| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Leiomyoma | D007889 | 8 associated lipids |
isoliquiritigenin
Isoliquiritigenin is a lipid of Polyketides (PK) class. Isoliquiritigenin is associated with abnormalities such as abnormal fragmented structure, Gastric ulcer, Gastric mucosa lesion, Peptic Ulcer and Wiskott-Aldrich Syndrome. The involved functions are known as Mass-to-Charge Ratio, Anabolism, Oxidation, inhibitors and Energy Absorption. Isoliquiritigenin often locates in Microsomes, Liver, Hepatic, Microsomes, Immune system and Vacuole. The associated genes with Isoliquiritigenin are P4HTM gene, BCL2 gene, AP1AR gene, oxytocin, 1-desamino-(O-Et-Tyr)(2)- and ODAM gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of isoliquiritigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with isoliquiritigenin?
isoliquiritigenin is suspected in Gastric mucosa lesion, Gastric ulcer, Peptic Ulcer, Nodule, Infertility and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with isoliquiritigenin
PubChem Associated disorders and diseases
What pathways are associated with isoliquiritigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with isoliquiritigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with isoliquiritigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with isoliquiritigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with isoliquiritigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with isoliquiritigenin?
Knock-out
Knock-out are used in the study 'Two activators of in vitro fertilization in mice from licorice.' (Tung NH et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with isoliquiritigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| pmid:29039445 | ||||
| Sunkaria A et al. | 4-Hydroxy TEMPO attenuates dichlorvos induced microglial activation and apoptosis. | 2014 | ACS Chem Neurosci | pmid:24369695 |
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| Khamsan S et al. | The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry. | 2012 | Acta Pharm | pmid:22750816 |
| Pan X et al. | In vitro inhibition of rat monoamine oxidase by liquiritigenin and isoliquiritigenin isolated from Sinofranchetia chinensis. | 2000 | Acta Pharmacol. Sin. | pmid:11501051 |
| An W et al. | Metallothionein mediates cardioprotection of isoliquiritigenin against ischemia-reperfusion through JAK2/STAT3 activation. | 2006 | Acta Pharmacol. Sin. | pmid:17049118 |
| Han B et al. | Determination of isoliquiritigenin and its distribution in mice by synchronous fluorescence spectrometry. | 2011 | Anal Sci | pmid:22076338 |
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| Chen G et al. | Mammalian target of rapamycin regulates isoliquiritigenin-induced autophagic and apoptotic cell death in adenoid cystic carcinoma cells. | 2012 | Apoptosis | pmid:21956714 |
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| Kape R et al. | Isoliquiritigenin, a strong nod gene- and glyceollin resistance-inducing flavonoid from soybean root exudate. | 1992 | Appl. Environ. Microbiol. | pmid:1622242 |
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| Herles C et al. | First bacterial chalcone isomerase isolated from Eubacterium ramulus. | 2004 | Arch. Microbiol. | pmid:15127184 |
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| Lee HK et al. | Inhibitory effects of Glycyrrhizae radix and its active component, isoliquiritigenin, on Aβ(25-35)-induced neurotoxicity in cultured rat cortical neurons. | 2012 | Arch. Pharm. Res. | pmid:22644857 |
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| Oguro S et al. | Probing biosynthesis of plant polyketides with synthetic N-acetylcysteamine thioesters. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15530429 |
| Tung NH et al. | Two activators of in vitro fertilization in mice from licorice. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26392313 |
| Cho S et al. | Isoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABAA receptors and shows hypnotic effects. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21945440 |
| Lee JE et al. | Molecular signatures in response to Isoliquiritigenin in lymphoblastoid cell lines. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22995316 |
| Yang EJ et al. | Isoliquiritigenin isolated from Glycyrrhiza uralensis protects neuronal cells against glutamate-induced mitochondrial dysfunction. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22538371 |
| Chen X et al. | Isoliquiritigenin protects against sepsis-induced lung and liver injury by reducing inflammatory responses. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29180018 |
| Liu S et al. | Anti-osteoclastogenic activity of isoliquiritigenin via inhibition of NF-κB-dependent autophagic pathway. | 2016 | Biochem. Pharmacol. | pmid:26947453 |
| Choi SH et al. | AMPK-mediated GSK3beta inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress. | 2010 | Biochem. Pharmacol. | pmid:20026081 |
| Kumar S et al. | Isoliquiritigenin inhibits IkappaB kinase activity and ROS generation to block TNF-alpha induced expression of cell adhesion molecules on human endothelial cells. | 2007 | Biochem. Pharmacol. | pmid:17276410 |
| Jez JM et al. | Role of hydrogen bonds in the reaction mechanism of chalcone isomerase. | 2002 | Biochemistry | pmid:11955065 |
| Jung JI et al. | Isoliquiritigenin (ISL) inhibits ErbB3 signaling in prostate cancer cells. | 2006 | Biofactors | pmid:17473376 |
| Iwata S et al. | Antitumorigenic activities of chalcones. I. Inhibitory effects of chalcone derivatives on 32Pi-incorporation into phospholipids of HeLa cells promoted by 12-O-tetradecanoyl-phorbol 13-acetate (TPA). | 1995 | Biol. Pharm. Bull. | pmid:8787793 |
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| Baba M et al. | Saponins isolated from Allium chinense G. Don and antitumor-promoting activities of isoliquiritigenin and laxogenin from the same drug. | 2000 | Biol. Pharm. Bull. | pmid:10823685 |
| Hayashi H et al. | Seasonal variation of glycyrrhizin and isoliquiritigenin glycosides in the root of Glycyrrhiza glabra L. | 1998 | Biol. Pharm. Bull. | pmid:9781853 |
| Sato Y et al. | Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. | 2007 | Biol. Pharm. Bull. | pmid:17202675 |
| De Bartolo L et al. | Effect of isoliquiritigenin on viability and differentiated functions of human hepatocytes maintained on PEEK-WC-polyurethane membranes. | 2005 | Biomaterials | pmid:15927248 |
| Yamada C et al. | Rikkunshito, a Japanese kampo medicine, ameliorates decreased feeding behavior via ghrelin and serotonin 2B receptor signaling in a novelty stress murine model. | 2013 | Biomed Res Int | pmid:24288687 |
| Peng F et al. | The application of HPLC-MS/MS to studies of pharmacokinetics and interconversion of isoliquiritigenin and neoisoliquiritigenin in rats. | 2016 | Biomed. Chromatogr. | pmid:26577957 |
| Han SY et al. | A new approach for pharmacokinetic studies of natural products: measurement of isoliquiritigenin levels in mice plasma, urine and feces using modified automated dosing/blood sampling system. | 2013 | Biomed. Chromatogr. | pmid:23339046 |
| Yuan X et al. | Involvement of the mitochondrion-dependent and the endoplasmic reticulum stress-signaling pathways in isoliquiritigenin-induced apoptosis of HeLa cell. | 2013 | Biomed. Environ. Sci. | pmid:23534467 |
| Yang Z et al. | Autophagy participates in isoliquiritigenin-induced melanin degradation in human epidermal keratinocytes through PI3K/AKT/mTOR signaling. | 2018 | Biomed. Pharmacother. | pmid:29091873 |
| Fioravanti R et al. | Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action. | 2012 | Bioorg. Med. Chem. | pmid:22743086 |
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| Yang EJ et al. | The comparison of neuroprotective effects of isoliquiritigenin and its Phase I metabolites against glutamate-induced HT22 cell death. | 2016 | Bioorg. Med. Chem. Lett. | pmid:27815122 |
| Kim SJ et al. | Synthesis of licochalcone analogues with increased anti-inflammatory activity. | 2014 | Bioorg. Med. Chem. Lett. | pmid:24316124 |