| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Adenoid Cystic | D003528 | 3 associated lipids |
| Choroidal Neovascularization | D020256 | 5 associated lipids |
| Leiomyoma | D007889 | 8 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
isoliquiritigenin
Isoliquiritigenin is a lipid of Polyketides (PK) class. Isoliquiritigenin is associated with abnormalities such as abnormal fragmented structure, Gastric ulcer, Gastric mucosa lesion, Peptic Ulcer and Wiskott-Aldrich Syndrome. The involved functions are known as Mass-to-Charge Ratio, Anabolism, Oxidation, inhibitors and Energy Absorption. Isoliquiritigenin often locates in Microsomes, Liver, Hepatic, Microsomes, Immune system and Vacuole. The associated genes with Isoliquiritigenin are P4HTM gene, BCL2 gene, AP1AR gene, oxytocin, 1-desamino-(O-Et-Tyr)(2)- and ODAM gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of isoliquiritigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with isoliquiritigenin?
isoliquiritigenin is suspected in Gastric mucosa lesion, Gastric ulcer, Peptic Ulcer, Nodule, Infertility and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with isoliquiritigenin
PubChem Associated disorders and diseases
What pathways are associated with isoliquiritigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with isoliquiritigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with isoliquiritigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with isoliquiritigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with isoliquiritigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with isoliquiritigenin?
Knock-out
Knock-out are used in the study 'Two activators of in vitro fertilization in mice from licorice.' (Tung NH et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with isoliquiritigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kang SW et al. | Licorice isoliquiritigenin dampens angiogenic activity via inhibition of MAPK-responsive signaling pathways leading to induction of matrix metalloproteinases. | 2010 | J. Nutr. Biochem. | pmid:19157825 |
| Park I et al. | Isoliquiritigenin induces G2 and M phase arrest by inducing DNA damage and by inhibiting the metaphase/anaphase transition. | 2009 | Cancer Lett. | pmid:19167809 |
| Lee SH et al. | Isoliquiritigenin, from Dalbergia odorifera, up-regulates anti-inflammatory heme oxygenase-1 expression in RAW264.7 macrophages. | 2009 | Inflamm. Res. | pmid:19169644 |
| Zu Y et al. | Cytotoxic activity of isoliquiritigenin towards CCRF-CEM leukemia cells and its effect on DNA damage. | 2009 | Planta Med. | pmid:19291608 |
| Lee YM et al. | Induction of cell cycle arrest in prostate cancer cells by the dietary compound isoliquiritigenin. | 2009 | J Med Food | pmid:19298190 |
| Jeon JP et al. | Proteomic and behavioral analysis of response to isoliquiritigenin in brains of acute cocaine treated rats. | 2008 | J. Proteome Res. | pmid:19367698 |
| Hsu YL et al. | Shallot and licorice constituent isoliquiritigenin arrests cell cycle progression and induces apoptosis through the induction of ATM/p53 and initiation of the mitochondrial system in human cervical carcinoma HeLa cells. | 2009 | Mol Nutr Food Res | pmid:19536869 |
| Farag MA et al. | Integrated metabolite and transcript profiling identify a biosynthetic mechanism for hispidol in Medicago truncatula cell cultures. | 2009 | Plant Physiol. | pmid:19571306 |
| Yoon G et al. | Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19632832 |
| Youn UJ et al. | Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides. | 2009 | J. Nat. Prod. | pmid:19757853 |
| Park SJ et al. | Suppression of the TRIF-dependent signaling pathway of toll-like receptors by isoliquiritigenin in RAW264.7 macrophages. | 2009 | Mol. Cells | pmid:19809799 |
| Lee MJ et al. | Protective effects of isoliquiritigenin against methamphetamine-induced neurotoxicity in mice. | 2009 | J. Pharmacol. Sci. | pmid:19834288 |
| Srinivasan B et al. | Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities. | 2009 | J. Med. Chem. | pmid:19883086 |
| Shibano M et al. | Determination of flavonoids in licorice using acid hydrolysis and reversed-phase HPLC and evaluation of the chemical quality of cultivated licorice. | 2010 | Planta Med. | pmid:20013636 |
| Choi SH et al. | AMPK-mediated GSK3beta inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress. | 2010 | Biochem. Pharmacol. | pmid:20026081 |
| Lau GT et al. | The licorice flavonoid isoliquiritigenin suppresses phorbol ester-induced cyclooxygenase-2 expression in the non-tumorigenic MCF-10A breast cell line. | 2010 | Planta Med. | pmid:20033868 |
| Cuendet M et al. | Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice. | 2010 | Cancer Prev Res (Phila) | pmid:20068129 |
| Li J et al. | Isoliquiritigenin entails blockade of TGF-beta1-SMAD signaling for retarding high glucose-induced mesangial matrix accumulation. | 2010 | J. Agric. Food Chem. | pmid:20146476 |
| Park SJ and Youn HS | Isoliquiritigenin suppresses the Toll-interleukin-1 receptor domain-containing adapter inducing interferon-beta (TRIF)-dependent signaling pathway of Toll-like receptors by targeting TBK1. | 2010 | J. Agric. Food Chem. | pmid:20356041 |
| Zhang X et al. | Isoliquiritigenin, a natural anti-oxidant, selectively inhibits the proliferation of prostate cancer cells. | 2010 | Clin. Exp. Pharmacol. Physiol. | pmid:20456427 |