| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Leiomyoma | D007889 | 8 associated lipids |
isoliquiritigenin
Isoliquiritigenin is a lipid of Polyketides (PK) class. Isoliquiritigenin is associated with abnormalities such as abnormal fragmented structure, Gastric ulcer, Gastric mucosa lesion, Peptic Ulcer and Wiskott-Aldrich Syndrome. The involved functions are known as Mass-to-Charge Ratio, Anabolism, Oxidation, inhibitors and Energy Absorption. Isoliquiritigenin often locates in Microsomes, Liver, Hepatic, Microsomes, Immune system and Vacuole. The associated genes with Isoliquiritigenin are P4HTM gene, BCL2 gene, AP1AR gene, oxytocin, 1-desamino-(O-Et-Tyr)(2)- and ODAM gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of isoliquiritigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with isoliquiritigenin?
isoliquiritigenin is suspected in Gastric mucosa lesion, Gastric ulcer, Peptic Ulcer, Nodule, Infertility and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with isoliquiritigenin
PubChem Associated disorders and diseases
What pathways are associated with isoliquiritigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with isoliquiritigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with isoliquiritigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with isoliquiritigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with isoliquiritigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with isoliquiritigenin?
Knock-out
Knock-out are used in the study 'Two activators of in vitro fertilization in mice from licorice.' (Tung NH et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with isoliquiritigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Krishnaveni KS and Rao JV | An isoflavone from Pterocarpus santalinus. | 2000 | Phytochemistry | pmid:10724187 |
| Kong LD et al. | Inhibition of xanthine oxidase by liquiritigenin and isoliquiritigenin isolated from Sinofranchetia chinensis. | 2000 | Cell. Mol. Life Sci. | pmid:10823249 |
| Baba M et al. | Saponins isolated from Allium chinense G. Don and antitumor-promoting activities of isoliquiritigenin and laxogenin from the same drug. | 2000 | Biol. Pharm. Bull. | pmid:10823685 |
| Iwashita K et al. | Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11055382 |
| Shibata S | A drug over the millennia: pharmacognosy, chemistry, and pharmacology of licorice. | 2000 | Yakugaku Zasshi | pmid:11082698 |
| Zubieta C et al. | Structures of two natural product methyltransferases reveal the basis for substrate specificity in plant O-methyltransferases. | 2001 | Nat. Struct. Biol. | pmid:11224575 |
| Tanaka S et al. | Influence of natural and synthetic compounds on cell surface expression of cell adhesion molecules, ICAM-1 and VCAM-1. | 2001 | Planta Med. | pmid:11301853 |
| Pan X et al. | In vitro inhibition of rat monoamine oxidase by liquiritigenin and isoliquiritigenin isolated from Sinofranchetia chinensis. | 2000 | Acta Pharmacol. Sin. | pmid:11501051 |
| Ma J et al. | Apoptosis induced by isoliquiritigenin in human gastric cancer MGC-803 cells. | 2001 | Planta Med. | pmid:11731922 |
| Buolamwini JK and Assefa H | CoMFA and CoMSIA 3D QSAR and docking studies on conformationally-restrained cinnamoyl HIV-1 integrase inhibitors: exploration of a binding mode at the active site. | 2002 | J. Med. Chem. | pmid:11831895 |
| Baba M et al. | Studies on cancer chemoprevention by traditional folk medicines XXV. Inhibitory effect of isoliquiritigenin on azoxymethane-induced murine colon aberrant crypt focus formation and carcinogenesis. | 2002 | Biol. Pharm. Bull. | pmid:11853176 |
| Jez JM et al. | Role of hydrogen bonds in the reaction mechanism of chalcone isomerase. | 2002 | Biochemistry | pmid:11955065 |
| Yamazaki S et al. | Isoliquiritigenin suppresses pulmonary metastasis of mouse renal cell carcinoma. | 2002 | Cancer Lett. | pmid:12049811 |
| Maggiolini M et al. | Estrogenic and antiproliferative activities of isoliquiritigenin in MCF7 breast cancer cells. | 2002 | J. Steroid Biochem. Mol. Biol. | pmid:12589938 |
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| Shindo H et al. | The role of cyclic adenosine 3',5'-monophosphate and polyol metabolism in diabetic neuropathy. | 1992 | J. Clin. Endocrinol. Metab. | pmid:1370506 |
| Basu NK et al. | Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. | 2004 | J. Biol. Chem. | pmid:14557274 |
| Martin HJ et al. | The inhibitory effects of flavonoids and antiestrogens on the Glut1 glucose transporter in human erythrocytes. | 2003 | Chem. Biol. Interact. | pmid:14642735 |
| Wang YF et al. | [Studies on chemical constituents from the root of Polygonatum kingianum]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015331 |
| Ii T et al. | Induction of cell cycle arrest and p21(CIP1/WAF1) expression in human lung cancer cells by isoliquiritigenin. | 2004 | Cancer Lett. | pmid:15050731 |
| Herles C et al. | First bacterial chalcone isomerase isolated from Eubacterium ramulus. | 2004 | Arch. Microbiol. | pmid:15127184 |
| Takahashi T et al. | Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development. | 2004 | Cancer Sci. | pmid:15132774 |
| Hsu YL et al. | Isoliquiritigenin inhibits the proliferation and induces the apoptosis of human non-small cell lung cancer a549 cells. | 2004 | Clin. Exp. Pharmacol. Physiol. | pmid:15236626 |
| Cao Y et al. | Determination of liquiritigenin and isoliquiritigenin in Glycyrrhiza uralensis and its medicinal preparations by capillary electrophoresis with electrochemical detection. | 2004 | J Chromatogr A | pmid:15296407 |
| Sung MW and Li PC | Chemical analysis of raw, dry-roasted, and honey-roasted licorice by capillary electrophoresis. | 2004 | Electrophoresis | pmid:15490450 |
| Oguro S et al. | Probing biosynthesis of plant polyketides with synthetic N-acetylcysteamine thioesters. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15530429 |
| Tawata M et al. | Anti-platelet action of isoliquiritigenin, an aldose reductase inhibitor in licorice. | 1992 | Eur. J. Pharmacol. | pmid:1555643 |
| Hsu YL et al. | Isoliquiritigenin inhibits cell proliferation and induces apoptosis in human hepatoma cells. | 2005 | Planta Med. | pmid:15729620 |
| Hsu YL et al. | Isoliquiritigenin induces apoptosis and cell cycle arrest through p53-dependent pathway in Hep G2 cells. | 2005 | Life Sci. | pmid:15878356 |
| De Bartolo L et al. | Effect of isoliquiritigenin on viability and differentiated functions of human hepatocytes maintained on PEEK-WC-polyurethane membranes. | 2005 | Biomaterials | pmid:15927248 |
| Bomati EK et al. | Structural elucidation of chalcone reductase and implications for deoxychalcone biosynthesis. | 2005 | J. Biol. Chem. | pmid:15970585 |
| Eggler AL et al. | Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16006525 |
| Ma CJ et al. | One step isolation and purification of liquiritigenin and isoliquiritigenin from Glycyrrhiza uralensis Risch. using high-speed counter-current chromatography. | 2005 | J Chromatogr A | pmid:16007997 |
| Chowdhury SA et al. | Tumor-specificity and apoptosis-inducing activity of stilbenes and flavonoids. | 2005 May-Jun | Anticancer Res. | pmid:16158945 |
| Kape R et al. | Isoliquiritigenin, a strong nod gene- and glyceollin resistance-inducing flavonoid from soybean root exudate. | 1992 | Appl. Environ. Microbiol. | pmid:1622242 |
| Takahashi T et al. | Cyclooxygenase-2 plays a suppressive role for induction of apoptosis in isoliquiritigenin-treated mouse colon cancer cells. | 2006 | Cancer Lett. | pmid:16399234 |
| Luczkiewicz M and Kokotkiewicz A | Genista tinctoria hairy root cultures for selective production of isoliquiritigenin. | 2005 Nov-Dec | Z. Naturforsch., C, J. Biosci. | pmid:16402547 |
| Zhan C and Yang J | Protective effects of isoliquiritigenin in transient middle cerebral artery occlusion-induced focal cerebral ischemia in rats. | 2006 | Pharmacol. Res. | pmid:16459097 |
| Li H et al. | Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 | J. Mol. Graph. Model. | pmid:16497524 |
| Jung JI et al. | Isoliquiritigenin induces apoptosis by depolarizing mitochondrial membranes in prostate cancer cells. | 2006 | J. Nutr. Biochem. | pmid:16517140 |
| Cuendet M et al. | Quinone reductase induction as a biomarker for cancer chemoprevention. | 2006 | J. Nat. Prod. | pmid:16562858 |
| Kim DC et al. | Isoliquiritigenin selectively inhibits H(2) histamine receptor signaling. | 2006 | Mol. Pharmacol. | pmid:16675659 |
| An W et al. | Metallothionein mediates cardioprotection of isoliquiritigenin against ischemia-reperfusion through JAK2/STAT3 activation. | 2006 | Acta Pharmacol. Sin. | pmid:17049118 |
| Sato Y et al. | Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. | 2007 | Biol. Pharm. Bull. | pmid:17202675 |
| Kwon HM et al. | Blockade of cytokine-induced endothelial cell adhesion molecule expression by licorice isoliquiritigenin through NF-kappaB signal disruption. | 2007 | Exp. Biol. Med. (Maywood) | pmid:17259331 |
| Smith AD and Dar MS | Involvement of the alpha4beta2 nicotinic receptor subtype in nicotine-induced attenuation of delta9-THC cerebellar ataxia: role of cerebellar nitric oxide. | 2007 | Pharmacol. Biochem. Behav. | pmid:17275078 |
| Kumar S et al. | Isoliquiritigenin inhibits IkappaB kinase activity and ROS generation to block TNF-alpha induced expression of cell adhesion molecules on human endothelial cells. | 2007 | Biochem. Pharmacol. | pmid:17276410 |