| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Adenoid Cystic | D003528 | 3 associated lipids |
| Choroidal Neovascularization | D020256 | 5 associated lipids |
| Leiomyoma | D007889 | 8 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
isoliquiritigenin
Isoliquiritigenin is a lipid of Polyketides (PK) class. Isoliquiritigenin is associated with abnormalities such as abnormal fragmented structure, Gastric ulcer, Gastric mucosa lesion, Peptic Ulcer and Wiskott-Aldrich Syndrome. The involved functions are known as Mass-to-Charge Ratio, Anabolism, Oxidation, inhibitors and Energy Absorption. Isoliquiritigenin often locates in Microsomes, Liver, Hepatic, Microsomes, Immune system and Vacuole. The associated genes with Isoliquiritigenin are P4HTM gene, BCL2 gene, AP1AR gene, oxytocin, 1-desamino-(O-Et-Tyr)(2)- and ODAM gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of isoliquiritigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with isoliquiritigenin?
isoliquiritigenin is suspected in Gastric mucosa lesion, Gastric ulcer, Peptic Ulcer, Nodule, Infertility and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with isoliquiritigenin
PubChem Associated disorders and diseases
What pathways are associated with isoliquiritigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with isoliquiritigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with isoliquiritigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with isoliquiritigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with isoliquiritigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with isoliquiritigenin?
Knock-out
Knock-out are used in the study 'Two activators of in vitro fertilization in mice from licorice.' (Tung NH et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with isoliquiritigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li ZX et al. | Novel insights into the apoptosis mechanism of DNA topoisomerase I inhibitor isoliquiritigenin on HCC tumor cell. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26159926 |
| Dunlap TL et al. | Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It. | 2015 | Chem. Res. Toxicol. | pmid:26134484 |
| Tian WW et al. | [Isoliquiritigenin relaxes the cerebral basilar artery by enhancing BKCa current in spontaneously hypertensive rat: role of sGC/cGMP]. | 2015 | Sheng Li Xue Bao | pmid:26109306 |
| Wang N et al. | Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation. | 2015 | Oncotarget | pmid:25918249 |
| Peng F et al. | A Review: The Pharmacology of Isoliquiritigenin. | 2015 | Phytother Res | pmid:25907962 |
| Zhou B et al. | The influence of compatibility of processed radix Aconiti Kusnezoffii on the pharmacokinetic of four components in Glycyrrhiza uralensis Fisch. | 2015 | J Ethnopharmacol | pmid:25889555 |
| Choi YH et al. | In vivo gastroprotective effect along with pharmacokinetics, tissue distribution and metabolism of isoliquiritigenin in mice. | 2015 | Planta Med. | pmid:25875506 |
| Wang R et al. | Flavonoids derived from liquorice suppress murine macrophage activation by up-regulating heme oxygenase-1 independent of Nrf2 activation. | 2015 | Int. Immunopharmacol. | pmid:25871879 |
| Link P et al. | Extracts of Glycyrrhiza uralensis and isoliquiritigenin counteract amyloid-β toxicity in Caenorhabditis elegans. | 2015 | Planta Med. | pmid:25782036 |
| Kwon SS et al. | Physicochemical properties of pH-sensitive hydrogels based on hydroxyethyl cellulose-hyaluronic acid and for applications as transdermal delivery systems for skin lesions. | 2015 | Eur J Pharm Biopharm | pmid:25753198 |
| Hsia SM et al. | Isoliquiritigenin as a cause of DNA damage and inhibitor of ataxia-telangiectasia mutated expression leading to G2/M phase arrest and apoptosis in oral squamous cell carcinoma. | 2016 | Head Neck | pmid:25580586 |
| Gong H et al. | A protective mechanism of licorice (Glycyrrhiza uralensis): isoliquiritigenin stimulates detoxification system via Nrf2 activation. | 2015 | J Ethnopharmacol | pmid:25557030 |
| Zhao Z et al. | Isoliquiritigenin attenuates oxidative hepatic damage induced by carbon tetrachloride with or without buthionine sulfoximine. | 2015 | Chem. Biol. Interact. | pmid:25450236 |
| Jung SK et al. | Isoliquiritigenin induces apoptosis and inhibits xenograft tumor growth of human lung cancer cells by targeting both wild type and L858R/T790M mutant EGFR. | 2014 | J. Biol. Chem. | pmid:25368326 |
| Fu H et al. | Synthesis and anti-tumor activity of novel aminomethylated derivatives of isoliquiritigenin. | 2014 | Molecules | pmid:25365296 |
| Honda H et al. | Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation. | 2014 | J. Leukoc. Biol. | pmid:25210146 |
| Wang N et al. | Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling. | 2014 | Carcinogenesis | pmid:25194164 |
| Wong TY et al. | The licorice flavonoid isoliquiritigenin reduces DNA-binding activity of AhR in MCF-7 cells. | 2014 | Chem. Biol. Interact. | pmid:25110319 |
| Zheng H et al. | Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion. | 2014 | Toxicol. Appl. Pharmacol. | pmid:25094029 |
| Zhao H et al. | Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6. | 2014 | Toxicol. Appl. Pharmacol. | pmid:25026504 |