isoliquiritigenin

Isoliquiritigenin is a lipid of Polyketides (PK) class. Isoliquiritigenin is associated with abnormalities such as abnormal fragmented structure, Gastric ulcer, Gastric mucosa lesion, Peptic Ulcer and Wiskott-Aldrich Syndrome. The involved functions are known as Mass-to-Charge Ratio, Anabolism, Oxidation, inhibitors and Energy Absorption. Isoliquiritigenin often locates in Microsomes, Liver, Hepatic, Microsomes, Immune system and Vacuole. The associated genes with Isoliquiritigenin are P4HTM gene, BCL2 gene, AP1AR gene, oxytocin, 1-desamino-(O-Et-Tyr)(2)- and ODAM gene. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of isoliquiritigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with isoliquiritigenin?

isoliquiritigenin is suspected in Gastric mucosa lesion, Gastric ulcer, Peptic Ulcer, Nodule, Infertility and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with isoliquiritigenin

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Precancerous Conditions D011230 48 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Leiomyoma D007889 8 associated lipids
Per page 10 20 | Total 13

PubChem Associated disorders and diseases

What pathways are associated with isoliquiritigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with isoliquiritigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with isoliquiritigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with isoliquiritigenin?

Related references are published most in these journals:

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What genes are associated with isoliquiritigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with isoliquiritigenin?

Knock-out

Knock-out are used in the study 'Two activators of in vitro fertilization in mice from licorice.' (Tung NH et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with isoliquiritigenin

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Per page 10 20 50 100 | Total 275
Authors Title Published Journal PubMed Link
Negi S et al. Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules. 2018 Toxicol In Vitro pmid:29933105
Chen J et al. Isoliquiritigenin Suppresses Osteosarcoma U2OS Cell Proliferation and Invasion by Regulating the PI3K/Akt Signalling Pathway. 2018 Chemotherapy pmid:29936511
Liu X et al. Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 Pathway. 2018 Oxid Med Cell Longev pmid:29854090
Nakamura S et al. Isoliquiritigenin Ameliorates Indomethacin-Induced Small Intestinal Damage by Inhibiting NOD-Like Receptor Family, Pyrin Domain-Containing 3 Inflammasome Activation. 2018 Pharmacology pmid:29393276
Zhang B et al. Antineoplastic activity of isoliquiritigenin, a chalcone compound, in androgen-independent human prostate cancer cells linked to G2/M cell cycle arrest and cell apoptosis. 2018 Eur. J. Pharmacol. pmid:29277717
Lin Y et al. Isoliquiritigenin inhibits the proliferation and induces the differentiation of human glioma stem cells. 2018 Oncol. Rep. pmid:29251326
Yang Z et al. Autophagy participates in isoliquiritigenin-induced melanin degradation in human epidermal keratinocytes through PI3K/AKT/mTOR signaling. 2018 Biomed. Pharmacother. pmid:29091873
Li Y et al. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. 2018 Toxicol. Lett. pmid:29753067
Lian D et al. Cathepsin B-Mediated NLRP3 Inflammasome Formation and Activation in Angiotensin II -Induced Hypertensive Mice: Role of Macrophage Digestion Dysfunction. 2018 Cell. Physiol. Biochem. pmid:30359991
Chen C et al. Suppression of lung cancer progression by isoliquiritigenin through its metabolite 2, 4, 2', 4'-Tetrahydroxychalcone. 2018 J. Exp. Clin. Cancer Res. pmid:30285892
Sechet E et al. Natural molecules induce and synergize to boost expression of the human antimicrobial peptide β-defensin-3. 2018 Proc. Natl. Acad. Sci. U.S.A. pmid:30275324
Zhang XR et al. Isoliquiritigenin inhibits proliferation and metastasis of MKN28 gastric cancer cells by suppressing the PI3K/AKT/mTOR signaling pathway. 2018 Mol Med Rep pmid:30066879
Zhang W et al. Protective Effects of Isoliquiritigenin on LPS-Induced Acute Lung Injury by Activating PPAR-γ. 2018 Inflammation pmid:29654430
Ji B et al. Isoliquiritigenin blunts osteoarthritis by inhibition of bone resorption and angiogenesis in subchondral bone. 2018 Sci Rep pmid:29379010
Chen X et al. Isoliquiritigenin protects against sepsis-induced lung and liver injury by reducing inflammatory responses. 2018 Biochem. Biophys. Res. Commun. pmid:29180018
Yan F et al. Isoliquiritigenin suppresses human T Lymphocyte activation via covalently binding cysteine 46 of IκB kinase. 2017 Oncotarget pmid:27626700
Genthe JR et al. Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway. 2017 ACS Chem. Biol. pmid:28787124
Gao F et al. iRGD-modified lipid-polymer hybrid nanoparticles loaded with isoliquiritigenin to enhance anti-breast cancer effect and tumor-targeting ability. 2017 Int J Nanomedicine pmid:28615942
Hou C et al. Synthetic Isoliquiritigenin Inhibits Human Tongue Squamous Carcinoma Cells through Its Antioxidant Mechanism. 2017 Oxid Med Cell Longev pmid:28203317
Yu H et al. Effect of isoliquiritigenin for the treatment of atopic dermatitis-like skin lesions in mice. 2017 Arch. Dermatol. Res. pmid:29026975
Chen HY et al. Isoliquiritigenin Induces Autophagy and Inhibits Ovarian Cancer Cell Growth. 2017 Int J Mol Sci pmid:28934130
Chen T et al. The inhibitory effect of Isoliquiritigenin on the proliferation of human arterial smooth muscle cell. 2017 BMC Pharmacol Toxicol pmid:28716056
Yerra VG et al. Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy. 2017 J. Nutr. Biochem. pmid:28528294
Bueno-Silva B et al. The effect of seasons on Brazilian red propolis and its botanical source: chemical composition and antibacterial activity. 2017 Nat. Prod. Res. pmid:27701899
Wu N et al. Construction of a chalcone reductase expression vector and transformation of soybean plants. 2017 Mol Med Rep pmid:28901382
Kuang Y et al. Screening of hepatoprotective compounds from licorice against carbon tetrachloride and acetaminophen induced HepG2 cells injury. 2017 Phytomedicine pmid:28899510
Patricia Moreno-Londoño A et al. Isoliquiritigenin pretreatment attenuates cisplatin induced proximal tubular cells (LLC-PK1) death and enhances the toxicity induced by this drug in bladder cancer T24 cell line. 2017 Food Chem. Toxicol. pmid:28870684
Zeng J et al. Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway. 2017 J Neuroinflammation pmid:28610608
Köksal Z et al. The inhibition effects of some natural products on lactoperoxidase purified from bovine milk. 2017 J. Biochem. Mol. Toxicol. pmid:28594102
Kim DH et al. Isoliquiritigenin inhibits the proliferation of human renal carcinoma Caki cells through the ROS-mediated regulation of the Jak2/STAT3 pathway. 2017 Oncol. Rep. pmid:28560439
Yang HH et al. Isoliquiritigenin Induces Cytotoxicity in PC-12 Cells In Vitro. 2017 Appl. Biochem. Biotechnol. pmid:28488118
Chen XY et al. Reprogramming induced by isoliquiritigenin diminishes melanoma cachexia through mTORC2-AKT-GSK3β signaling. 2017 Oncotarget pmid:28410220
Boyapelly K et al. Synthesis and Characterization of a Phosphate Prodrug of Isoliquiritigenin. 2017 J. Nat. Prod. pmid:28252963
Chi JH et al. Isoliquiritigenin inhibits TNF-α-induced release of high-mobility group box 1 through activation of HDAC in human intestinal epithelial HT-29 cells. 2017 Eur. J. Pharmacol. pmid:28012970
Wu CH et al. Isoliquiritigenin induces apoptosis and autophagy and inhibits endometrial cancer growth in mice. 2016 Oncotarget pmid:27708238
Jin XY et al. Isoliquiritigenin suppresses tumor necrosis factor-α-induced inflammation via peroxisome proliferator-activated receptor-γ in intestinal epithelial cells. 2016 Arch. Pharm. Res. pmid:27539609
Cao L- et al. Isoliquiritigenin protects against triptolide-induced hepatotoxicity in mice through Nrf2 activation. 2016 Pharmazie pmid:29441915
Kong BJ et al. Properties and in vitro drug release of hyaluronic acid-hydroxyethyl cellulose hydrogels for transdermal delivery of isoliquiritigenin. 2016 Carbohydr Polym pmid:27178954
Wang Y et al. Isoliquiritigenin Inhibits Proliferation and Induces Apoptosis via Alleviating Hypoxia and Reducing Glycolysis in Mouse Melanoma B16F10 Cells. 2016 Recent Pat Anticancer Drug Discov pmid:26951491
Liu S et al. Anti-osteoclastogenic activity of isoliquiritigenin via inhibition of NF-κB-dependent autophagic pathway. 2016 Biochem. Pharmacol. pmid:26947453
Choi YH et al. Isoliquiritigenin ameliorates dextran sulfate sodium-induced colitis through the inhibition of MAPK pathway. 2016 Int. Immunopharmacol. pmid:26771170
Peng F et al. Cytotoxic Evaluation against Breast Cancer Cells of Isoliquiritigenin Analogues from Spatholobus suberectus and Their Synthetic Derivatives. 2016 J. Nat. Prod. pmid:26690274
Park SM et al. Isoliquiritigenin in licorice functions as a hepatic protectant by induction of antioxidant genes through extracellular signal-regulated kinase-mediated NF-E2-related factor-2 signaling pathway. 2016 Eur J Nutr pmid:26593436
Yamaura K et al. Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry. 2016 Nat. Chem. Biol. pmid:27526031
Weis KE and Raetzman LT Isoliquiritigenin exhibits anti-proliferative properties in the pituitary independent of estrogen receptor function. 2016 Toxicol. Appl. Pharmacol. pmid:27702603
Gaur R et al. Drug Resistance Reversal Potential of Isoliquiritigenin and Liquiritigenin Isolated from Glycyrrhiza glabra Against Methicillin-Resistant Staphylococcus aureus (MRSA). 2016 Phytother Res pmid:27388327
Peng F et al. The application of HPLC-MS/MS to studies of pharmacokinetics and interconversion of isoliquiritigenin and neoisoliquiritigenin in rats. 2016 Biomed. Chromatogr. pmid:26577957
Chen X et al. Differentiation-inducing and anti-proliferative activities of isoliquiritigenin and all-trans-retinoic acid on B16F0 melanoma cells: Mechanisms profiling by RNA-seq. 2016 Gene pmid:27461947
Mahalingam S et al. Effects of isoliquiritigenin on ovarian antral follicle growth and steroidogenesis. 2016 Reprod. Toxicol. pmid:27773742
Park SJ et al. Isoliquiritigenin impairs insulin signaling and adipocyte differentiation through the inhibition of protein-tyrosine phosphatase 1B oxidation in 3T3-L1 preadipocytes. 2016 Food Chem. Toxicol. pmid:27117918