| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
isoliquiritigenin
Isoliquiritigenin is a lipid of Polyketides (PK) class. Isoliquiritigenin is associated with abnormalities such as abnormal fragmented structure, Gastric ulcer, Gastric mucosa lesion, Peptic Ulcer and Wiskott-Aldrich Syndrome. The involved functions are known as Mass-to-Charge Ratio, Anabolism, Oxidation, inhibitors and Energy Absorption. Isoliquiritigenin often locates in Microsomes, Liver, Hepatic, Microsomes, Immune system and Vacuole. The associated genes with Isoliquiritigenin are P4HTM gene, BCL2 gene, AP1AR gene, oxytocin, 1-desamino-(O-Et-Tyr)(2)- and ODAM gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of isoliquiritigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with isoliquiritigenin?
isoliquiritigenin is suspected in Gastric mucosa lesion, Gastric ulcer, Peptic Ulcer, Nodule, Infertility and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with isoliquiritigenin
PubChem Associated disorders and diseases
What pathways are associated with isoliquiritigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with isoliquiritigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with isoliquiritigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with isoliquiritigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with isoliquiritigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with isoliquiritigenin?
Knock-out
Knock-out are used in the study 'Two activators of in vitro fertilization in mice from licorice.' (Tung NH et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with isoliquiritigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhan C and Yang J | Protective effects of isoliquiritigenin in transient middle cerebral artery occlusion-induced focal cerebral ischemia in rats. | 2006 | Pharmacol. Res. | pmid:16459097 |
| Li H et al. | Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 | J. Mol. Graph. Model. | pmid:16497524 |
| Jung JI et al. | Isoliquiritigenin induces apoptosis by depolarizing mitochondrial membranes in prostate cancer cells. | 2006 | J. Nutr. Biochem. | pmid:16517140 |
| Cuendet M et al. | Quinone reductase induction as a biomarker for cancer chemoprevention. | 2006 | J. Nat. Prod. | pmid:16562858 |
| Kim DC et al. | Isoliquiritigenin selectively inhibits H(2) histamine receptor signaling. | 2006 | Mol. Pharmacol. | pmid:16675659 |
| An W et al. | Metallothionein mediates cardioprotection of isoliquiritigenin against ischemia-reperfusion through JAK2/STAT3 activation. | 2006 | Acta Pharmacol. Sin. | pmid:17049118 |
| Sato Y et al. | Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. | 2007 | Biol. Pharm. Bull. | pmid:17202675 |
| Kwon HM et al. | Blockade of cytokine-induced endothelial cell adhesion molecule expression by licorice isoliquiritigenin through NF-kappaB signal disruption. | 2007 | Exp. Biol. Med. (Maywood) | pmid:17259331 |
| Smith AD and Dar MS | Involvement of the alpha4beta2 nicotinic receptor subtype in nicotine-induced attenuation of delta9-THC cerebellar ataxia: role of cerebellar nitric oxide. | 2007 | Pharmacol. Biochem. Behav. | pmid:17275078 |
| Kumar S et al. | Isoliquiritigenin inhibits IkappaB kinase activity and ROS generation to block TNF-alpha induced expression of cell adhesion molecules on human endothelial cells. | 2007 | Biochem. Pharmacol. | pmid:17276410 |
| Jung JI et al. | Isoliquiritigenin (ISL) inhibits ErbB3 signaling in prostate cancer cells. | 2006 | Biofactors | pmid:17473376 |
| Chin YW et al. | Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra). | 2007 | J. Agric. Food Chem. | pmid:17516657 |
| Ruiz-PernÃa JJ et al. | Enzymatic effects on reactant and transition states. The case of chalcone isomerase. | 2007 | J. Am. Chem. Soc. | pmid:17602559 |
| Xie J et al. | Simultaneous analysis of glycyrrhizin, paeoniflorin, quercetin, ferulic acid, liquiritin, formononetin, benzoic acid and isoliquiritigenin in the Chinese proprietary medicine Xiao Yao Wan by HPLC. | 2007 | J Pharm Biomed Anal | pmid:17709224 |
| Brown AK et al. | Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II. | 2007 | Microbiology (Reading, Engl.) | pmid:17906131 |
| Guo J et al. | In vitro metabolism of isoliquiritigenin by human liver microsomes. | 2008 | Drug Metab. Dispos. | pmid:18006650 |
| Deng Y et al. | Anthraquinones with quinone reductase-inducing activity and benzophenones from Morinda citrifolia (noni) roots. | 2007 | J. Nat. Prod. | pmid:18076142 |
| Hattori T et al. | Saireito probably prevents mesangial cell proliferation in HIGA mice via PDGF-BB tyrosine kinase inhibition. | 2007 | Clin. Exp. Nephrol. | pmid:18085387 |
| Chen S et al. | Down-regulation of androgen-receptor and PSA by phytochemicals. | 2008 | Int. J. Oncol. | pmid:18202763 |
| Kim JY et al. | Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-kappaB in RAW 264.7 macrophages. | 2008 | Eur. J. Pharmacol. | pmid:18295200 |