| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Proteinuria | D011507 | 30 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
butein
Butein is a lipid of Polyketides (PK) class. Butein is associated with abnormalities such as Glomerulonephritis, Fibrosis, Liver, Kidney Failure, Acute, Mastocytosis and Chimera disorder. The involved functions are known as Phosphorylation, Transcription, Genetic, IkappaB kinase activity, Gene Expression and Signal Transduction. Butein often locates in Membrane, Cytoplasmic, IkappaB kinase complex, Protoplasm and Plasma membrane. The associated genes with Butein are ICAM1 gene, MAPK8 gene, MYC gene, BCL2 gene and BCL2L1 gene. The related lipids are Promega. The related experimental models are Xenograft Model, Knock-out and Mouse Model.
Cross Reference
Introduction
To understand associated biological information of butein, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with butein?
butein is suspected in Janiceps, Glomerulonephritis, Fibrosis, Liver, Kidney Failure, Acute, Mastocytosis, Chimera disorder and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with butein
PubChem Associated disorders and diseases
What pathways are associated with butein
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with butein?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with butein?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with butein?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with butein?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with butein?
Xenograft Model
Xenograft Model are used in the study 'Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo.' (Rajendran P et al., 2011).
Mouse Model
Mouse Model are used in the study 'Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo.' (Rajendran P et al., 2011).
Knock-out
Knock-out are used in the study 'Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo.' (Rajendran P et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with butein
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Negi S et al. | Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules. | 2018 | Toxicol In Vitro | pmid:29933105 |
| Liao W et al. | Butein Inhibited In Vitro Hexokinase-2-Mediated Tumor Glycolysis in Hepatocellular Carcinoma by Blocking Epidermal Growth Factor Receptor (EGFR). | 2018 | Med. Sci. Monit. | pmid:29777095 |
| Jayasooriya RGPT et al. | Molecular chemotherapeutic potential of butein: A concise review. | 2018 | Food Chem. Toxicol. | pmid:29258953 |
| Ansari MY et al. | Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1β Stimulated Human Chondrocytes. | 2018 | Cell. Physiol. Biochem. | pmid:30184535 |
| Alshammari GM et al. | Butein protects the nonalcoholic fatty liver through mitochondrial reactive oxygen species attenuation in rats. | 2018 | Biofactors | pmid:29672963 |
| Nam TG et al. | Stokes Extract and Its Flavonoids Protect PC-12 Cells against HO-Induced Cytotoxicity. | 2017 | J. Microbiol. Biotechnol. | pmid:28376611 |
| Wang Z et al. | Butein induction of HO-1 by p38 MAPK/Nrf2 pathway in adipocytes attenuates high-fat diet induced adipose hypertrophy in mice. | 2017 | Eur. J. Pharmacol. | pmid:28213287 |
| Padmavathi G et al. | Butein in health and disease: A comprehensive review. | 2017 | Phytomedicine | pmid:28190465 |
| Zheng W et al. | Butein inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes and slows the progression of osteoarthritis in mice. | 2017 | Int. Immunopharmacol. | pmid:27863298 |
| Ishikawa C et al. | Butein inhibits NF-κB, AP-1 and Akt activation in adult T-cell leukemia/lymphoma. | 2017 | Int. J. Oncol. | pmid:28586006 |
| Yang J et al. | [Butein promotes the role of mH2A in MAPK signaling pathway through targeting GRP78 in regulating biological behaviors of melanoma]. | 2017 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:29093242 |
| Mori M et al. | Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia. | 2017 | Sci Rep | pmid:28526832 |
| Molitor C et al. | Aurone synthase is a catechol oxidase with hydroxylase activity and provides insights into the mechanism of plant polyphenol oxidases. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26976571 |
| Lee DS and Jeong GS | Butein provides neuroprotective and anti-neuroinflammatory effects through Nrf2/ARE-dependent haem oxygenase 1 expression by activating the PI3K/Akt pathway. | 2016 | Br. J. Pharmacol. | pmid:27465039 |
| Song NJ et al. | Prdm4 induction by the small molecule butein promotes white adipose tissue browning. | 2016 | Nat. Chem. Biol. | pmid:27159578 |
| Choi HS et al. | Rhus verniciflua Stokes (RVS) and butein induce apoptosis of paclitaxel-resistant SKOV-3/PAX ovarian cancer cells through inhibition of AKT phosphorylation. | 2016 | BMC Complement Altern Med | pmid:27121110 |
| Tang YL et al. | Butein inhibits cell proliferation and induces cell cycle arrest in acute lymphoblastic leukemia via FOXO3a/p27kip1 pathway. | 2016 | Oncotarget | pmid:26919107 |
| Woo SM et al. | p53 causes butein‑mediated apoptosis of chronic myeloid leukemia cells. | 2016 | Mol Med Rep | pmid:26676515 |
| Yang EJ et al. | The comparison of neuroprotective effects of isoliquiritigenin and its Phase I metabolites against glutamate-induced HT22 cell death. | 2016 | Bioorg. Med. Chem. Lett. | pmid:27815122 |
| Song Z et al. | Butein and Its Role in Chronic Diseases. | 2016 | Adv. Exp. Med. Biol. | pmid:27671826 |
| Toprak M | Fluorescence study on the interaction of human serum albumin with Butein in liposomes. | 2016 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:26519918 |
| Lai YW et al. | Butein inhibits metastatic behavior in mouse melanoma cells through VEGF expression and translation-dependent signaling pathway regulation. | 2015 | BMC Complement Altern Med | pmid:26694191 |
| Zhang L et al. | Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38Â MAPK pathways by targeting FoxO3a. | 2015 | Int. J. Mol. Med. | pmid:26310353 |
| Kaintz C et al. | Site-directed mutagenesis around the CuA site of a polyphenol oxidase from Coreopsis grandiflora (cgAUS1). | 2015 | FEBS Lett. | pmid:25697959 |
| Lee SD et al. | Butein effects in colitis and interleukin-6/signal transducer and activator of transcription 3 expression. | 2015 | World J. Gastroenterol. | pmid:25593461 |
| Seo WY et al. | Butein, a tetrahydroxychalcone, suppresses pro-inflammatory responses in HaCaT keratinocytes. | 2015 | BMB Rep | pmid:25541056 |
| Sung J and Lee J | Anti-Inflammatory Activity of Butein and Luteolin Through Suppression of NFκB Activation and Induction of Heme Oxygenase-1. | 2015 | J Med Food | pmid:25692285 |
| Lee JH et al. | Antiplatelet effects of Rhus verniciflua stokes heartwood and its active constituents--fisetin, butein, and sulfuretin--in rats. | 2015 | J Med Food | pmid:25372471 |
| Padmavathi G et al. | Potential of butein, a tetrahydroxychalcone to obliterate cancer. | 2015 | Phytomedicine | pmid:26598915 |
| Sundarrajan S et al. | Computational evaluation of phytocompounds for combating drug resistant tuberculosis by multi-targeted therapy. | 2015 | J Mol Model | pmid:26323856 |
| Yang PY et al. | Butein Shows Cytotoxic Effects and Induces Apoptosis in Human Ovarian Cancer Cells. | 2015 | Am. J. Chin. Med. | pmid:26119952 |
| Bai X et al. | Butein suppresses cervical cancer growth through the PI3K/AKT/mTOR pathway. | 2015 | Oncol. Rep. | pmid:25962638 |
| Kojima R et al. | Butein suppresses ICAM-1 expression through the inhibition of IκBα and c-Jun phosphorylation in TNF-α- and PMA-treated HUVECs. | 2015 | Int. Immunopharmacol. | pmid:25533502 |
| Jung SK et al. | Butein, a novel dual inhibitor of MET and EGFR, overcomes gefitinib-resistant lung cancer growth. | 2015 | Mol. Carcinog. | pmid:24974831 |
| Zhang Q et al. | Inhibitory activities of Lignum Sappan extractives on growth and growth-related signaling of tumor cells. | 2014 | Chin J Nat Med | pmid:25156286 |
| Cho SG et al. | Butein suppresses breast cancer growth by reducing a production of intracellular reactive oxygen species. | 2014 | J. Exp. Clin. Cancer Res. | pmid:24919544 |
| Li Y et al. | Butein induces cell apoptosis and inhibition of cyclooxygenase‑2 expression in A549 lung cancer cells. | 2014 | Mol Med Rep | pmid:24337484 |
| Huang YT et al. | The depletion of securin enhances butein-induced apoptosis and tumor inhibition in human colorectal cancer. | 2014 | Chem. Biol. Interact. | pmid:24931875 |
| Liu SC et al. | Inhibitory effects of butein on cancer metastasis and bioenergetic modulation. | 2014 | J. Agric. Food Chem. | pmid:25137351 |
| Wang Z et al. | Inhibition of adipocyte inflammation and macrophage chemotaxis by butein. | 2014 | Eur. J. Pharmacol. | pmid:24877688 |
| Szuster-Ciesielska A et al. | Butein inhibits ethanol-induced activation of liver stellate cells through TGF-β, NFκB, p38, and JNK signaling pathways and inhibition of oxidative stress. | 2013 | J. Gastroenterol. | pmid:22722906 |
| Song NJ et al. | Butein is a novel anti-adipogenic compound. | 2013 | J. Lipid Res. | pmid:23468131 |
| Tesio AY et al. | Electrochemical oxidation of butein at glassy carbon electrodes. | 2013 | Bioelectrochemistry | pmid:23434740 |
| Lu M et al. | Butein inhibits NF-κB activation and reduces infiltration of inflammatory cells and apoptosis after spinal cord injury in rats. | 2013 | Neurosci. Lett. | pmid:23499960 |
| Lee DS et al. | Butein protects human dental pulp cells from hydrogen peroxide-induced oxidative toxicity via Nrf2 pathway-dependent heme oxygenase-1 expressions. | 2013 | Toxicol In Vitro | pmid:23318726 |
| Khan N et al. | Butein induces apoptosis and inhibits prostate tumor growth in vitro and in vivo. | 2012 | Antioxid. Redox Signal. | pmid:22114764 |
| Cui Z et al. | Butein induces apoptosis in human uveal melanoma cells through mitochondrial apoptosis pathway. | 2012 | Curr. Eye Res. | pmid:22578288 |
| Chen YH et al. | Generation of reactive oxygen species mediates butein-induced apoptosis in neuroblastoma cells. | 2012 | Oncol. Rep. | pmid:22245810 |
| Cioce M et al. | Butein impairs the protumorigenic activity of malignant pleural mesothelioma cells. | 2012 | Cell Cycle | pmid:22185775 |
| Chen YN et al. | Antirestenosis effect of butein in the neointima formation progression. | 2012 | J. Agric. Food Chem. | pmid:22690754 |
| Yang LH et al. | Butein inhibits the proliferation of breast cancer cells through generation of reactive oxygen species and modulation of ERK and p38 activities. | 2012 | Mol Med Rep | pmid:22895548 |
| Jang JH et al. | Inhibitory effect of butein on tumor necrosis factor-α-induced expression of cell adhesion molecules in human lung epithelial cells via inhibition of reactive oxygen species generation, NF-κB activation and Akt phosphorylation. | 2012 | Int. J. Mol. Med. | pmid:23064245 |
| Sehrawat A and Kumar V | Butein imparts free radical scavenging, anti-oxidative and proapoptotic properties in the flower extracts of Butea monosperma. | 2012 | Biocell | pmid:23185781 |
| Rajendran P et al. | Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo. | 2011 | Clin. Cancer Res. | pmid:21131551 |
| Jeong GS et al. | Butein from Rhus verniciflua protects pancreatic β cells against cytokine-induced toxicity mediated by inhibition of nitric oxide formation. | 2011 | Biol. Pharm. Bull. | pmid:21212525 |
| Sung B et al. | Butein, a tetrahydroxychalcone, suppresses cancer-induced osteoclastogenesis through inhibition of receptor activator of nuclear factor-kappaB ligand signaling. | 2011 | Int. J. Cancer | pmid:21170936 |
| Ma CY et al. | Butein inhibits the migration and invasion of SK-HEP-1 human hepatocarcinoma cells through suppressing the ERK, JNK, p38, and uPA signaling multiple pathways. | 2011 | J. Agric. Food Chem. | pmid:21770460 |
| Yang YC et al. | Induction of glutathione synthesis and heme oxygenase 1 by the flavonoids butein and phloretin is mediated through the ERK/Nrf2 pathway and protects against oxidative stress. | 2011 | Free Radic. Biol. Med. | pmid:21964506 |
| Szuster-Ciesielska A et al. | Betulin, betulinic acid and butein are inhibitors of acetaldehyde-induced activation of liver stellate cells. | 2011 | Pharmacol Rep | pmid:22180353 |
| Kantevari S et al. | Synthesis and evaluation of novel 2-butyl-4-chloro-1-methylimidazole embedded chalcones and pyrazoles as angiotensin converting enzyme (ACE) inhibitors. | 2011 | Bioorg. Med. Chem. | pmid:21782455 |
| Moon DO et al. | Butein suppresses the expression of nuclear factor-kappa B-mediated matrix metalloproteinase-9 and vascular endothelial growth factor in prostate cancer cells. | 2010 | Toxicol In Vitro | pmid:20696233 |
| Chua AW et al. | Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells. | 2010 | Biochem. Pharmacol. | pmid:20699088 |
| Lau GT et al. | Butein downregulates phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in cancerous and non-cancerous breast cells. | 2010 | Eur. J. Pharmacol. | pmid:20826149 |
| Chang HC et al. | Butein up-regulates the expression of the π class of glutathione S-transferase in rat primary hepatocytes through the ERK/AP-1 pathway. | 2010 | J. Agric. Food Chem. | pmid:20681544 |
| Moon DO et al. | Butein induces G(2)/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation. | 2010 | Cancer Lett. | pmid:19643530 |
| Moon DO et al. | Butein sensitizes human hepatoma cells to TRAIL-induced apoptosis via extracellular signal-regulated kinase/Sp1-dependent DR5 upregulation and NF-kappaB inactivation. | 2010 | Mol. Cancer Ther. | pmid:20515942 |
| Schlangen K et al. | Cloning, functional expression, and characterization of a chalcone 3-hydroxylase from Cosmos sulphureus. | 2010 | J. Exp. Bot. | pmid:20566567 |
| Rasheed Z et al. | Butrin, isobutrin, and butein from medicinal plant Butea monosperma selectively inhibit nuclear factor-kappaB in activated human mast cells: suppression of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8. | 2010 | J. Pharmacol. Exp. Ther. | pmid:20164300 |
| Song DG et al. | Inhibitory effects of polyphenols isolated from Rhus verniciflua on Aldo-keto reductase family 1 B10. | 2010 | BMB Rep | pmid:20423612 |
| Pandey MK et al. | Butein suppresses constitutive and inducible signal transducer and activator of transcription (STAT) 3 activation and STAT3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1. | 2009 | Mol. Pharmacol. | pmid:19103760 |
| Moon DO et al. | Butein suppresses c-Myc-dependent transcription and Akt-dependent phosphorylation of hTERT in human leukemia cells. | 2009 | Cancer Lett. | pmid:19560862 |
| Wang G and Ma C | [Studies on phenolic compounds from Sophora alopecuroides]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19673386 |
| Kim N | Butein sensitizes human leukemia cells to apoptosis induced by tumor necrosis factor-related apoptosis inducing ligand (TRAIL). | 2008 | Arch. Pharm. Res. | pmid:18806962 |
| Zhang L et al. | A novel anticancer effect of butein: inhibition of invasion through the ERK1/2 and NF-kappa B signaling pathways in bladder cancer cells. | 2008 | FEBS Lett. | pmid:18472007 |
| Rothweiler U et al. | NMR screening for lead compounds using tryptophan-mutated proteins. | 2008 | J. Med. Chem. | pmid:18680271 |
| Lee EH et al. | Inhibitory effect of the compounds isolated from Rhus verniciflua on aldose reductase and advanced glycation endproducts. | 2008 | Biol. Pharm. Bull. | pmid:18670102 |
| Brown AK et al. | Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II. | 2007 | Microbiology (Reading, Engl.) | pmid:17906131 |
| Lee SH et al. | Butein blocks tumor necrosis factor alpha-induced interleukin 8 and matrix metalloproteinase 7 production by inhibiting p38 kinase and osteopontin mediated signaling events in HT-29 cells. | 2007 | Life Sci. | pmid:17977560 |
| Kim SY et al. | Butein suppresses bile acid-induced hepatocyte apoptosis through a JNK-dependent but ERK-independent pathway. | 2007 | Planta Med. | pmid:17592815 |
| Pandey MK et al. | Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue. | 2007 | J. Biol. Chem. | pmid:17439942 |
| da-Silva WS et al. | The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation. | 2007 | Diabetes | pmid:17327447 |
| Sharma SK et al. | Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR). | 2007 | J. Med. Chem. | pmid:17263522 |
| Sanchez-Gonzalez M and Rosazza JP | Biocatalytic synthesis of butein and sulfuretin by Aspergillus alliaceus. | 2006 | J. Agric. Food Chem. | pmid:16787010 |
| Wright DC et al. | Are tyrosine kinases involved in mediating contraction-stimulated muscle glucose transport? | 2006 | Am. J. Physiol. Endocrinol. Metab. | pmid:16159907 |
| Samoszuk M et al. | The chalcone butein from Rhus verniciflua Stokes inhibits clonogenic growth of human breast cancer cells co-cultured with fibroblasts. | 2005 | BMC Complement Altern Med | pmid:15757513 |
| Wang Y et al. | The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase. | 2005 | Life Sci. | pmid:15848217 |
| Lee SH et al. | Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by butein in RAW 264.7 cells. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15351711 |
| Lee HW et al. | Determination of butein in rat serum by high performance liquid chromatography. | 2004 | J Pharm Biomed Anal | pmid:14738938 |
| Herles C et al. | First bacterial chalcone isomerase isolated from Eubacterium ramulus. | 2004 | Arch. Microbiol. | pmid:15127184 |
| Kang DG et al. | Butein ameliorates renal concentrating ability in cisplatin-induced acute renal failure in rats. | 2004 | Biol. Pharm. Bull. | pmid:14993804 |
| Kang DG et al. | Hypotensive effect of butein via the inhibition of angiotensin converting enzyme. | 2003 | Biol. Pharm. Bull. | pmid:12951484 |
| Woo SW et al. | Butein suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture. | 2003 | J. Pharm. Pharmacol. | pmid:12724040 |
| Zhu L and Xu X | Selective separation of active inhibitors of epidermal growth factor receptor from Caragana jubata by molecularly imprinted solid-phase extraction. | 2003 | J Chromatogr A | pmid:12741595 |
| Lee SH et al. | The chalcone butein from Rhus verniciflua shows antifibrogenic activity. | 2003 | Planta Med. | pmid:14735434 |
| Yang EB et al. | Inhibition of epidermal growth factor receptor tyrosine kinase by chalcone derivatives. | 2001 | Biochim. Biophys. Acta | pmid:11755203 |
| Kim NY et al. | Butein, a plant polyphenol, induces apoptosis concomitant with increased caspase-3 activity, decreased Bcl-2 expression and increased Bax expression in HL-60 cells. | 2001 | Pharmacol. Toxicol. | pmid:11393587 |
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