| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Leiomyoma | D007889 | 8 associated lipids |
isoliquiritigenin
Isoliquiritigenin is a lipid of Polyketides (PK) class. Isoliquiritigenin is associated with abnormalities such as abnormal fragmented structure, Gastric ulcer, Gastric mucosa lesion, Peptic Ulcer and Wiskott-Aldrich Syndrome. The involved functions are known as Mass-to-Charge Ratio, Anabolism, Oxidation, inhibitors and Energy Absorption. Isoliquiritigenin often locates in Microsomes, Liver, Hepatic, Microsomes, Immune system and Vacuole. The associated genes with Isoliquiritigenin are P4HTM gene, BCL2 gene, AP1AR gene, oxytocin, 1-desamino-(O-Et-Tyr)(2)- and ODAM gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of isoliquiritigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with isoliquiritigenin?
isoliquiritigenin is suspected in Gastric mucosa lesion, Gastric ulcer, Peptic Ulcer, Nodule, Infertility and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with isoliquiritigenin
PubChem Associated disorders and diseases
What pathways are associated with isoliquiritigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with isoliquiritigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with isoliquiritigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with isoliquiritigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with isoliquiritigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with isoliquiritigenin?
Knock-out
Knock-out are used in the study 'Two activators of in vitro fertilization in mice from licorice.' (Tung NH et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with isoliquiritigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Negi S et al. | Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules. | 2018 | Toxicol In Vitro | pmid:29933105 |
| Chen J et al. | Isoliquiritigenin Suppresses Osteosarcoma U2OS Cell Proliferation and Invasion by Regulating the PI3K/Akt Signalling Pathway. | 2018 | Chemotherapy | pmid:29936511 |
| Liu X et al. | Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 Pathway. | 2018 | Oxid Med Cell Longev | pmid:29854090 |
| Nakamura S et al. | Isoliquiritigenin Ameliorates Indomethacin-Induced Small Intestinal Damage by Inhibiting NOD-Like Receptor Family, Pyrin Domain-Containing 3 Inflammasome Activation. | 2018 | Pharmacology | pmid:29393276 |
| Zhang B et al. | Antineoplastic activity of isoliquiritigenin, a chalcone compound, in androgen-independent human prostate cancer cells linked to G2/M cell cycle arrest and cell apoptosis. | 2018 | Eur. J. Pharmacol. | pmid:29277717 |
| Lin Y et al. | Isoliquiritigenin inhibits the proliferation and induces the differentiation of human glioma stem cells. | 2018 | Oncol. Rep. | pmid:29251326 |
| Yang Z et al. | Autophagy participates in isoliquiritigenin-induced melanin degradation in human epidermal keratinocytes through PI3K/AKT/mTOR signaling. | 2018 | Biomed. Pharmacother. | pmid:29091873 |
| Li Y et al. | Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. | 2018 | Toxicol. Lett. | pmid:29753067 |
| Lian D et al. | Cathepsin B-Mediated NLRP3 Inflammasome Formation and Activation in Angiotensin II -Induced Hypertensive Mice: Role of Macrophage Digestion Dysfunction. | 2018 | Cell. Physiol. Biochem. | pmid:30359991 |
| Chen C et al. | Suppression of lung cancer progression by isoliquiritigenin through its metabolite 2, 4, 2', 4'-Tetrahydroxychalcone. | 2018 | J. Exp. Clin. Cancer Res. | pmid:30285892 |
| Sechet E et al. | Natural molecules induce and synergize to boost expression of the human antimicrobial peptide β-defensin-3. | 2018 | Proc. Natl. Acad. Sci. U.S.A. | pmid:30275324 |
| Zhang XR et al. | Isoliquiritigenin inhibits proliferation and metastasis of MKN28 gastric cancer cells by suppressing the PI3K/AKT/mTOR signaling pathway. | 2018 | Mol Med Rep | pmid:30066879 |
| Zhang W et al. | Protective Effects of Isoliquiritigenin on LPS-Induced Acute Lung Injury by Activating PPAR-γ. | 2018 | Inflammation | pmid:29654430 |
| Ji B et al. | Isoliquiritigenin blunts osteoarthritis by inhibition of bone resorption and angiogenesis in subchondral bone. | 2018 | Sci Rep | pmid:29379010 |
| Chen X et al. | Isoliquiritigenin protects against sepsis-induced lung and liver injury by reducing inflammatory responses. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29180018 |
| Yan F et al. | Isoliquiritigenin suppresses human T Lymphocyte activation via covalently binding cysteine 46 of IκB kinase. | 2017 | Oncotarget | pmid:27626700 |
| Genthe JR et al. | Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway. | 2017 | ACS Chem. Biol. | pmid:28787124 |
| Gao F et al. | iRGD-modified lipid-polymer hybrid nanoparticles loaded with isoliquiritigenin to enhance anti-breast cancer effect and tumor-targeting ability. | 2017 | Int J Nanomedicine | pmid:28615942 |
| Hou C et al. | Synthetic Isoliquiritigenin Inhibits Human Tongue Squamous Carcinoma Cells through Its Antioxidant Mechanism. | 2017 | Oxid Med Cell Longev | pmid:28203317 |
| Yu H et al. | Effect of isoliquiritigenin for the treatment of atopic dermatitis-like skin lesions in mice. | 2017 | Arch. Dermatol. Res. | pmid:29026975 |
| Chen HY et al. | Isoliquiritigenin Induces Autophagy and Inhibits Ovarian Cancer Cell Growth. | 2017 | Int J Mol Sci | pmid:28934130 |
| Chen T et al. | The inhibitory effect of Isoliquiritigenin on the proliferation of human arterial smooth muscle cell. | 2017 | BMC Pharmacol Toxicol | pmid:28716056 |
| Yerra VG et al. | Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy. | 2017 | J. Nutr. Biochem. | pmid:28528294 |
| Bueno-Silva B et al. | The effect of seasons on Brazilian red propolis and its botanical source: chemical composition and antibacterial activity. | 2017 | Nat. Prod. Res. | pmid:27701899 |
| Wu N et al. | Construction of a chalcone reductase expression vector and transformation of soybean plants. | 2017 | Mol Med Rep | pmid:28901382 |
| Kuang Y et al. | Screening of hepatoprotective compounds from licorice against carbon tetrachloride and acetaminophen induced HepG2 cells injury. | 2017 | Phytomedicine | pmid:28899510 |
| Patricia Moreno-Londoño A et al. | Isoliquiritigenin pretreatment attenuates cisplatin induced proximal tubular cells (LLC-PK1) death and enhances the toxicity induced by this drug in bladder cancer T24 cell line. | 2017 | Food Chem. Toxicol. | pmid:28870684 |
| Zeng J et al. | Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway. | 2017 | J Neuroinflammation | pmid:28610608 |
| Köksal Z et al. | The inhibition effects of some natural products on lactoperoxidase purified from bovine milk. | 2017 | J. Biochem. Mol. Toxicol. | pmid:28594102 |
| Kim DH et al. | Isoliquiritigenin inhibits the proliferation of human renal carcinoma Caki cells through the ROS-mediated regulation of the Jak2/STAT3 pathway. | 2017 | Oncol. Rep. | pmid:28560439 |
| Yang HH et al. | Isoliquiritigenin Induces Cytotoxicity in PC-12 Cells In Vitro. | 2017 | Appl. Biochem. Biotechnol. | pmid:28488118 |
| Chen XY et al. | Reprogramming induced by isoliquiritigenin diminishes melanoma cachexia through mTORC2-AKT-GSK3β signaling. | 2017 | Oncotarget | pmid:28410220 |
| Boyapelly K et al. | Synthesis and Characterization of a Phosphate Prodrug of Isoliquiritigenin. | 2017 | J. Nat. Prod. | pmid:28252963 |
| Chi JH et al. | Isoliquiritigenin inhibits TNF-α-induced release of high-mobility group box 1 through activation of HDAC in human intestinal epithelial HT-29 cells. | 2017 | Eur. J. Pharmacol. | pmid:28012970 |
| Wu M et al. | Isoliquiritigenin decreases the incidence of colitis-associated colorectal cancer by modulating the intestinal microbiota. | 2016 | Oncotarget | pmid:27863401 |
| Wu CH et al. | Isoliquiritigenin induces apoptosis and autophagy and inhibits endometrial cancer growth in mice. | 2016 | Oncotarget | pmid:27708238 |
| Jin XY et al. | Isoliquiritigenin suppresses tumor necrosis factor-α-induced inflammation via peroxisome proliferator-activated receptor-γ in intestinal epithelial cells. | 2016 | Arch. Pharm. Res. | pmid:27539609 |
| Cao L- et al. | Isoliquiritigenin protects against triptolide-induced hepatotoxicity in mice through Nrf2 activation. | 2016 | Pharmazie | pmid:29441915 |
| Kong BJ et al. | Properties and in vitro drug release of hyaluronic acid-hydroxyethyl cellulose hydrogels for transdermal delivery of isoliquiritigenin. | 2016 | Carbohydr Polym | pmid:27178954 |
| Wang Y et al. | Isoliquiritigenin Inhibits Proliferation and Induces Apoptosis via Alleviating Hypoxia and Reducing Glycolysis in Mouse Melanoma B16F10 Cells. | 2016 | Recent Pat Anticancer Drug Discov | pmid:26951491 |
| Liu S et al. | Anti-osteoclastogenic activity of isoliquiritigenin via inhibition of NF-κB-dependent autophagic pathway. | 2016 | Biochem. Pharmacol. | pmid:26947453 |
| Choi YH et al. | Isoliquiritigenin ameliorates dextran sulfate sodium-induced colitis through the inhibition of MAPK pathway. | 2016 | Int. Immunopharmacol. | pmid:26771170 |
| Yamaura K et al. | Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry. | 2016 | Nat. Chem. Biol. | pmid:27526031 |
| Weis KE and Raetzman LT | Isoliquiritigenin exhibits anti-proliferative properties in the pituitary independent of estrogen receptor function. | 2016 | Toxicol. Appl. Pharmacol. | pmid:27702603 |
| Gaur R et al. | Drug Resistance Reversal Potential of Isoliquiritigenin and Liquiritigenin Isolated from Glycyrrhiza glabra Against Methicillin-Resistant Staphylococcus aureus (MRSA). | 2016 | Phytother Res | pmid:27388327 |
| Wu J et al. | Simultaneous Determination of Multiple Components in Guanjiekang in Rat Plasma via the UPLC-MS/MS Method and Its Application in Pharmacokinetic Study. | 2016 | Molecules | pmid:27999285 |
| Yang EJ et al. | The comparison of neuroprotective effects of isoliquiritigenin and its Phase I metabolites against glutamate-induced HT22 cell death. | 2016 | Bioorg. Med. Chem. Lett. | pmid:27815122 |
| Chen X et al. | Differentiation-inducing and anti-proliferative activities of isoliquiritigenin and all-trans-retinoic acid on B16F0 melanoma cells: Mechanisms profiling by RNA-seq. | 2016 | Gene | pmid:27461947 |
| Mahalingam S et al. | Effects of isoliquiritigenin on ovarian antral follicle growth and steroidogenesis. | 2016 | Reprod. Toxicol. | pmid:27773742 |
| Park SJ et al. | Isoliquiritigenin impairs insulin signaling and adipocyte differentiation through the inhibition of protein-tyrosine phosphatase 1B oxidation in 3T3-L1 preadipocytes. | 2016 | Food Chem. Toxicol. | pmid:27117918 |