| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Leiomyoma | D007889 | 8 associated lipids |
isoliquiritigenin
Isoliquiritigenin is a lipid of Polyketides (PK) class. Isoliquiritigenin is associated with abnormalities such as abnormal fragmented structure, Gastric ulcer, Gastric mucosa lesion, Peptic Ulcer and Wiskott-Aldrich Syndrome. The involved functions are known as Mass-to-Charge Ratio, Anabolism, Oxidation, inhibitors and Energy Absorption. Isoliquiritigenin often locates in Microsomes, Liver, Hepatic, Microsomes, Immune system and Vacuole. The associated genes with Isoliquiritigenin are P4HTM gene, BCL2 gene, AP1AR gene, oxytocin, 1-desamino-(O-Et-Tyr)(2)- and ODAM gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of isoliquiritigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with isoliquiritigenin?
isoliquiritigenin is suspected in Gastric mucosa lesion, Gastric ulcer, Peptic Ulcer, Nodule, Infertility and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with isoliquiritigenin
PubChem Associated disorders and diseases
What pathways are associated with isoliquiritigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with isoliquiritigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with isoliquiritigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with isoliquiritigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with isoliquiritigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with isoliquiritigenin?
Knock-out
Knock-out are used in the study 'Two activators of in vitro fertilization in mice from licorice.' (Tung NH et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with isoliquiritigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pan X et al. | In vitro inhibition of rat monoamine oxidase by liquiritigenin and isoliquiritigenin isolated from Sinofranchetia chinensis. | 2000 | Acta Pharmacol. Sin. | pmid:11501051 |
| Shibata S | A drug over the millennia: pharmacognosy, chemistry, and pharmacology of licorice. | 2000 | Yakugaku Zasshi | pmid:11082698 |
| Krishnaveni KS and Rao JV | An isoflavone from Pterocarpus santalinus. | 2000 | Phytochemistry | pmid:10724187 |
| Iwashita K et al. | Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11055382 |
| Artico M et al. | Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling. | 1998 | J. Med. Chem. | pmid:9767632 |
| Dinkova-Kostova AT et al. | Chemoprotective properties of phenylpropenoids, bis(benzylidene)cycloalkanones, and related Michael reaction acceptors: correlation of potencies as phase 2 enzyme inducers and radical scavengers. | 1998 | J. Med. Chem. | pmid:9857096 |
| Hayashi H et al. | Seasonal variation of glycyrrhizin and isoliquiritigenin glycosides in the root of Glycyrrhiza glabra L. | 1998 | Biol. Pharm. Bull. | pmid:9781853 |
| Wegener JW and Nawrath H | Cardiac effects of isoliquiritigenin. | 1997 | Eur. J. Pharmacol. | pmid:9178653 |
| Vaya J et al. | Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation. | 1997 | Free Radic. Biol. Med. | pmid:9199893 |
| Wegener JW and Nawrath H | Differential effects of isoliquiritigenin and YC-1 in rat aortic smooth muscle. | 1997 | Eur. J. Pharmacol. | pmid:9105881 |
| Ichimura M et al. | Enzymic O-methylation of isoliquiritigenin and licodione in alfalfa and licorice cultures. | 1997 | Phytochemistry | pmid:9055445 |
| Tropf S et al. | Reaction mechanisms of homodimeric plant polyketide synthase (stilbenes and chalcone synthase). A single active site for the condensing reaction is sufficient for synthesis of stilbenes, chalcones, and 6'-deoxychalcones. | 1995 | J. Biol. Chem. | pmid:7713888 |
| Iwata S et al. | Antitumorigenic activities of chalcones. I. Inhibitory effects of chalcone derivatives on 32Pi-incorporation into phospholipids of HeLa cells promoted by 12-O-tetradecanoyl-phorbol 13-acetate (TPA). | 1995 | Biol. Pharm. Bull. | pmid:8787793 |
| Yu SM and Kuo SC | Vasorelaxant effect of isoliquiritigenin, a novel soluble guanylate cyclase activator, in rat aorta. | 1995 | Br. J. Pharmacol. | pmid:7599926 |
| Shindo H et al. | The role of cyclic adenosine 3',5'-monophosphate and polyol metabolism in diabetic neuropathy. | 1992 | J. Clin. Endocrinol. Metab. | pmid:1370506 |
| Tawata M et al. | Anti-platelet action of isoliquiritigenin, an aldose reductase inhibitor in licorice. | 1992 | Eur. J. Pharmacol. | pmid:1555643 |
| Kape R et al. | Isoliquiritigenin, a strong nod gene- and glyceollin resistance-inducing flavonoid from soybean root exudate. | 1992 | Appl. Environ. Microbiol. | pmid:1622242 |
| Yamamoto S et al. | The potent anti-tumor-promoting agent isoliquiritigenin. | 1991 | Carcinogenesis | pmid:1899810 |
| Wakasugi M et al. | Effects of aldose reductase inhibitors on prostacyclin (PGI2) synthesis by aortic rings from rats with streptozotocin-induced diabetes. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1840007 |
| Welle R et al. | Induced plant responses to pathogen attack. Analysis and heterologous expression of the key enzyme in the biosynthesis of phytoalexins in soybean (Glycine max L. Merr. cv. Harosoy 63). | 1991 | Eur. J. Biochem. | pmid:1840523 |
| Aida K et al. | Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix. | 1990 | Planta Med. | pmid:2118267 |
| Welle R and Grisebach H | Phytoalexin synthesis in soybean cells: elicitor induction of reductase involved in biosynthesis of 6'-deoxychalcone. | 1989 | Arch. Biochem. Biophys. | pmid:2500065 |
| Brown S and Griffiths LA | Metabolism and excretion of butein, 2',3,4-trihydroxychalcone, 3-O-methylbutein, 4-O-methylbutein and 2',4',4-trihydroxychalcone in the rat. | 1983 | Xenobiotica | pmid:6673378 |
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