| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Leiomyoma | D007889 | 8 associated lipids |
isoliquiritigenin
Isoliquiritigenin is a lipid of Polyketides (PK) class. Isoliquiritigenin is associated with abnormalities such as abnormal fragmented structure, Gastric ulcer, Gastric mucosa lesion, Peptic Ulcer and Wiskott-Aldrich Syndrome. The involved functions are known as Mass-to-Charge Ratio, Anabolism, Oxidation, inhibitors and Energy Absorption. Isoliquiritigenin often locates in Microsomes, Liver, Hepatic, Microsomes, Immune system and Vacuole. The associated genes with Isoliquiritigenin are P4HTM gene, BCL2 gene, AP1AR gene, oxytocin, 1-desamino-(O-Et-Tyr)(2)- and ODAM gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of isoliquiritigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with isoliquiritigenin?
isoliquiritigenin is suspected in Gastric mucosa lesion, Gastric ulcer, Peptic Ulcer, Nodule, Infertility and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with isoliquiritigenin
PubChem Associated disorders and diseases
What pathways are associated with isoliquiritigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with isoliquiritigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with isoliquiritigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with isoliquiritigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with isoliquiritigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with isoliquiritigenin?
Knock-out
Knock-out are used in the study 'Two activators of in vitro fertilization in mice from licorice.' (Tung NH et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with isoliquiritigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li X et al. | A new flavonol from Oxytropis ochrocephala Bunge. | 2013 | Nat. Prod. Res. | pmid:22494026 |
| Yuan X et al. | Involvement of endoplasmic reticulum stress in isoliquiritigenin-induced SKOV-3 cell apoptosis. | 2013 | Recent Pat Anticancer Drug Discov | pmid:22963151 |
| Lee SK et al. | The inhibitory effect of roasted licorice extract on human metastatic breast cancer cell-induced bone destruction. | 2013 | Phytother Res | pmid:23401151 |
| Hajirahimkhan A et al. | Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms. | 2013 | PLoS ONE | pmid:23874474 |
| Chen H et al. | Isoliquiritigenin-induced effects on Nrf2 mediated antioxidant defence in the HL-60 cell monocytic differentiation. | 2013 | Cell Biol. Int. | pmid:23881796 |
| Zhao H et al. | Isoliquiritigen enhances the antitumour activity and decreases the genotoxic effect of cyclophosphamide. | 2013 | Molecules | pmid:23887720 |
| Chen YP et al. | Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase. | 2013 | Eur J Med Chem | pmid:23786711 |
| Zhang XY et al. | Preparation of isoliquiritigenin-loaded nanostructured lipid carrier and the in vivo evaluation in tumor-bearing mice. | 2013 | Eur J Pharm Sci | pmid:23624327 |
| Zhou GS et al. | Isoliquiritigenin inhibits proliferation and induces apoptosis of U87 human glioma cells in vitro. | 2013 | Mol Med Rep | pmid:23229626 |
| Lu H et al. | Isoliquiritigenin showed strong inhibitory effects towards multiple UDP-glucuronosyltransferase (UGT) isoform-catalyzed 4-methylumbelliferone (4-MU) glucuronidation. | 2013 | Fitoterapia | pmid:23237733 |
| Yang L et al. | Development of sample preparation method for isoliquiritigenin, liquiritin, and glycyrrhizic acid analysis in licorice by ionic liquids-ultrasound based extraction and high-performance liquid chromatography detection. | 2013 | Food Chem | pmid:23265473 |
| Wang KL et al. | Inhibitory effects of isoliquiritigenin on the migration and invasion of human breast cancer cells. | 2013 | Expert Opin. Ther. Targets | pmid:23327692 |
| Han SY et al. | A new approach for pharmacokinetic studies of natural products: measurement of isoliquiritigenin levels in mice plasma, urine and feces using modified automated dosing/blood sampling system. | 2013 | Biomed. Chromatogr. | pmid:23339046 |
| Lee KK et al. | Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix. | 2013 | J Ethnopharmacol | pmid:23164761 |
| Sun C et al. | Isoliquiritigenin enhances radiosensitivity of HepG2 cells via disturbance of redox status. | 2013 | Cell Biochem. Biophys. | pmid:23086355 |
| Yuan X et al. | Involvement of the mitochondrion-dependent and the endoplasmic reticulum stress-signaling pathways in isoliquiritigenin-induced apoptosis of HeLa cell. | 2013 | Biomed. Environ. Sci. | pmid:23534467 |
| Arai T et al. | Rikkunshito and isoliquiritigenin counteract 5-HT-induced 2C receptor-mediated activation of pro-opiomelanocortin neurons in the hypothalamic arcuate nucleus. | 2013 | Neuropeptides | pmid:23756052 |
| Yamada C et al. | Rikkunshito, a Japanese kampo medicine, ameliorates decreased feeding behavior via ghrelin and serotonin 2B receptor signaling in a novelty stress murine model. | 2013 | Biomed Res Int | pmid:24288687 |
| Robinson SJ et al. | Selected furanochalcones as inhibitors of monoamine oxidase. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23860591 |
| Wang Z et al. | Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway. | 2013 | PLoS ONE | pmid:23861918 |
| Li Y et al. | Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23747687 |
| Zhang X et al. | Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway. | 2013 | Mediators Inflamm. | pmid:24163504 |
| Lee YK et al. | Pharmacokinetics of isoliquiritigenin and its metabolites in rats: low bioavailability is primarily due to the hepatic and intestinal metabolism. | 2013 | Planta Med. | pmid:24108436 |
| Hirchaud F et al. | Isoliquiritigenin induces caspase-dependent apoptosis via downregulation of HPV16 E6 expression in cervical cancer Ca Ski cells. | 2013 | Planta Med. | pmid:24214831 |
| Hong H et al. | Rat α-Fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities. | 2012 | Chem. Res. Toxicol. | pmid:23013281 |
| Liu MM et al. | Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy. | 2012 | Eur J Med Chem | pmid:22445328 |
| Zhu L et al. | Licorice isoliquiritigenin suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo. | 2012 | Int. J. Biochem. Cell Biol. | pmid:22521613 |
| Chen G et al. | Mammalian target of rapamycin regulates isoliquiritigenin-induced autophagic and apoptotic cell death in adenoid cystic carcinoma cells. | 2012 | Apoptosis | pmid:21956714 |
| Lee JE et al. | Molecular signatures in response to Isoliquiritigenin in lymphoblastoid cell lines. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22995316 |
| Muanprasat C et al. | Novel action of the chalcone isoliquiritigenin as a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor: potential therapy for cholera and polycystic kidney disease. | 2012 | J. Pharmacol. Sci. | pmid:22186622 |
| Fioravanti R et al. | Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action. | 2012 | Bioorg. Med. Chem. | pmid:22743086 |
| Yang YM et al. | Decrease of microRNA-122 causes hepatic insulin resistance by inducing protein tyrosine phosphatase 1B, which is reversed by licorice flavonoid. | 2012 | Hepatology | pmid:22807119 |
| Khamsan S et al. | The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry. | 2012 | Acta Pharm | pmid:22750816 |
| Honda H et al. | Glycyrrhizin and isoliquiritigenin suppress the LPS sensor toll-like receptor 4/MD-2 complex signaling in a different manner. | 2012 | J. Leukoc. Biol. | pmid:22422925 |
| Hwang CK and Chun HS | Isoliquiritigenin isolated from licorice Glycyrrhiza uralensis prevents 6-hydroxydopamine-induced apoptosis in dopaminergic neurons. | 2012 | Biosci. Biotechnol. Biochem. | pmid:22451397 |
| Yuan X et al. | Isoliquiritigenin treatment induces apoptosis by increasing intracellular ROS levels in HeLa cells. | 2012 | J Asian Nat Prod Res | pmid:22694287 |
| Lee HK et al. | Inhibitory effects of Glycyrrhizae radix and its active component, isoliquiritigenin, on Aβ(25-35)-induced neurotoxicity in cultured rat cortical neurons. | 2012 | Arch. Pharm. Res. | pmid:22644857 |
| Chen X et al. | Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. | 2012 | J. Mol. Med. | pmid:22648519 |
| Yang EJ et al. | Isoliquiritigenin isolated from Glycyrrhiza uralensis protects neuronal cells against glutamate-induced mitochondrial dysfunction. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22538371 |
| Shi Y et al. | Analgesic and uterine relaxant effects of isoliquiritigenin, a flavone from Glycyrrhiza glabra. | 2012 | Phytother Res | pmid:22389128 |
| Chen X et al. | Isoliquiritigenin-induced differentiation in mouse melanoma B16F0 cell line. | 2012 | Oxid Med Cell Longev | pmid:23304254 |
| Chen H et al. | NADPH oxidase-derived reactive oxygen species are involved in the HL-60 cell monocytic differentiation induced by isoliquiritigenin. | 2012 | Molecules | pmid:23147401 |
| Srinivasan B et al. | Chalcone-based inhibitors against hypoxia-inducible factor 1--structure activity relationship studies. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21112783 |
| Kawakami Z et al. | Isoliquiritigenin is a novel NMDA receptor antagonist in kampo medicine yokukansan. | 2011 | Cell. Mol. Neurobiol. | pmid:21691759 |
| Han B et al. | Determination of isoliquiritigenin and its distribution in mice by synchronous fluorescence spectrometry. | 2011 | Anal Sci | pmid:22076338 |
| Yang H et al. | Isoliquiritigenin (4,2',4'-trihydroxychalcone): a new matrix-assisted laser desorption/ionization matrix with outstanding properties for the analysis of neutral oligosaccharides. | 2011 | Anal. Chim. Acta | pmid:21763807 |
| Feldman M et al. | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. | 2011 | J. Nat. Prod. | pmid:21866899 |
| Sano S et al. | Reinvestigation of the synthesis of isoliquiritigenin: application of Horner-Wadsworth-Emmons reaction and Claisen-Schmidt condensation. | 2011 | Chem. Pharm. Bull. | pmid:21720042 |
| Thiyagarajan P et al. | Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents. | 2011 | Inflammopharmacology | pmid:21328091 |
| Chandrasekaran CV et al. | Dual inhibitory effect of Glycyrrhiza glabra (GutGardâ„¢) on COX and LOX products. | 2011 | Phytomedicine | pmid:20864324 |