| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
isoliquiritigenin
Isoliquiritigenin is a lipid of Polyketides (PK) class. Isoliquiritigenin is associated with abnormalities such as abnormal fragmented structure, Gastric ulcer, Gastric mucosa lesion, Peptic Ulcer and Wiskott-Aldrich Syndrome. The involved functions are known as Mass-to-Charge Ratio, Anabolism, Oxidation, inhibitors and Energy Absorption. Isoliquiritigenin often locates in Microsomes, Liver, Hepatic, Microsomes, Immune system and Vacuole. The associated genes with Isoliquiritigenin are P4HTM gene, BCL2 gene, AP1AR gene, oxytocin, 1-desamino-(O-Et-Tyr)(2)- and ODAM gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of isoliquiritigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with isoliquiritigenin?
isoliquiritigenin is suspected in Gastric mucosa lesion, Gastric ulcer, Peptic Ulcer, Nodule, Infertility and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with isoliquiritigenin
PubChem Associated disorders and diseases
What pathways are associated with isoliquiritigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with isoliquiritigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with isoliquiritigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with isoliquiritigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with isoliquiritigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with isoliquiritigenin?
Knock-out
Knock-out are used in the study 'Two activators of in vitro fertilization in mice from licorice.' (Tung NH et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with isoliquiritigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Khamsan S et al. | The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry. | 2012 | Acta Pharm | pmid:22750816 |
| Honda H et al. | Glycyrrhizin and isoliquiritigenin suppress the LPS sensor toll-like receptor 4/MD-2 complex signaling in a different manner. | 2012 | J. Leukoc. Biol. | pmid:22422925 |
| Srinivasan B et al. | Chalcone-based inhibitors against hypoxia-inducible factor 1--structure activity relationship studies. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21112783 |
| Kawakami Z et al. | Isoliquiritigenin is a novel NMDA receptor antagonist in kampo medicine yokukansan. | 2011 | Cell. Mol. Neurobiol. | pmid:21691759 |
| Birari RB et al. | Antiobesity and lipid lowering effects of Glycyrrhiza chalcones: experimental and computational studies. | 2011 | Phytomedicine | pmid:21315569 |
| Han B et al. | Determination of isoliquiritigenin and its distribution in mice by synchronous fluorescence spectrometry. | 2011 | Anal Sci | pmid:22076338 |
| Yang H et al. | Isoliquiritigenin (4,2',4'-trihydroxychalcone): a new matrix-assisted laser desorption/ionization matrix with outstanding properties for the analysis of neutral oligosaccharides. | 2011 | Anal. Chim. Acta | pmid:21763807 |
| Feldman M et al. | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. | 2011 | J. Nat. Prod. | pmid:21866899 |
| Cui FC et al. | Elucidation of the methyl transfer mechanism catalyzed by chalcone O-methyltransferase: a density functional study. | 2011 | J Comput Chem | pmid:21815175 |
| Jhanji V et al. | Isoliquiritigenin from licorice root suppressed neovascularisation in experimental ocular angiogenesis models. | 2011 | Br J Ophthalmol | pmid:21719569 |
| Sano S et al. | Reinvestigation of the synthesis of isoliquiritigenin: application of Horner-Wadsworth-Emmons reaction and Claisen-Schmidt condensation. | 2011 | Chem. Pharm. Bull. | pmid:21720042 |
| Cho S et al. | Isoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABAA receptors and shows hypnotic effects. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21945440 |
| Thiyagarajan P et al. | Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents. | 2011 | Inflammopharmacology | pmid:21328091 |
| Chandrasekaran CV et al. | Dual inhibitory effect of Glycyrrhiza glabra (GutGardâ„¢) on COX and LOX products. | 2011 | Phytomedicine | pmid:20864324 |
| Kang SW et al. | Licorice isoliquiritigenin dampens angiogenic activity via inhibition of MAPK-responsive signaling pathways leading to induction of matrix metalloproteinases. | 2010 | J. Nutr. Biochem. | pmid:19157825 |
| Park SJ and Youn HS | Isoliquiritigenin suppresses the Toll-interleukin-1 receptor domain-containing adapter inducing interferon-beta (TRIF)-dependent signaling pathway of Toll-like receptors by targeting TBK1. | 2010 | J. Agric. Food Chem. | pmid:20356041 |
| Sun ZJ et al. | Mammalian target of rapamycin pathway promotes tumor-induced angiogenesis in adenoid cystic carcinoma: its suppression by isoliquiritigenin through dual activation of c-Jun NH2-terminal kinase and inhibition of extracellular signal-regulated kinase. | 2010 | J. Pharmacol. Exp. Ther. | pmid:20484154 |
| Zhang X et al. | Isoliquiritigenin, a natural anti-oxidant, selectively inhibits the proliferation of prostate cancer cells. | 2010 | Clin. Exp. Pharmacol. Physiol. | pmid:20456427 |
| Li J et al. | Isoliquiritigenin entails blockade of TGF-beta1-SMAD signaling for retarding high glucose-induced mesangial matrix accumulation. | 2010 | J. Agric. Food Chem. | pmid:20146476 |
| Cuendet M et al. | Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice. | 2010 | Cancer Prev Res (Phila) | pmid:20068129 |