| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
isoliquiritigenin
Isoliquiritigenin is a lipid of Polyketides (PK) class. Isoliquiritigenin is associated with abnormalities such as abnormal fragmented structure, Gastric ulcer, Gastric mucosa lesion, Peptic Ulcer and Wiskott-Aldrich Syndrome. The involved functions are known as Mass-to-Charge Ratio, Anabolism, Oxidation, inhibitors and Energy Absorption. Isoliquiritigenin often locates in Microsomes, Liver, Hepatic, Microsomes, Immune system and Vacuole. The associated genes with Isoliquiritigenin are P4HTM gene, BCL2 gene, AP1AR gene, oxytocin, 1-desamino-(O-Et-Tyr)(2)- and ODAM gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of isoliquiritigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with isoliquiritigenin?
isoliquiritigenin is suspected in Gastric mucosa lesion, Gastric ulcer, Peptic Ulcer, Nodule, Infertility and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with isoliquiritigenin
PubChem Associated disorders and diseases
What pathways are associated with isoliquiritigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with isoliquiritigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with isoliquiritigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with isoliquiritigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with isoliquiritigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with isoliquiritigenin?
Knock-out
Knock-out are used in the study 'Two activators of in vitro fertilization in mice from licorice.' (Tung NH et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with isoliquiritigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lee CK et al. | Isoliquiritigenin inhibits tumor growth and protects the kidney and liver against chemotherapy-induced toxicity in a mouse xenograft model of colon carcinoma. | 2008 | J. Pharmacol. Sci. | pmid:18360095 |
| Wakasugi M et al. | Effects of aldose reductase inhibitors on prostacyclin (PGI2) synthesis by aortic rings from rats with streptozotocin-induced diabetes. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1840007 |
| Welle R et al. | Induced plant responses to pathogen attack. Analysis and heterologous expression of the key enzyme in the biosynthesis of phytoalexins in soybean (Glycine max L. Merr. cv. Harosoy 63). | 1991 | Eur. J. Biochem. | pmid:1840523 |
| Takeda H et al. | Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism. | 2008 | Gastroenterology | pmid:18439428 |
| Li X et al. | Same-single-cell analysis for the study of drug efflux modulation of multidrug resistant cells using a microfluidic chip. | 2008 | Anal. Chem. | pmid:18447319 |
| Liu B et al. | Isoliquiritigenin, a flavonoid from licorice, relaxes guinea-pig tracheal smooth muscle in vitro and in vivo: role of cGMP/PKG pathway. | 2008 | Eur. J. Pharmacol. | pmid:18462716 |
| Ruiz-PernÃa JJ et al. | Dynamic effects on reaction rates in a Michael addition catalyzed by chalcone isomerase. Beyond the frozen environment approach. | 2008 | J. Am. Chem. Soc. | pmid:18479090 |
| Kim DC et al. | Induction of growth inhibition and apoptosis in human uterine leiomyoma cells by isoliquiritigenin. | 2008 | Reprod Sci | pmid:18487228 |
| Jang EY et al. | Isoliquiritigenin suppresses cocaine-induced extracellular dopamine release in rat brain through GABA(B) receptor. | 2008 | Eur. J. Pharmacol. | pmid:18495107 |
| Woo SW et al. | Isoliquiritigenin inhibits cell proliferation by a heme oxygenase-dependent pathway in rat hepatic stellate cells. | 2008 | Planta Med. | pmid:18563666 |
| Sekine-Osajima Y et al. | Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replication. | 2009 | Hepatol. Res. | pmid:18647187 |
| Guo J et al. | Biotransformation of the chemopreventive agent 2',4',4-trihydroxychalcone (isoliquiritigenin) by UDP-glucuronosyltransferases. | 2008 | Drug Metab. Dispos. | pmid:18653743 |
| Kwon GT et al. | Isoliquiritigenin inhibits migration and invasion of prostate cancer cells: possible mediation by decreased JNK/AP-1 signaling. | 2009 | J. Nutr. Biochem. | pmid:18824345 |
| Yamamoto S et al. | The potent anti-tumor-promoting agent isoliquiritigenin. | 1991 | Carcinogenesis | pmid:1899810 |
| Ye L et al. | Dietary administration of the licorice flavonoid isoliquiritigenin deters the growth of MCF-7 cells overexpressing aromatase. | 2009 | Int. J. Cancer | pmid:19065667 |
| Chen G et al. | Isoliquiritigenin, a flavonoid from licorice, plays a dual role in regulating gastrointestinal motility in vitro and in vivo. | 2009 | Phytother Res | pmid:19067384 |
| Noguchi C et al. | Inhibitory effects of isoliquiritigenin and licorice extract on voltage-dependent K(+) currents in H9c2 cells. | 2008 | J. Pharmacol. Sci. | pmid:19098391 |
| Li D et al. | Isoliquiritigenin induces monocytic differentiation of HL-60 cells. | 2009 | Free Radic. Biol. Med. | pmid:19110051 |
| Hultman KA et al. | Small molecule modifier screen for kit-dependent functions in zebrafish embryonic melanocytes. | 2008 | Zebrafish | pmid:19133826 |
| Auyeung KK and Ko JK | Novel herbal flavonoids promote apoptosis but differentially induce cell cycle arrest in human colon cancer cell. | 2010 | Invest New Drugs | pmid:19139819 |