| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Leiomyoma | D007889 | 8 associated lipids |
isoliquiritigenin
Isoliquiritigenin is a lipid of Polyketides (PK) class. Isoliquiritigenin is associated with abnormalities such as abnormal fragmented structure, Gastric ulcer, Gastric mucosa lesion, Peptic Ulcer and Wiskott-Aldrich Syndrome. The involved functions are known as Mass-to-Charge Ratio, Anabolism, Oxidation, inhibitors and Energy Absorption. Isoliquiritigenin often locates in Microsomes, Liver, Hepatic, Microsomes, Immune system and Vacuole. The associated genes with Isoliquiritigenin are P4HTM gene, BCL2 gene, AP1AR gene, oxytocin, 1-desamino-(O-Et-Tyr)(2)- and ODAM gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of isoliquiritigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with isoliquiritigenin?
isoliquiritigenin is suspected in Gastric mucosa lesion, Gastric ulcer, Peptic Ulcer, Nodule, Infertility and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with isoliquiritigenin
PubChem Associated disorders and diseases
What pathways are associated with isoliquiritigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with isoliquiritigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with isoliquiritigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with isoliquiritigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with isoliquiritigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with isoliquiritigenin?
Knock-out
Knock-out are used in the study 'Two activators of in vitro fertilization in mice from licorice.' (Tung NH et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with isoliquiritigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kwon HM et al. | Blockade of cytokine-induced endothelial cell adhesion molecule expression by licorice isoliquiritigenin through NF-kappaB signal disruption. | 2007 | Exp. Biol. Med. (Maywood) | pmid:17259331 |
| Lorusso V and Marech I | Novel plant-derived target drugs: a step forward from licorice? | 2013 | Expert Opin. Ther. Targets | pmid:23425066 |
| Wang KL et al. | Inhibitory effects of isoliquiritigenin on the migration and invasion of human breast cancer cells. | 2013 | Expert Opin. Ther. Targets | pmid:23327692 |
| Lu H et al. | Isoliquiritigenin showed strong inhibitory effects towards multiple UDP-glucuronosyltransferase (UGT) isoform-catalyzed 4-methylumbelliferone (4-MU) glucuronidation. | 2013 | Fitoterapia | pmid:23237733 |
| Denzer I et al. | S-allyl-L-cysteine and isoliquiritigenin improve mitochondrial function in cellular models of oxidative and nitrosative stress. | 2016 | Food Chem | pmid:26471626 |
| Yang L et al. | Development of sample preparation method for isoliquiritigenin, liquiritin, and glycyrrhizic acid analysis in licorice by ionic liquids-ultrasound based extraction and high-performance liquid chromatography detection. | 2013 | Food Chem | pmid:23265473 |
| Park SJ et al. | Isoliquiritigenin impairs insulin signaling and adipocyte differentiation through the inhibition of protein-tyrosine phosphatase 1B oxidation in 3T3-L1 preadipocytes. | 2016 | Food Chem. Toxicol. | pmid:27117918 |
| Patricia Moreno-Londoño A et al. | Isoliquiritigenin pretreatment attenuates cisplatin induced proximal tubular cells (LLC-PK1) death and enhances the toxicity induced by this drug in bladder cancer T24 cell line. | 2017 | Food Chem. Toxicol. | pmid:28870684 |
| Vaya J et al. | Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation. | 1997 | Free Radic. Biol. Med. | pmid:9199893 |
| Kim YM et al. | Inhibition of liver X receptor-α-dependent hepatic steatosis by isoliquiritigenin, a licorice antioxidant flavonoid, as mediated by JNK1 inhibition. | 2010 | Free Radic. Biol. Med. | pmid:20840863 |
| Li D et al. | Isoliquiritigenin induces monocytic differentiation of HL-60 cells. | 2009 | Free Radic. Biol. Med. | pmid:19110051 |
| Takeda H et al. | Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism. | 2008 | Gastroenterology | pmid:18439428 |
| Chen X et al. | Differentiation-inducing and anti-proliferative activities of isoliquiritigenin and all-trans-retinoic acid on B16F0 melanoma cells: Mechanisms profiling by RNA-seq. | 2016 | Gene | pmid:27461947 |
| Hsia SM et al. | Isoliquiritigenin as a cause of DNA damage and inhibitor of ataxia-telangiectasia mutated expression leading to G2/M phase arrest and apoptosis in oral squamous cell carcinoma. | 2016 | Head Neck | pmid:25580586 |
| Sekine-Osajima Y et al. | Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replication. | 2009 | Hepatol. Res. | pmid:18647187 |
| Yang YM et al. | Decrease of microRNA-122 causes hepatic insulin resistance by inducing protein tyrosine phosphatase 1B, which is reversed by licorice flavonoid. | 2012 | Hepatology | pmid:22807119 |
| Lee SH et al. | Isoliquiritigenin, from Dalbergia odorifera, up-regulates anti-inflammatory heme oxygenase-1 expression in RAW264.7 macrophages. | 2009 | Inflamm. Res. | pmid:19169644 |
| Zhang W et al. | Protective Effects of Isoliquiritigenin on LPS-Induced Acute Lung Injury by Activating PPAR-γ. | 2018 | Inflammation | pmid:29654430 |
| Thiyagarajan P et al. | Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents. | 2011 | Inflammopharmacology | pmid:21328091 |
| Zhao S et al. | Inhibitory effect of DNA topoisomerase inhibitor isoliquiritigenin on the growth of glioma cells. | 2015 | Int J Clin Exp Pathol | pmid:26722447 |
| Du F et al. | Isoliquiritigenin Attenuates Atherogenesis in Apolipoprotein E-Deficient Mice. | 2016 | Int J Mol Sci | pmid:27869741 |
| Li B et al. | Experimental and Theoretical Investigations on the Supermolecular Structure of Isoliquiritigenin and 6-O-α-D-Maltosyl-β-cyclodextrin Inclusion Complex. | 2015 | Int J Mol Sci | pmid:26247946 |
| Chen HY et al. | Isoliquiritigenin Induces Autophagy and Inhibits Ovarian Cancer Cell Growth. | 2017 | Int J Mol Sci | pmid:28934130 |
| Gao F et al. | iRGD-modified lipid-polymer hybrid nanoparticles loaded with isoliquiritigenin to enhance anti-breast cancer effect and tumor-targeting ability. | 2017 | Int J Nanomedicine | pmid:28615942 |
| Choi YH et al. | Isoliquiritigenin ameliorates dextran sulfate sodium-induced colitis through the inhibition of MAPK pathway. | 2016 | Int. Immunopharmacol. | pmid:26771170 |
| Wang R et al. | Flavonoids derived from liquorice suppress murine macrophage activation by up-regulating heme oxygenase-1 independent of Nrf2 activation. | 2015 | Int. Immunopharmacol. | pmid:25871879 |
| Zhu L et al. | Licorice isoliquiritigenin suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo. | 2012 | Int. J. Biochem. Cell Biol. | pmid:22521613 |
| Ye L et al. | Dietary administration of the licorice flavonoid isoliquiritigenin deters the growth of MCF-7 cells overexpressing aromatase. | 2009 | Int. J. Cancer | pmid:19065667 |
| Chen S et al. | Down-regulation of androgen-receptor and PSA by phytochemicals. | 2008 | Int. J. Oncol. | pmid:18202763 |
| Auyeung KK and Ko JK | Novel herbal flavonoids promote apoptosis but differentially induce cell cycle arrest in human colon cancer cell. | 2010 | Invest New Drugs | pmid:19139819 |
| Cao L et al. | In vitro screening for angiostatic potential of herbal chemicals. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20671276 |
| Yuan X et al. | Isoliquiritigenin treatment induces apoptosis by increasing intracellular ROS levels in HeLa cells. | 2012 | J Asian Nat Prod Res | pmid:22694287 |
| Cao Y et al. | Determination of liquiritigenin and isoliquiritigenin in Glycyrrhiza uralensis and its medicinal preparations by capillary electrophoresis with electrochemical detection. | 2004 | J Chromatogr A | pmid:15296407 |
| Ma CJ et al. | One step isolation and purification of liquiritigenin and isoliquiritigenin from Glycyrrhiza uralensis Risch. using high-speed counter-current chromatography. | 2005 | J Chromatogr A | pmid:16007997 |
| Cui FC et al. | Elucidation of the methyl transfer mechanism catalyzed by chalcone O-methyltransferase: a density functional study. | 2011 | J Comput Chem | pmid:21815175 |
| Gong H et al. | A protective mechanism of licorice (Glycyrrhiza uralensis): isoliquiritigenin stimulates detoxification system via Nrf2 activation. | 2015 | J Ethnopharmacol | pmid:25557030 |
| Zhou B et al. | The influence of compatibility of processed radix Aconiti Kusnezoffii on the pharmacokinetic of four components in Glycyrrhiza uralensis Fisch. | 2015 | J Ethnopharmacol | pmid:25889555 |
| Lee KK et al. | Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix. | 2013 | J Ethnopharmacol | pmid:23164761 |
| Lee YM et al. | Induction of cell cycle arrest in prostate cancer cells by the dietary compound isoliquiritigenin. | 2009 | J Med Food | pmid:19298190 |
| Zeng J et al. | Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway. | 2017 | J Neuroinflammation | pmid:28610608 |
| Xie J et al. | Simultaneous analysis of glycyrrhizin, paeoniflorin, quercetin, ferulic acid, liquiritin, formononetin, benzoic acid and isoliquiritigenin in the Chinese proprietary medicine Xiao Yao Wan by HPLC. | 2007 | J Pharm Biomed Anal | pmid:17709224 |
| Park SJ and Youn HS | Isoliquiritigenin suppresses the Toll-interleukin-1 receptor domain-containing adapter inducing interferon-beta (TRIF)-dependent signaling pathway of Toll-like receptors by targeting TBK1. | 2010 | J. Agric. Food Chem. | pmid:20356041 |
| Li J et al. | Isoliquiritigenin entails blockade of TGF-beta1-SMAD signaling for retarding high glucose-induced mesangial matrix accumulation. | 2010 | J. Agric. Food Chem. | pmid:20146476 |
| Chin YW et al. | Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra). | 2007 | J. Agric. Food Chem. | pmid:17516657 |
| Nerya O et al. | Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots. | 2003 | J. Agric. Food Chem. | pmid:12590456 |
| Simmler C et al. | Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay. | 2013 | J. Agric. Food Chem. | pmid:23427769 |
| Ruiz-PernÃa JJ et al. | Enzymatic effects on reactant and transition states. The case of chalcone isomerase. | 2007 | J. Am. Chem. Soc. | pmid:17602559 |
| Ruiz-PernÃa JJ et al. | Dynamic effects on reaction rates in a Michael addition catalyzed by chalcone isomerase. Beyond the frozen environment approach. | 2008 | J. Am. Chem. Soc. | pmid:18479090 |
| Köksal Z et al. | The inhibition effects of some natural products on lactoperoxidase purified from bovine milk. | 2017 | J. Biochem. Mol. Toxicol. | pmid:28594102 |
| Jung SK et al. | Isoliquiritigenin induces apoptosis and inhibits xenograft tumor growth of human lung cancer cells by targeting both wild type and L858R/T790M mutant EGFR. | 2014 | J. Biol. Chem. | pmid:25368326 |