isoliquiritigenin

Isoliquiritigenin is a lipid of Polyketides (PK) class. Isoliquiritigenin is associated with abnormalities such as abnormal fragmented structure, Gastric ulcer, Gastric mucosa lesion, Peptic Ulcer and Wiskott-Aldrich Syndrome. The involved functions are known as Mass-to-Charge Ratio, Anabolism, Oxidation, inhibitors and Energy Absorption. Isoliquiritigenin often locates in Microsomes, Liver, Hepatic, Microsomes, Immune system and Vacuole. The associated genes with Isoliquiritigenin are P4HTM gene, BCL2 gene, AP1AR gene, oxytocin, 1-desamino-(O-Et-Tyr)(2)- and ODAM gene. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of isoliquiritigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with isoliquiritigenin?

isoliquiritigenin is suspected in Gastric mucosa lesion, Gastric ulcer, Peptic Ulcer, Nodule, Infertility and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with isoliquiritigenin

MeSH term MeSH ID Detail
Weight Loss D015431 56 associated lipids
Choroidal Neovascularization D020256 5 associated lipids
Carcinoma, Adenoid Cystic D003528 3 associated lipids
Per page 10 20 | Total 13

PubChem Associated disorders and diseases

What pathways are associated with isoliquiritigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with isoliquiritigenin?

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What functions are associated with isoliquiritigenin?


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Function Cross reference Weighted score Related literatures

What lipids are associated with isoliquiritigenin?

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What genes are associated with isoliquiritigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with isoliquiritigenin?

Knock-out

Knock-out are used in the study 'Two activators of in vitro fertilization in mice from licorice.' (Tung NH et al., 2015).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with isoliquiritigenin

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Authors Title Published Journal PubMed Link
Negi S et al. Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules. 2018 Toxicol In Vitro pmid:29933105
Chen J et al. Isoliquiritigenin Suppresses Osteosarcoma U2OS Cell Proliferation and Invasion by Regulating the PI3K/Akt Signalling Pathway. 2018 Chemotherapy pmid:29936511
Liu X et al. Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 Pathway. 2018 Oxid Med Cell Longev pmid:29854090
Nakamura S et al. Isoliquiritigenin Ameliorates Indomethacin-Induced Small Intestinal Damage by Inhibiting NOD-Like Receptor Family, Pyrin Domain-Containing 3 Inflammasome Activation. 2018 Pharmacology pmid:29393276
Zhang B et al. Antineoplastic activity of isoliquiritigenin, a chalcone compound, in androgen-independent human prostate cancer cells linked to G2/M cell cycle arrest and cell apoptosis. 2018 Eur. J. Pharmacol. pmid:29277717
Lin Y et al. Isoliquiritigenin inhibits the proliferation and induces the differentiation of human glioma stem cells. 2018 Oncol. Rep. pmid:29251326
Yang Z et al. Autophagy participates in isoliquiritigenin-induced melanin degradation in human epidermal keratinocytes through PI3K/AKT/mTOR signaling. 2018 Biomed. Pharmacother. pmid:29091873
Li Y et al. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. 2018 Toxicol. Lett. pmid:29753067
Lian D et al. Cathepsin B-Mediated NLRP3 Inflammasome Formation and Activation in Angiotensin II -Induced Hypertensive Mice: Role of Macrophage Digestion Dysfunction. 2018 Cell. Physiol. Biochem. pmid:30359991
Chen C et al. Suppression of lung cancer progression by isoliquiritigenin through its metabolite 2, 4, 2', 4'-Tetrahydroxychalcone. 2018 J. Exp. Clin. Cancer Res. pmid:30285892
Sechet E et al. Natural molecules induce and synergize to boost expression of the human antimicrobial peptide β-defensin-3. 2018 Proc. Natl. Acad. Sci. U.S.A. pmid:30275324
Zhang XR et al. Isoliquiritigenin inhibits proliferation and metastasis of MKN28 gastric cancer cells by suppressing the PI3K/AKT/mTOR signaling pathway. 2018 Mol Med Rep pmid:30066879
Zhang W et al. Protective Effects of Isoliquiritigenin on LPS-Induced Acute Lung Injury by Activating PPAR-γ. 2018 Inflammation pmid:29654430
Ji B et al. Isoliquiritigenin blunts osteoarthritis by inhibition of bone resorption and angiogenesis in subchondral bone. 2018 Sci Rep pmid:29379010
Chen X et al. Isoliquiritigenin protects against sepsis-induced lung and liver injury by reducing inflammatory responses. 2018 Biochem. Biophys. Res. Commun. pmid:29180018
Yan F et al. Isoliquiritigenin suppresses human T Lymphocyte activation via covalently binding cysteine 46 of IκB kinase. 2017 Oncotarget pmid:27626700
Genthe JR et al. Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway. 2017 ACS Chem. Biol. pmid:28787124
Gao F et al. iRGD-modified lipid-polymer hybrid nanoparticles loaded with isoliquiritigenin to enhance anti-breast cancer effect and tumor-targeting ability. 2017 Int J Nanomedicine pmid:28615942
Hou C et al. Synthetic Isoliquiritigenin Inhibits Human Tongue Squamous Carcinoma Cells through Its Antioxidant Mechanism. 2017 Oxid Med Cell Longev pmid:28203317
Yu H et al. Effect of isoliquiritigenin for the treatment of atopic dermatitis-like skin lesions in mice. 2017 Arch. Dermatol. Res. pmid:29026975
Chen HY et al. Isoliquiritigenin Induces Autophagy and Inhibits Ovarian Cancer Cell Growth. 2017 Int J Mol Sci pmid:28934130
Chen T et al. The inhibitory effect of Isoliquiritigenin on the proliferation of human arterial smooth muscle cell. 2017 BMC Pharmacol Toxicol pmid:28716056
Yerra VG et al. Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy. 2017 J. Nutr. Biochem. pmid:28528294
Bueno-Silva B et al. The effect of seasons on Brazilian red propolis and its botanical source: chemical composition and antibacterial activity. 2017 Nat. Prod. Res. pmid:27701899
Wu N et al. Construction of a chalcone reductase expression vector and transformation of soybean plants. 2017 Mol Med Rep pmid:28901382
Kuang Y et al. Screening of hepatoprotective compounds from licorice against carbon tetrachloride and acetaminophen induced HepG2 cells injury. 2017 Phytomedicine pmid:28899510
Patricia Moreno-Londoño A et al. Isoliquiritigenin pretreatment attenuates cisplatin induced proximal tubular cells (LLC-PK1) death and enhances the toxicity induced by this drug in bladder cancer T24 cell line. 2017 Food Chem. Toxicol. pmid:28870684
Zeng J et al. Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway. 2017 J Neuroinflammation pmid:28610608
Köksal Z et al. The inhibition effects of some natural products on lactoperoxidase purified from bovine milk. 2017 J. Biochem. Mol. Toxicol. pmid:28594102
Kim DH et al. Isoliquiritigenin inhibits the proliferation of human renal carcinoma Caki cells through the ROS-mediated regulation of the Jak2/STAT3 pathway. 2017 Oncol. Rep. pmid:28560439
Yang HH et al. Isoliquiritigenin Induces Cytotoxicity in PC-12 Cells In Vitro. 2017 Appl. Biochem. Biotechnol. pmid:28488118
Chen XY et al. Reprogramming induced by isoliquiritigenin diminishes melanoma cachexia through mTORC2-AKT-GSK3β signaling. 2017 Oncotarget pmid:28410220
Boyapelly K et al. Synthesis and Characterization of a Phosphate Prodrug of Isoliquiritigenin. 2017 J. Nat. Prod. pmid:28252963
Chi JH et al. Isoliquiritigenin inhibits TNF-α-induced release of high-mobility group box 1 through activation of HDAC in human intestinal epithelial HT-29 cells. 2017 Eur. J. Pharmacol. pmid:28012970
Wu M et al. Isoliquiritigenin decreases the incidence of colitis-associated colorectal cancer by modulating the intestinal microbiota. 2016 Oncotarget pmid:27863401
Wu CH et al. Isoliquiritigenin induces apoptosis and autophagy and inhibits endometrial cancer growth in mice. 2016 Oncotarget pmid:27708238
Jin XY et al. Isoliquiritigenin suppresses tumor necrosis factor-α-induced inflammation via peroxisome proliferator-activated receptor-γ in intestinal epithelial cells. 2016 Arch. Pharm. Res. pmid:27539609
Cao L- et al. Isoliquiritigenin protects against triptolide-induced hepatotoxicity in mice through Nrf2 activation. 2016 Pharmazie pmid:29441915
Kong BJ et al. Properties and in vitro drug release of hyaluronic acid-hydroxyethyl cellulose hydrogels for transdermal delivery of isoliquiritigenin. 2016 Carbohydr Polym pmid:27178954
Wang Y et al. Isoliquiritigenin Inhibits Proliferation and Induces Apoptosis via Alleviating Hypoxia and Reducing Glycolysis in Mouse Melanoma B16F10 Cells. 2016 Recent Pat Anticancer Drug Discov pmid:26951491
Liu S et al. Anti-osteoclastogenic activity of isoliquiritigenin via inhibition of NF-κB-dependent autophagic pathway. 2016 Biochem. Pharmacol. pmid:26947453
Choi YH et al. Isoliquiritigenin ameliorates dextran sulfate sodium-induced colitis through the inhibition of MAPK pathway. 2016 Int. Immunopharmacol. pmid:26771170
Peng F et al. Cytotoxic Evaluation against Breast Cancer Cells of Isoliquiritigenin Analogues from Spatholobus suberectus and Their Synthetic Derivatives. 2016 J. Nat. Prod. pmid:26690274
Park SM et al. Isoliquiritigenin in licorice functions as a hepatic protectant by induction of antioxidant genes through extracellular signal-regulated kinase-mediated NF-E2-related factor-2 signaling pathway. 2016 Eur J Nutr pmid:26593436
Denzer I et al. S-allyl-L-cysteine and isoliquiritigenin improve mitochondrial function in cellular models of oxidative and nitrosative stress. 2016 Food Chem pmid:26471626
Wu Y et al. Isoliquiritigenin prevents the progression of psoriasis-like symptoms by inhibiting NF-κB and proinflammatory cytokines. 2016 J. Mol. Med. pmid:26383911
Hsia SM et al. Isoliquiritigenin as a cause of DNA damage and inhibitor of ataxia-telangiectasia mutated expression leading to G2/M phase arrest and apoptosis in oral squamous cell carcinoma. 2016 Head Neck pmid:25580586
Yamaura K et al. Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry. 2016 Nat. Chem. Biol. pmid:27526031
Weis KE and Raetzman LT Isoliquiritigenin exhibits anti-proliferative properties in the pituitary independent of estrogen receptor function. 2016 Toxicol. Appl. Pharmacol. pmid:27702603
Du F et al. Isoliquiritigenin Attenuates Atherogenesis in Apolipoprotein E-Deficient Mice. 2016 Int J Mol Sci pmid:27869741
Molitor C et al. Aurone synthase is a catechol oxidase with hydroxylase activity and provides insights into the mechanism of plant polyphenol oxidases. 2016 Proc. Natl. Acad. Sci. U.S.A. pmid:26976571
Watanabe Y et al. Isoliquiritigenin Attenuates Adipose Tissue Inflammation in vitro and Adipose Tissue Fibrosis through Inhibition of Innate Immune Responses in Mice. 2016 Sci Rep pmid:26975571
Gaur R et al. Drug Resistance Reversal Potential of Isoliquiritigenin and Liquiritigenin Isolated from Glycyrrhiza glabra Against Methicillin-Resistant Staphylococcus aureus (MRSA). 2016 Phytother Res pmid:27388327
Wu J et al. Simultaneous Determination of Multiple Components in Guanjiekang in Rat Plasma via the UPLC-MS/MS Method and Its Application in Pharmacokinetic Study. 2016 Molecules pmid:27999285
Peng F et al. The application of HPLC-MS/MS to studies of pharmacokinetics and interconversion of isoliquiritigenin and neoisoliquiritigenin in rats. 2016 Biomed. Chromatogr. pmid:26577957
Yang EJ et al. The comparison of neuroprotective effects of isoliquiritigenin and its Phase I metabolites against glutamate-induced HT22 cell death. 2016 Bioorg. Med. Chem. Lett. pmid:27815122
Chen X et al. Differentiation-inducing and anti-proliferative activities of isoliquiritigenin and all-trans-retinoic acid on B16F0 melanoma cells: Mechanisms profiling by RNA-seq. 2016 Gene pmid:27461947
Mahalingam S et al. Effects of isoliquiritigenin on ovarian antral follicle growth and steroidogenesis. 2016 Reprod. Toxicol. pmid:27773742
Park SJ et al. Isoliquiritigenin impairs insulin signaling and adipocyte differentiation through the inhibition of protein-tyrosine phosphatase 1B oxidation in 3T3-L1 preadipocytes. 2016 Food Chem. Toxicol. pmid:27117918
Ma X et al. The effect of isoliquiritigenin on learning and memory impairments induced by high-fat diet via inhibiting TNF-α/JNK/IRS signaling. 2015 Biochem. Biophys. Res. Commun. pmid:26188513
Li ZX et al. Novel insights into the apoptosis mechanism of DNA topoisomerase I inhibitor isoliquiritigenin on HCC tumor cell. 2015 Biochem. Biophys. Res. Commun. pmid:26159926
Kwon SS et al. Physicochemical properties of pH-sensitive hydrogels based on hydroxyethyl cellulose-hyaluronic acid and for applications as transdermal delivery systems for skin lesions. 2015 Eur J Pharm Biopharm pmid:25753198
Ng JL et al. Flavonoids and Auxin Transport Inhibitors Rescue Symbiotic Nodulation in the Medicago truncatula Cytokinin Perception Mutant cre1. 2015 Plant Cell pmid:26253705
Hajirahimkhan A et al. Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women's Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A. 2015 Chem. Res. Toxicol. pmid:26473469
Dunlap TL et al. Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It. 2015 Chem. Res. Toxicol. pmid:26134484
Zhao S et al. Inhibitory effect of DNA topoisomerase inhibitor isoliquiritigenin on the growth of glioma cells. 2015 Int J Clin Exp Pathol pmid:26722447
Guo A et al. Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents. 2015 Sci Rep pmid:26370586
Wu S et al. Isoliquiritigenin Inhibits Interferon-γ-Inducible Genes Expression in Hepatocytes through Down-Regulating Activation of JAK1/STAT1, IRF3/MyD88, ERK/MAPK, JNK/MAPK and PI3K/Akt Signaling Pathways. 2015 Cell. Physiol. Biochem. pmid:26315837
Traboulsi H et al. The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection. 2015 Antimicrob. Agents Chemother. pmid:26248373
Li B et al. Experimental and Theoretical Investigations on the Supermolecular Structure of Isoliquiritigenin and 6-O-α-D-Maltosyl-β-cyclodextrin Inclusion Complex. 2015 Int J Mol Sci pmid:26247946
Kitagawa H et al. Pharmacokinetic Profiles of Active Ingredients and Its Metabolites Derived from Rikkunshito, a Ghrelin Enhancer, in Healthy Japanese Volunteers: A Cross-Over, Randomized Study. 2015 PLoS ONE pmid:26186592
Tian WW et al. [Isoliquiritigenin relaxes the cerebral basilar artery by enhancing BKCa current in spontaneously hypertensive rat: role of sGC/cGMP]. 2015 Sheng Li Xue Bao pmid:26109306
Wang N et al. Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation. 2015 Oncotarget pmid:25918249
Gong H et al. A protective mechanism of licorice (Glycyrrhiza uralensis): isoliquiritigenin stimulates detoxification system via Nrf2 activation. 2015 J Ethnopharmacol pmid:25557030
Peng F et al. A Review: The Pharmacology of Isoliquiritigenin. 2015 Phytother Res pmid:25907962
Zhou B et al. The influence of compatibility of processed radix Aconiti Kusnezoffii on the pharmacokinetic of four components in Glycyrrhiza uralensis Fisch. 2015 J Ethnopharmacol pmid:25889555
Choi YH et al. In vivo gastroprotective effect along with pharmacokinetics, tissue distribution and metabolism of isoliquiritigenin in mice. 2015 Planta Med. pmid:25875506
Link P et al. Extracts of Glycyrrhiza uralensis and isoliquiritigenin counteract amyloid-β toxicity in Caenorhabditis elegans. 2015 Planta Med. pmid:25782036
Wang R et al. Flavonoids derived from liquorice suppress murine macrophage activation by up-regulating heme oxygenase-1 independent of Nrf2 activation. 2015 Int. Immunopharmacol. pmid:25871879
Tung NH et al. Two activators of in vitro fertilization in mice from licorice. 2015 Biochem. Biophys. Res. Commun. pmid:26392313
Zhao Z et al. Isoliquiritigenin attenuates oxidative hepatic damage induced by carbon tetrachloride with or without buthionine sulfoximine. 2015 Chem. Biol. Interact. pmid:25450236
Wang N et al. Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling. 2014 Carcinogenesis pmid:25194164
Sunkaria A et al. 4-Hydroxy TEMPO attenuates dichlorvos induced microglial activation and apoptosis. 2014 ACS Chem Neurosci pmid:24369695
Zhou Y and Ho WS Combination of liquiritin, isoliquiritin and isoliquirigenin induce apoptotic cell death through upregulating p53 and p21 in the A549 non-small cell lung cancer cells. 2014 Oncol. Rep. pmid:24247527
Jung SK et al. Isoliquiritigenin induces apoptosis and inhibits xenograft tumor growth of human lung cancer cells by targeting both wild type and L858R/T790M mutant EGFR. 2014 J. Biol. Chem. pmid:25368326
Fu H et al. Synthesis and anti-tumor activity of novel aminomethylated derivatives of isoliquiritigenin. 2014 Molecules pmid:25365296
Honda H et al. Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation. 2014 J. Leukoc. Biol. pmid:25210146
Wang Z et al. MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin. 2014 Oncotarget pmid:25026296
Robb EL and Stuart JA Multiple phytoestrogens inhibit cell growth and confer cytoprotection by inducing manganese superoxide dismutase expression. 2014 Phytother Res pmid:23526725
Gaur R et al. In vivo anti-diabetic activity of derivatives of isoliquiritigenin and liquiritigenin. 2014 Phytomedicine pmid:24262065
Adianti M et al. Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species. 2014 Microbiol. Immunol. pmid:24397541
Zheng H et al. Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion. 2014 Toxicol. Appl. Pharmacol. pmid:25094029
Qiao H et al. Pharmacokinetics, biodistribution and bioavailability of isoliquiritigenin after intravenous and oral administration. 2014 Pharm Biol pmid:24102672
Kim SJ et al. Synthesis of licochalcone analogues with increased anti-inflammatory activity. 2014 Bioorg. Med. Chem. Lett. pmid:24316124
Zhao H et al. Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6. 2014 Toxicol. Appl. Pharmacol. pmid:25026504
Wong TY et al. The licorice flavonoid isoliquiritigenin reduces DNA-binding activity of AhR in MCF-7 cells. 2014 Chem. Biol. Interact. pmid:25110319
Sun C et al. Isoliquiritigenin enhances radiosensitivity of HepG2 cells via disturbance of redox status. 2013 Cell Biochem. Biophys. pmid:23086355
Yuan X et al. Involvement of the mitochondrion-dependent and the endoplasmic reticulum stress-signaling pathways in isoliquiritigenin-induced apoptosis of HeLa cell. 2013 Biomed. Environ. Sci. pmid:23534467
Arai T et al. Rikkunshito and isoliquiritigenin counteract 5-HT-induced 2C receptor-mediated activation of pro-opiomelanocortin neurons in the hypothalamic arcuate nucleus. 2013 Neuropeptides pmid:23756052
Yamada C et al. Rikkunshito, a Japanese kampo medicine, ameliorates decreased feeding behavior via ghrelin and serotonin 2B receptor signaling in a novelty stress murine model. 2013 Biomed Res Int pmid:24288687