| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Leiomyoma | D007889 | 8 associated lipids |
isoliquiritigenin
Isoliquiritigenin is a lipid of Polyketides (PK) class. Isoliquiritigenin is associated with abnormalities such as abnormal fragmented structure, Gastric ulcer, Gastric mucosa lesion, Peptic Ulcer and Wiskott-Aldrich Syndrome. The involved functions are known as Mass-to-Charge Ratio, Anabolism, Oxidation, inhibitors and Energy Absorption. Isoliquiritigenin often locates in Microsomes, Liver, Hepatic, Microsomes, Immune system and Vacuole. The associated genes with Isoliquiritigenin are P4HTM gene, BCL2 gene, AP1AR gene, oxytocin, 1-desamino-(O-Et-Tyr)(2)- and ODAM gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of isoliquiritigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with isoliquiritigenin?
isoliquiritigenin is suspected in Gastric mucosa lesion, Gastric ulcer, Peptic Ulcer, Nodule, Infertility and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with isoliquiritigenin
PubChem Associated disorders and diseases
What pathways are associated with isoliquiritigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with isoliquiritigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with isoliquiritigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with isoliquiritigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with isoliquiritigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with isoliquiritigenin?
Knock-out
Knock-out are used in the study 'Two activators of in vitro fertilization in mice from licorice.' (Tung NH et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with isoliquiritigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Srinivasan B et al. | Chalcone-based inhibitors against hypoxia-inducible factor 1--structure activity relationship studies. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21112783 |
| Iwashita K et al. | Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11055382 |
| Hwang CK and Chun HS | Isoliquiritigenin isolated from licorice Glycyrrhiza uralensis prevents 6-hydroxydopamine-induced apoptosis in dopaminergic neurons. | 2012 | Biosci. Biotechnol. Biochem. | pmid:22451397 |
| Chen T et al. | The inhibitory effect of Isoliquiritigenin on the proliferation of human arterial smooth muscle cell. | 2017 | BMC Pharmacol Toxicol | pmid:28716056 |
| Jhanji V et al. | Isoliquiritigenin from licorice root suppressed neovascularisation in experimental ocular angiogenesis models. | 2011 | Br J Ophthalmol | pmid:21719569 |
| Yu SM and Kuo SC | Vasorelaxant effect of isoliquiritigenin, a novel soluble guanylate cyclase activator, in rat aorta. | 1995 | Br. J. Pharmacol. | pmid:7599926 |
| Yamazaki S et al. | Isoliquiritigenin suppresses pulmonary metastasis of mouse renal cell carcinoma. | 2002 | Cancer Lett. | pmid:12049811 |
| Park I et al. | Isoliquiritigenin induces G2 and M phase arrest by inducing DNA damage and by inhibiting the metaphase/anaphase transition. | 2009 | Cancer Lett. | pmid:19167809 |
| Takahashi T et al. | Cyclooxygenase-2 plays a suppressive role for induction of apoptosis in isoliquiritigenin-treated mouse colon cancer cells. | 2006 | Cancer Lett. | pmid:16399234 |
| Ii T et al. | Induction of cell cycle arrest and p21(CIP1/WAF1) expression in human lung cancer cells by isoliquiritigenin. | 2004 | Cancer Lett. | pmid:15050731 |
| Cuendet M et al. | Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice. | 2010 | Cancer Prev Res (Phila) | pmid:20068129 |
| Takahashi T et al. | Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development. | 2004 | Cancer Sci. | pmid:15132774 |
| Kong BJ et al. | Properties and in vitro drug release of hyaluronic acid-hydroxyethyl cellulose hydrogels for transdermal delivery of isoliquiritigenin. | 2016 | Carbohydr Polym | pmid:27178954 |
| Yamamoto S et al. | The potent anti-tumor-promoting agent isoliquiritigenin. | 1991 | Carcinogenesis | pmid:1899810 |
| Wang N et al. | Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling. | 2014 | Carcinogenesis | pmid:25194164 |
| Sun C et al. | Isoliquiritigenin enhances radiosensitivity of HepG2 cells via disturbance of redox status. | 2013 | Cell Biochem. Biophys. | pmid:23086355 |
| Chen H et al. | Isoliquiritigenin-induced effects on Nrf2 mediated antioxidant defence in the HL-60 cell monocytic differentiation. | 2013 | Cell Biol. Int. | pmid:23881796 |
| Kong LD et al. | Inhibition of xanthine oxidase by liquiritigenin and isoliquiritigenin isolated from Sinofranchetia chinensis. | 2000 | Cell. Mol. Life Sci. | pmid:10823249 |
| Kawakami Z et al. | Isoliquiritigenin is a novel NMDA receptor antagonist in kampo medicine yokukansan. | 2011 | Cell. Mol. Neurobiol. | pmid:21691759 |
| Wu S et al. | Isoliquiritigenin Inhibits Interferon-γ-Inducible Genes Expression in Hepatocytes through Down-Regulating Activation of JAK1/STAT1, IRF3/MyD88, ERK/MAPK, JNK/MAPK and PI3K/Akt Signaling Pathways. | 2015 | Cell. Physiol. Biochem. | pmid:26315837 |
| Lian D et al. | Cathepsin B-Mediated NLRP3 Inflammasome Formation and Activation in Angiotensin II -Induced Hypertensive Mice: Role of Macrophage Digestion Dysfunction. | 2018 | Cell. Physiol. Biochem. | pmid:30359991 |
| Zhao Z et al. | Isoliquiritigenin attenuates oxidative hepatic damage induced by carbon tetrachloride with or without buthionine sulfoximine. | 2015 | Chem. Biol. Interact. | pmid:25450236 |
| Wong TY et al. | The licorice flavonoid isoliquiritigenin reduces DNA-binding activity of AhR in MCF-7 cells. | 2014 | Chem. Biol. Interact. | pmid:25110319 |
| Martin HJ et al. | The inhibitory effects of flavonoids and antiestrogens on the Glut1 glucose transporter in human erythrocytes. | 2003 | Chem. Biol. Interact. | pmid:14642735 |
| Sano S et al. | Reinvestigation of the synthesis of isoliquiritigenin: application of Horner-Wadsworth-Emmons reaction and Claisen-Schmidt condensation. | 2011 | Chem. Pharm. Bull. | pmid:21720042 |
| Hong H et al. | Rat α-Fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities. | 2012 | Chem. Res. Toxicol. | pmid:23013281 |
| Hajirahimkhan A et al. | Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women's Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A. | 2015 | Chem. Res. Toxicol. | pmid:26473469 |
| Dunlap TL et al. | Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It. | 2015 | Chem. Res. Toxicol. | pmid:26134484 |
| Chen J et al. | Isoliquiritigenin Suppresses Osteosarcoma U2OS Cell Proliferation and Invasion by Regulating the PI3K/Akt Signalling Pathway. | 2018 | Chemotherapy | pmid:29936511 |
| Hattori T et al. | Saireito probably prevents mesangial cell proliferation in HIGA mice via PDGF-BB tyrosine kinase inhibition. | 2007 | Clin. Exp. Nephrol. | pmid:18085387 |
| Hsu YL et al. | Isoliquiritigenin inhibits the proliferation and induces the apoptosis of human non-small cell lung cancer a549 cells. | 2004 | Clin. Exp. Pharmacol. Physiol. | pmid:15236626 |
| Zhang X et al. | Isoliquiritigenin, a natural anti-oxidant, selectively inhibits the proliferation of prostate cancer cells. | 2010 | Clin. Exp. Pharmacol. Physiol. | pmid:20456427 |
| Guo J et al. | In vitro metabolism of isoliquiritigenin by human liver microsomes. | 2008 | Drug Metab. Dispos. | pmid:18006650 |
| Guo J et al. | Biotransformation of the chemopreventive agent 2',4',4-trihydroxychalcone (isoliquiritigenin) by UDP-glucuronosyltransferases. | 2008 | Drug Metab. Dispos. | pmid:18653743 |
| Sung MW and Li PC | Chemical analysis of raw, dry-roasted, and honey-roasted licorice by capillary electrophoresis. | 2004 | Electrophoresis | pmid:15490450 |
| Liu MM et al. | Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy. | 2012 | Eur J Med Chem | pmid:22445328 |
| Chen YP et al. | Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase. | 2013 | Eur J Med Chem | pmid:23786711 |
| Park SM et al. | Isoliquiritigenin in licorice functions as a hepatic protectant by induction of antioxidant genes through extracellular signal-regulated kinase-mediated NF-E2-related factor-2 signaling pathway. | 2016 | Eur J Nutr | pmid:26593436 |
| Kwon SS et al. | Physicochemical properties of pH-sensitive hydrogels based on hydroxyethyl cellulose-hyaluronic acid and for applications as transdermal delivery systems for skin lesions. | 2015 | Eur J Pharm Biopharm | pmid:25753198 |
| Zhang XY et al. | Preparation of isoliquiritigenin-loaded nanostructured lipid carrier and the in vivo evaluation in tumor-bearing mice. | 2013 | Eur J Pharm Sci | pmid:23624327 |
| Welle R et al. | Induced plant responses to pathogen attack. Analysis and heterologous expression of the key enzyme in the biosynthesis of phytoalexins in soybean (Glycine max L. Merr. cv. Harosoy 63). | 1991 | Eur. J. Biochem. | pmid:1840523 |
| Wegener JW and Nawrath H | Cardiac effects of isoliquiritigenin. | 1997 | Eur. J. Pharmacol. | pmid:9178653 |
| Wegener JW and Nawrath H | Differential effects of isoliquiritigenin and YC-1 in rat aortic smooth muscle. | 1997 | Eur. J. Pharmacol. | pmid:9105881 |
| Tawata M et al. | Anti-platelet action of isoliquiritigenin, an aldose reductase inhibitor in licorice. | 1992 | Eur. J. Pharmacol. | pmid:1555643 |
| Kim JY et al. | Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-kappaB in RAW 264.7 macrophages. | 2008 | Eur. J. Pharmacol. | pmid:18295200 |
| Liu B et al. | Isoliquiritigenin, a flavonoid from licorice, relaxes guinea-pig tracheal smooth muscle in vitro and in vivo: role of cGMP/PKG pathway. | 2008 | Eur. J. Pharmacol. | pmid:18462716 |
| Zhang B et al. | Antineoplastic activity of isoliquiritigenin, a chalcone compound, in androgen-independent human prostate cancer cells linked to G2/M cell cycle arrest and cell apoptosis. | 2018 | Eur. J. Pharmacol. | pmid:29277717 |
| Jang EY et al. | Isoliquiritigenin suppresses cocaine-induced extracellular dopamine release in rat brain through GABA(B) receptor. | 2008 | Eur. J. Pharmacol. | pmid:18495107 |
| Chi JH et al. | Isoliquiritigenin inhibits TNF-α-induced release of high-mobility group box 1 through activation of HDAC in human intestinal epithelial HT-29 cells. | 2017 | Eur. J. Pharmacol. | pmid:28012970 |
| Kanazawa M et al. | Isoliquiritigenin inhibits the growth of prostate cancer. | 2003 | Eur. Urol. | pmid:12706007 |