| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Leiomyoma | D007889 | 8 associated lipids |
isoliquiritigenin
Isoliquiritigenin is a lipid of Polyketides (PK) class. Isoliquiritigenin is associated with abnormalities such as abnormal fragmented structure, Gastric ulcer, Gastric mucosa lesion, Peptic Ulcer and Wiskott-Aldrich Syndrome. The involved functions are known as Mass-to-Charge Ratio, Anabolism, Oxidation, inhibitors and Energy Absorption. Isoliquiritigenin often locates in Microsomes, Liver, Hepatic, Microsomes, Immune system and Vacuole. The associated genes with Isoliquiritigenin are P4HTM gene, BCL2 gene, AP1AR gene, oxytocin, 1-desamino-(O-Et-Tyr)(2)- and ODAM gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of isoliquiritigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with isoliquiritigenin?
isoliquiritigenin is suspected in Gastric mucosa lesion, Gastric ulcer, Peptic Ulcer, Nodule, Infertility and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with isoliquiritigenin
PubChem Associated disorders and diseases
What pathways are associated with isoliquiritigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with isoliquiritigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with isoliquiritigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with isoliquiritigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with isoliquiritigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with isoliquiritigenin?
Knock-out
Knock-out are used in the study 'Two activators of in vitro fertilization in mice from licorice.' (Tung NH et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with isoliquiritigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Peng F et al. | Cytotoxic Evaluation against Breast Cancer Cells of Isoliquiritigenin Analogues from Spatholobus suberectus and Their Synthetic Derivatives. | 2016 | J. Nat. Prod. | pmid:26690274 |
| Park SM et al. | Isoliquiritigenin in licorice functions as a hepatic protectant by induction of antioxidant genes through extracellular signal-regulated kinase-mediated NF-E2-related factor-2 signaling pathway. | 2016 | Eur J Nutr | pmid:26593436 |
| Denzer I et al. | S-allyl-L-cysteine and isoliquiritigenin improve mitochondrial function in cellular models of oxidative and nitrosative stress. | 2016 | Food Chem | pmid:26471626 |
| Wu Y et al. | Isoliquiritigenin prevents the progression of psoriasis-like symptoms by inhibiting NF-κB and proinflammatory cytokines. | 2016 | J. Mol. Med. | pmid:26383911 |
| Hsia SM et al. | Isoliquiritigenin as a cause of DNA damage and inhibitor of ataxia-telangiectasia mutated expression leading to G2/M phase arrest and apoptosis in oral squamous cell carcinoma. | 2016 | Head Neck | pmid:25580586 |
| Du F et al. | Isoliquiritigenin Attenuates Atherogenesis in Apolipoprotein E-Deficient Mice. | 2016 | Int J Mol Sci | pmid:27869741 |
| Molitor C et al. | Aurone synthase is a catechol oxidase with hydroxylase activity and provides insights into the mechanism of plant polyphenol oxidases. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26976571 |
| Watanabe Y et al. | Isoliquiritigenin Attenuates Adipose Tissue Inflammation in vitro and Adipose Tissue Fibrosis through Inhibition of Innate Immune Responses in Mice. | 2016 | Sci Rep | pmid:26975571 |
| Peng F et al. | The application of HPLC-MS/MS to studies of pharmacokinetics and interconversion of isoliquiritigenin and neoisoliquiritigenin in rats. | 2016 | Biomed. Chromatogr. | pmid:26577957 |
| Ma X et al. | The effect of isoliquiritigenin on learning and memory impairments induced by high-fat diet via inhibiting TNF-α/JNK/IRS signaling. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26188513 |
| Li ZX et al. | Novel insights into the apoptosis mechanism of DNA topoisomerase I inhibitor isoliquiritigenin on HCC tumor cell. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26159926 |
| Kwon SS et al. | Physicochemical properties of pH-sensitive hydrogels based on hydroxyethyl cellulose-hyaluronic acid and for applications as transdermal delivery systems for skin lesions. | 2015 | Eur J Pharm Biopharm | pmid:25753198 |
| Ng JL et al. | Flavonoids and Auxin Transport Inhibitors Rescue Symbiotic Nodulation in the Medicago truncatula Cytokinin Perception Mutant cre1. | 2015 | Plant Cell | pmid:26253705 |
| Hajirahimkhan A et al. | Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women's Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A. | 2015 | Chem. Res. Toxicol. | pmid:26473469 |
| Dunlap TL et al. | Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It. | 2015 | Chem. Res. Toxicol. | pmid:26134484 |
| Zhao S et al. | Inhibitory effect of DNA topoisomerase inhibitor isoliquiritigenin on the growth of glioma cells. | 2015 | Int J Clin Exp Pathol | pmid:26722447 |
| Guo A et al. | Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents. | 2015 | Sci Rep | pmid:26370586 |
| Wu S et al. | Isoliquiritigenin Inhibits Interferon-γ-Inducible Genes Expression in Hepatocytes through Down-Regulating Activation of JAK1/STAT1, IRF3/MyD88, ERK/MAPK, JNK/MAPK and PI3K/Akt Signaling Pathways. | 2015 | Cell. Physiol. Biochem. | pmid:26315837 |
| Traboulsi H et al. | The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection. | 2015 | Antimicrob. Agents Chemother. | pmid:26248373 |
| Li B et al. | Experimental and Theoretical Investigations on the Supermolecular Structure of Isoliquiritigenin and 6-O-α-D-Maltosyl-β-cyclodextrin Inclusion Complex. | 2015 | Int J Mol Sci | pmid:26247946 |
| Kitagawa H et al. | Pharmacokinetic Profiles of Active Ingredients and Its Metabolites Derived from Rikkunshito, a Ghrelin Enhancer, in Healthy Japanese Volunteers: A Cross-Over, Randomized Study. | 2015 | PLoS ONE | pmid:26186592 |
| Tian WW et al. | [Isoliquiritigenin relaxes the cerebral basilar artery by enhancing BKCa current in spontaneously hypertensive rat: role of sGC/cGMP]. | 2015 | Sheng Li Xue Bao | pmid:26109306 |
| Wang N et al. | Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation. | 2015 | Oncotarget | pmid:25918249 |
| Gong H et al. | A protective mechanism of licorice (Glycyrrhiza uralensis): isoliquiritigenin stimulates detoxification system via Nrf2 activation. | 2015 | J Ethnopharmacol | pmid:25557030 |
| Peng F et al. | A Review: The Pharmacology of Isoliquiritigenin. | 2015 | Phytother Res | pmid:25907962 |
| Zhou B et al. | The influence of compatibility of processed radix Aconiti Kusnezoffii on the pharmacokinetic of four components in Glycyrrhiza uralensis Fisch. | 2015 | J Ethnopharmacol | pmid:25889555 |
| Choi YH et al. | In vivo gastroprotective effect along with pharmacokinetics, tissue distribution and metabolism of isoliquiritigenin in mice. | 2015 | Planta Med. | pmid:25875506 |
| Link P et al. | Extracts of Glycyrrhiza uralensis and isoliquiritigenin counteract amyloid-β toxicity in Caenorhabditis elegans. | 2015 | Planta Med. | pmid:25782036 |
| Wang R et al. | Flavonoids derived from liquorice suppress murine macrophage activation by up-regulating heme oxygenase-1 independent of Nrf2 activation. | 2015 | Int. Immunopharmacol. | pmid:25871879 |
| Tung NH et al. | Two activators of in vitro fertilization in mice from licorice. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26392313 |
| Zhao Z et al. | Isoliquiritigenin attenuates oxidative hepatic damage induced by carbon tetrachloride with or without buthionine sulfoximine. | 2015 | Chem. Biol. Interact. | pmid:25450236 |
| Wang N et al. | Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling. | 2014 | Carcinogenesis | pmid:25194164 |
| Sunkaria A et al. | 4-Hydroxy TEMPO attenuates dichlorvos induced microglial activation and apoptosis. | 2014 | ACS Chem Neurosci | pmid:24369695 |
| Zhou Y and Ho WS | Combination of liquiritin, isoliquiritin and isoliquirigenin induce apoptotic cell death through upregulating p53 and p21 in the A549 non-small cell lung cancer cells. | 2014 | Oncol. Rep. | pmid:24247527 |
| Jung SK et al. | Isoliquiritigenin induces apoptosis and inhibits xenograft tumor growth of human lung cancer cells by targeting both wild type and L858R/T790M mutant EGFR. | 2014 | J. Biol. Chem. | pmid:25368326 |
| Fu H et al. | Synthesis and anti-tumor activity of novel aminomethylated derivatives of isoliquiritigenin. | 2014 | Molecules | pmid:25365296 |
| Honda H et al. | Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation. | 2014 | J. Leukoc. Biol. | pmid:25210146 |
| Wang Z et al. | MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin. | 2014 | Oncotarget | pmid:25026296 |
| Robb EL and Stuart JA | Multiple phytoestrogens inhibit cell growth and confer cytoprotection by inducing manganese superoxide dismutase expression. | 2014 | Phytother Res | pmid:23526725 |
| Gaur R et al. | In vivo anti-diabetic activity of derivatives of isoliquiritigenin and liquiritigenin. | 2014 | Phytomedicine | pmid:24262065 |
| Adianti M et al. | Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species. | 2014 | Microbiol. Immunol. | pmid:24397541 |
| Zheng H et al. | Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion. | 2014 | Toxicol. Appl. Pharmacol. | pmid:25094029 |
| Qiao H et al. | Pharmacokinetics, biodistribution and bioavailability of isoliquiritigenin after intravenous and oral administration. | 2014 | Pharm Biol | pmid:24102672 |
| Kim SJ et al. | Synthesis of licochalcone analogues with increased anti-inflammatory activity. | 2014 | Bioorg. Med. Chem. Lett. | pmid:24316124 |
| Zhao H et al. | Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6. | 2014 | Toxicol. Appl. Pharmacol. | pmid:25026504 |
| Wong TY et al. | The licorice flavonoid isoliquiritigenin reduces DNA-binding activity of AhR in MCF-7 cells. | 2014 | Chem. Biol. Interact. | pmid:25110319 |
| Yang N et al. | Glycyrrhiza uralensis flavonoids present in anti-asthma formula, ASHMIâ„¢, inhibit memory Th2 responses in vitro and in vivo. | 2013 | Phytother Res | pmid:23165939 |
| Foresti R et al. | Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells. | 2013 | Pharmacol. Res. | pmid:23942037 |
| Lorusso V and Marech I | Novel plant-derived target drugs: a step forward from licorice? | 2013 | Expert Opin. Ther. Targets | pmid:23425066 |
| Simmler C et al. | Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay. | 2013 | J. Agric. Food Chem. | pmid:23427769 |