butein

Butein is a lipid of Polyketides (PK) class. Butein is associated with abnormalities such as Glomerulonephritis, Fibrosis, Liver, Kidney Failure, Acute, Mastocytosis and Chimera disorder. The involved functions are known as Phosphorylation, Transcription, Genetic, IkappaB kinase activity, Gene Expression and Signal Transduction. Butein often locates in Membrane, Cytoplasmic, IkappaB kinase complex, Protoplasm and Plasma membrane. The associated genes with Butein are ICAM1 gene, MAPK8 gene, MYC gene, BCL2 gene and BCL2L1 gene. The related lipids are Promega. The related experimental models are Xenograft Model, Knock-out and Mouse Model.

Cross Reference

Introduction

To understand associated biological information of butein, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with butein?

butein is suspected in Janiceps, Glomerulonephritis, Fibrosis, Liver, Kidney Failure, Acute, Mastocytosis, Chimera disorder and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with butein

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Lung Neoplasms D008175 171 associated lipids
Inflammation D007249 119 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Proteinuria D011507 30 associated lipids
Leukemia D007938 74 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with butein

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with butein?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with butein?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with butein?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with butein?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with butein?

Xenograft Model

Xenograft Model are used in the study 'Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo.' (Rajendran P et al., 2011).

Mouse Model

Mouse Model are used in the study 'Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo.' (Rajendran P et al., 2011).

Knock-out

Knock-out are used in the study 'Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo.' (Rajendran P et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with butein

Download all related citations
Per page 10 20 50 100 | Total 110
Authors Title Published Journal PubMed Link
Negi S et al. Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules. 2018 Toxicol In Vitro pmid:29933105
Liao W et al. Butein Inhibited In Vitro Hexokinase-2-Mediated Tumor Glycolysis in Hepatocellular Carcinoma by Blocking Epidermal Growth Factor Receptor (EGFR). 2018 Med. Sci. Monit. pmid:29777095
Jayasooriya RGPT et al. Molecular chemotherapeutic potential of butein: A concise review. 2018 Food Chem. Toxicol. pmid:29258953
Ansari MY et al. Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1β Stimulated Human Chondrocytes. 2018 Cell. Physiol. Biochem. pmid:30184535
Alshammari GM et al. Butein protects the nonalcoholic fatty liver through mitochondrial reactive oxygen species attenuation in rats. 2018 Biofactors pmid:29672963
Wang Z et al. Butein induction of HO-1 by p38 MAPK/Nrf2 pathway in adipocytes attenuates high-fat diet induced adipose hypertrophy in mice. 2017 Eur. J. Pharmacol. pmid:28213287
Padmavathi G et al. Butein in health and disease: A comprehensive review. 2017 Phytomedicine pmid:28190465
Zheng W et al. Butein inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes and slows the progression of osteoarthritis in mice. 2017 Int. Immunopharmacol. pmid:27863298
Yang J et al. [Butein promotes the role of mH2A in MAPK signaling pathway through targeting GRP78 in regulating biological behaviors of melanoma]. 2017 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:29093242
Mori M et al. Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia. 2017 Sci Rep pmid:28526832