| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Adenoid Cystic | D003528 | 3 associated lipids |
| Choroidal Neovascularization | D020256 | 5 associated lipids |
| Leiomyoma | D007889 | 8 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
isoliquiritigenin
Isoliquiritigenin is a lipid of Polyketides (PK) class. Isoliquiritigenin is associated with abnormalities such as abnormal fragmented structure, Gastric ulcer, Gastric mucosa lesion, Peptic Ulcer and Wiskott-Aldrich Syndrome. The involved functions are known as Mass-to-Charge Ratio, Anabolism, Oxidation, inhibitors and Energy Absorption. Isoliquiritigenin often locates in Microsomes, Liver, Hepatic, Microsomes, Immune system and Vacuole. The associated genes with Isoliquiritigenin are P4HTM gene, BCL2 gene, AP1AR gene, oxytocin, 1-desamino-(O-Et-Tyr)(2)- and ODAM gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of isoliquiritigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with isoliquiritigenin?
isoliquiritigenin is suspected in Gastric mucosa lesion, Gastric ulcer, Peptic Ulcer, Nodule, Infertility and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with isoliquiritigenin
PubChem Associated disorders and diseases
What pathways are associated with isoliquiritigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with isoliquiritigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with isoliquiritigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with isoliquiritigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with isoliquiritigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with isoliquiritigenin?
Knock-out
Knock-out are used in the study 'Two activators of in vitro fertilization in mice from licorice.' (Tung NH et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with isoliquiritigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sun ZJ et al. | Mammalian target of rapamycin pathway promotes tumor-induced angiogenesis in adenoid cystic carcinoma: its suppression by isoliquiritigenin through dual activation of c-Jun NH2-terminal kinase and inhibition of extracellular signal-regulated kinase. | 2010 | J. Pharmacol. Exp. Ther. | pmid:20484154 |
| Youns M et al. | Sensitivity and resistance towards isoliquiritigenin, doxorubicin and methotrexate in T cell acute lymphoblastic leukaemia cell lines by pharmacogenomics. | 2010 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:20668838 |
| Cao L et al. | In vitro screening for angiostatic potential of herbal chemicals. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20671276 |
| Park SJ and Youn HS | Suppression of homodimerization of toll-like receptor 4 by isoliquiritigenin. | 2010 | Phytochemistry | pmid:20701936 |
| Gaur R et al. | Liquiritigenin derivatives and their hepatotoprotective activity. | 2010 | Nat Prod Commun | pmid:20839627 |
| Kim YM et al. | Inhibition of liver X receptor-α-dependent hepatic steatosis by isoliquiritigenin, a licorice antioxidant flavonoid, as mediated by JNK1 inhibition. | 2010 | Free Radic. Biol. Med. | pmid:20840863 |
| Chandrasekaran CV et al. | Dual inhibitory effect of Glycyrrhiza glabra (GutGardâ„¢) on COX and LOX products. | 2011 | Phytomedicine | pmid:20864324 |
| Zorko BA et al. | Effects of ILTG on DAPK1 promoter methylation in colon and leukemia cancer cell lines. | 2010 | Anticancer Res. | pmid:21036707 |
| Srinivasan B et al. | Chalcone-based inhibitors against hypoxia-inducible factor 1--structure activity relationship studies. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21112783 |
| Aida K et al. | Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix. | 1990 | Planta Med. | pmid:2118267 |
| Birari RB et al. | Antiobesity and lipid lowering effects of Glycyrrhiza chalcones: experimental and computational studies. | 2011 | Phytomedicine | pmid:21315569 |
| Thiyagarajan P et al. | Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents. | 2011 | Inflammopharmacology | pmid:21328091 |
| Kawakami Z et al. | Isoliquiritigenin is a novel NMDA receptor antagonist in kampo medicine yokukansan. | 2011 | Cell. Mol. Neurobiol. | pmid:21691759 |
| Jhanji V et al. | Isoliquiritigenin from licorice root suppressed neovascularisation in experimental ocular angiogenesis models. | 2011 | Br J Ophthalmol | pmid:21719569 |
| Sano S et al. | Reinvestigation of the synthesis of isoliquiritigenin: application of Horner-Wadsworth-Emmons reaction and Claisen-Schmidt condensation. | 2011 | Chem. Pharm. Bull. | pmid:21720042 |
| Yang H et al. | Isoliquiritigenin (4,2',4'-trihydroxychalcone): a new matrix-assisted laser desorption/ionization matrix with outstanding properties for the analysis of neutral oligosaccharides. | 2011 | Anal. Chim. Acta | pmid:21763807 |
| Cui FC et al. | Elucidation of the methyl transfer mechanism catalyzed by chalcone O-methyltransferase: a density functional study. | 2011 | J Comput Chem | pmid:21815175 |
| Feldman M et al. | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. | 2011 | J. Nat. Prod. | pmid:21866899 |
| Cho S et al. | Isoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABAA receptors and shows hypnotic effects. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21945440 |
| Chen G et al. | Mammalian target of rapamycin regulates isoliquiritigenin-induced autophagic and apoptotic cell death in adenoid cystic carcinoma cells. | 2012 | Apoptosis | pmid:21956714 |