| MeSH term | MeSH ID | Detail |
|---|---|---|
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
| Choroidal Neovascularization | D020256 | 5 associated lipids |
isoliquiritigenin
Isoliquiritigenin is a lipid of Polyketides (PK) class. Isoliquiritigenin is associated with abnormalities such as abnormal fragmented structure, Gastric ulcer, Gastric mucosa lesion, Peptic Ulcer and Wiskott-Aldrich Syndrome. The involved functions are known as Mass-to-Charge Ratio, Anabolism, Oxidation, inhibitors and Energy Absorption. Isoliquiritigenin often locates in Microsomes, Liver, Hepatic, Microsomes, Immune system and Vacuole. The associated genes with Isoliquiritigenin are P4HTM gene, BCL2 gene, AP1AR gene, oxytocin, 1-desamino-(O-Et-Tyr)(2)- and ODAM gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of isoliquiritigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with isoliquiritigenin?
isoliquiritigenin is suspected in Gastric mucosa lesion, Gastric ulcer, Peptic Ulcer, Nodule, Infertility and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with isoliquiritigenin
PubChem Associated disorders and diseases
What pathways are associated with isoliquiritigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with isoliquiritigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with isoliquiritigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with isoliquiritigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with isoliquiritigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with isoliquiritigenin?
Knock-out
Knock-out are used in the study 'Two activators of in vitro fertilization in mice from licorice.' (Tung NH et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with isoliquiritigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dinkova-Kostova AT et al. | Chemoprotective properties of phenylpropenoids, bis(benzylidene)cycloalkanones, and related Michael reaction acceptors: correlation of potencies as phase 2 enzyme inducers and radical scavengers. | 1998 | J. Med. Chem. | pmid:9857096 |
| Li H et al. | Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 | J. Mol. Graph. Model. | pmid:16497524 |
| Wu Y et al. | Isoliquiritigenin prevents the progression of psoriasis-like symptoms by inhibiting NF-κB and proinflammatory cytokines. | 2016 | J. Mol. Med. | pmid:26383911 |
| Chen X et al. | Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. | 2012 | J. Mol. Med. | pmid:22648519 |
| Peng F et al. | Cytotoxic Evaluation against Breast Cancer Cells of Isoliquiritigenin Analogues from Spatholobus suberectus and Their Synthetic Derivatives. | 2016 | J. Nat. Prod. | pmid:26690274 |
| Youn UJ et al. | Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides. | 2009 | J. Nat. Prod. | pmid:19757853 |
| Feldman M et al. | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. | 2011 | J. Nat. Prod. | pmid:21866899 |
| Deng Y et al. | Anthraquinones with quinone reductase-inducing activity and benzophenones from Morinda citrifolia (noni) roots. | 2007 | J. Nat. Prod. | pmid:18076142 |
| Cuendet M et al. | Quinone reductase induction as a biomarker for cancer chemoprevention. | 2006 | J. Nat. Prod. | pmid:16562858 |
| Boyapelly K et al. | Synthesis and Characterization of a Phosphate Prodrug of Isoliquiritigenin. | 2017 | J. Nat. Prod. | pmid:28252963 |
| Kwon GT et al. | Isoliquiritigenin inhibits migration and invasion of prostate cancer cells: possible mediation by decreased JNK/AP-1 signaling. | 2009 | J. Nutr. Biochem. | pmid:18824345 |
| Kang SW et al. | Licorice isoliquiritigenin dampens angiogenic activity via inhibition of MAPK-responsive signaling pathways leading to induction of matrix metalloproteinases. | 2010 | J. Nutr. Biochem. | pmid:19157825 |
| Jung JI et al. | Isoliquiritigenin induces apoptosis by depolarizing mitochondrial membranes in prostate cancer cells. | 2006 | J. Nutr. Biochem. | pmid:16517140 |
| Yerra VG et al. | Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy. | 2017 | J. Nutr. Biochem. | pmid:28528294 |
| Sun ZJ et al. | Mammalian target of rapamycin pathway promotes tumor-induced angiogenesis in adenoid cystic carcinoma: its suppression by isoliquiritigenin through dual activation of c-Jun NH2-terminal kinase and inhibition of extracellular signal-regulated kinase. | 2010 | J. Pharmacol. Exp. Ther. | pmid:20484154 |
| Noguchi C et al. | Inhibitory effects of isoliquiritigenin and licorice extract on voltage-dependent K(+) currents in H9c2 cells. | 2008 | J. Pharmacol. Sci. | pmid:19098391 |
| Lee MJ et al. | Protective effects of isoliquiritigenin against methamphetamine-induced neurotoxicity in mice. | 2009 | J. Pharmacol. Sci. | pmid:19834288 |
| Lee CK et al. | Isoliquiritigenin inhibits tumor growth and protects the kidney and liver against chemotherapy-induced toxicity in a mouse xenograft model of colon carcinoma. | 2008 | J. Pharmacol. Sci. | pmid:18360095 |
| Muanprasat C et al. | Novel action of the chalcone isoliquiritigenin as a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor: potential therapy for cholera and polycystic kidney disease. | 2012 | J. Pharmacol. Sci. | pmid:22186622 |
| Jeon JP et al. | Proteomic and behavioral analysis of response to isoliquiritigenin in brains of acute cocaine treated rats. | 2008 | J. Proteome Res. | pmid:19367698 |