-methylumbelliferone (4-MU) glucuronidation. | 2013 | Fitoterapia | pmid:23237733 |
| Yang L et al. | Development of sample preparation method for isoliquiritigenin, liquiritin, and glycyrrhizic acid analysis in licorice by ionic liquids-ultrasound based extraction and high-performance liquid chromatography detection. | 2013 | Food Chem | pmid:23265473 |
| Chen X et al. | Isoliquiritigenin-induced differentiation in mouse melanoma B16F0 cell line. | 2012 | Oxid Med Cell Longev | pmid:23304254 |
| Wang KL et al. | Inhibitory effects of isoliquiritigenin on the migration and invasion of human breast cancer cells. | 2013 | Expert Opin. Ther. Targets | pmid:23327692 |
| Han SY et al. | A new approach for pharmacokinetic studies of natural products: measurement of isoliquiritigenin levels in mice plasma, urine and feces using modified automated dosing/blood sampling system. | 2013 | Biomed. Chromatogr. | pmid:23339046 |
| Lee SK et al. | The inhibitory effect of roasted licorice extract on human metastatic breast cancer cell-induced bone destruction. | 2013 | Phytother Res | pmid:23401151 |
| Lorusso V and Marech I | Novel plant-derived target drugs: a step forward from licorice? | 2013 | Expert Opin. Ther. Targets | pmid:23425066 |
| Simmler C et al. | Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay. | 2013 | J. Agric. Food Chem. | pmid:23427769 |
| Robb EL and Stuart JA | Multiple phytoestrogens inhibit cell growth and confer cytoprotection by inducing manganese superoxide dismutase expression. | 2014 | Phytother Res | pmid:23526725 |
| Yuan X et al. | Involvement of the mitochondrion-dependent and the endoplasmic reticulum stress-signaling pathways in isoliquiritigenin-induced apoptosis of HeLa cell. | 2013 | Biomed. Environ. Sci. | pmid:23534467 |
| Zhang XY et al. | Preparation of isoliquiritigenin-loaded nanostructured lipid carrier and the in vivo evaluation in tumor-bearing mice. | 2013 | Eur J Pharm Sci | pmid:23624327 |
| Li Y et al. | Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23747687 |
| Arai T et al. | Rikkunshito and isoliquiritigenin counteract 5-HT-induced 2C receptor-mediated activation of pro-opiomelanocortin neurons in the hypothalamic arcuate nucleus. | 2013 | Neuropeptides | pmid:23756052 |
| Chen YP et al. | Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase. | 2013 | Eur J Med Chem | pmid:23786711 |
| Robinson SJ et al. | Selected furanochalcones as inhibitors of monoamine oxidase. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23860591 |
| Wang Z et al. | Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway. | 2013 | PLoS ONE | pmid:23861918 |
| Hajirahimkhan A et al. | Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms. | 2013 | PLoS ONE | pmid:23874474 |
| Chen H et al. | Isoliquiritigenin-induced effects on Nrf2 mediated antioxidant defence in the HL-60 cell monocytic differentiation. | 2013 | Cell Biol. Int. | pmid:23881796 |
| Zhao H et al. | Isoliquiritigen enhances the antitumour activity and decreases the genotoxic effect of cyclophosphamide. | 2013 | Molecules | pmid:23887720 |
| Foresti R et al. | Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells. | 2013 | Pharmacol. Res. | pmid:23942037 |
| Qiao H et al. | Pharmacokinetics, biodistribution and bioavailability of isoliquiritigenin after intravenous and oral administration. | 2014 | Pharm Biol | pmid:24102672 |
| Lee YK et al. | Pharmacokinetics of isoliquiritigenin and its metabolites in rats: low bioavailability is primarily due to the hepatic and intestinal metabolism. | 2013 | Planta Med. | pmid:24108436 |
| Zhang X et al. | Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway. | 2013 | Mediators Inflamm. | pmid:24163504 |
| Hirchaud F et al. | Isoliquiritigenin induces caspase-dependent apoptosis via downregulation of HPV16 E6 expression in cervical cancer Ca Ski cells. | 2013 | Planta Med. | pmid:24214831 |
| Zhou Y and Ho WS | Combination of liquiritin, isoliquiritin and isoliquirigenin induce apoptotic cell death through upregulating p53 and p21 in the A549 non-small cell lung cancer cells. | 2014 | Oncol. Rep. | pmid:24247527 |
| Gaur R et al. | In vivo anti-diabetic activity of derivatives of isoliquiritigenin and liquiritigenin. | 2014 | Phytomedicine | pmid:24262065 |
| Yamada C et al. | Rikkunshito, a Japanese kampo medicine, ameliorates decreased feeding behavior via ghrelin and serotonin 2B receptor signaling in a novelty stress murine model. | 2013 | Biomed Res Int | pmid:24288687 |
| Kim SJ et al. | Synthesis of licochalcone analogues with increased anti-inflammatory activity. | 2014 | Bioorg. Med. Chem. Lett. | pmid:24316124 |
| Sunkaria A et al. | 4-Hydroxy TEMPO attenuates dichlorvos induced microglial activation and apoptosis. | 2014 | ACS Chem Neurosci | pmid:24369695 |
| Adianti M et al. | Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species. | 2014 | Microbiol. Immunol. | pmid:24397541 |
| Welle R and Grisebach H | Phytoalexin synthesis in soybean cells: elicitor induction of reductase involved in biosynthesis of 6'-deoxychalcone. | 1989 | Arch. Biochem. Biophys. | pmid:2500065 |
| Wang Z et al. | MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin. | 2014 | Oncotarget | pmid:25026296 |
| Zhao H et al. | Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6. | 2014 | Toxicol. Appl. Pharmacol. | pmid:25026504 |
| Zheng H et al. | Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion. | 2014 | Toxicol. Appl. Pharmacol. | pmid:25094029 |
| Wong TY et al. | The licorice flavonoid isoliquiritigenin reduces DNA-binding activity of AhR in MCF-7 cells. | 2014 | Chem. Biol. Interact. | pmid:25110319 |
| Wang N et al. | Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling. | 2014 | Carcinogenesis | pmid:25194164 |
| Honda H et al. | Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation. | 2014 | J. Leukoc. Biol. | pmid:25210146 |
| Fu H et al. | Synthesis and anti-tumor activity of novel aminomethylated derivatives of isoliquiritigenin. | 2014 | Molecules | pmid:25365296 |
| Jung SK et al. | Isoliquiritigenin induces apoptosis and inhibits xenograft tumor growth of human lung cancer cells by targeting both wild type and L858R/T790M mutant EGFR. | 2014 | J. Biol. Chem. | pmid:25368326 |
| Zhao Z et al. | Isoliquiritigenin attenuates oxidative hepatic damage induced by carbon tetrachloride with or without buthionine sulfoximine. | 2015 | Chem. Biol. Interact. | pmid:25450236 |
| Gong H et al. | A protective mechanism of licorice (Glycyrrhiza uralensis): isoliquiritigenin stimulates detoxification system via Nrf2 activation. | 2015 | J Ethnopharmacol | pmid:25557030 |
| Hsia SM et al. | Isoliquiritigenin as a cause of DNA damage and inhibitor of ataxia-telangiectasia mutated expression leading to G2/M phase arrest and apoptosis in oral squamous cell carcinoma. | 2016 | Head Neck | pmid:25580586 |
| Kwon SS et al. | Physicochemical properties of pH-sensitive hydrogels based on hydroxyethyl cellulose-hyaluronic acid and for applications as transdermal delivery systems for skin lesions. | 2015 | Eur J Pharm Biopharm | pmid:25753198 |
| Link P et al. | Extracts of Glycyrrhiza uralensis and isoliquiritigenin counteract amyloid-β toxicity in Caenorhabditis elegans. | 2015 | Planta Med. | pmid:25782036 |
| Wang R et al. | Flavonoids derived from liquorice suppress murine macrophage activation by up-regulating heme oxygenase-1 independent of Nrf2 activation. | 2015 | Int. Immunopharmacol. | pmid:25871879 |
| Choi YH et al. | In vivo gastroprotective effect along with pharmacokinetics, tissue distribution and metabolism of isoliquiritigenin in mice. | 2015 | Planta Med. | pmid:25875506 |
| Zhou B et al. | The influence of compatibility of processed radix Aconiti Kusnezoffii on the pharmacokinetic of four components in Glycyrrhiza uralensis Fisch. | 2015 | J Ethnopharmacol | pmid:25889555 |
| Peng F et al. | A Review: The Pharmacology of Isoliquiritigenin. | 2015 | Phytother Res | pmid:25907962 |
| Wang N et al. | Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation. | 2015 | Oncotarget | pmid:25918249 |
| Tian WW et al. | [Isoliquiritigenin relaxes the cerebral basilar artery by enhancing BKCa current in spontaneously hypertensive rat: role of sGC/cGMP]. | 2015 | Sheng Li Xue Bao | pmid:26109306 |
| Dunlap TL et al. | Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It. | 2015 | Chem. Res. Toxicol. | pmid:26134484 |
| Li ZX et al. | Novel insights into the apoptosis mechanism of DNA topoisomerase I inhibitor isoliquiritigenin on HCC tumor cell. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26159926 |
| Kitagawa H et al. | Pharmacokinetic Profiles of Active Ingredients and Its Metabolites Derived from Rikkunshito, a Ghrelin Enhancer, in Healthy Japanese Volunteers: A Cross-Over, Randomized Study. | 2015 | PLoS ONE | pmid:26186592 |
| Ma X et al. | The effect of isoliquiritigenin on learning and memory impairments induced by high-fat diet via inhibiting TNF-α/JNK/IRS signaling. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26188513 |
| Li B et al. | Experimental and Theoretical Investigations on the Supermolecular Structure of Isoliquiritigenin and 6-O-α-D-Maltosyl-β-cyclodextrin Inclusion Complex. | 2015 | Int J Mol Sci | pmid:26247946 |
| Traboulsi H et al. | The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection. | 2015 | Antimicrob. Agents Chemother. | pmid:26248373 |
| Ng JL et al. | Flavonoids and Auxin Transport Inhibitors Rescue Symbiotic Nodulation in the Medicago truncatula Cytokinin Perception Mutant cre1. | 2015 | Plant Cell | pmid:26253705 |